Sequences used in Protein Phylogenies Accession numbers, alignments, and QML trees. (Trees are drawn in unrooted fashion, with branches not proportional to the amount of evolutionary change. * indicates outgroup sequences used to root trres.) Actin P45520 Lesimania major CAC22667 L. major actin a AAL83658 L. donovani P53477 Trypanosoma cruzi P12432 T. brucei actin A A27724 T. brucei actin 1 P12433 T. brucei actin B B27724 T. brucei actin 2 *AAC99646 Euglena gracilis P45520 -MADNEQSSIVCDNGSGMVKAGFSGDDAPRHVFPSIVGRPKNMQAMMGSANKTVYVGDEAQSKRGVLSLKYPIEHGIVTNWDDMEKIWHHTFYNDVRVNPEQHNVLLTEAPMNPKQNREKMTQIMFETFNVPSLYIGIQAVLSLYSSGRTTGIVLDAGDGVTHTVPIYEGYSLPHAVRRVDMAGRDLTEYLMKIMMETGTTFTTTAEKEIVRNVKEQLCYVALDFEEEMTNSAKSAN-EEAFELPDGNVMMVGNQRFRCPEVLFKPSLIGLDEAPGFPEMVYQSINKCDIDVRRELYGNIVLSGGSTMFLNLPERLAKEISNLAPSSIKPKVVAPPERKYSVWIGGSILSSLTTFQTMWVKKSEYDESGPSIVHNKCF CAC22667 -MADNEQSSIVCDNGSGMVKAGFSGDDAPRHVFPSIVGRPKNMQAMMGSANKTVYVGDEAQSKRGVLSLKYPIEHGIVTNWDDMEKIWHHTFYNELRVNPEQHNVLLTEAPMNPKQNREKMTQIMFETFNVPSLYIGIQAVLSLYSSGRTTGIVLDAGDGVTHTVPIYEGYSLPHAVRRVDMAGRDLTEYLMKIMMETGTTFTTTAEKEIVRNVKEQLCYVALDFEEEMTNSAKSAN-EEAFELPDGNVMMVGNQRFRCPEVLFKPSLIGLDEAPGFPEMVYQSINKCDIDVRRELYGNIVLSGGSTMFLNLPERLAKEISNLAPSSIKPKVVAPPERKYSVWIGGSILSSLTTFQTMWVKKSEYDESGPSIVHNKCF AAL83658 -MADNEQSSIVCDNGSGMVKAGFSGDDAPRHVFPSIVGRPKNMQAMMGSANKTVYVGDEAQSKRGVLSLKYPIEHGIVTNWDDMEKIWHHTFYNELRVNPEQHNVLLTEAPMNPKQNREKMTQIMFETFNVPSLYIGIQAVLSLYSSGRTTGIVLDAGDGVTHTVPIYEGYSLPHAVRRVDMAGRDLTEYLMKIMMETGMTFTTTAEKEIVRNVKEQLCYVALDFEEEMTNSAKSAN-EEAFELPDGNVMMVGNQRFRCPEVLFKPSLIGLDEAPGFPEMVYQSINKCDIDVRRELYGNIVLSGGSTMFRNLPERLAKEISNLAPSSIKPKVVAPPERKYSVWIGGSILSSLTTFQTMWVKKSEYDESGPSIVHNKCF P53477 -MSDEEQSAIVCDNGSGMVKAGFSGDDALCHVFPSIVGRPKNEQAMMGSASKKLFVGDEAQAKRGVLSLKYPIEHGIVTNWDDMEKIWHHTFYNDVRVNPESHSVLLTEAPMNPKQNREKMTQIMFETFGVPAMYVGIQAVLSLYSSGRTTGIVLDAGDGVTHTVPIYEGYSLPHAIRRMDMAGRDLTEYLMKLLMESGMTFTTSAEKEIVRNVKEQLCYVALDFDEEVTNSAKTVN-EEPFELPDGTIMQVGNQRFRCPEALFKPMLIGLDEAPGFHEMTFQSINKCDIDVRRDLYGNIVLSGGTTMFKNLPERLGKEISNLAPSSIKPKVVAPPERKYSVWIGGSILSSLTTFQTMWIKKSEYDEAGPSIVHNKCF P12432 -MSDEEQTAIVCDNGSGMVKSGFSGDDAPRHVFPSIVGRPKNEQAMMGSANKKLFVGDEAQAKRGVLALKYPIEHGIVTNWDDMEKVWHHTFYNELRVNPESHNVLLTEAPMNPKQNREKMTQIMFETFGVPAMYVGIQAVLSLYSSGRTTGIVLDAGDGVTHTVPIYEGYSLPHAIRRVDMAGRDLTEYLMKILMHTGMTFTTSAEKEIVRNIKEQLCYVALDFDEEMTNSAKSVS-EEPFELPDGNVMQVGNQRFRCPEALFKPALIGLDEAPGFHEMTFQSINKCDIDVRRDLYGNIVLSGGTTMFKNLPERLAKEISNLPPSSIKPKVVAPPERKYSVWIGGSILSSLTTFQSMWITKSEYDESGPSIVHSKCF A27724 -MSDCEQTAIVCDNGSGMVKSGFSGDDAPRHVFPSIVGRPKNEQAMMGSANKKLFVGDEAQAKRGVLALKYPIEHGIVTNWDDMEKVWHHTFYNELRVNPESHNVLLTEAPMNPKQNREKMTQIMFETFGVPAMYVGIQAVLSLYSSGRTTGIVLDAGDGVTHTVPIYEGYSLPHAIRRVDMAGRDLTEYLMKILMETGMTFTTSAEKEIVRNIKEQLCYVALDFDEEMTNSAKSVS-EEPFELPDGNVMQVGNQRFRCPEALFKPALIGLDEAPGFHEMTFQSINKCDIDVRRDLYGNIVLSGGTTMFKNLPERLGKEISNLAPSSIKPKVVAPPERKYSVWIGGSILSSLTTFQSMWITKSEYDESGPSIVHSKCF P12433 -MSDEEQTAIVCDNGSGMVKSGFSGDDAPRHLFPSIVGPPKNEQAMMGSAKQEMFVGDEAQAKRGVLALKYPIEHGIVTNWDDMEKVWHHTFYNELRVNPESHNVLLTEAPMNPKQNREKMTQIMFETFGVPAMYVGIQAVLSLYSSGRTTGIVLDAGDGVTHTVPIYEGYSLPHAIRRVDMAGRDLTEYLMKILMETGMTFTTSAQKEIVRNIKEQLCYVALDFDEEMTNSAKSVS-EEPFELPDGNVMQVGNQRFRCPQALFKPALIGLDEAPGFHEMTFQSINKCDIDVRRDLYGNIVLSGGTTMFKNLPERLGKEISNLAPSSIKPKVVAPPERKYSVWIGGSILSSLTTFQSMWITKSEYDESGPSIVHSKCF B27724 -MSDEEQTAIVCDNGSGMVKSGFSGDDAPRHVFPSIVGRPKNEQAMMGSAKQEMFVGDEAQAKRGVLALKYPIEHGIVTNWDDMEKVWHHTFYNELRVNPESHNVLLTEAPMNPKQNREKMTQIMFETFGVPAMYVGIQAVLSLYSSGRTTGIVLDAGDGVTHTVPIYEGYSLPHAIRRVDMAGRDLTEYLMKILMETGMTFTTSAEKEIVRNIKEQLCYVALDFDEEMTNSAKSVS-EEPFELPDGNVMQVGNQRFRCPEALFKPALIGLDEAPGFHEMTFQSINKCDIDVRRDLYGNIVLSGGTTMFKNLPERLGKEISNLAPSSIKPKVVAPPERKYSVWIGGSILSSLTTFQSMWITKSEYDESGPSIVHSKCF AAC99646 MAEEIEQQALVCDNGSGMVKAGFAGDDAPRCVFPSIVGRRKNDSAMMGTAKKDAYIGDDAQAKRGILFIKYPIEHGIVTNWDDMEKIWHHTFFNELRVAPEDHPVLLTEAPMNPKSNREKMTQIMFETFNVPALYVSIQAVLSLYSSGRTTGIVLDCGDGVSHTVPIYEGYSLPHAVLRIDMAGRDLTDYMMKLLTERGLSFTTSAEREIVRDVKEKLCYVALDFDEEMSLATSSSSVEKEYELPDGNIIQVGSERFRCPEVLMKPSMIGL-EACGVHETTFNSINKCDIDVRKDLYSNIVLSGGTTMYEGLPERMSKEITNLAPNSMKIKVVAPPERKYSVWIGGSILASLSTFQSMWIKKEEYDEAGPGIVHRKCF QUARTET PUZZLING TREE :---P12433 :-97: : :---B27724 :100: : :-------P12432 :100: : : : :-------A27724 : : : :-----------P53477 : : :---P45520 : :-99: :----100: :---CAC22667 : : : :-------AAL83658 : :---------------AAC99646 Adenylate cyclase Q25263 L. donovani Q27675 L. donovani CAA09737 T. cruzi AAC32776 T. cruzi AAC61849 T. cruzi CAA09919 T. cruzi Q99279 T. brucei CAD21877 T. brucei CAD21883 T. brucei Q26721 T. brucei Q99280 T. brucei AAF69135 T. brucei *P14605 Schizosaccharomyces pombe Q25263 ---------------MYADATHPRRACWCGAG---GVSGCVRQRHAYRCSRLLAGVLLIVGALTLTLAVSTVPAAWAAGAVASSDEPVYLLNAMYSLSDYNAKHAKALWLGIDSALHAVGYTAARGRP----IKIIEPDP--T-----DDLSDIVAVVLKAL-----KDYPT---LLGVIGPYSDTRLGAVLISPEIQN------SGLMFLGPFTG-------------------SSSMRAWNENLYFMRAE-------PR-----LEIMAMVKHIANTFRARR--TA------FMYLTGEQYGSFEHKSLVELMTSLSLDPPA-VYSASYS-TSTAVNMTAFD----AMADTRPQVII-----IWGIPAGQVEEL-------LKVVLTDP-RTSSAYIMPSFALQ--QMTFQVYYDLAMAGKLTPVD--GQIISSATSF-PLTEPASVHLRVFRAQMGEYMVKTGRVDASLWADEAKAVQQYGPWEHEASSSDSAAYVNNFFN--EHPCVTQLMIAG--WISGSLIAQTLAEENRI----ANRTAY--RQYMFSQQRYIVGEDFVLGDYG---GPCNGVAEFLGAVCYC-NQGGHSAVLSRLDRAVWT--------VITES--GVSFTQKNC-------YSDGTTLPRPLNFLTLIFAEHPLLAQVGLTFKTSISTLVA---YLQYNASPVNAATVN----VTDTTPQALHDAVTTNYTTDVVVG-VTVKGMNVDGYLVPSP----IHPRP----HLV-----ELLRNYVY--LMPT-----LEQ---QMFVLYAKLSAVRGVTSIDSAVHMILHGY-----ASDEVANITAVLRKSAATFNYDNPTVTAVPS----TKTVGSALAHGQINFV-LAVTAADVADIVDFLVEEKTSIVVIVFDDLVIQYPTLVTALKSKPAS--VQARVITFTNLPLWSDTSESAHAASKLLTVFHDALPDPSQHTPGFLSAVLTGSFCASMRRLADSVHSTSLTDMVYREGSVTTF-----AEPFGRFQWGCTTT---PTDRFCVYHNYGAQGIVMLSVQRMLDPTVPQLSSPMTPTMDYRPRQRSHALTPAQRGGAIAGIALLTVILLAVA------GLA-LYCCMD----NRNNDAAPKDGDEPVTLLFT--------DIESSTALWAALPQLMSDAIAAHH-RVIRQLVKK--YGC----YEVKT-----IG--DSFMIACRSAHSAVSLACEIQTKLLKHDWGTEALDRAYREFELARVDTLDDYEPPTARLSEEE-YAALWCGLRVRVGIHTGLTD-------IRYDEVTRGY-----------DYYGDTSNMAARTEAVANGGQVVATEAAWWALSND-ERAGIAH-------TAMGPQGLR---GVPFAVE----MFQLNAVPGRRHAALRTEIEAILPDDTATDTASSAAGALLSSVGTINGPAA--GIAFVLASCFAPY-PVAQRVRELQPLLSK-WGVGAPPRSRLVSEEDYCQGLMNRLAIRIAT-------------------VSQARCPVGNNGAAVDLDVQHAGTA--EVMNPLLGEGSFISDGARARHSG--LTAVPPSAEPSAMRMRRVGRK---VP---ERPTVCNVRGAH---------------------------------------------------------------------------------------------------- Q27675 ----------------MAMQIRPSLGGCLRHG---GAG----DHAARRLSRLRAAKVFVPTAVVCVLLC-CAPWVMAEITNDAEREPVYILNAMYSTEAYTNEDAKALWTGMDMAFYNSHYKAAGGRP----IKILHPDPD-Q-----DNLYDIAEVILHSL-----ARQEK---LLAVLGPYLDGRLTAALSNADVVQ------SGLMLIAPFTG-------------------SSGVRTWSDSVYFTRAE-------PM-----VELKVVLMHIVNRLRARR--VA------FMRLTGMHFGGEELTYVQDTLTSLLRDPAV-LYTVPYSESSVEVDEEAFD----AMADTNPQVII-----VWAAPVQQVIYF-------LEKVLTDP-RTSSAYVISCSMIQ--RVVFDVYKRLLSAGSIKPQD--GRILASATTS-PVSGEGLKYMEVLKAQMSNYIENSGSFDYYPDDDSTETLGRKARSEAPLSR---KYTVDEFFQ--AHPSIAKLMALG--WLSGTLVQQTLEQTDWI----VNRSTY--KAGLFNQNRFVIGGDYVLGDYG---GPCEPLAQFLGASCYC-NQGGHSSILTVLQNASWD--------IVPDS--SFKYPQSEC-------NSSKSQIVKAVSVLALLNQGYPKLIDAGMQLNEVLPHAFD---DNLCKGYKVSSIFLR----VETAKAQQLFDAEVSNYSVDIIAG-PIFQALDVGEIFVLNP----LYNHP----QLR-----TEKRNYVY--LMPT-----LEQ---QIYVMYSKIDALRTRTDVFEDTAVVLRGY-----SAQEVVEISEILFKTAGTFNLPDPSVATISF----TDSLRGLLSPRAINVV-IGMKDGDSAHFANFLAKYTDVMVVVCFDELTMYYEELRATFSVQPTS--VQARLMSFSSLPLWTDASAEAKARWPILGHFHKIFPDPINHTPSLLRDVIIAGFIQELVSTTTVAETKLLTNAVYINGGVTTY-----GFTLGNFEWGCTAT---TSGDSCVYKNYGASNIEILSIQRMLDPTVPQLSSPSTPTMEYRPRQRSHALTPAQRNGLIAGCVVGAVVLIATC------TLL-LYCCMD----NRNNDAAPKDGDEPVTLLFT--------DIESSTALWAALPQLMSDAIAAHH-RVIRQLVKK--YGC----YEVKT-----IG--DSFMIACRSAHSAVSLACEIQTKLLKHDWGTEALDRAYREFELARVDTLDDYEPPTARLSEEE-YAALWCGLRVRVGIHTGLTD-------IRYDEVTKGY-----------DYYGDTSNMAARTEAVANGGQVVATEAAWWALSND-ERAGIAH-------TAMGPQGLR---GVPFAVE----MFQLNAVPGRRHAALRTEIEAILPDDTATDTASSAAGALLSSVETMSDPAA--GIAFVLASCFAPY-PVAQRVRELQPLLSK-WGVGAPPRSRLVSEEDYCQGLMNRLAIRIAT-------------------VSQARLRLTR-EDAADGKFKLA-SS--EALNPLAREGDSAAGGVRPRLPGSPVTSLPAGGS-SSMREWRVFTR---LMNDTQHPSVTHLSQQRPSNLTSFTEAQDAAFPLNAHCGPESRVENSGADDEEIVIVRVSRNPHYARHAFE---------------------------------------------- CAA09737 --------------------MVTGWAVMMAAA---RQGPGL-HKETGCCGGIPLLGWRLSTYALYLVLLLLLLPQSGVGQAACPEIEVKVLTLNVTDLPIPTYLSESLYHGFVAALWSRNYIVGDNVR----VTFINKLT--------TMAESGKAVEEAFQ-----ANPS----IFILANAIGDA--TLEYYLPVIRN------REIISFAPFTG-------------------STVIRGWDPYLYFVRAD-------PL-----AELFALIRYALTFLRVRR--LG------FMYLEDVSFGDEEYEATKNVMTRFGYNLSG-VFAVKSSLA-HEAENSVFDAAWEAFANTRPQAVI-----VFGAPVKDTAKF-------VQRMLTDN-RTAGAYLLAPSAVQ--DVAVETWRSAVKDD-IKFVS--GQVITTVTNP-LADDTRYAAIRRFQDVMG----EFLP-----------------------GK---QCFSQGTFP--DNAIAGEMMVAG--WIAGEILSQTLSSREWA----KNRDAY--LASLYNQRRYMV-DNLVIGDYG---GSCQGVAESEGAMCYC-NQGGRTVYMKEFVDGHRA--------DPLVD-GTISFRTWEC-------NPSEAVIVPPLNGFAIAMRDNPLAIFALRAFGVGAKAAVN--NNSLIRRFAFTVNFVN----STVDGAAAALVSELKVKLVDVVAGVVTKGMLEVEDVAFIDP----IYLQP----RIG-----RFRKNVIR--LLPT-----LEQ---QFFVIAEYLGKK-----SDGLAHAVIR--------SDDGATMANVLRLSLDTFGGSLLSTKQLAG----GDVLVDHLPEEGDVLV-VGISAEDVGAIAQHVVSHDGVRVFVIFLEFSMLYPEFVAAFRDGAG----ADRVVFATNLPHWNDD----KATSVTAQKFNAAVPDVNKRTPLAMMGFTTGLLLA-VRSRMEKVSVEPFENFFFSNVAVRVD-----DMLYGPFIDGNACP--VIQSGAGCGRNYGATQISVWPLARALDPAVPVLSPAVTPSMEYRMPVAS-GLTARQLTGTIVGSVVAALLLIALI------LLL-LHFCRD----SRDNANAPKERKDPVTLVFT--------DIESSTALWAACPEAMPDALATHH-RLIRSLIAK--YRC----YEVKT-----IG--DSFMIACKNAFAAVQLVRELQQVFLQHDWGTSVIDDAYHRFEEDRAEDDEEYVPPTARLDDAV-YRQYWDGLRVRVGMHTGLCE-------IRHDEVTKGY-----------DYYGATSNMAARTESVGNGGQVLLTRAAYFALSTA-EREQVEV-------TALGGVALR---GVPKPVE----MYQLDAVPVRTFAALRLDRD--VPDLDDG--SDFESSEDAFMYSARTGTVQ--AVVSVLTVTYGTL-AAPQRLKALMLLCER-WNVRLPRRPSLVQDEEYCRLVIARLAVKISN-------------------VMERKAQLGMDQNMSFTLSATAPGA--HDTASGTWGRRGGEQVHARRFR---------------EAAPQS-------------NSVEVHN---------FAADEPQFLTDDSVVTVRARRFR----------------------------------------------------------------------- AAC32776 --------------------MVTGWAVMMAAA---RQGPGL-HKKTGCCGGIPLLGWRLSTYALYLVLLLLLLPRSGVGQAACPEINVNVLTLNVTDLPMPAYLSEALYYGFVAALWSRKYVVGENVR----VTLINKST--------TIAESGNSVEKAFQ-----DNPG----IFILANVIGDK--NLQYYLPVIRD------RKIISFAPFTGST-----------------STVIRGWDPYLYFVRAD-------PL-----AELFTLIRYALTFLRVRR--LG------FMYLEGVSFGDEEYEATKNVMTRFGYNLSG-VFAVKSSLA-HEAENSVFDAAWEAFANTLPQAVI-----VFGAPVKDTAKF-------IQRMLTDN-RTAGAYLLAPSAVQ--DITVETWRSAVAGG-IKFVS--GQVITTGTNP-VARDIQYAAIRRFQDVMRRFMEKFLP-----------------------ES---SSIRK-KFP--DDDIEGEMMVAG--WIAGEILSQTLSSREWA----NNRDAY--LASLYNQRRYMV-DNLVIGDYG---GSCQGVAESEGAMCYC-NQGGRTVYMKKFVDGHRA--------DPLVD-GTISFWTWQC-------SPSEAVIVPPLNGFAIAMRDNPLAIFALRAFGVGARAAVV--NNSLIKRFAFTVQVVN----STVDGAAAALVSELKVKLVDVVTGVVTKGMLEVEDVAFINP----MYLQP----RIG-----RFRKNVIR--LLPT-----LEQ---QFFVIAEYLGNV-----SDGSVHAVIR--------GDDGATMAEVLRLSLETFGGSLLSTKLLAG----GDKMADHLPEEGDVFV-VGISADDVGAIAQHVVSHDGVRVFVIFLEFSMLYPEFVAAFRDGAG----ADRVVFATNLPHWNDD----KTTSVTAQKFNAAVPEVNKRTPLAMMGFTTGLLVVTVRSRMEKVNVELFENFFFSNVAVRVD-----DMLYGPFIDGNACP--VTQSGAGCGRNYGATQISAWSLARALDPAVPALSPAVTPSMEYRMPVAS-GLTARQLIGVIVGSVAAALLLIALI------LLL-LHFCRD----SRDNENAPKERTDPVTLVFT--------DIESSTALWAACPEAMPDAVATHH-RLIRSLIAK--YHC----YEVKT-----IG--DSFMIACKSVFAAVQLVRELQQMFLQQDWGTSVIDDAYHKFEEDRAENDEEYVPPTARLDDAV-YRQYWNGLRVRVGVHTGLCD-------IRRDEVTKGY-----------DYYGGTSNMAARTESVGNGGQVLLTRAAYMSLSTA-EREQVEV-------TALGGVALR---GVPVPVE----MYQLDAVPGRTFAALRLDRE--MPDLDDG--SDFESSEDVSMYSARTGTAQ--AVVSVLTVTYGTL-APRQRLKALMPLCER-WNVRLPRRPSFLQDEEYCRLVIDRLAVKMSS-------------------VMERKGQLGMDQNMSFTLSATAPGA--HDPASGTGGRRGGEQAHARRFRRRRR---KVILSRCILLRPTSRVP---RWMIRLLLSVLVASGNLGNVCCRLLCFMSFFTAADGSRLPLAPHTRPAQMYWM---------------------------------------------------------------- AAC61849 --------------------MAVGWVAVWPRE---RRA----------CA---A--S-RCLFVALLLLLDL--PY-AVAQPSGGDRVVKVVSF-EFDFTLLDAFFRNIMAGFKASLHSRNNSIMNGVR----VEIVEKK---------TKFTNYAIDLSAAL-----KDEND---IFAVVGHCGDK--LLLNIKDVLAE------RDVVAFSPFTG-------------------SSLVRGWNPNFYFLRAE-------PA-----AELLALLRYALAHLRVRR--LG------FMYLQGVSFGDREYAQAQRVMSERNLTFSG-VFSVESSVT-GGARKEVFDAAWEAFADTRPQAVI-----VFGSPITDTAEF-------FRRMLTDR-RTAGAYLLAPSLLQ--ELVLRVWRAAVAGG-VEFVP--GQVITTGTNP-LAKDTQYEAIQRFQEVMRAY-LTHSG-----------------------QK---DYADKDHFL--KDDGDGEMMVAG--WIAGEVLSQALGSREWV----KDRKSF--LASLYNQRRYMV-DDIVIGDYG---GECKAGAASQGAACRC-NQGGRTVYIKKFVESFR---------AVYADWGTLVVPLSEC-------EASGLMLRGTLNGVGFMLVDIPPVSKVISELRKGFYGGRMMHNAFLITSDEVSMQLIS----STRNGAPDALRETMEAKRVDFVGGVVTEAMLEMEGVDFIDP----LLLEP----RLN-----RFRRNVMC--LSPT-----LEQ---QFFVLAEYLGNA-----SGGSAHAVIR--------SGEAAAMADVLRRSLLTFGVSLASATLLAG----GDALVDHLPVEGDVFV-VGLSAGDAGAIARHVSSHGGVRVFVVFLEFALLHAEFVAAFRDGAG----ADRVVFATSLPHWNDR----GSASETARKFAAAVTREEDRTPLSLMSFAATRLVHTALSRMYRVSAEQLADFFYNNVAVAVD-----DMLYGPFADGRACP--ATESGAGCGRNYGATRISVWPLARALDPAVPELFPAVTPSMKYADPAAG-GLTARLLIGVIAGCAAA-LLLVAVL------RY----FSHS----SRDNANAPKERLHPVTLVFT--------DIESSTALWAACPETMPDAVATHH-RLIRSLIAK--YRC----YEVKT-----IG--DSFMIACKSAFAAVQLVRELQQVFLQHDWGTSVIDDAYRMFEEDRAEEDAEYVPPTARLDAAV-YRQYWNGLRVRVGVHTGLCD-------IRHDEVTKGY-----------DYYGGTSNMAARTESVGNGGQVLLTRAAYFALSTA-EREQVEV-------TALGAVALR---GVPKLVE----MYQLDAVPGRVVAGLRLDKD--DGAVDDY--SDCASG-SSGASRNTCYES----AVSFISGLMSPY-ASRQRAGVLESLCRR-WRVRVVE-KGVMSYDDYCAALVERLAGRVSR-------------------VIGYRVDG--LSG-VSLAEIAAASA--VSSQRQSRIRSFQFIGRSGSSSCTELSSVVSPVDGSEALPQESLVC---PIVMRPTVLRELGWR----------VHVSSVTSYSDSLDPDAMRPRGHEVCVTCQLSFFLSVDVLLCFSDGAIFVGSPSIPQ----------------------------------- CAA09919 ----------------------MRWVAA-P-----------------------------YLFFALILLLALFSPQGAISQAAVTDIHVRLWLMRKINQSSLKDTALAFYSGMNASLWARKFIVVEGVR----VEVVEKEE--------VQEDNIAALEEDIR-----KDEN----VLALVGMQSQG--FLRLVLPLLKK------YDLVSFAPFTG-------------------SSLLSGWNPNLYLVRAE-------PA-----AELLALLRHALANMHVIR--VG------FMYLQGVSFGDGEYAQAQRMMSERNLTFSG-VFSVESSVT-GGAKKEVFDAAWEKFADTRPQAVI-----AFAPPIQDTIKF-------IGRMLTDR-RTAGAYILLPLILQ--DLVLLLPRAAVAGG-VDFVP--GQVIRTGTNP-LGRNTEYKAIQRFQEVMEDY-LAHSG-----------------------QK---DYADKDHFL--KDDGDGEMMVAG--WIAGEVLSQALGIREWV----KDRKSF--LASLYNQRRYVV-DDIVIGNYG---GECEPGAASRGAACLC-NQGGRNVYIKAIMDGCRL--------KPFED--VMQFRVSVC-------GALGVKFPPFFVGMYLLMNDTAVAQKACHQFGIMFKVASSRHHDWWGKRRVFCGTFMQF---NTHDSAGD-LRSALQSWRVEGVIGVATDAMLEVEGVVFIDP----LLLEP----RLN-----RFRRNVIR--LSPT-----LEQ---QFFVLAEYLGNT-----IGGSARAVIR--------GEEASAMADLLRWSLLTFGMSLAPATLLAG----GDTLVDHLPVEGDVFV-VGLSPGDARAIAPHVAFHRGVPLFLLFSEFALLHPQFVAAFRESAG----ADRVVFATSLPHWNDR----VSASETARKFAAAVTREEDRTPLSLMGFAATRLVHTVFSRMHHLSAKLLTEL-YKNVAVPVD-----DMLYGSFADGRACP--ATESGAGCGRNYGATRISVWSLARALDPAVPELFHAVTPSMKYADPAAG-RLTTRQLIGVIAGCAAAALLLVAVL------LY----FCRG----SRDNANAPRERTDPVTLVFT--------DIESSTALWAACPETMPDAVAAHH-RLIRSLIEK--YRC----YEVKT-----IG--DAFMIACKSVFAAVQLVRELQQVFLQHDWGTSVIDDAYRMVEEDRAEEDAEYVPPTARLDAAV-YRQYWNGLRVRVGVHTGLCD-------IRHDEVTKGY-----------DYYGGTSNMAARTENVVNGGQVLLTRAAYFALSTA-EREHAEV-------TALGAVALR---GVPKPVE----MYQLDAVSGRTFAALRLDRE--MPDLDDE--SDLASG-DGSVSTERSGPSG--YIASVLAVLFGTF-AAPQRLKALFPLCQR-WSVRMPRGAGARCDQDACRVVIGRLAANVCG-------------------VIKKRVSGDSIEGGLRTMSLSEGAF--IGSDGALRLRRFS-VERAG------L---LGELHRRSGLRQASLSS-----------AEEVWW-------------VE-----EDPVATIQVRRR---V------------------------------------------------------------------- Q99279 ----------------MHWQEGGGRGCVYTHG---NCRRNL-TAR-ALQALQHVEALTCHYCVSLLHLLPLLLMWMPPVCADDSAVTVNVLSM-MYNPEYYVEKVNAINAGFDASLSAHGWKTGSGAT----ISVIRPPS-YN-----TTAEDIFQLGVK-------QSEGK---LLVVFGPLGTD--PVVWVRDKLKE------NDLVAIAPIAY-------------------SSEVRGWNPHLYSISVE-------PN-----AELLALIRYAVVYLGLPR--VG------LMYAKGNGFDKESYEFTMRIMEIMGRKPCG-VFAVESSGG-RDVLEGQLNTKWGQFVATRPQAVL-----LFSSLEEETTGW-------FVKKIAQDNRTVDMYLLAPSSFQ--HFLIKTWSDALVSLNRTFTP--GQLITTGTVP-LASDNRSSMVRHFQRDMDNYLDTNSD---------------------WKG-----FAKPEHYL--KDDKLGEMMVFG--WLAGEVLFEALNNAPQL----TNRTSF--MESLYKQRRYVI-DDFVVGDFG---GECDEALHYRVPCVIA-IKAAAWTHMRVVDDSLSL--------KPMKK-GSVTWSVSEC-------SSANVQVSAPLIGLYVVLTDDKVAQRASMRWSLGARSIEE--ADDVDK--RIFFHSLK----VNLKNLTQSLEQVRDTKAVAAVLG-VTADILSVPNMTFIGP----IPLFP----RLN-----KFWRNVIH--LQPL-----LAH---ELYVLAVYLSNT-----SSTGVKALVR--------GGEASEVVDTLDKSLVTFGVSLDSSKTLGD----GDPMSSYLSGNGDVFC-IGLTPPDVAAVARHLQTHLRARVFVPFNDILLFYQEFVAGFNASKESIASSEGLLFATSFPHWGKK----NRKSDMVARFHRHVN-ESHWDPLTFLGFATTRLLQVVISNMRKVNAEPLADRIYTESNIRVD-----DVGFGPFSDAECVS-GTSVSANECASNFGATNISVWSMG--ACAEFKLAQDTGWDDTVYGLCYS--ARGSTHTVTDSWNNFWVCIRLVII-------YCP-WCVPTHLPAERRNNNRAPKEPTDPVTLIFT--------DIESSTALWAAHPDLMPDAVAAHH-RMVRSLIGR--YKC----YEVKT-----VG--DSFMIASKSPFAAVQLAQELQLCFLHHDWGTNALDDSYREFEEQRAEGECEYTPPTAHMDPEV-YSRLWNGLRVRVGIHTGLCDI------IRHDEVTKGY-----------DYYGRTPNMAARTESVANGGQVLMTHAAYMSLSAE-DRKQIDV-------TALGDVALR---GVSDPVK----MYQLNTVPSRNFAALRLDREYFFDEGEDG--TTTSTSDHSSSRADVSESGQ--IIATALQSLLSTF-KTAHREKLLLPYCER-WRVPLPRKAASEWDDAYCEEVVRRIAVKVGR-------------------VADHGADSGSESSSTQGSSS-------------IIIVPFYDMHLQEY-------------------------------------------------------------------------------------------------------------------------------------------------- CAD21877 ----------------MNMLHLSDRNASLAPS---GGEHSL-PT--GGAVCRAVMDTLPVILRAPVALLLLLVVVPQLSVGAEANVTVKVLSA-AWNWYMPRKYVTAINAGFNASLKSRNWTVAGSVK----VEVVYPSN-LD-----MMPEDFIKEQLQGE-----TNMSS---IVIVYGPLGDQ--SVMHSIPHLMN------HRVVAFGLMTG-------------------STFIRQWNPYLYFLRAD-------PA-----AETLVLIRYSLCQLRVLR--LG------FMYLQGVHYGDEEYALTVNVMSRMGYELHG-VFTVMSPDG-KSAPDAEFKEEFERFATALPQAII-----VFGAPVDDTAKF-------LMMMAVDE-RIARSYILCPSSVQ--LSLIEMWQLALEAAGASFAP--GQLLFTGTNP-LAKDSQYIAIKRFQEVMSEYLKAHVG---------------------ETN-----ITETDYFL--THDLEGELMVYG--WISGEVLSQALSNLEWL----KDRATF--VRSLYDQRRYVI-NDIVIGDYG---GTCEGDAAKHGATCEC-NQGSKAVYVKEMLENGQK--------TSVRS-GFTVLKASRC-------YTDSSELHGPLNGLVVFMKDDDIASKAAALWQKGASHLVG--KGDLGYSDRFFLHAFN----TTIAEAANDLRHEQGDRIVTAVFGPVTEAVLDTPNITFIDP----LELKP----RLN-----KFRRHVIH--LSPT-----LEQ---QLYVLSSYLAGA-----GVGTVDAVIC--------SKEADGIADFLRSSLTEFAVSLRSAVIRED----GEDVGKYLPMSGTVFV-IGLSVPDVREIARKLEERNDLRVIVLFGEFSFLYDLFATALNNTAS----AARLVFATSLPHWGDT----ETSSKTAQLFHDVEKDSRLWTPLSLLAFATGRLMRVILLHVEEMSPETLVNFFYTDSSIVSD-----DMRYGVFDDTKCVDTANKLSKNGCASNYGATQISVWSMARALNASIPPLTNPMTPSMTFRNSNAG-RISGASLVGVIIGGALALFLVVALG------VVP-YFFLRN----TRDNNLAPKELTDPVTLIFT--------DIESSTALWAAHPEVMPDAVATHH-CLIRTLISK--YEC----YEVKT-----VG--DSFMIASKSPFAAVQFAQELQLCFLQHDWGTNAIDNSYQKFEQQRAEDDSDYTPPTARLDPKV-YSRLWNGLRVRVGIHTGLCD-------IRHDEVTKGY-----------DYYGRTSNMAARTESVGNGGQVLMTTAAYMSLSAE-EREQIDV-------TALGDVPLR---GVPKPVE----MYQLNAVPGRTFSVLRLELE-LLNDDEDQ--TTTSCSDHSSSRTDLSVAAQ--TIAASLQSLLGTF-TPAQRQKALIPFCER-WRVPLPQKVGNVWDNDGCQEVIRRVAAKVGR-------------------VMDFGTRKPSS-SVTSLERGGSLFS--GGGAAAIMLASSSSSSCVDGHC-------GTVQLIDLENDSATT-------------------------------------------------------------------------------------------------------------------------- CAD21883 ----------------MNMLHLGDRNASLAPS---GGEHSL-PT--GGAVCRAVMDTLPVILRAPVALLLLLVVVPQLSVGAEANVTVKVLSA-AWNWYMPRKYVTAINAGFNASLESRQWTVAGSVK----VEVVYPSN-LD-----LMPEDFIKKQLELE-----TDQNK---IVIVYGPLGDQ--SVMHSIPHLMN------HRVVAFGLMTG-------------------STFIRQWNPYLYFLRAD-------PA-----AETLVLIRYSLCQLRVLR--LG------FMYLQGVHYGEEEYALTVNVMSRMGYELHG-VFTVMSPDG-KPAPDAEFKEEFERFATALPQAII-----FFGAPVDDTAKF-------LMMMAVDE-RIARSHILCPSSVQ--LSLIEMWQLALEAAGASFAP--GQLLFTGTNP-LAKDSQYIAIKRFQEVMSEYLKAHVG---------------------ETN-----ITEADYFL--THDLEGELMVYG--WISGEVLSQALSNLEWL----KDRATF--VRSLYDQRRYVI-NDIVIGDYG---GTCEGDAAKHGATCEC-NQGSKAVYVKEMLENGQK--------TSVRS-GFTVLKASRC-------YTDSSELHGPLDGLVVFMKDDDIASKAAALWQKGTSHLVG--KGDLGYSDRFFLHAFN----TTIAEAANDLRRDQGERIVTAVFGPVTEAMLDTPNITFIDP----LELKP----RLN-----KFRRHVIH--LSPT-----LEQ---QLYVLSSYLAGA-----GVGTVDAVIC--------SKEADGIADFLWSSLTEFAVSLRSAVIRED----GEDVGKYLPMSGTVFV-IGLSVPDVREIARKLEERNDLRVIVLFGEFSFLYDLFATALNNTAG----AARLVFATSLPHWGDT----ETSSKTAQLFHDVEKDSRLWTPLSVLAFATGRLMRVILLHVEEMSPETLVNFFYTDSSIVSD-----DMRYGVFDDTKCVDTANKLSKNGCASNYGATQISVWSMARALNASIPPLTNPMTPSMTFRNSNAG-RISGASLVGIIIGGALALFLVVALG------VVP-YFFLRN----TRDNNLAPKELTDPVTLIFT--------DIESSTALWAAHPEVMPDAVATHH-RLIRTLISK--YEC----YEVKT-----VG--DSFMIASKSPFAAVQLAQELQLCFLHHDWGTNAIDKSYQQFEQQRAEDDSDYTPPTARLDPKV-YSRLWNGLRVRVGIHTGLCD-------IRHDEVTKGY-----------DYYGRTSNMAARTESVGNGGQVLMTTAAYMSLSAE-EREQIDV-------TALGDVPLR---GVPKPVE----MYQLNAVPGRTFAGLRLELE-LLNDGEDQ--NTTSCSDHSSSRTDLSVAAQ--TIAASLQSLLGTF-TPAQRQKALIPFCER-WRVPLPQKVGNVWDDDGCQEVVRRVAAKVGR-------------------VMDFGTRKPSS-SVTSLERGGSVFS--GGGAAAIMLASSSSSSCVDGHC-------VTVQLIDLENDSATT-------------------------------------------------------------------------------------------------------------------------- Q26721 ----------------MNMLHLSDRNASLAPS---GGEHSL-PT--GGAVCRDAMDILPVILRAPVALLLLLVVLPQLSVGAEANVTVKVLSA-TWNWYMPRKYVTAINAGFNASLKSRNWTVAGSVN----VQVVYPSN-LD-----LMPEDFIKKQLELE-----TDQNK---IVIVYGPLGDK--SVMHSIPHLMN------HRVVAFGLITG-------------------STFIRQWNPYLYFLRAD-------PA-----AETLVLIRYSLCQLRVLR--LG------FMYLQGVHYGDEEYALTVNVMSRMGYELHG-VFTVMSPDG-KPAPDAEFKEVFERFATALPQAII-----VFGAPVDDTAKF-------LMMMAVDE-RIARSYILSPSSVQ--LSLIEMWQLALEAAGASFAP--GQLLFTGTNP-LAKDSQYTAIKRFQEVMSEYLKAHVG---------------------ETN-----ITEADYFL--THDLEGELMVYG--WISGEVLSQALSNLEWL----KDRATF--VRSLYDQRRYVI-NDIVIGDYG---GTCEGDAAKHGATCEC-NQGSKAVYVKEMLENGQK--------TSVRS-GFTVLKASLC-------YTDSSELHGPLDGLVVFMKDDDIASKAAALWQKGTSHLVG--KGDLGYSDRFFLHAFN----TTIAEAANDLRRDQGERIVTAVFGPVTEAMLDTPNITFIDP----LELKP----RLN-----KFRRNVIH--LSPT-----LEQ---QLYVLSSYLAGA-----GVGNVDAVIC--------SNEADGIADFLRSSLTEFAVSLRSAVIRED----GEDVGKYLPMSGTVFV-IGLSVPDVKEIARKLEERNDLRVIVLFGEFSFLYDLFATALNNTAG----AARLVFATSLPHWGDT----ETSSKTAQLFHDVEKDSRLWTPLSVLAFATGRLMRVILLHVEEMSPETLVNFFYTDSSIVSD-----DMRYGVFDDTKCVDTANKLSKNGCASNYGATQISVWSMARALNASIPPLTNPMTPSMTFRNSNAG-RISGASLVGIIIGGALALFLVVALG------VVP-YFFLRN----TVITICTKDDR--PVTLIFT--------DIESSTALWAAHPEVMPDAVATHH-RLIRTLISK--YEC----YEVKT-----VG--DSFMIASKSPFAAVQLAQELQLCFLHHDWGTNAIDESYQQFEQQRAEDDSDYTPPTARLDPKV-YSRLWNGLRVRVGIHTGLCD-------IRRDEVTKGY-----------DYYGRTSNMAARTESVANGGQVLMTHAAYMSLSAE-ERQQIDV-------TALGDVPLR---GVPKPVE----MYRLNAVPGRTFSVLRLELE-LLNDDEDQ--TTTSCSDHSSSRTDLSVAAQ--TIAASLQSLLGTF-TPAQRQKALIPFCER-WRVPLPQKVGNVWDDDGCQEVVRRVAAKVGR-------------------VMDFGTRKPSS-SVTSWKG--------------VEVSSQVEERLL---------------------------------------------------------------------------------------------------------------------------------------------------- Q99280 ---------------------MIARVCRLTKH---SKPPHL-P----------ITLTTPTLFLVVLVLLQLHPICVLVNVDDGGGVTVKAISL-LYSRKWNVKVINAVNAGLNASLAARNWTVAPGVN----VEVVRPPS-YD-----IDPAQFLDVYLKVL-----NDDKS---LLVVLGPMGND--DAEKLYDTLEE------NRLVGFGPMTV-------------------STRHEGYMPHLYFLRPE-------AT-----GESYCPSTLCGESLRVLR--QG------FMYLDGLLGGSEAYDHAVDFISRMGYSFCC-VFTVEDKAGGQGGSSEEFDAVWDEFAGGNPQAVI-----MFATMKPDAKKF-------LVRLVSDP-RTEDTFVLTPIFLQ--KSIVSIWKETLEEANVPLHP--HRVIQTGSNP-LAKEDYIDAIKRFQTEMRNYLTEYKE---------------------WSG-----FNDADHFL--KNDADGELMVNG--WIAGEVLRRALRSHGWM----NTATAF--LESLYEQRRYVI-DDIVVGDFG---GECDSFTSANGATCRC-NRGGKNVYMREIAEDYRL--------QPLVG-GHIMTTPLQC-------HIDPSILRPPLTGLTVDMEDHEELLRGSTQFETGVSTTTS--SGKAGEMNSFFLQKVV----TDTQKVSNELNTLRQERIVTAVFGIVTKAVLGLPGLTFIDP----ITPTP----HLN-----SFSRNVIH--LSPT-----LEQ---QLYVLVNYLSSI-----RADFPNCVIR--------GGEAPAIIDALRKTLVTFGLNLSSTVVLTP----GDTVGEHLPKSGITFI-IGLAVDDIVVIEEHLRIHTKARVLVQFSDIALLYNEFVQAFNNSDG----AKHLLFATSLPHWADV----DTTSETVRRFHEAVREVEKWTPLSLLGFTTGRLIQENLQNMERVTSDLLVDLFFNQTVITID-----DMHYGPYKHYDCIING-VVTADDCMANFGATDISVWSMARALRSDEPLLQNPMSPSLVYTVPNGN-ALTPAQLAGVVGGSLFVVALAICLS------VLA-CFTLRG----TRDNDSAPKEPTGPVTLIFT--------DIESSTALWAAHPDLMPDAVATHH-RLIRSLITR--YEC----YEVKT-----VG--DSFMIASKSPFAAVQLAQELQLRFLRLDWETNALDESYREFEEQRAEGECEYTPPTAHMDPEV-YSRLWNGLRVRVGIHTGLCD-------IRYDEVTKGY-----------DYYGRTSNMAARTESVANGGQVLMTHAAYMSLSGE-DRNQLDV-------TTLGATVLR---GVPEPVR----MYQLNAVPGRNFAALRLDRE-LFNDGEDE--TTTSCSDHSSLRAELSIAAQ--TIAASLQSLLGTF-TPAQRQKALTPFCER-CGVTLPRKMGHVWDNDSCQEVIRRIAAKVGH-------------------VVDRHAAETRERSVCTLSSG------------SVIIISNDLSDMIRV-------------------------------------------------------------------------------------------------------------------------------------------------- AAF69135 -------------------------------------------------MVTFMRELYVRDGAVTYVVFSLLLQVLTASSLANDKIQVKVYNM-LYSNKISAKIYDPIIAGFNASITNGNPPSGANVE----VVYVPPMDDSD-----YVGHLNSETSFSND-----NNGKE---LPVILGPVGDK--NTLGLLKYFKE------KNVISFSPFTG-------------------SSKVRSWNPNLYFLTAS-------PA-----AEMLALLRYAITQLRLHR--LG------FMYLKDVSYGDDEHKLAVELTTRMDRKLCG-VFALKSQIG-KESDDSSFSAEWNKFANTRPQGVI-----VFGSPIPDTKRF-------LIKSLEDE-RTKGGYLLIPSTLQ--YVIENKWGKELGRD--RFVP--DKIIITGTNP-LAKDDGYDAIKRFRDDMAKFLRVHGNNFLK---------------DKWNVN---LSVDENNFT--EQDTEGELMVSG--WIAGEVLKQALSCREWL----TSRDAF--ITSLYNQRRYVI-DDVVVGDFG---GECRGMAGERGASCLC-NQGGNVVYMKKMGKDLRL--------YPMKE-GVLTLTSSRC-------YRDLSQLYAPLSGIMFKLTDDPKALRTAEAIYDGAFYVVG--KGQLGHSDRFFLHWLS----SKSHDTSTALYDEVKERVVTAVFGVVDDSLLSTKGMAFIDP----ITLTP----QLS-----NPRRNVIH--LSPT-----LEQ---QLFVIVEHIIQN-----GAGKMHAIVR--------SGDTRGVRKVLQKTLDIFNASLSSFVASGE----GSTLRDKLPTAGEVLV-AGLISDDIPIILSHLGKHHNVRIFVPFFDVALLYNELVSAFRDKPF----TDRLLFATNLPHWGDK----NTKSDLVREFHRVVQNESKWKPLSLLGYVTARAMINVLQRMGHVTPEELVDAIFSQSVITVD-----DMRYGPFDD-KCTN-GASFEEKHCAVNYGATHISVWSMSRVLNPSVSPVVTQVTPLMMDGYAKWF-RLKRAHIAAIAVSCVVVLALFVTVL------VLV-IRSLRRN---ARDNNNAPKEPTDPVTLIFT--------DIESSTAQWAAHPEQMPDLVATHH-RLIRSLITR--YEC----YEVKT-----VG--DSFMIACKSPFAAAQLACDLQRDFLNHDWKTTELDESYREFERQRAEDDSDYTPPTASLDPEV-YRQLWNGLRVRVGIHTGLCD-------IRHDEVTKGY-----------DYYGRTSNMAARTESVGNGGQVLMTLAAYHALSTL-EREQINV-------TPLGDVPLR---GVPKPVE----MYQLNAVPGRTFAALRLDREAEEEAKESEG-IFTDVSDICSSTHELCGSSL--HVAQSLETVFSTL-PATQRQRMLTSICER-WRVPPPKSAKNRWDKATFRLVIRHIAVRAGP-------------------VMSVNIRNAAAAALCAERRP-CPPS--HSICDVSQLGRQHPLPSVRFHT-------PMEVKEYLCMSPTDKFD----FSIYSCSTIDINMFN--GTLEKFDSREPLFGTSLGDNGKNS--------------------------------------------------------------------------- P14605 MDQSKRLLKSAVPNPPEHFKTGISWLDDLDEKDDDSATSVNYDIPEITEANLCNDSHEALSPCTQPVGNSGRPVEAFKTYPSTPAVPSKSVLFHFYEPDENFSLSDTGRTKSDTALAARESSEKSEVPRDTRSAGIKPYKENNSSNCAISKEAGLRRLIDKDRESFDKNLNQSFTNLTFPEPISDDSDSVEFQRDSLNNNWPASLEGSIHELPRNSDDDGIPASAAHILDLDYHRDSYDSPWKKFLPYPSILSDDSWKAPESWGTSLPTEAIPKQVFTTRFFARPSLGNRKKEFFLRVYRDDRTSVSFICPIGIQTHEVIKLLARLFFLPSSAN-FYLLLIQFNTERILLPHEQPCIIFERLLSLFGCKVTSDEEINEEDNYSVARLVFTT-MDIGADVLRKFSEKKITANLDISRSNLEVIPVKIYPYAHELISLNVSHNLSLDLPLDFMERCVKLKRLDISNNLRSPRG--K--PITALR-QLEVLNMSRNDIYELDPLIFSGLSRNSLKELNIANNKLFFLPHSTRYLVNLTYLDLSYNNFVTFPLIITELSQLETLNFSHNLLSQISSKIGSLVKLKHLYLQFNDLSNRLPQEIGLLKNLETIDLSYNAITNIASLSECPKLNSINVACNLLSFYEYSNPSATFIDFSFCPLTTIDPAFSYSNLVYFDISHAKLIGLKDSVIETLVNVETVKVNYNHFTSISDAISAMQNLKYLSCTNCEMSYVSPNLGKLKHLVHLDLHANNIKIFPEEVWQVSSLKVVNLSSNILEKIKLPVATSKKLTRTISQLKIMRTLSGNPVSSLSSQEFVMPTVEELYLVDNRLGNDCFTALEYFKCLKVLNLSYNYLTEIPSKFFQNFSDLKHLFVSGNELANLSISSTAQVLLETLYANGNRLSSFPKNEALSKSLRFLDISTNNLQNLAVEKAEKKSLTKLPQLEYL----NLSGNTWFRFSEHEDTNFTKSYLKNLKFLSIMDLNTKFSNAPSDVLNHFIQRNSPQPNILRYGVCGYLSRSIPVISACELVVNNFLHPQSSLYCVLDSDISAGKNNRVLKFVYDNLASCLAHEINAADSSSEQICNALRRGFLRLNKKLGNVIHYDLRKSSEGDVDSNYVTTMNISEKGYSMDSSCLDIGVSIILVYVRDTRAFVANVGTSMAIMSTRNDSEPTTLSVMHDVYNRDEIRRIVDSCGFISGEIKSTTTRAIGRLSQFPGVQAVPYVNVQYLSELNEFIILANQEFWSVLSKRTVIDVVRANRHSPLLASTKLRDYAIAYGAEKNVLVVIVELNGLFEENSLNFNQLRGDEKTLAISEKNDNMSFVQDLPDDSSLARMNREVSPPKGCIAMVFTDIKNSTLLWERHPIAMRSAIKTHNTIMRRQLRATGGYEVKTEGDAFMVCFQTVPAALLWCFSVQLQLLSADWPNEIVESVQGRLVLGSKNEVLYRGLSVRIGVNYGVTVSELDPITRRMDYYGPVVNRTSRVVSVADGGQIAVSAEVVSVLNQLDSETMSSEKTN--------------VNEMEVRALKQIGYIIHNLGEFKLKGLDTTEMISLVYPVQLQGRLERLIKSRSLGTPTALPETQTYTPVRSRSNSLRPMLARLSDSKSVHGEEGGSGKRSVSSLRNVSPSESTGGYEGCIFDDQQYQLLYELCERLEDHAAILHGFPEPPPCDTGLAAPVNQAEE--YSLFYRLTLRIENTIYCVSQMLGHTG QUARTET PUZZLING TREE :---Q25263 :----100: : :---Q27675 : : :---CAD21877 : :-99: :100: :---CAD21883 : : : :-------Q26721 : : :---AAC61849 : :100: : : :---CAA09919 :-99: : : :---CAA09737 : :100: : :---AAC32776 : :-----------Q99279 : :-----------Q99280 : :-----------AAF69135 : :-----------P14605 ATPase, subunit 6 AAA81668 T.cruzi AAA97428 T. brucei AAA96695 L. tarentolae AAD09165 Herpetomonas muscarum AAD09166 Herpetomonas pessoai *AAA32122 T. brucei cytochome-c oxidase III *A25877 Crithidia fasciculata cytochrome-c oxidase III AAA81668 ----------MFLFFFCDLFWLRLLLWLYYCVWSRLCFVVYFNC----------LLLIFDFLLFCLFDLYSFIGLCLFLLLWFMLFNLYSLIL-----YYCITYLN-LYLLFCIVFLYYMSFLF--LFCFLLDFFLFNN--------LLVGDNFMDVFFIRFLLCFLECFS----LLCRC---LSTFLRLFCN---LLSSHFLLLMFFDFLYFFFV-------FFIFFCFLDFLVFILFIFVFCFCLLFYGFLYLLDLFA----------------AILQLFIFCNMILQLIMDFLLFLLFC---------------------- AAA97428 ----------MFLFFFCDLFWLRLLLCMYYCVWSRLCFIVYFNC----------LMLIFDFLLFCLFDLYLFVGLCLFLLLWFMLFNLYSLIL-----YYCITYLN-LYLLFCIVFLLYIAFLF--LFCFLCDFFLFNN--------LLVGDSFMDVFFIRFLLCFLECFS----LLCRC---LSTFLRLFCN---LLSSHFLLLMFFDFFYFIFV-------FFFYGVFC--YWFILFIFVFCFCLLFYVFLYLLDLFA----------------AILQLFIFCNMILQLIMDFLLFLLFV---------------------- AAA96695 ----------MFVFFVCDLVIMRILLCFCYSVWSRIIFVLFYN-----------VFYICTELMFCIFDVYLFVGLCMFICLWFVLFNFYGLIV-----YYCITYLN-VYILFCIVFMYYMAFLF--CFCFLLDFILFGS--------LLVGDAFMDVFFLRYLLCVLECFS----LLCRC---ISTFLRMFCN---LLSSHFLMLMFCDFVYFFII-------FFLFFIMCDFIYFIIFTFAMLFCIIFYLFLYALDMFC----------------ALLQIFIFCNMIMQLIMDFLLLLSFH---------------------- AAD09165 ---MFLFRVIFVGVSGVFVFLSLPAVCIVYYVICLCGFMICCFGS------FVFVDMCFVFFFFGLLFCILLLLCDLFVDFLRGIFDFCNFLR--VLQYCFMWFVFSELVLFMSFFTVVFGYVI--FLCCEFAFVFCLP--------MLFCCLLVDYGFVFYWFFMDLFNLLINTFLLFVSG-LFCNFFLFC----VWFRFFVVCIFVLWCGILFGFL----FLWNQLWEFALLFVTVSCGVFGSILFVIDLLHFTHVLLGVFLLFIVFMRLFNFLCMDTRFVFLYVVVLYWHFVDCVWFFLLR------FVYFDVLCCLYLCV AAD09166 ---MFLFRVIFVGVSGVFVFLSLPAVVICYYVVCLCGFMICCFGS------FLFVDMCFVFFLVCLLFCILLLFCDVFVDFLRGIFDFLTFIR--CLQYCFIWFVISELVLFLTFFTVVFGYCI--FLCCEFAFVFVLP--------MLFCCLLVDYGFVFYWFFIDLFNLLINTFLLFVSG-LFCNFLFFC----VWFRFFVVCVFVLWCGILFGFL----FLWNQLWEFALLFVTCSCGVFGSILFVIDLLHFTHVVLGVFLLFIVFCRLFNFLCMDTRFVFLYVVVFYWHFVDCVWFFLLR------FVYFDVLCCVYLCV AAA32122 ---MFLFRCIFVGVSGVFVFLSLPAIVIVYWLFCLLGFICLLFGS------FLFVDCGFIFFFVGFCICLLLLLLDLFCDFLRGLFDFCVLLR--CIQYCFLWFLCSEFVLFMAFFVVLFGLCL--FLCCEFAFVFCLP--------YMFCCLLCDYGFVFYWYFLDLFNLLINTFYLFVSG-LFVNFFVLC----FWFRFFCCCCFVLWLSLLFGFL----FLWNQLWEFALLFITLSCGVFGSILFLLDLLHFMHVFLGVLLLFICFMRLFNFLCMDTRFVFLYCVCLYWHFVDLVWFFLLR------FVYFDVLCVMYLCV A25877 SSPIYQFNYRRRGWGG----YSLPAICIVYLVFCLCGLFCIMFGS------FVFIDYCFVCFFACLGFCIVCLLCDLFVDSLRGLFDVCCFIR--CIQYCFIWFVISELVLFISFFYVVFSLVL--FVCVEFAFVFVIP--------VMFCCLICDYGFVFYWYFIDVFNLLINTFLLFVSG-LFVNFVLFL----FWFRFFLCVLFVLWSAILFGFL----FLWNQVWEFALLFVTCSCGVFGSILFLIDLLHFSHVLLGIFLLFICFGRCFNFLSMDTRFVFLYVVCLYWHFVDCVWFFLLR------FVYFDVLCVVYLCA QUARTET PUZZLING TREE :---AAD09165 :100: : :---AAD09166 :100: : :-------AAA32122 :100: : : : :-------A25877 : : : :-----------AAA96695 : :---------------AAA97428 : :---------------AAA81668 Alpha tubulin P04106 T. brucei Q27352 T. cruzi AAL75955 T. cruzi CAB95264 L. major AAA58321 L. donovani *AAK37831 Euglena gracilis *P33625 Euglena gracilis P04106 MREAICIHIGQAGCQVGNACWELFCLEHGIQPDGAMPSDKTIGVEDDAFNTFFSETGAGKHVPRAVFLDLEPTVVDEVRTGTYRQLFHPEQLISGKEDAANNYARGHYTIGKEIVDLCLDRIRKLADNCTGLQGFLVYHAVGGGTGSGLGALLLERLSVDYGKKSKLGYTVYPSPQVSTAVVEPYNSVLSTHSLLEHTDVAAMLDNEAIYDLTRRNLDIERPTYTNLNRLIGQVVSSLTASLRFDGALNVDLTEFQTNLVPYPRIHFVLTSYAPVISAEKAYHEQLSVSEISNAVFEPASMMTKCDPRHGKYMACCLMYRGDVVPKDVNAAVATIKTKRTIQFVDWSPTGFKCGINYQPPTVVPGGDLAKVQRAVCMIANSTAIAEVFARIDHKFDLMYSKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGAESADMDGEEDVEEY Q27352 MREAICIHIGQAGCQVGNACWELFCLEHGIQPDGAMPSDKTIGVEDDAFNTFFSETGAGKHVPRAVFLDLEPTVVDEIRTGTYRQLFHPEQLISGKEDAANNYARGHYTIGKEIVDLCLDRIRKLADNCTGLQGFLVYHAVGGGTGSGLGALLLERLSVDYGKKSKLGYTVYPSPQVSTAVVEPYNSVLSTHSLLEHTDVAAMLDNEAIYDLTRANLDIERPTYTNLNRLIGQVVSALTASLRFDGALNVDLTEFQTNLVPYPRIHFVLTTYAPVISAEKAYHEQLSVSEISNAVFEPASMMTKCDPRHGKYMACCLMYRGDVVPKDVNAAVATIKTKRTIQFVDWSPTGFKCGINYQPPTVVPGGDLAKVQRAVCMIANSTAIAEVFARIDHKFDLMYSKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGAESADMEGEEDVEEY AAL75955 MREAICIHIGQAGCQVGNACWELFCLEHGIQPDGAMPSDKTIGVEDDAFNTFFSETGAGKHVPRAVFLDLEPTVVDEIRTGTYRQLFHPEQLISGKEDAANNYARGHYTIGKEIVDLCLDRIRKLADNCTGLQGFLVYHAVGGGTGSGLGALLLERLSVDYGKKSKLGYTVYPSPQVSTAVVEPYNSVLSTHSLLEHTDVAAMLDNEAIYDLTRRNLDIERPTYTNLNRLIGQVVSALTASLRFDGALNVDLTEFQTNLVPYPRIHFVLTSYAPVISAEKAYHEQLSVSEISNAVFEPASMMTKCDPRHGKYMACCLMYRGDVVPKDVNAAVATIKTKRTIQFVDWSPTGFKCGINYQPPTVVPGGDLAKVQRAVCMIANSTAIAEVFARIDHKFDLMYSKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGAESADMEGEEDVEEY CAB95264 MREAICIHIGQAGCQVGNACWELFCLEHGIQPDGSMPSDKCIGVEDDAFNTFFSETGAGKHVPRCIFLDLEPTVVDEVRTGTYRQLFNPEQLVSGKEDAANNYARGHYTIGKEIVDLALDRIRKLADNCTGLQGFMVFHAVGGGTGSGLGALLLERLSVDYGKKSKLGYTVYPSPQVSTAVVEPYNCVLSTHSLLEHTDVATMLDNEAIYDLTRRSLDIERPSYTNVNRLIGQVVSSLTASLRFDGALNVDLTEFQTNLVPYPRIHFVLTSYAPVVSAEKAYHEQLSVADITNSVFEPAGMLTKCDPRHGKYMSCCLMYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKCGINYQPPTVVPGGDLAKVQRAVCMIANSTAIAEVFARIDHKFDLMYSKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGAESADDMGEEDVEEY AAA58321 MREAICIHIGQAGCQVGNACWELFCLEHGIQPDGSMPSDKCIGVEDDAFNTFFSETGAGKHVPRCIFLDLEPTVVDEVRTGTYRQLFNPEQLVSGKEDAANNYARGHYTIGKEIVDLALDRIRKLADNCTGLQGFMVFHAVGGGTGSGLGALLLERLSVDYGKKSKLGYTVYPSPQVSTAVVEPYNCVLSTHSLLEHTDVATMLDNEAIYDLTRRSLDIERPSYTNVNRLIGQVVSSLTASLRFDGALNVDLTEFQTNLVPYPRIHFVLTSYAPVVSAEKAYHEQLSVADITNSVFEPAGMLTKCDPRHGKYMSCCLMYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKCGINYQPPTVVPGGDLAKVQRAVCMIANSTAIAEVFARIDHKFDLMYSKRAFVHWYVGEGMEEGEFSEAREDLAAVEKDYEEVGAESADDMGEEDVEEY AAK37831 MREIISIHLGQGGIQIGNACWELYCLEHGIQPDGSMPSDKAIGVEDDAFNTFFSETGAGKHVPRAVFLDLEPSVVDEVRTGTYRQLFHPEQLISGKEDAANNYARGHYTIGKEIVDLCLDRIRKLADNCTGLQGFLAFHAVGGGTGSGLGALLLERLSVDYGKKSKLGFTIYPSPQISTAVVEPYNSVLSTHSLLEHTDVAVMLDNEAIYDICRRNLDIERPTYTNLNRLIAQVISSLTASLRFDGALNVDITEFQTNLVPYPRIHFVLSSYAPIISAEKAYHEQLSVAEITNAAFEPASMMAKCDPRHGKYMACCLMYRGDVVPKDVNASVATIKTKRTIQFVDWCPTGFKCGINYQPPTVVPGGDLAKVQRAVCMISNSTAIAEVFARIDHKFDLMYSKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGAESADVEGEEDVEEY P33625 MREIISIHLGQGGIQIGNACWELYCLEHGIQPDGSMPSDKAIGVEDDAFNTFFSETGAGKHVPRAVFLDLEPSVVDEVRTGTYRQLFHPEQLISGKEDAANNYARGHYTIGKEIVDLCLDRIRKLADNCTGLQGFLAFHAVGGGTGSGLGRLLLERLSVDYGKKSKLGFTIYPSPQISTAVVEPYNSVLSTHSLLEHTDVAVMLDNEAIYDICRRNLDIERPTYTNLNRLIAQVISSLTASLRFDGALNVDITEFQTNLVPYPRIHFVLSSYAPIISAEKAYHEQLSVAEITNAAFEPASMMAKCDPRHGKYMACCLMYRGDVVPKDVNASVATIKTKRTIQFVDWCPTGFKCGINYQPPTVVPGGDLAKVQRAVCMISNSTAIAEVFARIDHKFDLMYSKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGAESADVEGEEDVEEY QUARTET PUZZLING TREE :---Q27352 :----100: : :---AAL75955 : : :---CAB95264 : :100: : : :---AAA58321 :100: : : :---AAK37831 : :100: : :---P33625 : :-----------P04106 Beta tubulin P08562 T. cruzi P04107 T. brucei AAK31149 L. mexicana CAB86715 L. major P21148 L. mexicana *AAK37834 Euglena gracilis *AAD49555 Eutosiphon sulcatum P08562 MREIVCVQAGQCGNQIGSKFWEVISDEHGVDPTGTYQGDSDLQLERINVYFDEATGGRYVPRAVLIDLEPGTMDSVRAGPYGQIFRPDNFIFGQSGAGNNWAKGHYTEGAELIDSVLDVCRKEAESCDCLQGFQICHSLGGGTGSGMGTLLISKLREEYPDRIMMTFSIIPSPKVSDTVVEPYNTTLSVHQLVENSDESMCIDNEALYDICFRTLKLTTPTFGDLNHLVSAVVSGVTCCLRFPGQLNSDLR-KLAVNLVPFPRLHFFMMGFAPLSSRGSQQYR-GLSVPDVTQQMFDAKNMMQAADPAHGRYLTASALFRGRMSTKEVDEQMLNVQNKNSSYFIEWIPNNIKSSICDIPPKGLKMAVTFVGNNTCIQEMFRRVGEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATIEEEGEFDEEEQY--- P04107 MREIVCVQAGQCGNQIGSKFWEVISDEHGVDPTGTYQGDSDLQLERINVYFDEATGGRYVPRSVLIDLEPGTMDSVRAGPYGQIFRPDNFIFGQSGAGNNWAKGHYTEGAELIDSVLDVCCKEAESCDCLQGFQICHSLGGGTGSGMGTLLISKLREQYPDRIMMTFSIIPSPKVSDTVVEPYNTTLSVHQLVENSDESMCIDNEALYDICFRTLKLTTPTFGDLNHLVSAVVSGVTCCLRFPGQLNSDLR-KLAVNLVPFPRLHFFMMGFAPLTSRGSQQYR-GLSVPELTQQMFDAKNMMQAADPRHGRYLTASALFRGRMSTKEVDEQMLNVQNKNSSYFIEWIPNNIKSSVCDIPPKGLKMAVTFIGNNTCIQEMFRRVGEQFTLMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATIEEEGEFDEEEQY--- AAK31149 MREIVSCQAGQCGNQIGSKFWEVISDEHGVDPTGTYQGDSDLQLERINVYFDESTGGRYVPRAVLMDLEPGTMDSVRAGPYGQLFRPDNFIFGQSGAGNNWAKGHYTEGAELIDSVLDVCRKEAESCDCLQGFQLSHSLGGGTGSGMGTLLISKLREEYPDRIMMTFSVIPSPRVSDTVVEPYNTTLSVHQLVENSDESMCIDNEALYDICFRTLKLTTPTFGDLNHLVAAVMSGVTCCLRFPGQLNSDLR-KLAVNLVPFPRLHFFMMGFAPLTSRGSQQYR-GLSVAELTQQMFDAKNMMQAADPRHGRYLTASALFRGRMSTKEVDEQMLNVQNKNSSYFIEWIPNNIKSSICDIPPKGLKMSVTFIGNNTCIQEMFRRVGEQFTGMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATVEEEGEYDEEQEAY-- CAB86715 MREIVSCQAGQCGNQIGSKFWEVISDEHGVDPTGTYQGDSDLQLERINVYFDESTGGRYVPRAVLMDLEPGTMDSVRAGPYGQLFRPDNFIFGQSGAGNNWAKGHYTEGAELIDSVLDVCRKEAESCDCLQGFQLSHSLGGGTGSGMGTLLISKLREEYPDRIMMTFSVIPSPRVSDTVVEPYNTTLSVHQLVENSDESMCIDNEALYDICFRTLKLTTPTFGDLNHLVAAVMSGVTCCLRFPGQLNSDLR-KLAVNLVPFPRLHFFMMGFAPLTSRGSQQYR-GLSVAELTQQMFDAKNMMQAADPRHGRYLTASALFRGRMSTKEVDEQMLNVQNKNSSYFIEWIPNNIKSSICDIPPKGLKMSVTFIGNNTCIQEMFRRVGEQFTGMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATVEEEGEYDEEEEAY-- P21148 MREIVSCQAGQCGNQIGSKFWEVIADEHGVDPTGSYQGDSDLQLERINVYFDESAGGRYVPRAVLMDLEPGTMDSVRAGPYGQLFRPDNFIFGQSGAGNNWAKGHYTEGAELIDSVLDVCRKEAESCDCLQGFQLSHSLGGGTGSGMGTLLISKLREEYPDRIMMTFSVIPSPRVSDTVVEPYNTTLSVHQLVENSDESMCIDNEALYDICFRTLKLTTPTFGDLNHLVAAVMSGVTCCLRFPGQLNSDLRNRLAVNLVPFPRLHFFMMGFAPLTSRGSQEYRQGLSVADVTQQMFDAKNMMQAADPRHGRYLTASALFRGRMSTKEVDEQMLNVQNKNSSYFIEWIPNNIKSSICDIPPKGLKMSVTFIGNNTCIQEMFRRVGEQFTGMFRRKRFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATVEEEGEFDEEEEAY-- AAK37834 MREIVHIQAGQCGNQIGSKFWEVISDEHGVDPTGTYQGDSDLQLERINVYYNEATGGRYVPRAILMDLEPGTMDSVRAGPYGQIFRPDNFVFGQTGAGNNWAKGHYTEGAELIDSVLDVVRKEAESCDCLQGFQIAHSLGGGTGSGMGTLLISKIREEYPDRMMMTFSVIPSPKVSDTVVEPYNTTLSVHQLVENADEVMCIDNEALYDICFRTLKLTTPTFGDLNHLVSAVMSGVTCCLRFPGQLNSDLR-KLAVNLIPFPRLHFFLVGFAPLTSRGSQQYR-ALTVPELTQQMFDAKNMMAASDPRHGRYLTASAMFRGRMSTKEVDEQMLNVQNKNSSYFVEWIPNNIKSSVCDIPPKGLKMSATFIGNNTAIQEMFKRVSEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATVEEEGEFDEEEDVEQY AAD49555 MREIVHIQAGQCGNQIGSKFWEVISDEHGVDPTGTYQGDSDLQLERINVYYNEATGGRYVPRAILMDLEPGTMDSVRAGPYGQIFRPDNFVFGQTGAGNNWAKGHYTEGAELIDSVLDVVRKEAESCDCLQGFQIAHSLGGGTGSGMGTLLISKIREEYPDRMMLTFSVIPSPKVSDTVVEPYNTTLSVHQLVENADEVMCIDNEALYDICFRTLKLTTPTFGDLNHLVSAVMSGVTCCLRFPGQLNSDLR-KLAVNLIPFPRLHFFLVGFAPLTSRGSQQYR-ALTVPELTQQMFDAKNMMAASDPRHGRYLTASAMFRGRMSTKEVDEQMLNVQNKNSSYFVEWIPNNIKSSVCDIPPKGLKMAATFIGNNTAIQEMFKRVSEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATVEEEGEFDEEEDAEQY QUARTET PUZZLING TREE :---P08562 :----100: : :---P04107 :100: : : :---AAK31149 : : :-58: : :100: :---CAB86715 : : : :-------P21148 : :---------------AAK37834 : :---------------AAD49555 Calreticulin AAB17728 L. donovani AAK52926 T. congolense AAD22175 T. cruzi *CAA70945 Euglena gracilis AAB17728 MLAAVVGVLVL---CVYVVQAEIFFHEEFNT--MDGWVQSEHTSDYGKVALSVGAIHVDAEKEQGLKLMEDAKFYAVSKKLPKAVSNDGKSIIVSFSVKNEQKLTCGGTYLKFFSELDQKDLHGESAYWLMFGPDTCGSSTRLQFILSYNGTNHLWKKLWRPKTDKATHVYTVEIAPNNTYQLYVDGMHIQEGSFEEEWDMLPPKTIPDPTDEKPADWVDDMMMDDPSDTKPEHWDDEPATITDSEAVKPVDWDDAEDGVWEAPKIPNPNYRGAWTPRRIHNPDYKGKWAARQIPNPAYKEDPNLYRAPAPLQYVGIDVWQVEGGSIFDDIIIGDDITEVLGVVKSTYGAMAEKERDLIQAEEKKEATKEP-------------AEAAAEKPNVGEHADHTPDEGDSEDKEDL- AAK52926 MRRGTIVCALLGLVAAATVQGTIYFHEKFTS--INHWTPSKARSDYGKVELSAGKFFADAEKSKGLRLTEDARFYALSTPLTTPISNEKKDFVVSFSVKHEQGLRCGGGYIKLMPNMNPAEFKGETKYWLMFGPDRCGYNNKIHIIINYNNTNMEWKKHPRYPYDKLTHAYTLHIAPDNSYKFYLDGSPTEKGNLEDDWDFFPPKEIEDPEDKKPADWVDAKTIDDPEDKKPDDWDNEPETIVDPDAKKPDDWNDAEDGTWEAPMIPNPKSKGPWSPRKITNPAYKGPWAPRKIANPAYKSDPNLYMIPEPLTHVGIDVWQVESGSIYKDIVVGDDLKEVLDIVQSTYGDMKKAEEEAFDAFEKKEEEERKSKEAKEEEKKEEEEKKEKEKKEEEKKEEEKKEEGKKEEKADL- AAD22175 MRAAIFFCALLGLATLSAVHGTVYFHEEFKS--MEHWTTSKHRDDFGKVEISAGKFYADAEKRKGLRLTEDARFYALSTAFPTPITNEKKSLVVSFSVKHEQDLKCGGGYIKLLPSMDPEKFHGETKYWLMFGPDRCGSQNRVHIILHYNGENREWSKRISFPEDKLTHVYTLHIAADNSYEFFLDGESKAKGQLEEDWSLLLPREIVDETDKKPEDWVDEETMDDPEDKKPEDWDNEPAMIPDPDAKKPDDWDDAEDGPWEAPMIRTRSRKAHGSHVKFPTRRTRACGSRGRFLIQNFVEDSELHKVREPLTHVGIDVWQVESRSIFKDIVIGDDLKEVLDLVEKTYGRPEEGGGGSLKVMEDMEKEKRK----KEE---EEEREKEKENPEEEKDEEELEEKGDRD-KEDL- CAA70945 MRKELWLGLLL---SSQAVLSTIYYKETFEPDWETRWTHSTAKSDYGKFKLTSGKFYGDKAKDAGIQTSQDAKFYAISSPIASSFSNEGKDLVLQFSVKHEQDIDCGGGYLKLLPSVDAAKFTGDTPYHIMFGPDICGATKKIHFILTYKGKNLLWKKEPRCETDTLSHTYTAVIKADRTYEVLVDQVKKESGTLEEDWEILKPKTIPDPEDKKPADWVDEPDMVDPEDKKPEDWDKEPAQIPDPDATQPDDWDEEEDGKWEAPMISNPKYKGEWKAKKIPNPAYKGVWKPRDIPNPEYEADDKVH-IFDEIAAVGFDLWQVKSGTIFDNIIVTDSLAEAKAFYDQTNGATKDAEKKAFDSAEADKRKKEED---------ERKKQEEEEKKTAEEDEDDDDEEEEEDDKKDEL QUARTET PUZZLING TREE :---AAK52926 :100: : :---AAD22175 : :-------AAB17728 : :-------CAA70945 Cdc2-related kinase 3 AAC48317 T. cruzi CAA52688 T. brucei CAA04648 L. mexicana AAD08994 L. major CAD20058 L. donovani *NP_001249 Homo sapiens AAC48317 MTTLTTLPSRPLSSNTREQFERYNRMDILGEGTYGVVYRAVDKITGQIVALKKVRLDRTEEGIPQTALREVSILQEIHHPNVVNLLDVICTDGKLYLIFEYVDYDLKKAIEKRGCT-FTGVTLKKLVYQLLDGLFFCHRHRIVHSDLKPANILITSDNVLKLADFGLARTFQIPMHTYTHEVVTLWYRAPEILLGEKHYTPAVDIWSVGCIFAELARGKVIFRGDSEIGQLFEIFQILGTPMDNEGSWPGVSSLPDYRDVFPRWAGKPLAQVIPQLDSEAIDLISRMLKYSPAERISAKEALQHSWFSEIRT-------------- CAA52688 MTMLGALTGRQLSSGLKDQFDRYNRMDILGEGTYGVVYRAVDRATGQIVALKKVRLDRTDEGIPQTALREVSILQEIHHPNIVNLLDVICADGKLYLIFEYVDHDLKKALEKRGGA-FTGTTLKKIIYQLLEGLSFCHRHRIVHRDLKPANILVTTDNSVKIADFGLARAFQIPMHTYTHEVVTLWYRAPEILLGEKHYTPAVDMWSIGCIFAELARGKVLFRGDSEIGQLFEIFQVLGTPMDAEGSWLGVSSLPDYRDVFPKWSGKPLTQVLPTLDGDAVDLLSQMLRYNPAERISAKAALQHPWFSDAMF-------------- CAA04648 MSSFGRVTARSGDAGTRDSLDRYNRLDVLGEGTYGVVYRAVDKITGQYVALKKVRLDRTEEGIPQTALREVSILQEFDHPNIVNLLDVICSDGKLYLVFEYVEADLKKAIEKQEGG-YSGMDLKRLIYQLLDGLYFCHRHRIIHRDLKPANILLTSGNVLKLADFGLARAFQVPMHTYTHEVVTLWYRAPEILLGEKHYTPAVDMWSVGCIFAELARRKVLFRGDSEIGQLFEIFQVLGTPTDTEGSWPGVSRLPDYRDVFPKWTAKRLGQVLPELHPDAIDLLSKMLKYDPRERISAKEALQHPWFSDLRW-------------- AAD08994 MSSFGRVTARSGDAGTRDSLDRYNRLDVLGEGTYGVVYRAVDKITGQYVALKKVRLDRTEEGIPQTALREVSILQEFDHPNIVNLLDVICSDGKLYLVFEYVEADLKKAIEKQEGG-YSGMDLKRLIYQLLDGLYFCHRHRIIHRDLKPANILLTSGNVLKLADFGLARAFQVPMHTYTHEVVTLWYRAPEILLGEKHYTPAVDMWSVGCIFAELTRRKVLFRGDSEIGQLFEIFQVLGTPTDTEGSWPGVSRLPDYRDVFPKWTAKRLGQVLPELHPDAIDLLSKMLKYDPRERISAKEALQHPWFSDLRW-------------- CAD20058 MSSFGRATARSGDAGTRDSLDRYNRLDVLGEGTYGVVYRAVDKITGQYVALKKVRLDRTEEGIPQTALREVSILQEFDHPNIVNLLDVICSDGKLYLVFEYVEADLKKAIEKQEGG-YSGMDLKRLIYQLLDGLYFCHRHRIIHRDLKPANILLTSGNVLKLADFGLARAFQVPMHTYTHEVVTLWYRAPEILLGEKHYTPAVDMWSVGCIFAELARRKVLFRGDSEIGQLFEIFQVLGTPTDTEGSWPGVSRLPDYRDVFPKWTAKRLGQVLPELHPDAIDLLSKMLKYDPRERISAKEALQHPWFSDLRW-------------- NP_001249 -------------------MDMFQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKHPNIVRLLDVVHNERKLYLVFEFLSQDLKKYMDSTPGSELPLHLIKSYLFQLLQGVSFCHSHRVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSKFYTTAVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPS--EDTWPGVTQLPDYKGSFPKWTRKGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYFSSPEPSPAARQYVLQRFRH QUARTET PUZZLING TREE :---AAC48317 :-99: : :---CAA52688 : : :---CAA04648 : : :-62:---AAD08994 : : : :---CAD20058 : :-------CDK3 CDKRS AAO22151 T. cruzi CAD43044 T. brucei Q25330 L. mexicana *Q24152 Drosophila melanogaster AAO22151 ---MSARDFFSITDPVQKEQARHMISKLQSKILYSEKYYDDEYEYRHVVLPKDFARLVPRHRLMDESEWRQLGVQQSVGWRHYMFHKPEPHVLLFKRPKTE CAD43044 ---MSGRDYFSITDPVQREQARMMISKLQSKILYSDKYYDDEYEYRHVILPKDFSRLVPRGRLMEESEWRQLGVQQSVGWRHYMLHAPEPHVLLFKRPKTQ Q25330 MPAKPAQDFFSLDANGQRE-ALIIIKKLQCKILYSDKYYDDMFEYRHVILPKDLARLVPTSRLMSEMEWRQLGVQQSQGWVHYMIHKPEPHVLLFKRPRT- Q24152 ---------------------------MSKDIYYSDKYYDEQFEYRHVVLPKELVKMVPKTHLMTEAEWRSIGVQQSRGWIHYMIHKPEPHILLFRRPKTD QUARTET PUZZLING TREE :---AAO22151 :100: : :---CAD43044 : :-------Q25330 : :-------Q24152 CRK1 P54664 T. congolense P38973 T. brucei AAC48318 T. cruzi Q06309 L. mexicana *P34117 Dictyostelium discoideum P54664 MGSRYQRLEKIGEGSYGVVYRARDITTDVIVALKRIRLESVEEGVPCTAIREISILKELRHENIVRLLDVCHSENRLNLVFEYMEMDLKKYMDRASGNLDPATIQEFMRSLLKGVRFCHERNVLHRDLKPPNLLISREKELKLADFGLGRAFGIPVKKYTHEVVTLWYRSPDVLLGSTQYGTPVDIWSVGCIFAEMAIGAPLFAGKNDADQLLRIFRFLGTPSSQVWPSMNLYPNSTNMLSKPEFQQNLIATCDEQFQTHPAYAKLGPQGIDLLRRLLRYEPGERLTAAQALEHPYFSVEF--- P38973 MGSRYERLQKIGEGSYGVVFRARDVTTGTIVAVKRIRLEKEEEGVPCTAIREISILKELRHENIVRLLDVCHSEKRLTLVFECMEMDLKKYMDHVGGDLDAGTIQEFMRSLLSGVRFCHERNVLHRDLKPPNLLISREKELKLADFGLGRAFGIPVKKFTQEVVTLWYRSPDVLLGSTQYGTPVDIWSVGCIFAEMAIGAPLFTGKNDADQLLRIFQFLGTPNRQVWPSMDTYPNSSNMLSRPEFQQTLAATCEEQFQTNPAYAKLGPQGIDLLRWLLRYEPSERLTAAQALEHPYFSVEF--- AAC48318 MSTRYERQEKIGEGTYGVVYRARDTATGATVALKRIRLDTEEEGVPCTAIREISLLKELRHANIVKLLDVCHSESRLTLVFEYMELDLKKYMDQEEGNLDAATIQDFMRDLLNGVRFCHDRNVLHRDLKPPNLLISREKSLKLADFGLGRAFGIPVKKFTHEVVTLWYRSPDVLLGSTQYGTPVDIWSVGCIFAEMVIGAPLFAGKNDADQLLRIFRFLGTPNNQVWPSMNQYPNSTNMLFKPEFLQNLAAECETQFRTVPAYAKLGPGGIDLLRRLLKYEPSERLTAAQALEHPYFSVEF--- Q06309 MTSRYERQEKIGEGTYGVVYKARDTSTAATVALKRIRLDSEEEGVPCTAIREISLLKELRHENIVKLLDVCHSEHRLTIVFEYLDLDLKKYLDRENGNLDAATIQHFMRDLLRGVAFCHQRSVLHRDLKPQNLLISREKELKLGDFGLGRSFAIPVRKFTNEVVTLWYRPPDVLLGSMQYGPPVDVWSVGCIFSEMATGTPLFAGKNDADQLMRIFRFLGTPNNRVWPSMNQYPNSNNMLSQPEFLQNFEPEWSNVLGSVPGYEKLGCAGVDLLERLLRYEPSERITAADALNHPYFSLQF--- P34117 -MEKYSKIEKLGEGTYGIVNKAKNRETGEIVALKRIRLDSEDEGVPCTAIREISLLKELKHPNIVRLHDVIHTERKLTLVFEYLDQDLKKYLDECGGEISKPTIKSFMYQLLKGVAFCHDHRVLHRDLKPQNLLINRKGELKLADFGLARAFGIPVRTYSHEVVTLWYRAPDVLMGSRKYSTPIDIWSALCIFAEMASGRPLFPGSGTSDQLFRIFKILGTPNEESWPSITELP-----EYKTDFPVHPAHQLSSIVH---G---LDEKGLNLLSKMLQYDPNQRITAAAALKHPYFDGLEPIN QUARTET PUZZLING TREE :---P54664 :100: :100: :---P38973 : : : :-------AAC48318 : :-----------Q06309 : :-----------P34117 Cyclophilin A AAB07896 T. brucei AAF05985 T. cruzi AAB07894 T. congolense AAB07895 T. vivax CAA73904 L. major *AAH05982 Homo sapiens AAB07896 MSYRPHHATVPTNPKVYFDVSIAGQAAGRITFELFADAVPKTAENFRALCTGEKGFGYAGSGFHRIIPQFMCQGGDFTRHNGTCGKSIYGEKFPDESFAGKAGKHFGAGTLSMANAGPNTNGSQFFICTAPTQWLDGKHVVFGQVLEGMDVVKAMEAVGSQGGSTSKPVKIDSCGQL- AAF05985 MSYKPHHATVPTNPKVFFDVSIGGQSAGRVVFELFADAVPKTAENFRALCTGEKNFGYAGSGFHRIIPQFMCQGGDFTNHNGTGGRSIYGEKFADESFAGKAGKHFGLGTLSMANAGPNTNGSQFFICTAPTQWLDGKHVVFGQVLEGIEVVKAMEAVGSQTGKTSKPVKIEASGQL- AAB07894 MSYKPHHPTVPTNPKVYFDITIGGTPAGRITFELFADAVPKTAENFRALCTGEKGFGYSGSGFHRIIPNFMCQGGDFTRHNGTGGKSIYGEKFPDESFAGKAGKHFGPGTLSMANAGPNTNGSQFFICTARTAWLDGKHVVFGQVLDGMNVVEGMEAVGSQTGSTDKPVMISESGQL- AAB07895 MSYEPHHPIVPSNPKVYFDISIGGQGAGRITFELFADAVPKTAENFRALCTGEKGFGFANSGFHRIIPNFMCQGGDFTNHNGTGGKSIYGAKFEDESFAGKAGKHFGPGTLSMANAGPNTNGSQFFICTARTQWLDGKHVVFGQVLEGMNVVKAVEGVGSQSGSTTKAVKIDSCGQL- CAA73904 MPYTPHYPVVESNPKVWMDIDIGGKPAGRVTMELFKDAVPQTAENFRALCTGEKGFGYANSPFHRVIPDFMCQGGDFTNGNGTGGKSIYGSKFADESFLGKAGKHFGPGTLSMANAGPNTNGSQFFLCTAPTSWLDGKHVVFGQVLEGYEVVKAMEAVGSRSGTTSKPVRVSACGQL- AAH05982 ----------MVNPTVFFDIAVDGEPLGRVSFELFADKVPKTAENFRALSTGEKGFGYKGSCFHRIIPGFMCQGGDFTRHNGTGGKSIYGEKFEDENFT---LKHTGPGILSMANAGPNTNGSQFFICTAKTEWLDGKHVVFGKVKEGMNIVEAMERFGSRNGKTSKKITIADCGQLE QUARTET PUZZLING TREE :---AAB07895 :-83: : :---CAA73904 :100: : : :---AAB07896 : :-60: : :---AAF05985 : :-----------AAB07894 : :-----------AAH05982 Cysteine proteinase P36400 L. mexicana CAA71085 L. mexicana CAC41275 L. mexicana CAA90237 L. mexicana AAL09443 L. donovani AAL09444 L. donovani AAB48120 L. major P25779 T. cruzi AAG35358 T. cruzi AAC00067 T. cruzi AAB41119 T. cruzi AAF75546 T. cruzi AAF75547 T. cruzi AAC37213 T. cruzi AAC14094 T. cruzi AAA79289 T. rangeli AAA79285 T. rangeli AAA79287 T. rangeli CAA81061 T. congolense AAA18215 T. congolense AAD24589 T. congolense CAA38238 T. brucei P14658 T. brucei P35591 L. pifanoi AAN34825 L. mexicana amazonensis AAL09448 L. donovani CAD12392 L. infantum CAC18865 L. major AAM09951 Cryptobia salmositica *AAB01769 Naegleria fowleri P36400 ----------------------------------MATSRAALCAVAVVCVVLAAACAPARAIHVGTPAAALFEEFKRTYGRAYETLAEEQQRLANFERNLELMREHQARNP-HAQFGIT-KFFDLSEAEFAARYLNGAAY---FAAAKRHAAQHYR-KARADLSAVPDAVDWREKGAVTPVKDQGACGSCWAFSAVGNIEGQWYLAGHELVSLSEQQLVSCDD----------MNDGCDGGLMLQAFDWLLQNTNGHLHTEDSYPYVSGNGYVPECSNSSE-LVVGAQIDGHVLIGSSEKAMAAWLAKNGPIAIALDASSFMSYKSGVLT----ACIGKQLNHGVLLVGYDMTGEVP-----YWVIKNSWGGDWGEQGYVRVVMGVNACLLSEYPVSAHVRESAAPGT----STSSETPAPRPVMVEQVICFDKNCTQGCRKTLIKANECHKNGGGGASMIKCSPQKVTMCTYSN-EFCVGGGLCFETPDGKCAPYFLGSIMNTCHYT------------------------------ CAA71085 ----------------------------------MATSRAALCAVAVVCVVLAAACAPARAIHVGTPAAALFEEFKRTYGRAYETLAEEQQRLANFERNLELMREHQARNP-HAQFGIT-KFFDLSEAEFAARYLNGAAY---FAAAKRHAAQHYR-KARADLSAVPDAVDWREKGAVTPVKNQGACGSCWAFSAVGNIEGQWYLAGHELVSLSEQQLVSCDD----------MDNGCSGGLMLQAFDWLLQNTNGHLYTEDSYPYVSGNGYVPECSNSSE-LVVGAQIDGHVLIGSSEKAMAAWLAKNGPIAIALDASSFMSYKSGVLT----ACIGKQLNHGVLLVGYDMTGEVP-----YWVIKNSWGGDWGEQGYVRVVMGVNACLLSEYPVSAHVRESAAPGT----STSSETPAPRPVVVEQVICFDKNCRRGCRKTLIKVNECRKNGGGGASMIKCSPQKVTMCTYSN-EFCVGGGLCFETHDGKCSPYFFGSIMNTCHYT------------------------------ CAC41275 ----------------------------------MATSRAALCAVAVVCVVLAAACAPARAIHVGTPAAALFEEFKRTYGRAYETLAEEQQRLANFERNLELMREHQARNP-HAQFGIT-KFFDLSEAEFAARYLNGAAY---FAAAKRHAAQHYR-KARADLSAVPDAVDWREKGAVTPVKDQGECGSCWAFSSVGNIEGQWYLAGHELVSLSEQQLVSCDD----------MNDGCDGGLMLQAFDWLLQNTNGHLYTEDSYPYVSGNGYLPECSNSSE-LVVGAQIDSHVLIGSSEKAMAAWLAKNGPIAIALDASSFMSYKSGVLT----ACIGKEVNHAVLLVGYDMTGEVP-----YWVIKNSWGGDWGEQGYVRVVMGVNACLLSEYPVSAHVRESAAPGT----STSSETPAQNG------------------------------------------------------------------------------------------------------------------- CAA90237 ----------------------------------MATSRAALCAVAVVCVVLAAACAPARAIHVGTPAAALFEEFKRTYGRAYETLAEEQQRLANFERNLELMREHQARNP-HAQFGIT-KFFDLSEAEFCARYLNGAAY---FAAAKRHTPQHYP-KARADLSAVPDAVDWREKGAVTPVKDQGACGSCWAFSAVGNIEGQWYLAGHELVSLSEQQLVSCDD----------MNDGCDGGLMLQAFDWLLQNTNGHLYTEDSYPYVSGNGYLPECSNSSK-LVVGAQIDGHVLIGSSEKAMAAWLAKNGPIAIALDASSFMSYKSGVLT----ACIGKQVNHAVLLVGYDMTGEVP-----YWVIKNSWGGDWGEQGYVRVVMGVNACLLSEYPVSAHVRESAAPGT----STSSETPAQNG------------------------------------------------------------------------------------------------------------------- AAL09443 ----------------------------------MATSRAALCAVAVVCVVLAAACAPARAIYVGTPAAALFEEFKRTYRRAYGTLAEEQQRLANFERNLELMREHQARNP-HARFGIT-KFFDLSEAEFAARYLNGAAY---FAAAKQHAGQHYR-KARADLSAVPDAVDWREKGAVTPVKNQGACGSCWAFSAVGNIESQWARVGHGLVSLSEQQLVSCDD----------KDNGCNGGLMLQAFEWLLRHMYGIVFTEKSYPYTSGNGDVAECLNSSK-LVPGAQIDGYVMIPSNETVMAAWLAENGPIAIAVDASSFMSYQSGVLT----SCAGDALNHGVLLVGYNKTGGVP-----YWVIKNSWGEDWGEKGYVRVAMGKNACLLSEYPVSAHVPRSLTPGP----GTESEERAPKRVTVEQVMCTDMYCREGCKKSLLTANVCYKNGGGGSSMTKCGPKKVLMCSYSN-PHCFGPGLCLETPDGKCAPYFLGSIMNTCQYT------------------------------ AAL09444 ----------------------------------MATSRAALCAVAVVCVVLAAACAPARAIYVGTPAAALFEEFKRTYRRAYGTLAEEQQRLANFERNLELMREHQARNP-HARFGIT-KFFDLSEAEFAARYLNGAAY---FAAAKQHAGQHYR-KARADLSAVPDAVDWREKGAVTPVKNQGACGSCWAFSAVGNIESQWARAGHGLVSLSEQQLVSCDD----------KDNGCNGGLMLQAFEWLLRHMYGIVFTEKSYPYTSGNGDVAECLNSSK-LVPGARIDGYVMIPSNETVMAAWLAENGPIAIGVDASSFMSYQSGVLT----SCAGDALNHGVLLVGYNTTGGVP-----YCVIKNSWGEDWGEKGYVRVAMGLNACLLSEYPVSAHVPQSLTPA-----LTASGNFCEACWTVMLHRILSVLKTNGWLLGRRPSARWREDGARGGQ------------------------------------------------------------------------------- AAB48120 ----------------------------------MATSRAALCAVAVVCVVLAVACAPARAIYVGTPAAALFEEFKRTYQRAYGTLTEEQQRLANFERNLELMREHQARNP-HARFGIT-KFFDLSEAEFAARYLNGAAY---FAAAKQHAGQHYR-KARADLSAVPDAVDWREKGAVTPVKNQGACGSCWAFSAVGNIESQWAVAGHKLVRLSEQQLVSCDH----------VDNGCGGGLMLQAFEWVLRNMNGTVFTEKSYPYVSGNGDVPECSNSSE-LAPGARIDGYVSMESSERVMAAWLAKNGPISIAVDASSFMSYHSGVLT----SCIGEQLNHGVLLVGYNMTGEVP-----YWVIKNSWGEDWGEKGYVRVTMGVNACLLTGYPVSVHVSQSPTPGP----NTTTTTHAPKRVTVKQITCTDYFCRKGCKTTVIPTKECLPNGAGGSFQMECGDHQVLKLTYTS-MNCTGEAKYTVTREGKCGISWSGSSKSICQYV------------------------------ P25779 ---------------------------------MSGWARALLL-AAVLVVMACLVPAATASLHAEETLTSQFAEFKQKHGRVYESAAEEAFRLSVFRENLFLARLHAAANP-HATFGVT-PFSDLTREEFRSRYHNGAAH---FAAAQERARVP----VKVEVVGAPAAVDWRARGAVTAVKDQGQCGSCWAFSAIGNVECQWFLAGHPLTNLSEQMLVSCDK----------TDSGCSGGLMNNAFEWIVQENNGAVYTEDSYPYASGEGISPPCTTSGH--TVGATITGHVELPQDEAQIAAWLAVNGPVAVAVDASSWMTYTGGVMT----SCVSEQLDHGVLLVGYNDSAAVP-----YWIIKNSWTTQWGEEGYIRIAKGSNQCLVKEEASSAVVGGPGPTPEPTTTTTTSAPGPSPS-YFVQMSCTDAACIVGCENVTLPTGQCLLTTSGVSAIVTCGAETLTEEVFLTSTHCSGPSVRSSVPLNKCNRLLRGSVEFFCGSSSSGRLADVD----RQRRHQPYHSRHRRL-- AAG35358 ---------------------------------MSGWARALLL-AAVLVVMACLVPAATASLHAEETLTSQFAEFKQKHGRVYESAAEEAFRLSVFRENLFLARLHAAANP-HATFGVT-PFSDLTREEFRSRYHNGAAH---FAAAQERARVP----VKVEVVGAPAAVDWRARGAVTAVKDQGQCGSCWAFSAIGNVECQWFLAGHPLTNLSEQMLVSCDK----------TDSGCSGGLMNNAFEWIVQENNGAVYTEDSYPYASGEGISPPCTTSGH--TVGATITGHVGLPQDEAQIAAWLAVNGPVAVAVDASSWMTYTGGVMT----SCVSEQLDHGVLLVGYNDSAAVP-----YWIIKNSRTTQWGEEGYIRIAKGSNQCLVKEEASSAVVLRSRPTPEPTTTTTTSAPGPSPS-YFVQMSCTDAACIVGCENVTLPTGQCLLTTSGVSAIVTCGAETLTEEVFLTSTHFSGPSVRSSVPLNKCNRLLRGSVEFFCGSSSSGRLADVD----RQRRHQPYHSRHRRL-- AAC00067 ---------------------------------MSGWARFVLL-AAVLVVMACLVPAATASLHAEETLTSQFAEFKQKHGRVYESAARRLP-LSVFRENLFLARLHAAANP-HATFGVT-PFSDLTREEFRSRYHNGAAH---FAAAQERARVP----VKVEVVGAPAAVDWRARGAVTAVKDQGQCGSCWAFSAIGNVECQWFLAGHPLTNLSEQMLVSCDK----------TDFGCSGGLMNNAFEWIVQENNGAVYTEDSYPYASGEGISPPCTTSGH--TVGATITGHVELPQDEAQIAACVAVNGPVAVAVDASSWMTYTGGVMT----SCVSEQLDHGVLLVGYNDSAAVP-----YWIIKNSWTTQ-GEEGYIRIAKGSNQCLVKEEASSAVVGGPGPTPEPTTTTTTSAPGPSPS-YFVQMSCTDAACIVGCENVTLPTGQCLLTTSGVSAIVTCGAETLTEEVFLTSTHCSGPSVRSSVPLNKCNRLLRGSVEFFCGSSSSGRLATWTGSVAISHTTAVIAASEGTLCF AAB41119 ---------------------------------MSGWARALSL-AAVLVVMACLVPAATASLHAEETLASQFAEFKQKHGRVYGSAAEEAFRLSVFRENLFLARLHAAANP-HATFGVT-AFSDLTREEFRSRYHNGAAH---FAAAQERARVP----VNVEVVGAPAAVDWRARGAVTAVKDQGQCGSCWAFSAIGNVECQWFLAGHPLTNLSEQMLVSCDK----------TDSGCGGGLMNNAFEWIVQENNGAVYTEDSYPYASGEGISPPCTTSGH--TVGATITGHVELPQDEAQIAAWLAVNGPVAVAVDASSWMTYTGGVMT----SCVSEQLDHGVLLVGYNDSAAVP-----YWVIKNSWTTQWGEDGYIRIAKGSNQCLVKEEASSAVVGGPGPTPEPTTTTTTSAPGPSPS-YFVQMSCTDAACIVGCENVTLPTGQCLLTTSGVSAIVTCGAETLTEEVFLTSTHCSGPSVRSSVPLNKCNRLLRGSVEFFCGSSSSGRLADVD----RQRRYQPYHSRHRRL-- AAF75546 ---------------------------------MSGWARALSL-AAVLVVMACLVPAATASLHAEETLASQFAEFKQKHGRVYESAAEEAFRLSVFRENLFLARLHAAANP-HATFGVT-PFSDLTREEFRSRYHNGAAH---FAAAQERARVP----VNVEVVGAPAAVDWRARGAVTAVKDQGQCGSCWAFSAIGNVECQWFLAGHPLTNLSEQMLVSCDK----------TDSGCGGGLMNNAFGWIVQENNGAVYTENSYPYASGEGISPPCTTSGH--TVGATITGHVELPQDEAQIAAWLAVNGPVAVAVDASSWMTYTGGVMT----SCVSEQLDHGVLLVGYNDSAAVP-----YWIIKNSWTAQWGEDGYIRIAKGSNQCLVKEEASSAVVGGPGPTPEPTTTTTTSAPGPSPS-YFVQMSCTDAACIVGCENVTLPTGQCLLTTSGVSAIVTCGAETLTEEVFLTSTHCSGPSVRSSVPLNQCNWLLRGSVEFFCGSSSSGRLADVD----RQRRYQPYQSRHRRL-- AAF75547 ---------------------------------MSGWARALSL-AAVLVVMACLVPAATASLHAEETLASQFAEFKQKHGRVYESAAEEAFRLSVFRENLFLARLHAAANP-HATFGVT-PFSDLTREEFWSRYHNGAAH---FAAAQERARVP----VNVEVVGAPAAVDWRARGAVTAVKDQGQCGSCWAFSAIGNVECQWFLAGHPLTNLSEQMLVSCDK----------TDSGCGGGLMNNAFEWIVQENNGAVYTEGSYPYASGEGISPPCTTSGH--TVGATITGHVEIPQDEAQIAAWLAVNGPVAVAVDASSWMTYTGGVMT----SCVSEQLDHGVLLVGYNDSAAVP-----YWVIKNSWTTHWGEGGYIRIAKGSNQCLVKEGVSSAVVGGPGTTPETNTTTTTSAPGPSPS-YFVQMSCTDAACSVGCENVTLPTGQCLLTTSGVSAIVTCGAETLTEEVFLTSTHCSGPSVRSSVPLNKCNRLLRGSVEFFRSSNSSGRLADVD----RQRRYQPYHSRHRRL-- AAC37213 ---------------------------------MSGWARALSL-AAVLVVMACLVPAATASLHAEETLASQFAEFKQKHGRVYGSAAEEAFRLSVFRANLFLARLHAAANP-HATFGVT-PFSDLTREEFRSRYHNGAAH---FAAAEERARVP----VDVEVVGAPAAKDWREEGAVTAVKNQGICGSCWAFAAIGNIEGQWFLAGNPLTRLSEQMLVSCDN----------TNSGCGGGLSSKAFEWIVQENNGAVYTEDSYPYHSCIGIKLPCKDSDR--TVGATITGHVELPQDEAQIAASGAVKGPLSVAVDASSWFFYTGGVLT----NCVSKRLSHAVLLVGYNDSAAVP-----YWIIKNSWTTHWGEGGYIRIAKGSNQCLVKEEVSSAVVGGPGTTPEPTTTTTTSAPGPSPS-YFVQMSCTDAACSVGCENVTLPTGQCLLTTSGVSAIVTCGAETLTEEVFLTSTHCSGPSVRSSVPLNKCNRLIRGSVEFFRSSNSSGRLADVD----RQRRYQPYHSRHRRL-- AAC14094 MLLLSTSTPARHHSLKVTLLKAHKEGNTPTQTVMSGWARALLL-AAVLVVMACLVPAATASLHAEETLASQFAEFKQKHGRVYESAAEEAFRLSVFRENLFLARLHAAANP-HATFGVT-PFSDLTREEFRSRYHNGAAH---FAAAQERARVP----VDVEVVGAPAAKDWRKEGAVTAVKNQGLCGSCWAFAAIGNVESQWFLAGHPLTRLSEQMLVSCDD----------TNFGCGGGWPLGAFKWIVDRNNGTVYTEESYPYHSCIVIKLPCKDSDR--TVGATVQDTVSSPQDEAQIVAWLAVNGPHFAVIDIIGWMFYTRGVFT------------------VYFCMCVFS-----LWTFK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------- AAA79289 ---------------------------------MTGPARTLSL-VAVLVVVLCLLPAAMASLRVEETLASQFAAFKQRHGKVYGSAAEETFRLGVFKENLLFARLHAAANP-HASFGVT-PFSDLTREEFRSRYHNAAAH---FAAAQKRVRVPVEVEVEVEVGGAPAAVDWRARGAVTAIKDQGNCSSCWAFSTIGNIEGQWHLAGNPLTGLSEQMLVSCDN----------ADNGCDGGLMDSAFDWIVEQNNGSVYTEASYSYVSGGGDSQTCDMSDH--VVGAVISGHVDLPQDEDKMAAWLAVNGPLAIAV------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ AAA79285 ---------------------------------MTGPARTLSL-VAVLVVVLCLLPAAMASLRVEETLASQFAAFKQRHGKVYGSAAEEAFRLGVFKENLLFARLHAAANP-HASFAVT-PFSDLTREEFRSRYHNAAAH---FAAAQKRVRVP--VEVEVEVGGPPAAVDWRARGAVTAIKDQGNCSSCWAFSTIGNIEGQWHLAGNPLTGLSEQMLVSCDN----------ADNGCDGGLMDSAFDWIVEQNNGSVYTEASYSYVSGGGDSQTCDMSDH--VVGAVISGHVDLPQDEDKMAAWLAVNGPLAIAV------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ AAA79287 ---------------------------------MTGPARTLSL-VAVLVVVLCLLPAAMASLRVEETLASQFAAFKQRHGKVYGSAAEEAFRLGVFKENLLFARLHAAANP-HASFGVT-PFSDLTREEFRSRYHNAAAH---FAAAQKRVRVP--VEVEVEVGGAPAAVDWRARGAVTAIKDQGGCGSCWAFSTIGNIEGQWHLAGNPLTGLSEQMLVSCDN----------ADNGCDGGLMDSAFDWIVGQNNGSVYTEASYSYVSGGGDSQTCNMSSH--VVGAVISGHVDLPQDEDKMAAWLAVNGPLAIAV------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ CAA81061 ------------------------------------MTRTLRFSVGLLAVAACFVPVALGVLHAEQSLQQQFAAFKQKYSRSYKDATEEAFRFRVFKQNMERAKEEAAANP-YATFGVT-RFSDMSPEEFRATYHNGAEY---YAAALKRPRKV----VNVSTGKAPPAVDWRKKGAVTPVKDQGACGSCWAFSAIGNIEGQWKVAGHELTSLSEQMLVSCDT----------TDYGCRGGLMDKSLQWIVSSNKGNVFTAQSYPYASGGGKMPPCNKSGK--VVGAKISGHINLPKDENAIAEWLAKNGPVAIAVDATSFLGYKGGVLT----SCISKGLDHDVLLVGYDDTSKPP-----YWIIKNSWSKGWGEEGYIRIEKGTNQCLMKNYARSAVVSG-----------PPPPPPPPAS-TFTQEFCEGAECQSGCTKATFPTGKCVQFGGAGSVIASCGSNNLTQIVYPLSSSCSGFSIPLTVPLDKCLPIVVGSVMYECSGKAPTESARLVRHE------------------ AAA18215 -------------------------------MPRSEMTRTLRFSVGLLAVAACFVPVALGVLHAEQSLQQQFAAFKQKYSRSYKDATEEAFRFRVFKQNMERAKEEAAANP-YATFGVT-RFSDMSPEEFRATYHNGAEY---YAAALKRPRKV----VNVSTGKAPEAVDWRKKGAVTPVKDQGQCGSCWAFSAIGNIEGQWKVAGHELTSLSEQMLVSCDT----------NDFGCEGGLMDDAFKWIVSSNKGNVFTEQSYPYASGGGNVPTCDKSGK--VVGAKIRDHVDLPEDENAIAEWLAKNGPVAIAVDATSFQSYTGGVLT----SCISEHLDHGVLLVGYDDTSKPP-----YWIIKNSWSKGWGEEGYSALRR-HNQCLMKNLPSSAVVSG-----------PPPPPPTP---TFTQELCEGAECQSKCTKATFPTGKCVQLSGAGSVIASCGSNNLTQIVYPLSSSCSGFSVPLTVPLDKCLPIVIGSVMYECSDKAPTESARLVRHE------------------ AAD24589 -------------------------------MPRSEMTRTLGFSVGLHAVAACFVPVALGVLHAEQSLQQQFAAFKQKYSRSYKDATEEAFRFRVFKQNMERAKEEAAANP-YATFGVT-RFSDMSPEEFRATYHNGAEY---YAAALKRPRKV----VNVSTGKAPPAIDWRKKGAVTPVKDQGQCHSSWAFSAIGNIEGQWKIAGHELTSLSEQMLVSCDT----------NDFGCGGGFSDPAFKWIVSSNKGNVFTEQSYPYASGGGNVPTCDKSGK--VVGAKIRDRVDLPRDENAIAEWLAKKGPVAIAVDATSFQSYTGGVLT----SCISEHLDHGVLLVGYDDTSKPP-----YWIIKNSWGKGWGEEGYIRIEKGTNQCLMKNLPSSAVVSG-----------PPPPPPTP---TFTQELCEGAECQSKCTKATFPTGKCVQLSGAGSVIASCGSNNLTQIVYPLSSSCSGFSVPLTVPLDKCLPIVIGSVMYECSDKAPTDPPG----------------------- CAA38238 -------------------------------MPRTEMVRFVRLPVVLLAMAACLASVALGSLHVEESLEMRFAAFKKKYGKVYKDAKEEAFRFRAFEENMEQAKIQAAANP-YATFGVT-PFSDMTREEFRARYRNGASY---FAAAQKRVRKT----VNVTTGRAPAAVDWREKGAVTPVKDQGQCGSCWAFSTIGNIEGQWQVAGNPLVSLSEQMLVSCDT----------IDFGCGGGLMDNAFNWIVNSNGGNVFTEASYPYVSGNGEQPQCQMNGH--EIGAAITDHVDLPQDEDAIAAYLAENGPLAIAVDATSFMDYNGGILT----SCTSEQLDHGVLLVGYNDNSNPP-----YWIIKNSWSNMWGEDGYIRIEKGTNQCLMNQAVSSAVVGGPTP--------PPPPPPPPSA-TFTQDFCEGKGCTKGCSHATFPTGECVQTTGVGSVIATCGASNLTQIIYPLSRSCSGPSVPITVPLDKCIPILIGSVEYHCSTNPPTKAARLVPHQ------------------ P14658 -------------------------------MPRTEMVRFVRLPVVLLAMAACLASVALGSLHVEESLEMRFAAFKKKYGKVYKDAKEEAFRFRAFEENMEQAKIQAAANP-YATFGVT-PFSDMTREEFRARYRNGASY---FAAAQKRLRKT----VNVTTGRAPAAVDWREKGAVTPVKVQGQCGSCWAFSTIGNIEGQWQVAGNPLVSLSEQMLVSCDT----------IDSGCNGGLMDNAFNWIVNSNGGNVFTEASYPYVSGNGEQPQCQMNGH--EIGAAITDHVDLPQDEDAIAAYLAENGPLAIAVDAESFMDYNGGILT----SCTSKQLDHGVLLVGYNDNSNPP-----YWIIKNSWSNMWGEDGYIRIEKGTNQCLMNQAVSSAVVGGPTP--------PPPPPPPPSA-TFTQDFCEGKGCTKGCSHATFPTGECVQTTGVGSVIATCGASNLTQIIYPLSRSCSGPSVPITVPLDKCIPILIGSVEYHCSTNPPTKAARLVPHQ------------------ P35591 ------------------------------MARRNPLLFAIVVTILFVVCYGSALIAQTPPPVDNFVASAHYGSFKKRHGKAFGGDAEEGHRFNAFKQNMQTAYFLNTQNP-HAHYDVSGKFADLTPQEFAKLYLNPDYY----ARHLKDHKED--VHVDDSAPSGVMSVDWRDKGAVTPVKNQGLCGSCWAFSAIGNIEGQWAASGHSLVSLSEQMLVSCDN----------IDEGCNGGLMDQAMNWIMQSHNGSVFTEASYPYTSGGGTRPPCHDEGE---VGAKITGFLSLPHDEERIAEWVEKRGPVAVAVDATTWQLYFGGVVS----LCLAWSLNHGVLIVGFNKNAKPP-----YWIVKNSWGSSWGEKGYIRLAMGSNQCMLKNYPVSATVE---------SPHTPHVPTTTA-------------------------------------------------------------------------------------------------------------------- AAN34825 ------------------------------MARRNPLLFAIVVTILFVVCYGSALIAQTPPAVDNFVASAHYGSFKKRHSKAFGGDAEEGHRFNAFKQNMQTAYFLNTQNP-HAHYDVSGKFADLTPQEFAKLYLNPDYY----TSHLKDHKED--VHVDDSAPSGVMSVDWRDKGAVTPVKNQGLCGSCWAFSAIGNIEGQWAASGHSLVSLSEQMLVSCDN----------VDEGCNGGLMDQAMNWIMQSHNGSVFTEASYPYTSGGGTRPPCHDEGE---VGAKITGFLSLPHDEERIADWVEKRGPVAVAVDATTWQLYFGGVVS----LCLAWSLNHGVLIVGFNKNAKPP-----YWIVKNSWGSSWGEKGYIRLAMGSNQCMLKNYPVSATVE---------SPHTPHVPTTTA-------------------------------------------------------------------------------------------------------------------- AAL09448 -------------------------------MARNPFFFAIVVTILFVVCYGSALIAQTPLGVDDFIASAHYGRFKKRHGKPFGEDAEEGRRFNAFKQNMQTAYFLNAHNP-HAHYDVSGKFADLTPQEFAKLYLNPNYY----ARHGKDYKEH--VHVDDSVRSGVMSVDWREKGVVTPVKNQGMCGSCWAFATTGNIEGQWALKNHSLVSLSEQVLVSCDN----------IDDGCNGGLMEQAMQWIINDHNGTVPTEDSYPYTSAGGTRPPCHDNGT---VGAKIAGYMSLPHDEEEIAAYVGKNGPVAVAVDATTWQLYFGGVVT----LCFGLSLNHGVLVVGFNRQAKPP-----YWIVKNSWGSSWGEKGYIRLAMGSNQCLLKNYAVTATID---------DSNTSHVPTTAA-------------------------------------------------------------------------------------------------------------------- CAD12392 ------------------------------MARRNPFFFAIVVTIRFVVCYGSALIAQTPLGVVDFIASAHYGRFKKRHGKPFGEDAEEGRRFNAFKQNMQTAYFLNAHNP-HAHYDVSGKFADLTPQEFAKLYLNPNYY----ARHGKDYKEH--VHVDDSVRSGVMSVDWREKGVVTPVKNQGMCGSCWAFATTGNIEGQWALKNHSLVSLSEQVLVSCDN----------IDDGCNGGLMQQAMQWIINDHNGTVPTEDSYPYTSAGGTRPPCHDNGT---VGAKIKGYMSLPHDEEEIAAYVGKNGPVAVAVDATTRQLYFGGVVT----LCFGLSLNHGVLVVGFNRQAKPP-----YWIVKNSWGSSWGEKGYIRLAMGSNQCLLKNYVVTATID---------DSNTSHVPTTAA-------------------------------------------------------------------------------------------------------------------- CAC18865 ------------------------------MARRNPFLFAIVVTILFVVCYGSALVAQTPLGVDNFIASAHYGRFKERHGKSFGEDADEGHRFNAFKQNMQTAYFLNTHNP-HAHYDVSGKFADLTPQEFAKLYLNPDYY----AHRGKDYKEH--VHVDDSVLSGAMSVDWREKGAVTPVKNQGMCGSCWAFSAIGNIESQWALKNHSLVSLSEQMLVSCDD----------IDDGCNGGLMDQAMEWIIQHHNGTVPTEKSYPYASAGGTSPPCHDKGE---FGARISGYMSLPHDEKAIAAYVEKKGPVAVAVDATTWQLYFGGVVT----LCFGLSLNHGVLVVGFNKRAKPP-----YWIVKNSWGTSWGEKGYIRLAMGSNQCLLKNYPVTATVD---------DSNTSHVPTTTA-------------------------------------------------------------------------------------------------------------------- AAM09951 --------------------------------------------------MG----APT--------TEVLFGNFKAAHARNYASPDEERKRFEIFAGNMKKAAVLNRKNP-MATFGPN-EFADMTSEEFQTRHNAARHYAAAKARPPKNTKTF--TAEEIKAAVG-QQIDWRLKGAVTPVKNQGACGSCWSFSTTGNIEGQHAIATGQLVAVSEQELVSCDP----------IDDGCNGGLMDNAFGWLISAHKGQIATEANYPYVSGNGIVPACSSSPESKPVGATISAFQDIARTEEDMAAFVFKHGPLSIGVDASTWQSYAGGIMS----YCPQDQIDHGVLIVGFDDTASTP-----YWIIKNSWTANWGEEGYIRVAKGSNQCGLTSHPSSSVVGN--------SPSPTPAPTTPGSGSLIQMYCFDDKCSNGCRKNTLPLHTCLPLNGGGSAIASCNPIQVILSIYQT-IDCTGPSQPNAMSLNQCLLGNTGYFENICTSNTNTAMPKGLLLPRGF--------------- AAB01769 ---------------------------------------SLLIAAVLLIACVGVVLAQEYKPLAESEMKKLFIKFSRKYAKVYG-TEEHNNRYQIFKANVEKSRYYNHVGK-RENFGIT-KFSDLTPEEFKRMFLMKTYTP--EEAKKILAAPQHAVLSEKEVQTAPTSFDWRQHGAVTRVKNQGACGSCWTFSTTGNVEGQWAIKKGKLVSLSEQQLVDCDHNCVTYQNQQACDSGCNGGLMWSAFQYVIK--NGGLDTEDSYPY---EGVDDTCRFNKS--NVAATISSWTSISSDENQMAAWLAANGPISIAINAEWLQYYTSGISDP--WFCNPQDLDHGVLIVGYGVGKSWLGSEENYWIVKNSWGSDWGEDGYFRIIRGKGKCGLNSVPSSSIV------------------------------------------------------------------------------------------------------------------------------------------ QUARTET PUZZLING TREE :---AAL09443 :-98: :-96: :---AAL09444 : : : :-------AAB48120 :-------------99: : : :---P36400 : : :-87: : : : :---CAA71085 : :-80: : : :---CAC41275 : :-83: : :---CAA90237 : : :---AAC37213 : :---------99: : : :---AAC14094 : : :-89: : :---P25779 : : :100: :-52: : : : : :-88: :---AAG35358 : : : : : : : : : : : :-------AAC00067 : : : :-76: : : : : :---AAB41119 : : :-99: : : : : : : :-----64:---AAF75546 : : : : : : : : : :---AAF75547 : : : : : : : : :---AAA79289 : : : : :100: : :-98: :--------100: :---AAA79285 :-89: : : : : : :-------AAA79287 : : : : : : :---CAA38238 : : : :----100: : : : : :---P14658 : : :---------98: : : : :---AAA18215 : : : :100: : : :100: :---AAD24589 : : : : : :-------CAA81061 : : : : :---P35591 : : :-----99: : : : :---AAN34825 : :-----------------88: : : :---AAL09448 : : :-95: : :-91: :---CAD12392 : : : :-------CAC18865 : :-----------------------------------AAM09951 : :-----------------------------------AAB01769 Cytochrome b P00164 T. brucei CAB53021 T. cruzi P14548 L. tarentolae AAA73455 Trypanoplasma borreli *AAG17790 Naegleria gruberi *AAD19675 Pedinomonas minor P00164 ------------MLYKSGEKRKGLLMSGCLYRIYGVGFSLGFFIALQIICGVCLAWLFFSCFICSNWYFVLFL-WDFDLGFVIRSVHICFTSLLYLLLYIHIFKSITLIILFDTHILVWFIGFILFVFIIIIAFIGYVLPCTMMSYWGLTVFSNIIATVPILGIWLCYWIWGSEFINDFTLLKLHVLHVLLPFILLIILILHLFCLHYFMSSDAFCDRFAFYCERLSFCMWFYLRDMFLAFSILLCMMYVIFINWYFVFHEESWVIVDTLKTSDKILPEWFFLYLFGFLKAIPDKFMGLFLMVI--LLFSLFLFILN---CILWFVYCRSSLLWLTYSLILFYSIWMSGFLALYVVLAYP----IWMELQYWVLLLFLLIVCR--LD----------------------------------------------------------------------------------------------------------------- CAB53021 -------------------------MSGCLYRVYGVGFSLGFFIALQIICGVCLAWMFFSCFICANWYFILFL-WDFDLGFVIRSVHICFTSLLYFLLYVHIFKCIILVILFDTHLLVWFVGFILFVFIIVIAFIGYVLPCTMMSYWGLTVFSNILATVPVFGQWLCYWIWGSEFINDFTLLKLHVLHVLLPFVLILV-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- P14548 --MFFR--VRFLLFFLLFRNLCCLLTSGCLLRVYGVGFSLGFFICMQIICGVCLAWLFFSCFICTNWYFVLFL-WDFDLGFVIRSTHICFTSLLFFLLYVHIFKCIVLIILFDTHILVWAVGFIIYIFIVVIGFIGYVLPCTMMSYWGLTVFSNILATVPVIGTWLCYWIWGSEYINDFTLLKLHVLHVLLPFVLILVIFMHLFCLHYFMSSDGFCDRFAFYCERLCFCMWFYLRDMFLAFLILFYVVYFIFINWYFVFHEESWVIVDTLKTSDKILPEWFFLFLFGFLKAVPDKFTGLLLMVI--LLFSLFLFILN---CILWFVYCRSSLLWFTYSLILFYSIFMSGFLALYVILAYP----IWMELQFWVLLLFMLVVCR--LD----------------------------------------------------------------------------------------------------------------- AAA73455 --MFFR--LRFLVFFVLFRNLCCLLLSGDLFRVYGLGFNLGVMIALQILVGICLSWFFFRCIIPQNWIFTLLIHLEFDLGFIIRSLHIIFTSLLYFLLYIHIIKVIFLCLIFDSSMLVWFFGFLIFIFILIIAFIGYTLPCTSMSYWGLTVFSNILATIPLIGIYICQWIWCSEFINDFTLLKLHSIHIFLPFVLLFLIGAHFFVLHYFLSSDGLLDRFPFYYERFFFFLLYYLRDLFLIINILCFLIYYICIYWFFVFHEESWIIVDTLKTSDKILPEWFFLSFFGFLKSVPDKFMGLFLLFV--LCFALFLFILN---CILIFIYCRSSLLWMSLSLVLFYYLCVGGFLSLYVVLCFP----LWMEIQFWVLLLFCFIVCR--LD----------------------------------------------------------------------------------------------------------------- AAG17790 MKYLNNILFVNFVSKALYSYLIKYPTPMNINYLWNFGFMSAIFLVIQIVSGLFLT-FFFTPHVDLAFFSVEHIMRDVNYGWLIRYIHANGASFFFFLVYIHILKGIYYGSYYFPRTLVWFTGVIIYILMMGTAFLGYVLPWGQMSYWAATVITNFVTVIPVVGKDIVYWVWGGYSINNATLNRFFSLHYLLPFVIALLSAYHIYQLHKSGSSNELGIR-SHYLNKISFYPYFLVKDFFGLFIILFVFSIFVFFFPEAFNHSDNYIKANPLVTPAHIVPEWYFLPLYGILRSILNKTYGIIIMFVSLLVLFILPFVDKSLIKNKTFKPFNRTLFWFFSFNFLFLG-YLGSQAPVYPYIEFGVICSHFHLLYFFLLIPLSVFFESSFFNYFFSSNETRGNFSFIYWLIGAGFVFSTLFISYYLGVNSGVDSVVTSLVDSLYILDPVHVELGLRDIEIEKYTNLIHNEFAFTSSFFSCLWHFIVTQFFLYSVTIILFILIIKL AAD19675 --MLS--LYNQPMFKALNEHFVFYQSPVIINYFWNFGSLAGVFLFIQILTGIFLA-MFYIPSADAAFASVEFLMRDVNNGWFIRFMHVNGASFFFIVVYAHIFRAFFYSSFTYPREFVWFIGIIILFLIILTAFIGYVLPWGQISFWGATVITSIVTAIPLLGNDLVTWVWGGFNVDDPTLHRFFSLHYLMPFVLLGLVVVHILALHQYGSNNPIGI--SIDADKVTLHPYFTIKDLAGVFLIFIFYFYFVCFEPDFLNHPDNCIPANSIKTPVHIVPEWYFLVVYAILRSIPNKLLGILAILLVFVCFALLPIVYGYSSRAMLFRPFHSLFFWVWVGSCIGLG-WVGGAPAATPYIEFG---QLFSIYFFFYLIVINFIFSN--LD----------------------------------------------------------------------------------------------------------------- QUARTET PUZZLING TREE :---P00164 : :---CAB53021 :100: : :---P14548 : : : :---AAA73455 : :-------AAG17790 : :-------AAD19675 Cytochrome-c oxidase II P14545 L. tarentolae CAA33189 Crithidia fasciculata P04372 T. brucei AAA16806 T. cruzi AAC38976 Bodo saltans S52050 Trypanoplasma borreli *CAD56915 Ciona intestinals *AAF27980 Hydra vulgaris P14545 --------------------------MAFI-LSFWMIFLLDSVIVLLSFVCFVCVWICALLFSTVLLVSKLN-NIYCTWDFTASKFIDVYWFTIGGMFSLGLLLRLCLLLYFGHLNFVSFDLCKVVGFQWYWVY--FIFGETTIFSNLILES-DYMIGDLRLLQCNHVLTLLSLVIYKLWLSAVDVIHSFAISSLGVKVDCIPGRCNEIVLFSSNNATVYGQCSELCGVLHGFMPIVICFI--------------- CAA33189 --------------------------MAFI-LSFWMIFLIDAVIVLLSFVCFVCIWICSLFFSSFLLVSKIN-NVYCTWDFTASKFIDAYWFTIGGMFVLCLLLRLCLLLYFGCLNFVSFDLCKVVGFQWYWVY--FIFGETTIFSNLILES-DYLIGDLRLLQCNHVLTLLSLVIYKLWLSAVDVIHSFAVSSLGIKVENLDVVMRLFYFLR--IIQQY--TVNAVNYVVSYMDLCL------------------ P04372 --------------------------MSFI-LTFWMIFLMDSIIVLISFSIFLSVWICALIIATVLTVTKIN-NIYCTWDFISSKFIDTYWFVLGMMFILCLLLRLCLLLYFSCINFVSFDLCKVIGFQWYWVY--FLFGETTIFSNLILES-DYLIGDLRILQCNHVLTLLSLVIYKLWVSAVDVIHSFTISSLGIKVDCIPGRCNEIILFATNNATLYGQCSELCGVLHGFMPIVINFI--------------- AAA16806 --------------------------MSFI-LSFWMIFLIDSVIVLLSFVCFVCVWICVLLLSTVLFVTKIN-NIYCTWDFVSSKFVDTYWFVIGVMFIMCLLLRLCLLLYFGCLNFVSFDLCKVVGFQWYWVY--FLFGETTIFSNLILES-DYLVGDMRLLQCNHVLTLLSLVIYKLWVSAVDVIHSFTLASLGIKVDCIPGRCNEIILFASNNATIYGQCSELCGVLHGFMPIVICFI--------------- AAC38976 --------------------------MSFI-ISFWMLFLIDSLIVLLSGAIFVCIWICSLFFLCILFICKLD-YIFCSWDFISAKFIDLYWFTLGCLFIVCLLIRLCLLLYFSCLNFVCFDLCKCIGFQWYWVY--FIFGETTIFSNLILES-DYLIGDLRLLQCNHVLTLLSLVIYKVWLSAIDVIHSFTLANLGIKVDCIPGRCNEIIIFSNSSSTIYGQCSELCGVLHGFMPIVVSFV--------------- S52050 --------------------------MLFF-INQLLLLLVDTFVILEIFSLFVCVFIIVMYILFINYNIFLK-NINVYLDFIGSKYLDLYWFLIGIFFVIVLLIRLCLLLYYSWISLLIFDLCKIMGFQWYWIF--FVFKENVIFSNLLIES-DYWIGDLRLLQCNNTFNLICLVVYKIWVTSIDVIHSFTISTLGIKIDCIPGRCNELTIFSNIGGTFYGQCSELCGVLHGFMPVVIEFI--------------- CAD56915 -----------------------MYPYSFIQLTDSNTFFGHEIVLFHDFSLASLVFILTAV---LLMSKALKKKKYVVLAYKGSNMLEFLWTFFPVFILISIGLPSLYLMYLLEGSFKGDLTFKVVGHQWYWSYEGGDFN-DFDMSSYMVPSEDLQEGQFRLLEVDNSMVLPYSTNIRLMITSYDVIHSWTLPSLKMKVDAVPGRLNTMNIFSFQPGSFYGQCSEICGLLHSFMPIHVEFVNWETFLNHVTEESFN AAF27980 MKNLIFLISFFTCLLFNNFIYKDIPEINQLSFQESASSCSNNLIFFHDNTMFYMIIILVLVG-WLLFSIIIN-KNYNKFLLEN-NFIEIVWTLIPAIILIIIAIPSLFLLYSIDENVEPSLTVKIVGHQWYWSYEYSNFSPNIEFDSYMIPTTDLNQGDFRLLETDNDLVLPVNTKIKLIVSSADVIHCWTVPSLGVKVDAIPGRLNQLNFIINRPGKFFGQCSELCGLNHSFMPISIYSVSQEKFINWSINKT-- QUARTET PUZZLING TREE :---P14545 :100: :-87: :---CAA33189 : : : :-------AAA16806 :-99: : :-----------P04372 :100: : : : :-----------AAC38976 : : : :---------------S52050 : :-------------------CAD56915 : :-------------------AAF27980 DHFR-TS Q27793 T. cruzi AAK71186 T. vespertilionis Q27783 T. brucei CAA36019 L. major AAA29272 L. tropica AAM88660 L. tropica AAM82248 L. infantum AAM88576 L. donovani chagasi P16126 L. mexicana amazonensis AAA30318 Crithidia fasciculata *NP_179230 Arabidopsis thaliana Q27793 ------MSLFKIRMPETVAEGTRLALRAFSLVVAVDEHGGIGDGRSIPWNVPEDMKFFRDLTTKLRGKNVKPSPAKRNAVVMGRKTWDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLHADSIVAVNGGLEQALRLLASPNYTPSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRASESSCSVFFRVPESGTEA------------------------AAGIEWQRETISEELTSANGNE------TKYYFEKLIPRNREEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLRNNRLPLLTTKRVFWRGVCEELLWFLRGETYAKKLSDKGVHIWDDNGSRAFLDSRGLTEYEEMDLGPVYGFQWRHFGAAYTHHDANYDGQGVDQIKAIVETLKTNPDDRRMLFTAWNPSALPRMALPPCHLLAQFYVSN--GELSCMLYQRSCDMGLGVPFNIASYALLTILIAKATGLRPGELVHTLGDAHVYSNHVEPCNEQLKRVPRAFPYLVFRREREFLEDYEEGDMEVIDYAPYPPISMKMAV AAK71186 ----------------TVAEGTRLALRAFSLVVAVDEHGGIGDGRSIPWNVPEDMKFFKDVTTKLRGKNVKPSPAKRNAVVMGRKTWDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLQDEEKRNLYADSIVAVNGGLEQALQLLASLNYTPSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRASESSCSVFFHVPEPGTEP------------------------AAGIEWQRETISEELTSANGNE------TKYYFEKLIPRNREEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLRNNRLPLLTTKRVFWRGVCEELLWFLRGETYAKKLSDKGVHIWDDNGSRAFLDSRGLTEYEEMDLGPVYGFQWRHFGAAYTHHDANYDGQGVDQIKAIVETLKTNPDDRRMLFTAWNPSALPRMALPPCHLLAQFYVSN--GELSCMLYQRSCDMGLGVPFNIASYALLTILIAKATGLRPGELVHTLGDAHVYSNHVEPCKEQLKRVPRAFPYLVFRREREFLEDYEE-------------------- Q27783 MLSLTRILRKKIPVHELAGKISRPPLRPFSVVVASDEKGGIGDGGTIPWEIPEDMQYFRRVTTNLRGKNVKPSPSKRNAVVMGRKTWDSLPPKFRPLSNRLNVVLSRSATKEQLLAGIPDPIKRAEAANDVVAVNGGLEDALRMLVSKEHTSSIETVFCIGGGTIYKQALCAPCVNVLQAIHRTVVRPASNSCSVFFDIPAAGTKT------------------------PEGLELVRESITDERVSTGAGG------KKYQFEKLVPRNSEEEQYLNLVGRIIDEGCTKCDRTGVGTRSLFGAQMRFSLRNNRLPLLTTKRVFWRGVCEELLWFLRGETNAKLLSDKGIHIWDGNGSRAFLDSRGLTDYDEMDLGPVYGFQWRHFGADYISCKVDSEGKGVDQIANIVKSLIENPDDRRMICTAWNPAALPRMALPPCHMMAQFYVSN--GELSCMLYQRSCDMGLGVPFNIASYALLTFLMAKASGLRPGELVHTLGDAHVYSNHVEPCRKQLKRVPRPFPFIVFKQDKEFLEDFQESDIEVIDYSPYPVISMEMAV CAA36019 --MSRAAARFKIPMPETKADFAFPSLRAFSIVVALDMQHGIGDGESIPWRVPEDMTFFKNQTTLLRNKKP-PTEKKRNAVVMGRKTWESVPVKFRPLKGRLNIVLSSKATVEELLAPLPEG-QRAAAAQDVVVVNGGLAEALRLLARPLYCSSIETAYCVGGAQVYADAMLSPCIEKLQEVYLTRIYATAPACTRFFPFPPEN----------------------------AATAWDLASSQGRRKSEAEG-------LEFEICKYVPRNHEERQYLELIDRIMKTGIVKEDRTGVGTISLFGAQMRFSLRDNRLPLLTTKRVFWRGVCEELLWFLRGETSAQLLADKDIHIWDGNGSREFLDSRGLTENKEMDLGPVYGFQWRHFGADYKGFEANYDGEGVDQIKLIVETIKTNPNDRRLLVTAWNPCALQKMALPPCHLLAQFYVNTDTSELSCMLYQRSCDMGLGVPFNIASYALLTILIAKATGLRPGELVHTLGDAHVYRNHVDALKAQLERVPHAFPTLIFKEERQYLEDYELTDMEVIDYVPHPAIKMEMAV AAA29272 --MSRAAARFKIPMPETKADFAFPSLRAFCIVVALDMQHGIGDGESIPWRSPEDMTFFKNQTTLLRNKKP-PTEEEAQRVVMGRKTWESVPVKFRPLKGRLNIVLSSKATVEELLAPLPEG-QRAAAARMLVVVNGGLAEALRLLARPLYCSSIETAYCVGGAQVYADAMLSPCIEKLQEVYLTRIYATAPACTRFFPFPPEN----------------------------AATAWDLASSQGRRKSEAEG-------LEFEICKYVPRNHEERQYLELIDRIMKTGIVKEDRTGVGTISLFGAQMRFSLRDNRLPLLTTKRVFWRGVCEELLWFLRGETSAQLLTDKDIHIWDGNGSREFLDSRGLTENKEMDLGPVYGFQWRHFGADYKGFEANYDGEGVDQIKLIVETIKTNPNDRRLLVTAWNPCALQKMAVPPCHLLAQFYVNTDTSELSCMLYQRSCDMGLGVPFNIASYALLTILIAKATGLRPGELVHTLGDAHVYRNHVDALKAQLERVPHAFPTLIFKEERQYLEDYELTDMEVIDYVPHPAIKMEMAV AAM88660 --MSRAAARFKILMPETKADFAFPSLRAFSIVVALDKQHGIGDGESIPWRVPEDMAFFKDQTTLLRNKKP-PTEKKRNAVVMGRKTWESVPVKFRPLKGRLNIVLSSKATVEELLAPLPEE-KRAAAEQDVVVVNGGLAEALRLLARPPYCSSIETAYCVGGAQVYADAMLSPCVEKLQEVYLTRIYTTAPACTRFFPFPPEN----------------------------AATAWDLASSQGRRKSEAEG-------LEFEICKYVPRNHEERQYLELIDRIMKTGIVKEDRTGVGTISLFGAQMRFSLRGNRLPLLTTKRVFWRGVCEELLWFLRGETNARLLADKDIHIWDGNGSREFLDSRGLTENKEMDLGPVYGFQWRHFGADYKGFEANYDGEGVDQIRFIVETIKANPNDRRLLVTAWNPCALQKMALPPCHLLAQFYVNTDTSELSCMLYQRSCDMGLGVPFNIASYALLTILIAKATGLRPGELVHTLGDAHVYRNHVDALKAQLERVPHAFPTLIFKAERQFLEDYELTDMEVIDYVPHPPIKMEMAL AAM82248 --MSRAAARFKIPMPATKADFAFPSLRAFSIVVALDKQHGIGDGESIPWRVPEDMAFFKDQTTLLRNKKP-PTEKKRNAVVMGRKTWESVPVKFRPLKGRLNIVLSSKATVEELLAPLPEG-KRAAAAQDVVVVNGGLAEALRLLARPPYCSSIETAYCVGGAQVYADAMLSPCVEKLQEVYLTRIYTTAPACTRFFPFPPEN----------------------------TTTAWDLASSQGRRKSEADG-------LEFEICKYVPRNHEERQYLELIDRIMKTGIVKEDRTGVGTISLFGAQMRFSLRDNRLPLLTTKRVFWRGVCEELLWFLRGETNAQLLADKDIHIWDGNGSREFLDSRGLTENKEMDLGPVYGFQWRHFGADYKGFEANYDGEGVDQIRSIVETIKANPNDRRLLFTAWNPCALQKMALPPCHLLAQFYVNTDTSELSCMLYQRSCDMGLGVPFNIASYALLTILIAKATGLRPGELVHTLGDAHVYRNHVGALKSQLERVPHAFPTLVFKEERQFLEDYELTDMEVIDYVPHPPIKMEMAV AAM88576 --MSRAALRLKIPMPATMADFAFPSLRAFSIVVALDKQHGIGDGESIPWRVPEDMAFFKDQTTLLRNKKP-PTEKKRNAVVMGRKTWESVPVKFRPLKGRLNIVLSSKATVEELLAPLPEG-KRAAAAQDVVVVNGGLAEALRLLARPPYCSSIETAYCVGGAQVYADAMLSPCVEKLQEVYLTRIYTTAPACTRFFPFPPEN----------------------------TTTAWDLASSQGRRKSEADG-------LEFEICKYVPRNHEERQYLELIDRIMKTGIVKEDRTGVGTISLFGAQMRFSLRDNRLPLLTTKRVFWRGVCEELLWFLRGETNAQLLADKDIHIWDGNGSREFLDSRGLTENKEMDLGPVYGFQWRHFGADYKGFEANYDGEGVDQIRSIVETIKANPNDRRLLFTAWNPCALQKMALPPCHLLAQFYVNTDTSELSCMLYQRSCDMGLGVPFNIASYALLTILIAKATGLRPGELVHTLGDAHVYRNHVGALKSQLERVPHAFPTLVFKEERQFLEDYELTDMEVIDYVPHPPIKMEMAV P16126 --MSRAAAKFKIPMPVTKADFAFPSLRAFSIVVALDKQHGIGDGESIPWRVPEDMAFFKDQTTLLRNKKP-PTDKKRNAVVMGRKTWESVPVKFRPLKGRLNVVLSSKATVEELLAPLPEE-KRAAAAQDIVVVNGGLAAAVRLLARPPYCSSIETAYCVGGAQVYADAMLSPCVEKLQEVYLTRIHTTAPACTRFFPFPPEN----------------------------AATAWDLASSQGRRKSAVDG-------LEFEICKYVPRNHEERQYLELIDRIMKTGIAKEDRTGVGTLSLFGAQMRFSLRDNRLPLLTTKRVFWRGVCEELLWFLRGETNAQLLADKDIHIWDGNGSREFLDSRGLTENTEMDLGPVYGFQWRHFGAEYRGLEANYDGEGVDQIKFIVETIKANPNDRRLLFTAWNPCALHKMALPPCHLLAQFYVNTEKSELSCMLYQRSCDMGLGVPFNIASYALLTILIAKATGLRPGELVHTLGDAHVYRSHIDALKAQLERVPHAFPTLVFKEERQFLEDYELMDMEVIDYVPHPPIKMEMAV AAA30318 --MSRAAAKFKIPMPVTKADFAFPSLRAFSIVVAADQQHGIGDGETIPWTVPETLAFFKDQTTLLRNKKP-PTEKKRNAVVMGRKTWE-VPLKFRPLKGRLNVVLSCRRPVDDLLAQLPEE-KRAAAAAD-VVINGGLKEALHLLARPPYCSSIETAYCIGGARVYTEAMQSPCVEKLKEVYLTRVH-TAPTCNRFYEFVRRRR---------------------------ARAAVDLESTSGVKVSDAAAH------LSYEIMKYVPHNAEERQYLELIDRIMKTGLVKEDRTGVGTISLFGAQM-FSLRDNQLPLLTTKRVFWRGVCEELIWFLRGETNAHVLADKDIHIWDGNGSREFLDSRGLTENKEMDLGPVYGFQWRHFGADYKGFDANYD-EGVDQIKTIVETLKTN--DRRLLVTAWNPCALHKMAVRPCHLLGQFYVNTQTKELSCMLYQRCCDMGLGVPFNIASYALLTILIAKATGLRPGELVHTLGTAHVYSNHVEALKEQLQRVPVAFPVLVFKKEREFLEDYESTDMEVVDYVPYPPIKMEMAV NP179230 -------MATTTLNDSVTTTLASEPQRTYQVVVAATKEMGIGKDGKLPWNLPTDLKFFKDIT--LTTSDS----SKKNAVVMGRKTWESIPIKYRPLSGRLNVVLTRSGGFD-------------IANTENVVTCSSVDSALDLLAAPPYCLSIERVFVIGGGDILREALNRP---SCDAIHLTEID-TSVDCDTFIPAIDTSVYQPWSSSFPVTENGLRFCFTTFVRVKSSADESSDESNGSQSLQFDGKK-------FLFLPKMVFDQHEEFLYLNMVEDIISNGNVKNDRTGTGTLSKFGCQMKFNLRRS-FPLLTTKRVFWRGVVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDGIGLTEREEGDLGPVYGFQWRHFGAKYTDMHADYTGQGFDQLVDVIDKIKNNPDDRRIIMSAWNPSDLKLMALPPCHMFAQFYVAE--GELSCQMYQRSADMGLGVPFNIASYSLLTCMLAHVCDLVPGDFIHVLGDAHVYKTHVRPLQEQLLNLPKPFPVMKINPEKKQIDSFVASDFDLTGYDPHKKIEMKMAV QUARTET PUZZLING TREE :---Q27793 :100: :------------100: :---AAK71186 : : : :-------Q27783 : : :---AAM82248 : :-----88: : : :---AAM88576 : :-85: : : : :---CAA36019 : : : :-98: : :-99: :-78: :---AAA29272 : : : : : : : :-------AAM88660 :-99: : : : :---------------P16126 : : : :-------------------AAA30318 : :-----------------------NP179230 DNA-directed RNA polymerase II, large subunit P17546 T. brucei AAK97604 T. cruzi AAC47792 L. major AAF36438 L. donovani AAK15346 Leptomonas seymouri *CAA21466 Arabidopsis thaliana P17546 MSGGAALPVSQMELHKVNEVQFEIFKERQIKSYAVCLVEHAKSYANAADQSGEASMICVWVPLTSNSACETCHRKHPECPGHFGYIELAEPVFNIGVFDLVLLVLKCVCKTCGALLLNTREQDVHKKLQHVTGLN-RLRQVAKMA--EAKCRVSTSTEDDMGIDGFDSAPFNGGSGMGPGATRG-CGASQPRVSRFYGIYPTLVIKA---VHEEQD---------AEWHADKVRQVLDRVSDDDARLMGFDPQRCHPRDLVLTVLPVPPPQVRPAISFGG-LRSDDELTHQIMSIVKRNNQLRRDKESDVQA-AIDRSRALLQEHVATYFNNASTYYKPTKVNDT-KKLKSLTERLKGKYGRLRGNLMGKRVDFSARTVITGDPNIDVDEVGVPFSVAMTLTFPERVNTVNKKRLTEFAR--RTVYPS---ANYIHHPNGTITKLALLRDRSKVTLNIGDVVERHVINGDVVLFNRQPTLHRMSMMGHRVRVLNYSTFRLNLSCTTPYNADFDGDEMNLHVPQSLLTKAELIEMMMVPKNFVSPNKSAPCMGIVQDSLLG-SYRLTDKDTFLDKYFVQSVALWLDLWQ--LPIPAILKPRPLWTGKQVFSLILPEVNHPAT------PQDRPPFPHNDSVVMIRRGQLLCGPITKSIVGAAPGSLIHVIFNEHGSDEVARFINGVQRVTTFFLLNFGFSVGVQDTVADSDTLRQMNDVLVKTRRNVEKIGAAANNRTLNRKAGMTLLQSFEADVNSALNKCREEAAKKALSNVRRTNSFKVMIEAGSKGTDLNICQIAVFVGQQNVAGSRIPFGFRRRTLPHFMLDDYGETSRGMANRGYVEGLKPHEFFFHTMAGREGLIDTAVKTSDTGYLQRKLIKALEDVHAAYDGTVRNANDELIQFMYGEDGLDGARIEGGQLFPLPFRDDKEMEDTYKYEYDVDGTFSGKVGGNYMDPHVRKMLRADPQNVRKLQEEYEQLTADREWSRKMLDLEDRDKLKLNLPVNPGRLIQNARSTMGKR-SQVSNLSPIT-IIDHVRKLQEDLMKLFPSYHRGGDGYIRNTLSRERIESALTLFNVHLRQLLASKRVLKEYKLNDRAFEYLLKEIRTKYHQSLTTPGENIGAIAAQSCGEPATQMTLNTFHNAGISSKNVTLGVPRLLELLNVSRNQKHASMTVSLFPPYDE-KRNAQKAQHLIEYCTLESITRRIQFIYDPDPRHTVVEADRDILELEWNVMDESDAELRIQEVVAGSPWVVRLELDVDMVTDKALDMKDVKQAILRVDESYIIETGMANNVRQRTIRMRSRYNEG-----ADSIP-----KLKREIPALLARVHLRGIPGVRRALLKDTTEFTVDQATGKMSGNKIWAIDTDGTALRRAFIGVVGEDGKNIINAVKTSSNKVPEVCSLLGIEAARSKMLTELREAYLAYGLNINYRHYTILVDTICQHGYLMAVSRSGINRSDTSGPLMRCSFEETVKVLMAAASFGECDPVRGVSANLVLGNQARVGTGLFDLVLNMAALQQAVPQAEAVAP-----------GKDVNVYHSLGSTLQQNIQSSIAYRP--RDHDATPFVNNASLFLRQGFGGGSSSAPVTASAPYNPSTTYH--GGRLEASAVHRSQAYSTSPALEYGGREASAS-QMYSVMSS--ASAFNPVSTRMSSVAHSYSEYSEASSYHLQHSVAPTSMQASLPRTDNSMTMQG--IGSVSVPYTPHAMSSAAPPSQVYASTEVGRSHSEDSRSQSALYVPTLSPTHAGYAIRGDEPSTHRSDSNVMWREAGGGREQDEEDDLSTNYMPTAKTPQQAAPPTA---AEFG---DEEEEEQ------------------------------------------------------------------------------------------------------------- AAK97604 MSGGAPLPPSQMDLQKVVEVQFEMFKEKQIKDYAVCLVEHAKSYERGQPVRGGINDLRMGT-TDFEFACETCHRKHPECPGHFGYIDLAEPVFNIGVFDIVLQVLKCVCKSCGALLMDTNDPQVHKKLQHLTGVN-RLRQVVKMC--GMKCRMS--T--------------DATTPEEAVVARG-CGATQPRIGRYLGIYPTLIIKA---TLEEQD---------MVWHADTARQVLDRVSDEDARVMGFDALRCHPRDLVLTVLPVPPPQVRPAISFGS-LKSDDELTHQIMSIVKRNNQLRKDKESDVQV-AVDRSRALLQEHVAAYFNNASMYYKPTKVNDT-KKLKSLTERLKGKYGRLRGNLMGKRVDFSARTVITGDPNIDVDEVGVPFSIAMTLTFPERVSAVNKKRLTEFVR--RPVYPS---ANYIHHPNGTTTKLALRRDRSKVTLNIGDVVERHVINGDVVLFNRQPTLHRMSMMGHRVRVLNYNTFRLNLSCTTPYNADFDGDEMNLHVPQSLLTKAELIEMMMVPKNFVSPNKSAPCMGIVQDSLLG-SYRLTDKDTFLDKYFVQSVALWLDLWQ--LPVPAVLKPRPLWTGKQVFSLILPEVNHPAT------PQERPPFPHNDSSIMIRRGQLLCGPITKGIVGAAPGSLIHVIFNERGSDEVARFINGVQRITTFFLINFGFSVGVQDTVADADTLRQMNEVLVKTRENVEKIGAAANNRTLNRKAGMTLLQSFEADVNSALNKCREEAAKKALSNVRRTNSFKVMIEAGSKGTDLNICQIAVFVGQQNVAGSRIPFGFRRRTLPHFMLDDYGETSRGMANRGYVEGLKPHEFFFHTMAGREGLIDTAVKTSDTGYLQRKLIKALEDVHAAYDGTVRNANQELIQFMYGEDGLDGARIEGGQLFPLPFRDNKEMESTYKYEYDETGAFNEKVGGAYMDPHVKKMLRADPENVRKLQSEFDQLMADRDWARRMMDLEEREKLKLNLPVNIGRLIQNARSTMGKR-SQVSNLSPVT-IIDHVRKLQEDMLKLFPCYHKGVDGRIHNLLSRQRIENALTLFSVHLRQLLASKRVLREYKLNDKAFEYLLKEIRTKYLQSLVSPGENIGAIAAQSCGEPATQMTLNTFHNAGISSKNVTLGVPRLLELLNVSRHQKHASMNVSLYPPWDK-KRTAQQAQHLIEYCTLESVTKRIQFIYDPDPRETVVEADRAILELEWSVMDESDERARLQEVENGSPWIARLELDADMFVDKALNMKDVKQAILRVDDGYVIETGMANDTKERTIRMRPKKNDG-----VDSIP-----RLKHAIPELLARVHLRGIPGVRKALLKDRTTFTVDPATGKMTGEKTWLIDTDGTALRRAFIGIVDEKGNNIINATRTSSNKVPEVCSLLGIEAARYKMLHELREAYLAYGLNINYRHYTILVDTICQRGYLMAVSRVGINRSEMSGPLMRCSFEETVKVLMAAAAFGERDPVRGVSANLVLGNQARIGTGLFDLVLNMAALQQAVPQEDAVAP-----------GKEVNVYHGLAST--QNLPSSMPYRA--KDHEATPFVNDASLFFREGVGGSSSAAPLTASTLY---------GGMHEASAVHFSQAYPAMGMSDQRVRASSVS-QPYSVMSS--ASVYNPASMQVPSALPSSVDYSEASSFHIQSSMAMPSVPSS-PQFEAPQAFGGGRFGGLSPAYVPSVMSSVATQP----YQCVGDSESQ----HSASYVPTLSPAYSAYTARRSVVASRASASRVDQ-------QSQQQEDDSASYLPKSPG-LHGLPPPV---GEFSLTEDPEEEEEGHQ---------------------------------------------------------------------------------------------------------- AAC47792 MSGGAALPPSQMPLQKVHEVQFEVFKEAQIKAYAKCIIEHAKSYASTASRCGAASTTCAWARQTSSIACETCGLRHPECPGHFGYVELAEPIFNINVFDVVLIALKCVCKYCGALLMDTNDPSEMKKIAHLQGLN-RLRMVAKLC--GSVCKRS----------------------KDIQGCEG-?GP-PAAHRPFVGIYPGLQIKV---TQEEQD---------YVWHAENARQVLDRVSDSDALIMGFDRRFCHPRDLDLTVLPIPPPQVRSSIYLGG-LMQVDDLTHQIMSIVKRNIQLRKDKESGVKA-AVDRSRALLQEHVATFFNNASTYYKPAKVGDT-KKLKSLTERLKGKYGRLRGNLMGKRVDFSARTVITGDPNIDVDEVGVPFSVAMTLTFPERVNVINKKRLTEFVQ--RTTYPS---ANYIIRPNGNVTKLALVKDRSAVHLDVGDVVERHVIDGDVVLFNRQPTLHRMSMMGHRVRVLNYNTFRLNLSCTTPYNADFDGDEMNLHVPQSLLTKAELIEMMMVPKNFVSPNKSAPCMGIVQDSVLG-SYKLTEKDTFLDKYFIAERPLWLDLWQ--LPIPTILKPRPLWTGKQIFSLILPEVNHPAS------PHDKPPFPHNDSKIMIQRGQLLGGAITKGVVGAAPGSLIHVIFNERGSDEVAKFINGVQRITTYFNYCFAFSVGVQDTVADATTLKEMNNVLHKTRQSVEKIGAAANNGKLTRKAGMSLLQSFEADVNSALNKCREEAAKKALSNVRRTNSFKVMIEAGSKGSDLNICQIAVFVGQQNVAGSRIPFGFRRRTLPHFMLDDYGETSRGMATRGYVEGLQPHEFYFHTMAGREGLIDTAVKTSDTGYLQRKLVKALEDVHASYDGTVRNANQELIQLAYGEDGLDGARIEGNQAFPIPHMTNSEMADKYRYEYNDEGSFSENMGGHYMDPFVRDSLLRDPQSVLKLQEEFEQLMKDRAMSRLVIDMEDKNKLKMNLPVNVARLIQNARTTMGKR-SQVSNLNPIT-VINRVRELQEDLVQLFPSYHKDYNGRFVNVLSQQRVERALTLFGIHLRQILGSKRVLKEYKLNDKAFEYLLKEIRTKYQQSLITPGEIIGAIAAQSCGEPATQMTLNTFHNAGISSKNVTLGVPRLLELLNVSKNQRNASVAVCLIREYQK-RNKAQEAQQFIEYCTLANITTTVQIIYDPDPRNTVVAEDEEMIRWEQAVMNAEDEEPDAEQPP--SPFIARLILDNDLFNDKRLNMKDVKSAIRQVDDTYMVQANMENDG-QRIVRLRPRKCTG-----ADS?P-----ALTKAVAQLLQSVHLRGIPGIKKTLLKEGNTFRVDPEAGGIKNESSWMVDTEGTALQRIFVGVVNSEGKNIIDFSKTSSNKIPEVVTVLGIEAARRKMLSELREAYLAYGLNINYRHYTILVDTMCQRGYLMAVSRTGINRSETSGPLMRCSFEETVKVLMTAAAFGEKDPVRGVSASLVLGNQARIGTGLFDLLLDMSKLQHVVPLDKATE------------ARTSNVYHTDASVAPGSSTLQGSHG----ELPPSTVHENSSLAA-----GASSVYPRHER-----AGMYG--GIPIEASEVQFSSALPTVMRTALACLEHDR--VPQQPPP---LWCFHVLGV--VGAAERESLDTELSSYHLQ-SVAPSTAYG----------------------YAPMAASGMPMPGA--TQLSVGEGGSLP------------------YPYEASNGERFGSLG------------GAASSRASAPYDPTQ------QPSQ-----EFSQTEEQEEP--------------------------------------------------------------------------------------------------------------- AAF36438 MSGGAPLPPSQMPLQKVHEVQFEVFKEAQIKAYAKCIIEHAKSYEHGQPVRGGIN-DLRMGTTDFEYSCETCGLKHPECPGHFGYVELAEPIFNINVFDVVLIALKCVCKYCGALLMDTNDPSEMKKIAHLQGLN-RLRMVAKLC--GSVCKRS----------------------KDIQGCEG-KGR-QPRIGRFAGIYPGLQIKV---TQEEQD---------YVWHAENARQVLDRVSDSDALIMGFDPRFCHPRDLILTVLPIPPPQVRPAVAFAS-AKSDDELTHQIMSIVKRNIQLRKDKESGVKA-AVDRSRALLQEHVATFFNNASTYYKPAKVGDT-KKLKSLTERLKGKYGRLRGNLMGSRVDFSARTVITGDPNIDVDEVGVPFSVAMTLTFPERVNVINKKRLTEFVQ--RTTYPS---ANYIIRPNGNVTKLALVKDRNAVHLDVGDVVERHVIDGDVVLFNRQPTLHRMSMMGHRVRVLNYNTFRLNLSCTTPYNADFDGDEMNLHVPQSLLTKAELIEMMMVPKNFVSPNKSAPCMGIVQDSLLG-SYRLTDKDTFVDKYFIQSVALWLDLWE--LPIPAILKPRPLWTGKQIFSLILPEVNHPAS------PYDKPPFPHNDKKIMIQRGQLLVGAITKGVVGAAPGSLIHVIFNERGSDEVAKFINGVQRITTYFNYCFAFSVGVQDTVADATTLKEMNNVLHKTRQSVEKIGAAANNGQLTRKAGMSLLQSFEADVNSALNKCREEAAKKALSNVRRTNSFKVMIEAGSKGSDLNICQIAVFVGQQNVAGSRIPFGFRRRTLPHFMLDDYGETSRGMATRGYVEGLQPHEFYFHTMAGREGLIDTAVKTSDTGYLQRKLVKALEDVHASYDGTVRNANQELIQLAYGEDGLDGARIEGNQAFPIPHMTNSEMADKYRYEYNDEGSFSENMGGHYMDPFVRDSLLRDPQSVLKVQEEFEQLMKDRAMSRLVIDMEDKNKLKMNLPVNVARLIQNARTTMGKR-SQVSNLNRITTVINRVRELQEDLVQLFPSYHKDYSGRFANVLSQQRVERALTLFGIHLRQILGSKRVLKEYKLNDKAFEYLLKEIRTKYQESLITPGEIIGAIAAQSCGEPATQMTLNTFHNAGISSKNVTLGVPRLLELLNVSKNQRNASVAVCLIREYQK-RNKAQEAQQFIEYCTLANITTTVQIIYDPDPRNTVVAEDEEMIRWEQAVMNEEDEEPDAEQPP--SPFIARLILDNDLFNDKRLNMKDVKSAIRQVDDTYMVQANMENDG-QRIVRLRPRKCTG-----ADSVP-----ALTKAVAQLLQSVHHRGIPGIKKTLLKEGNTFRVDPETGGIKNESSWMVDTEGTALQRIFVGVVNNEGKNIIDFSKTSSNKIPEVVTVLGIEAARRKLLSELREAYLAYGLNINYRHYTILVDTMCQRGYLMAVSRTGINRSETSGPLMRCSFEETVKVLMTAAAFGEKDPVRGVSASLVLGNQARIGTGLFDLLLDMSKLQHVVPLDKATE------------ARTSNVYHTDASVAPGSSTLQGSHG----ELPPSTVHENSSLAA-----GASSVYPRHER-----AGMYG--GIPIEASEVQFSSALPTVMGTVLAALEHDR--VPQQPPPP--LWCFHVLG---VGAAERECADTELSSYHLQ-SVARSTAYG----------------------YAPVTASGMPMPGG--AQLSVGEGGSMP------------------YPYEASNGERFGSLG------------GAASSRASAPYDPTQ------QPSQE---FEFSPTEEQEEP--------------------------------------------------------------------------------------------------------------- AAK15346 MSGGAPLPPSQMPLQKVHDVQFEVFKERQIKAYATCRIEHAKSYEHGQPVRGGIN-DLRMGTTDFDYSCETCGLKHPECPGHFGYIELAEPIFNINVFDVVLIALKCVCKYCGALLMDTNDPTEMKKITHVQGLN-RLRLVAKLC--GSVCKRS----------------------KDIQGCEG-KGR-QPRIGRFLGIYPGLQIKV---TQEEQD---------YVWHADNARQVLDRVSDSDATIMGFDPRFCHPRDLILTVVPIPPPQVRPAVAFGS-AKSDDELTHQIMSIVKREHQLRKDKESGVKA-AVDRSRALLQEHVATFFNNASTFYKPAKVGDT-KKLKSLTERLKGKYGRLRGNLMGKRVDFSARTVITGDPNIDVDEVGVPFSIAMTLTFPERVNVINKKRLTEFVQ--RSTYPS---ANYIMRPNGNVTKLALVKDRSAVHLDVGDVVERHVIDGDVVLFNRQPTLHRMSMMGHRVRVLNYNTFRLNLSCTTPYNADFDGDEMNLHVPQSLLTKAELIEMMMVPKNFVSPNKSAPCMGIVQDSLLG-SYRLTDKDTFVDKYFIQSVALWLDLWE--LPIPAILKPRPLWTGKQIFSLILPEVNHPAS------PYGKPPFPHNDKK-IIQRGLLLVGAITKGVVGAAPGSLIHVIFNERGSDEVAKFINGVQRITTYFNYCFAFSVGVQDTVADASTLKEMNNVLHKTRQSVEKIGAAANNGKLTRKAGMSLLQSFEADVNSALNKCREEAAKKALSNVRRTNSFKVMIEAGSKGSDLNICQIAVFVGQQNVAGSRIPFGFRRRTLPHFMLDDYGETSRGMATRGYVEGLQPHEFYFHTMAGREGLIDTAVKTSDTGYLQRKLIKALEDVHAAYDGTVRNANQELIQLAYGEDGLDGARIEGNQAFPIPHMANNEMIDKYRYEYNEEGSFSENMGGSYMDPFVRDSLLRDPQSVSKLQEEFDQLVKDRDMSRLIIDMEEKNKLKMNLPVNVARLIQNATTTMGQA-HQVSNLNPIT-VIQRVRDCRKTLVQLFPSYHKDYSGRFLNVLSQQRVKRALTLFDIHLRQILGSKRVLKEYKLNDKAFEYLLKEIRTKYQQSLITPGEIIGAIAAQSCGEPATQMTLNTFHNAGISSKNVTLGVPRLLELLNVSKNQRNASVAVCLTREYQQ-RQKAQEAQQYIEYCTLANITTTV-----PRPLNTVVVEDVNILEWEQAVMN-EDEGLDAAQP---SPFIARLILNTELFNNKQLNMKDVKSAIQQMDDSYLMQANLKNNIRHRVVRLRPRKCAG-----ADSVP-----ELTKAVAQLLQSVHLLGIPGIKKTLLKEGTTFNVDPATGGITKESSWMVDTEGTALQRIFVGVVNQHGVNIVDFAKTSSNKIPEIVTVLGIEAARPKLLFELCQAYLAYGLNINYRHYTILVDTMCQRGYLMAVSRTGINRSETSGPLMRCSFEETVKVLMTAAAFGEKDPVRGVSANLVMGNQARIGTGLFDLMLDMGNCSNVVPLDKADG------------GRTSNVYHTEASVVAGSS-VQGLHG----ELPSSAMHENSSVGI-----GASSVYPRHGGGAAG-AGLYA--GMAIEASQVQFSSALHPSTGSALAASNTSD--YQSSLRFS--GASTYVAS---PNMASMSALDAELSSYHLQ-SVAPSYQGGG---------------------YGPLQGR-IPMLG----VPSTG-GSGQP------------------YLFEASNGG-AGSVADAKS--------GAASSRASAPYDPN-------QPSQ-----DFSPTEEQEEQ--------------------------------------------------------------------------------------------------------------- CAA21466 --MDTRFPFSPAEVSKVRVVQFGILSPDEIRQMSVIHVEHSETTEKGKPKVGGLS-DTRLGTIDRKVKCETCMANMAECPGHFGYLELAKPMYHVGFMKTVLSIMRCVCFNCSKILADEVCRSLFRQAMKIKNPKNRLKKILDACKNKTKCDGGDD------IDDVQSHSTD----EPVKKSRGGCGAQQPKLT-IEGMKMIAEYKIQRKKNDEPDQLPEPAERKQTLGADRVLSVLKRISDADCQLLGFNPKFARPDWMILEVLPIPPPPVRPSVMMDATSRSEDDLTHQLAMIIRHNENLKRQEKNGAPAHIISEFTQLLQFHIATYFDNELPGQPRATQKSG-RPIKSICSRLKAKEGRIRGNLMGKRVDFSARTVITPDPTINIDELGVPWSIALNLTYPETVTPYNIERLKELVDYGPHPPPGKTGAKYIIRDDGQRLDLRYLKKSSDQHLELGYKVERHLQDGDFVLFNRQPSLHKMSIMGHRIRIMPYSTFRLNLSVTSPYNADFDGDEMNMHVPQSFETRAEVLELMMVPKCIVSPQANRPVMGIVQDTLLG-CRKITKRDTFIEKDVFMNTLMWWEDFDGKVPAPAILKPRPLWTGKQVFNLIIPKQINLLRYSAWHADTETGFITPGDTQVRIERGELLAGTLCKKTLGTSNGSLVHVIWEEVGPDAARKFLGHTQWLVNYWLLQNGFTIGIGDTIADSSTMEKINETISNAKTAVKDLIRQFQGKELDPEPGRTMRDTFENRVNQVLNKARDDAGSSAQKSLAETNNLKAMVTAGSKGSFINISQMTACVGQQNVEGKRIPFGFDGRTLPHFTKDDYGPESRGFVENSYLRGLTPQEFFFHAMGGREGLIDTAVKTSETGYIQRRLVKAMEDIMVKYDGTVRNSLGDVIQFLYGEDGMDAVWIE-SQKLDSLKMKKSEFDRTFKYEID-----DENWNPTYLSDEHLEDLKGIRELRDVFDAEYSKLETDRFQLGTEIATNGDS--TWPLPVNIKRHIWNAQKTFKIDLRKISDMHPVE-IVDAVDKLQERLL-VVP-------G--DDALSVEAQKNATLFFNILLRSTLASKRVLEEYKLSREAFEWVIGEIESRFLQSLVAPGEMIGCVAAQSIGEPATQMTLNTFHYAGVSAKNVTLGVPRLREIINVAKRIKTPSLSVYLTPEASKSKEGAKTVQCALEYTTLRSVTQATEVWYDPDPMSTIIEEDFEFVRSYYEMPD---EDVSPDKI---SPWLLRIELNREMMVDKKLSMADIAEKINLEFDDDLTCIFNDDNAQKLILRIRIMNDEGPKGELQDESA-EDDVFLKKIESNMLTEMALRGIPDINKVFIKQVR-KSRFDEEGGFKTSEEWMLDTEGVNL----LAVMCHED---VDPKRTTSNHLIEIIEVLGIEAVRRALLDELRVVISFDGSYVNYRHLAILCDTMTYRGHLMAITRHGINRNDT-GPLMRCSFEETVDILLDAAAYAETDCLRGVTENIMLGQLAPIGTGDCELYLNDEMLKNAIELQLPSYMDGLEFGMTPARSPVSGTPYHEGMMSPNYLLSPNMRLSPMSDAQFSPYVGGMAFSP----SSSPGYSPSSPG-YSPTSPGYSPTSPGYSPTSPGYSPTSPTYSPSSPGYSPTSPAYSPTSPSYSPTSPSYSPTS---PSYSPTSPSYSPTSPSYSP--TSPSYSPTS-------------------PAYSPTSPAYSPTSP---AYSPTSPSYSPTS-----------------PSYSPTSPSYSPTSPSYSP-------TSPSYSPTSPAYSPTSPGYSPTSPSYSPTSPSYGPTSPSYNPQSAKYSPSIAYSPSNARLSPASPYSPTSPNYSPTSPSYSPTSPSYSPSSPTYSPSSPYSSGASPDYSPSAGYSPTLPGYSPSSTGQYTPHEGDKKDKTGKKDASKDDKGNP QUARTET PUZZLING TREE :---AAC47792 :-81: :100: :---AAF36438 : : : :-------AAK15346 : : :---P17546 :----100: : :---AAK97604 : :-----------CAA21466 DNA topoisomerase II P30190 T. cruzi P12531 T. brucei AAF86355 L. infantum O61078 L. donovani chagasi P27570 Crithidia fasciculata AAL99217 Bodo saltans *AAA65448 Arabidopsis thaliana P30190 ----------------------------MAEASKYKKLTPIDHVLIRPEMYVGSVDTSSSSMFVFDHEKGRMVWESLKVNHGLLKIVDEILLNASDNIAN--KGGRMTYIRVHITEA-GEITIENDGAGIPIVRSKEHKLYIPEMVFGHLLTSSNYDDTSQNAVAGRHGYGAKLTNILSHRFSVCCRTKG--KEFHMSWHDHMRRATAPRVSNVDPKEKNLTRVKFLPDYERFGLDANKISHDMKRVLHKRIMDLAA-MFPSIEISLNGVPFAFKSFADYAMLYSSPS-----------SSGEMPPA------PFVYESRNGAIAFIPSLTAGT-RRIFGVVNGVVTHNGGTHCN-AAQEVLQSSLESVEKALKKDNKVIDTNRVLRHFMILVFLVQVQPKFDSQNKARLVSVPTMPRVPRQELMDFLLRMPFLEAHVNTVTGQLADELNKEMGAGRRMSSKSLISSITKLVDATTTRRDPRFVRTLIVTEGDSAKALAQNSLSSDQKRYTGVFPLRGKLLNVRNKNLKRLKNCKELQELFCALGLELGKIYKDAEELRYQRLLVMTDQDADGSHIKGLVINAFEALWPSLLNRNPGFISIFSTPIVKVRLRDKS--THSFFSLKEFHKWQKTHG--NVSYTAKYYKALGTSTTAEGKEYFKDMDKHTMRLVVE-RNDHKLLDSVFDSQEVEWRKDWMTKANAYTGEVDIDRSKKTLTVPDFVHKEMVHFALAGNARALAHAVDGLKPSQRKILWAIMRR-SGNESAKVAQLSGYISEVSAFHHGEMSLQETIIKMAQNFTGGNNINLLIPEGQFGSRQQLGNDHAAARYIFTKLSSLARILFPSEDEPLLDYVTEEGQQVEPNHYVPILPLLLCNGSVGIGFGFASNIPPFHPLDVSAAVRSMINGEAAKVVVRRLVPWAVGYQGEVRR----GPEGE------FIAAGSYQYYVDG---RVHVTEIPWTLSIEAFRDHISVLASKD---VVQRIADYSGANHVDIDLELTNGAMTTYAE--CESELSLTQRIYI-NGTVFSPTGVLTPLEGDLAPVLQWHYDRRLDLYKKRRQRNLGLLEAELAREKSTLKFVTHFREGKIDIVNATDD-SLAKTCSKLG---------------------------------------MVRVDDSYDYVLRKPITFYTKTSLENLNRKISETEKRIDKLKKTAPVQMWLDELDRFDRAFEEHENTAVATILKERRVNPPTGD-VSRNLQQPRLELEEVKVSSSGGKSVPMRVRVRKYVPPPPSKRPHVGQSVGGGGGGGSVRSSAAAVVAHVK---AEKKAARARSMQKM---LLDVVAR----QVARVLPRLPWFLF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- P12531 ----------------------------MAEAHKYKKLTPIEHVLTRPEMYIGSLDTTATPMFIYDEQKGHMVWETVKLNHGLLKIVDEILLNASDNISN--RSARMTYIRVTITDT-GEITIENDGAGIPIVRSREHKLYIPEMVFGHLLTSSNYDDDNQNAVAGRHGYGAKLTNILSLSFSVCCRTNG--REFHMSWQDHMRKATAPRVSNVGTKEKNVTRVKFLPDYERFGMKEKKISNDMKRVLYKRIMDLSA-MFPNIQITLNGSSFGFKSFKDYATLYSAMT-----------PKGEKPPP------PYVYESKSGCVAFIPSVVPGV-RRMFGVVNGVVTYNGGTHCN-AAQDILTGCLDGVERELKKENKVMDTNRVLRHFTILVFLVQVQPKFDSQNKARLVSTPTMPRVPRQDVMKYLLRMPFLEAHVSTITGQLAQELNKEIGTGRRMSSKTLLTSITKLVDATSTRRDPKHTRTLIVTEGDSAKALAQNSLSSDQKRYTGVFPLRGKLLNVRNKNLKRLRNCKELQELFCALGLELDKDYTDADELRYQRILIMTDQDADGSHIKGLVINAFESLWPSLLVRNPGFISIFSTPIVKARLRDKS--VVSFFSMKEFHKWQRSNA--NTPYTCKYYKGLGTSTTAEGKEYFKDMEKHTMRLLVD-RSDHKLLDNVFDSQEVEWRKDWMTKANAFTGEVDIDRSKKMLTVTDFVHKEMVHFALVGNARALAHSVDGLKPSQRKIIWALMRR-SGNEAAKVAQLSGYISEASAFHHGETSLQETMIKMAQSFTGGNNVNLLVPEGQFGSRQQLGNDHAAPRYIFTKLSKVARLLFPSEDDPLLDYIVEEGQQVEPNHYVPILPLLLCNGSVGIGFGFSSNIPPFHRLDVSAAVRAMISGERAKSVVRRLVPWAVGFQGEIRR----GPEGE------FIAVGTYTYCKGG---RVHVTELPWTCSVEAFREHISYLATKD---IVNRIADYSGANHVDIDVEVAQGAVNTYAE--CESELGLTQRIHI-NGTVFSPNGTLSPLESDLTPVLQWHYDRRLDLYKKRRQRNLTLLEQELAREKSTLKFVQHFGAGHIDFANATEA-TLEKVCSKLG---------------------------------------LVRVDDSFDYILRKPITFYTKTSFENLLKKIAETERRIEALKKTTPVQLWLGELDQFDRFFQDHEKKMVEAILKERRQRSPPSD-LLPGLQQPRLEVEEAK----GGKKFEMRVQVRKYVPPP-TKRGAGGRSDGDGG---ATAAGAAAAVGGRG---EKKGPGRAGGVRRM---VLDALAK----RVTRLLPRLLF------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ AAF86355 ----------------------------MTDASKYKKLTPIDHVLLRPEMYVGSIETQPTPMYIFDPEKGRMVWETMRVNQGLLKIVDEILLNAADNINNSKGSVRQTYISIHISDT-GEITVENDGAGLPIVRSREHKMYIPEMVFGHLLTSSNYNNDSTSTTAGRHGYGAKLTNILSTKFSVVCRTDG--REFHMSWTDHMRMATAPRVNRVDPKEKNVTRVKFMPDYAHFGFPNASISLDMKRVLHKRIMDLAA-MFSKIEVRLNNVPFGFRTFTDYARLYSLPG-----------LDGSMPPE------PFVYTSPNGSVAYVPQLTQSP-KRIVGVVNGVVTYNGGTHCN-AAMDILDSCLDSLSKNFKKNGKVVDTNRVQRHFTVLVFLIQTQPKFDSQSKARLVSTVTMPRVPKNTLEKYLERMPFLEAHVNSMDDQLANELNKEIGAGRRLSSKTLISAITKLVDATSSRPDGRNIRTLIITEGDSAKALALNSLSSEQKKYCGVFPLRGKLLNVRNKNLKRLKTCKELQDLFLSLGLELGKEYRSPAELRYQRLLVMTDQDADGSHIKGLVINAFESLWPKLLQNNPGYISLFSTPIVKIKVSGKSKEVIAFHSFRDFHRWQRAHP--SARYTAKYYKGLGTSTTAEGKEYFADMEKNIMQLTVD-ARDHQLLDSVFDAAEVEWRKEWMTKANAFQGEIDIDRSKKTLTIPEFVHKEMVHFALVGNARAIPHCVDGLKPSQRKILWAMLRR-HNSEASKVAQLSGYISEASAFHHGEASLQETIVKMAQNFTGGNNINLLVPEGQFGSRQQLGNDHAAPRYIFTKLSRFARLLFPEEDDPLLDYMDEEGTFVEPHHYVPILPMLLCNGAVGIGFGFATTIPSFHPLDVSAAVRGMINGESAKQVVRNIVPWAVGFQGTVRR----GPDNE------FIAVGKYTAHPNG---RFHISEIPWMTSIEAFRLHISSLASAD---VVQRIADYSGANHIDIDLIVRDGSLTTWAE--CETDLALAQRIYI-NGTVFSPTGTLNPIDSDLSPVLQWHYDRRLDLYKRRRTRKIGLMEMDLARLQSTRKFVEHFRQGQIDFLNATDD-TLHKTCVKLG---------------------------------------LVRVDESFDYILKKPITFFTRTSTEKLQADIAKTQAQIEELKRTTPVKMWLTELDKFDKTFQEYERVLINSIQKEQRSSSITGGVELPALRQPLLMLEASAK---GAT--AYRVHACQYEKPPPSKRRPGESVGGARPSDSAARTVGKRLVGSRSVFKNKKPMSRKNNVKVS---LSTRVAQFAGAQLGRLLPHVLM------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ O61078 ----------------------------MTYASKYKKLTPIDHVLLRPEMYVGSIETQPTPMYIFDPEKGRMVWETMRVNQGLLKIVDEILLNAADNINNSKGSVRQTYISIHISDT-GEITVENDGAGLPIVRSREHKMYIPEMVFGHLLTSSNYNNDSTSTTAGRHGYGAKLTNILSTKFSVVCRTDG--RESHMSWTDHMRMATAPRVNRVDPKEKSVTRVKFMPDYAHFGFPNASISLDMKRVLHKRIMDLAA-MFSKIEVRLNNVPFGFRTFTDYARLYSLPG-----------LDGSMPPE------PFVYTSPNGSVAYVPQLTQSP-KRIVGVVNGVVTYNGGTHCN-AAMDILDSCLDSLSKNFKKNGKVVDTNRVQRHFTVLVFLIQTQPKFDSQSKARLVSTVTMPRMPKNTLEKYLERMPFLEAHVNSMDDQLANELNKEIGAGRRLSSKTLISAITKLVDATSSQPDGRNIRTLIITEGDSAKALALNSLSSEQKKYCGVFPLRGKLLNVRNKNLKRLKTCKGLQDLFLSLGLELGKEYRSPAELRYQRLLVMTDQDADGSHIKGLVINAFESLWPKLLQNNPGYISLFSTPIVKIKVSGKSKEVIAFHSFRDFHRWQRAHP--SARYTAKYYKGLGTSTTAEGKEYFADMEKNIMQLTVD-ARDHQLLDSVFDAAEVEWRKEWMTKANAFQGEVDIDRSKKTLTIPEFVHKEMVHFALVGNARAIPHCVDGLKPSQRKILWAMLRR-HNSEASKVAQLSGYISEASAFHHGEASLQETIVKMAQNFTGGNNINLLVPEGQFGSRQQLGNDHAAPRYIFTKLSRFGRLLFPEEDDPLLDYMDEEGTFVEPHHYVPILPMLLCNGAVGIGFGFATTIPSFHPLDVSAAVRAMINGESAKQVVRNLVPWAVGFQGTVRR----GPDNE------FIAVGKYTAHPNG---RFHISEIPWMTSIEAFRLHISSLASAD---VVQRIADYSGANHIDIDLIVRDGSLTTWAE--CETDLALAQRIYI-NGTVFSPTGTLSPIDSDLSPVLQWHYDRRLDLYKRRRTRKIGLMKMDLARLQSTRKFVEHFRQGQIDFLNATDD-TLHKTCVKLG---------------------------------------LVRVDESFDYILKKPITFFTRTSTEKLQADIAKTQAQIEELKRTTPVKMWLTELDKFDKTFQEYERVLINSIQKEQRSSSITGGVELPALRQPLLMLGASAK---GAT--AYRVHACQYEKPPPSKRRPGESVGGARPSDSAARTVGKRLVGSRSEFKNKKPMSRKNNVKVS---LSTRVAQ?PGAQLGRLLPHVLM------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ P27570 ----------------------------MTDASKYQKLTPIDHVLLRPEMYVGSIETQSIPMFVFDPAKGKMVWESMQVNQGLLKIVDEILLNAADNINNSVRGARMTYISIKISDS-GEIMVENDGAGLPIVKSKEHKMYIPEMVFGHLLTSSNYNNDASSTTAGRHGYGAKLTNILSTKFSVVCRTAG--REFHMSWTDHMRMATTPRVSNVDPKEKNVTRVTFMPDYAHFGFPTAAISLDMKRVLHKRIMDLAA-MFSKIEVRLNNVPFGFQTFNDYARLYSLPG-----------ADGAMPPE------PFVHTGPNGSIAFVPQLTQSP-KRIVGVVNGVVTYNGGTHCT-SAMEILETGLDSLSRSLKKDGKVIDTNRVARHFTVLVFLIQSQPKFDSQSKARLVSTVTMPRVPRTALDQYLAAMPFLEAHMNSMDDQLAAELNKEIGTGKRLSSRSLISSITKLVDATSSRSDGKNIRTLIVTEGDSAKALALNSLSSEQKKFCGVFPLRGKLLNVRNKNLKRLKTCKELQDLFLALGLELGKTYKSPAELRYQRLLVMTDQDADGSHIKGLVINAFESLWPSLLQHNPGYISLFSTPIVKIKVNGKAKEVVAFHSFRDFHRWQRANP--NARYSAKYYKGLGTSTTAEGKEYFADMERNVMRLVVE-PKDHRLLDSVFDSAEVEWRKEWMSKANAFQGEVDIDRSKKLLTIGDFVHKEMVHFALVGNARAIPHCVDGLKPSQRKILWAMLKR-HSSEAAKVAQLSGYISEVSSFHHGEASLQETIVKMAQNFTGGNNINLLVPEGQFGSRQQLGNDHAAPRYIFTKLSRFARLLFPEDDDPLLDYIDEEGTMVEPNHYVPILPLLLCNGAVGIGFGFATNIPSFHPLDVSAAVRAMINGESAKQVVRNLVPWAVGFQGTVRR----GPEKE------YIAVGKYTAHRNG---RLHVSELPWMTSIEAFRSHISSLASSD---VVQRIADYSGANHIDIDLIVREGSMTTWAE--CETDLALSQRIYI-NGTVFSPDGTLSPIDADLSPVLQWHYDRRLDLYKRRRTRQIGLLEMDLARLQSTRKFVEHFRQGHIDFLAATDD-TLTKTCVKLG---------------------------------------LVRVDDGYDYILKKPITFYTKTSTEKLQADIKKTQDSIAVLKQTTPVKMWLTDLDKFDKTFQEYERVLIHSIQKEQRPASITGGEEVPALRQPPLMLEAPAK---GAASSSYRVHICRYEEPPASKRKPEDTYGGALSSGGSTRNVGKRLTGARG--AKKKKVVRRTRTKMS---LGTRVAEFAGAQLGRLLPQLPRLLF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- AAL99217 ------------------------------MAHKYKKLSPIDHVLLRPEMYVGSVESQPIQLFLLDDQHSKVEWTTADLNHGLLKIFDEIVLNAADNIHNS-KRNPMTFINVTIDETTGQITVENDGAGIPLVKSKDHKLLIPEMIFGHLLTSSNYDNDPDSMSAGRHGYGAKLTNIMSQEFIVYCRTAD--KEVTIRWTDHMRSIDDYQVQPTN-EAGNLTKITFTPDFSVFGVT--KLTKDMYRILHKRILDLAA-AFPSVTVSFNGTALDVGSFASYVKLFEAPASLFSAPTAPVVADGDAAPPPAELNKPFLFEVKHLRLAFIPQPQASVSRRTFAVVNGVVTYSGGTHVQ-AAQQILTDAVDALVAQKKKEGIIVTVNTFLRYFTTVVFLETTQPKFDSQSKVRLVSKVKFPRFPTGQLVEHLATMTFLSDASKGQMDVLNKELNALIQVSGKR--RPMISTLTKLVDAASAGGSGSEIRTLIVTEGDSAKALALNSLSNEQRKYFGVFPLRGKLLNVRNNNLARLKKCKELCDLFAALGIEIGRRYTSTESLRYQRLLVMTDQDADGTHIKGLLISAFESLWPSLLQHSLGFISIFSTPLIRATTRGGD--VHSFYNVQEFVAWKHDNARLASECFIKYYKGLGTSTTTEGKEYFKQMEQHLMPLQVT-PSDSQVLDNVFDSDEVQWRKEWLSAAPAVE-EATLDRRQKMLTIPTFVDKELIHFANAGNLRALPSAVDGLKPSQRKILWSCFRRGNANESLKVSQLSGYISEVSAFHHGEMSLQQTIIKMAQDYVGSNNINLLEPEGQFGSRQHLGSDHAAARYIFTKLSPLARLIFPKEDDELLQFVEDEGKYVEPRFYVPIIPMLLVNGSVGIGFGFACTVQMHHPLDVVTVVRRMMRKNTPTQALEGLRPWAVGYSGSVVQKTTVDEEGREVVSTTHVAMGRFTTRKVKGFPVVRVEELPWDRAIEQLRGRVAKLAEES---KVLRIADYSGANHVDSDVVLAADSFASPRE--IEKDFLLTSNVAN-NAAVYNPEMVLSPLGESVESIVQWHYEQRLAMYTKRKERQLLLLNTQLKKLKSTLTFTETLRSGDLDFRKMADENALVKQCSELK---------------------------------------LHRENDSFDYLTRRPVTYFTNNNVEKLKRDIEHCKSSIKSLESKSEVELWETDLAAFEKAFTAHEDALLLRIEADRR---------P-VFTAPEVDNLSQQR---SNE--KW--KFFRRKKGGSSSSSSGGAGGGAGEM--VVREFVPPPLPNQPPAAAAKAQAKAQVAKFVGGVLAMVATRLQVGVVGRLLLH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- AAA65448 MATKLPLQNSNAANVAKAPAKSRAAAGGKTIEEMYQKKSQLEHILLRPDTYIGSIEKHTQTLWVYEKDE--MVQRPVTYVPGLYKIFDEILVNAADNKQR---DAKMDSVQVVIDVEQNLISVCNSGAGVPVEIHQEEGIYVPEMIFGHLLTSSNYDDNVKKTTGGRNGYGAKLTNIFSTEFIIETADGKRLKKYKQVFENNMGKKSEPVITKCN-KSENWTKVTFKPDLKKFNMT--ELEDDVVALMSKRVFDIAGCLGKSVKVELNGKQIPVKSFTDYVDLYLSAAN-----------KSRTEDP-----LPRLTEKVNDRWEVCVSLSEGQ-FQQVSFVNSIATIKGGTHVDYVTSQITNHIVAAVNK--KNKNANVKAHNVKNHLWVFVNALIDNPAFDSQTKETLTLRQSSFGSKCELSEDFLKKVGK-SGVVENLLSWADFKQNKDLKKSDGAKTGRVL--VEKLDDAAEAGGKNSRLCTLILTEGDSAKSLALAGRSVLGNNYCGVFPLRGKLLNVREASTTQITNNKEIENLKKILGLKQNMKYENVNSLRYGQMMIMTDQDHDGSHIKGLLINFIHSFWPSLLQ-VPSFLVEFITPIVKATRKGTK-KVLSFYSMPEYEEWKESLKGNATGWDIKYYKGLGTSTAEEGKEYFSNLGLHKKDFVWEDEQDGEAIELAFSKKKIEARKNWLSSYVPGN---HLDQRQPKVTYSDFVNKELILFSMADLQRSIPSMVDGLKPGQRKILFVAFKK-IARKEMKVAQLVGYVSLLSAYHHGEQSLASAIIGMAQDYVGSNNINLLLPNGQFGTRTSGGKDSASARYIFTKLSPVTRILFPKDDDLLLDYLNEDGQRIEPTWYMPIIPTVLVNGAEGIGTGWSTFIPNYNPREIVANVRRLLNGESM---VP-MDPWYRGFKGTIEKTAS--KEGG----CTYTITGLYEEVDETT---IRITELPIRRWNDDYKNFLQSLKTDNGAPFFQDVKAYNDEKSVDFDLILSEENMLAARQEGFLKKFKLTTTIATSNMHLFDKKGVIKKYVTP-EQILEEFFDLRFEYYEKRKETVVKNMEIELLKLENKARFILAVLSGEIIVNKRKKA-DIVEDLRQKGFTPFPRKAESVEAAIAGAVDDDAAEEPEEILVDPESSSSYIPGSE-YDYLLAMAIASLTIEKVEELLADRDKMIIAVADMKKTTPKSLWLSDLESLDKELEKLDLKDA-----QVQQAIEAAQ---KKIRAKSGAAVKVKR---QAPKKPAPKKTTKKASESETTEASYSAMDTDNNVAEVVKPKARQGAKKKA-SESETTEASHSAMDTDNN-VAEVVKPKGRQGAKKKAPAAAKEVEEDEMLDLAQRLAQYNFGSAPADSSKTAETSKAIAVDDDDDDVVVEVAPVKKGGRKPAATKAAKPPAAPRKRGKQTVASTEVLAIGVSPEKKVRKMRSSPFNKKSSSVMSRLADNKEEESSENVAGNSSSEKSGGDVSAISRPQRANRRKMTYVLSDSESESANDSEFDDIEDDEDDE QUARTET PUZZLING TREE :---P30190 :----100: : :---P12531 :100: : : :---AAF86355 : : :100: : :100: :---O61078 : : : :-------P27570 : :---------------AAL99217 : :---------------AAA65448 EFH5 P41048 T. cruzi P41049 T. cruzi P25027 T. brucei P41045 L. tarentolae *P11118 Euglena gracilis P41048 MQARGTVKVQGDAKVDGKMSTGQHSHHQHLNSTQANATTTALEYRAMNRPLYRGPISHNIISEMAEGFYVLSGGYKKLFIPSKDVYALMQNVGMHLTEEEFHDALRVIGQSEPQNADELSFSDFLLLMTREVDDT-MADELRSAFFHYDKYKTGYVTRKQFTELFATLGERSTPEELEELLAVAEVDETDDKIDYNRFVNELTSRVNCM P41049 MQARGTVKVQGDANVDGKMSTGQHPHHQHLNSTQANATTTALEYRAMNRPLYRGPISHNIISEMAEGFYVLSGGYKKLFIPSKDVYALMQNVGMHLTEEEFHDALRVIGQSEPQNADELSFSDFLLLMTREVDDT-MADELRSAFFHYDKHKTGYVTRKQFTELFATLAERSTPEELEELLAVAEVDETDDKIDYNRFVNELTSRVNCM P25027 --------MKDKAPVS--------SQQDHFSRGGAVGGKPISDVRGTSRPFYRKPVSHNTIAELAEGFRVLSNGQKTISIPMKEVSALMASVGLHLSDEEFHEVMRVFGQGEQTNTEELSFKDFLSLMMCEVDDT-MLEEMRGAFLHYDKQKTGFVTKKQFTELFATGGECSTPEEVEELLTIAEQDETDDKIDYNRFINELIHRLNFM P41045 --------MSRSKEVS-----------PNLSQ-QKRGDVRSAGISGFSSPIYRGRLNHSASAELQEGYRILTGGQKANIISDKDLFKAIHSCGLHTSEEEVNDLLRVVHQDE--RTLGLEFPEFMMLMTKGIDEA-SIAEMRRPFSVLDKAKTGVITKKQFTELFVSSGEHSSAEELEELMLLAETSEELEVVDYNKLINELAILLNKM P11118 ----------------------------------------------------AEALTHEQIAEFKEAFSLFDKD-GDGTITTKELGTVMRSLGQNPTEAELQDMINEVDQDG---SGTIDFPEFLTLMSRKMHDTDTEEEIKEAFRVFDKDGNGFISAAELRHVMTNLGEKLTDEEVDEMIREADVD-GDGQINYEEFVKMMMSK---- QUARTET PUZZLING TREE :---P41048 :100: : :---P41049 : :-------P25027 : :-------P41045 : :-------P11118 EF-1a AAC01751 T. cruzi AAA57476 T. brucei AAL08019 L. donovani AAB48400 L. braziliensis *CAA34769 Euglena gracilis AAC01751 MGKEKVHMNLVVVGHVDAGKSTATGHLIYKCGGIDKRTIEKFEKEAAEIGKSSFKYAWVLDKLKAEREPGITIDIALWKFESPKSVFTIIDAPGHRDFIKNMITGTPQADAAVLVIASSQGEFEAGISKDGQTREHALLAFTLGVKQMVVCCNKMDDKSVNFAQERYDEIVKEVSAYLKKVGYNVEKVRFIPISGWQGDNMIDKSENMPWYKGPTLLEALDMLEPPVRPSDKPLRLPLQDVYKIGGIGTVPVGRVETGTMKPGDVVTFAPANVTTEVKSIEMHHEQLAEATPGDNVGFNVKNVSVKDIRRGNVCGNSKNDPPKEAADFTAQVIILNHPGQIGNGYAPVLDCHTCHIACKFAEIESKIDRRSGKELEKNPKSIKSGDAAMVRMVPQKPMCVEVFNDYAPLGRFAVRDMRQTVAVGIIKAVTKKDGGAGKVTKAAAKAAKK AAA57476 MGKEKVHMNLVVVGHVDAGKSTATGHLIYKCGGIDKRTIEKFEKEAADIGKASFKYAWVLDKLKAERERGITIDIALWKFESPKSVFTIIDAPGHRDFIKNMITGTSQADAAILIIASAQGEFEAGISKDGQTREHALLAFTLGVKQMVVCCNKMDDKTVNYGQERYDEIVKEVSAYIKKVGYNVEKVRFVPISGWQGDNMIEKSEKMPWYKGPTLLEALDMLEPPVRPSDKPLRLPLQTCTKIGGIGTVPVGRVETGVMKPGDVVTFAPANVTTEVKSIEMHHEQLAEATPGDNVGFNVKNVSVKDIRRGNVCGNTKNDPPKEAADFTAQVIILNHPGQIGNGYAPVLDCHTSHIACKFAEIESKIDRRSGKELEKAPKSIKSGDAAIVRMVPQKPMCVEVFNDYAPLGRFAVRDMRQTVAVGIIKAVTKKDGSGGKVTKAAVKASKK AAL08019 MGKDKVHMNLVVVGHVDAGKSTATGHLIYKCGGIDKRTIEKFEKEAAEIGKASFKYAWVLDKLKAERERGITIDIALWKFESPKSVFTIIDAPGHRDFIKNMITGTSQADAAILMIDSTHGGFEAGISKDGQTREHALLAFTLGVKQMVVCCNKMDDKTVTYAQSRYDEISKEVGAYLKRVGYNPEKVRFIPISGWQGDNMIERSDNMPWYKGPTLLDALDMLEPPVRPVDKPLRLPLQDVYKIGGIGTVPVGRVETGIMKPGDVVTFAPANVTTEVKSIEMHHEQLAEAQPGDNVGFNVKNVSVKDIRRGNVCGNSKNDPPKEAADFTAQVIVLNHPGQISNGYAPVLDCHTSHIACRFAEIESKIDRRSGKELEKNPKAIKSGDAAIVKMVPQKPMCVEVFNDYAPLGRFAVRDMRQTVAVGIIKGVNKKEGSGGKVTKAAAKAAKK AAB48400 MGKDKVHMNLVVVGHVDAGKSTATGHLIYKCGGIDKRTIEKFEKEAAEMGKASFKYAWVLDKLKAERERGITIDIALWKFESPKSVFTIIDAPGHRDFIKNMITGTSQADAAILMIDSTQGGFEAGVSKDGQTREHALLAFTLGVKQMVVCCNKMDDKTVQYSQARYEEISKEVGTYLKRVGYNPEKVRFIPISGWQGDNMIDKSESMAWYKGPTLLDALDMLAGAVRPVDKPGAAP-ADVYKIGGIGTVPVGRVETGIMKPGDVVTFAPANVTTEVKSIEMHHEQLAEAVPGDNVGFNVKNVSVKDIRRGNVWGNSKNDPAEEPADFTAQVIVLNHPGQISNGYAPVLDCHTSHIACRFGTIESKIDRRSGKDVEKNPKAIKSGDAAIVKMVPQKPMCVEVFNDYPPLGRFAVRDMRRTVAVGIIKAVSKKDGSR-KVTKAAAKAAKK CAA34769 MGKEKVHISLVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEASEMGKGSFKYAWVLDKLKAERERCITIDIALWKFETAKSVFTIIDAPGHRDFIKNMITGTSQADAAVLVIDSTTGGFEAGISKDGQTREHALLAYTLGVKQMIVATNKFDDKTVKYSQARYEEIKKEVSGYLKKVGYNPEKVPFIPISGWNGDNMIEASENMGWYKGLTLIGALDNLEPPKRPSDKPLRLPLQDVYKIGGIGTVPVGRVETGVLKPGDVVTFAPNNLTTEVKSVEMHHEALTEAVPGDNVGFNVKNVSVKDIRRGYVASNAKNDPAKEAADFTAQVIILNHPGQIGNGYAPVLDCHTCHIACKFATIQTKIDRRSGKELEAEPKFIKSGDAAIVLMKPQKPMCVESFTDYPPLG-VSCGDMRQTVAVGVIKSVNKKENTG-KVTKAAQK--KK QUARTET PUZZLING TREE :---AAC01751 :100: : :---AAA57476 : : :---AAL08019 :-76: : :---AAB48400 : :-------CAA34769 GAPDH P22512 T. brucei AAD17501 T. evansi AAD17502 T. vivax CAA37079 T. cruzi AAD17500 T. rangeli AAK54643 Leptomonas sp. AAK08119 Leptomonas sp. AAK11316 Blastocrithidia gerricola AAK11315 Leptomonas peterhoffi AAK11301 Wallaceina brevicula O96423 Crithidia fasciculata AAD17498 Crithidia luciliae AAK09324 Leptomonas sp. AAK32964 Leptomonas pyrrhocoris AAD02467 Leptomonas seymouri Q27890 L. mexicana AAD02466 Herpetomonas pessoai AAD02468 Phytomonas sp. CAA52632 Trypanoplasma borreli *AAC37245 Euglena gracilis P22512 -MTIKVGINGFGRIGRMVFQALCDDGLLGNEIDVVAVVDMNTDARYFAYQMKYDSVHGKFK-HSVSTTKSKPSVA-KDDTLVVNGHRILCVKAQRNPADLPWGKLGVEYVIESTGLFTVKSAAEGHLRGGARKVVISAPASGGAKTFVMGVNHNNYNPREQHVVSNASCTTNCLAPLVHVLVKEGFGISTGLMTTVHSYTATQKTVDGVSVKDWRGGRAAALNIIPSTTGAAKAVGMVIPSTQGKLTGMAFRVPTADVSVVDLTFIATRDTSIKEIDAALKRASKTYMKNILGYTDEELVSADFISDSRSSIYDSKATLQNNLPNERRFFKIVSWYDNEWGYSHRVVDLVRHMAARDRAAKL-- AAD17501 ------GINGFGRIGRMVFQALCDDGLLGNEIDVVAVVDMNTDARYFAYQMKYDSVHGKFK-HSVSTTKSKPSVA-KDDTLVVNGHRILCVKAQRSPADLPWGKLGVEYVIESTGLFTVKSAAEGHLRGGARKVVISAPASGGAKTFVMGVNHNDYNPREHHVVSNASCTTNCFAPFVHVLVKEGFGISTGLMTTVHSYTATQKTVDGVSVKDWRGGRAAALNIIPSTTGAAKAVGMVIPSTQGKLTGMAFRVPTADVSVVDLTFIATRDTSIKEIDAALKRASKTYMKNILGYTDEELVSADFISDSRSSIYDSKATLQNNLPNERRFFKIVSWYDNEWGYSHRVVDL--------------- AAD17502 ------GINGFGRIGRMVFQALCDDGLLGTEIDVVAVVDMNTDAKYFAYQMKYDSVHGKFK-HSVSTTKSSPSAK-SDDTLVVNGHRILCVKAQRNPADLPWGKLGVEYVIESTGLFTVKSAAEGHLRGGARKVVISAPASGGAKTFVMGVNHHEYNPREHHVVSNASCTTNCLAPFVHVLVKEGFGVSTGLMTTIHSYTATQKTVDGVSIEDWRGGRAAALNIIPSTTGAAKAVGMVIPSTQGKLTGMSFRVPTADVSVVDLTFTATRDTSIKEIDAALKRASKTYMKNILGYTDEELVSTDFINDNRSSIYDSKATLQNNLPNERRFFKIVSWYDNEWGYSHRVVDL--------------- CAA37079 -MPIKVGINGFGRIGRMVFQALCEDGLLGTEIDVVAVVDMNTDAEYFAYQMRYDTVHGKFK-YEVTTTKSSPSVA-KDDTLVVNGHRILCVKAQRNPADLPWGKLGVEYVIESTGLFTAKAAAEGHLRGGARKVVISAPASGGAKTLVMGVNHHEYNPSEHHVVSNASCTTNCLAPIVHVLVKEGFGVQTGLMTTIHSYTATQKTVDGVSVKDWRGGRAAAVNIIPSTTGAAKAVGMVIPSTQGKLTGMSFRVPTPDVSVVDLTFTAARDTSIQEIDAALKRASKTYMKGILGYTDEELVSADFINDNRSSIYDSKATLQNNLPKERRFFKIVSWYDNEWGYSHRVVDLVRHMASKDRSARL-- AAD17500 ------GINGFGRIGRMVFQAMCEADLLGTEIEVVAVVDMSTDAEYFAYQLRYDSVHGRLK-HKVTTAKSSPSVA-NDDVLVVNGHRILCVRAQRNPADLPWGKLGVEYVIESTGLFTSKAAAEGHLRGGARKVIISAPASGGAKTLVMGVEPRGYNPREHHVVSNASCTTNCLG?IVHVLVKEGFGVETGLMTTIHSNTATQKTVDGVSHRDWRGGRAAAINVIPSTTGAAKAVGMVIPSMQGKLTGMAFRVPTADVSVVDLTFTAKRDTSIKEIDAALKRASKTYMKGILGFTNEELVSTDFINDDRSS?YDSLATLQNNLPNERRFFKVVSWYDNEWGYSHRVVDL--------------- AAK54643 MAPLKVGINGFGRIGRMVFQSMCEDNVLGNELDVVAVVDMSTDAEYFAYQMKYDSVHGRPK-YTVEVAKSSPSMK-KPDVLVVNGHRILCVKAERNPADLPWKKLGVDYVIESTGLFTDKAKAEGHVKGGAKKVVISAPASGGAKTIVMGVNQHEYDPATHHVVSNASCTTNCLAPIVHVLTKENFGIETGLMTTIHSYTATQKTVDGVSIKDWRGGRAAAVNIIPSTTGAAKAVGMVIPSTKGKLTGMSFRVPTPDVSVVDLTFRATRDTSIQEIDAALKKASQTYMKGILGYTDEELVSTDFINDARSSIYDAKATLQNNLPGEKRFFKIVSWYDNEWGYSHRVVDLVRFMGAKDGASSKM- AAK08119 MAPLKVGINGFGRIGRMVFQSMCEDNVLGNELDVVAVVDMSTDAEYFAYQMKYDSVHGRPK-YTVEVAKSSPSMK-KPDVLVVNGHRILCVKAERNPADLPWKKLGVDYVIESTGLFTDKAKAEGHVKGGAKKVVISAPASGGAKTIVMGVNQHEYDPATHHVVSNASCTTNCLAPIVHVLTKENFGIETGLMTTIHSYTATQKTVDGVSIKDWRGGRAAAVNIIPSTTGAAKAVGMVIPSTKGKLTGMSFRVPTPDVSVVDLTFRATRDTSIQEIDAALKKASQTYMKGILGYTDEELVSTDFINDARSSIYDAKATLQNNLPGEKRFFKIVSWYDNEWGYSHRVVDLVRFMGAKDPASSKM- AAK11316 MAPIKAGINGFGRIGRMVFQSMCEDNVLGNELDVVAVVDMSTDAEYFAYQMKYDSVHGRPK-YTVEVAKSSPSMK-KPDVLVVNGHRILCVKAERNPADLPWKKLGVDHVIESTGLFTDKAKAEGHVKGGAKKSSSAAPASGGAKTIVMGVNQHEYDPATHHVVSNASCTTNCPAPIVHVLTKENFGIETGLMTTIHSYTATQKTVDGVSIKDWRGGRAAAVNIIPSTTGAAKAVGMVIPSTKGKLTGMSFRVPTPDVSVVDLTFRATRDTSIQEIDAALKKASQTYMKGILGYTDEELVSTDFINDARSSIYDAKATLQNNLPGEKRFFKIVSWYDNEWGYSHRVVDLVRFMGAKDRASSKM- AAK11315 MAPLKVGINGFGRIGRMVFQSICNDYELGKEIDVIAVVDMSTDAEYFAYQMKYDSVHGRPK-YTVEVAKSSPSMK-KPDVLVVNGHRILCVKAERNPADLPWKKLGVDYVIESTGLFTDKAKAEGHVKGGAKKVVISAPASGGAKTIVMGVNQHEYDPATHHVVSNASCTTNCLAPIVHVLTKENFGIETGLMTTIHSYTATQKTVDGVSIKDWRGGRAAAVNIIPSTTGAAKAVGMVIPSTKGKLTGMSFRVPTPDVSVVDLTFRATRDTSIQEIDAALKKASQTYMKGILGYTDEELVSTDFINDARSSIYDAKATLQNNLPGEKRFFKIVSWYDNEWGYSHRVVDLVRFMGAKDAASSKM- AAK11301 MAPIKVGINGFGRIGRMVFQSICNDYELGKEIDVIAVVDMSTDAEYFAYQMKYDSVHGRPK-YTVEVAKSSPSMK-KPDVLVVNGHRILCVKAERNPADLPWKKLGVDYVIESTGLFTDKAKAEGHVKGGAKEVVISAPASGGAKTIVMGVNQHEYDPATHHVVSNASCTTNCLAPIVHVLTKENFGIETGLMTTIHSYTATQKTVDGVSIKDWRGGRAAAVNIIPSTTGAAKAVGMVIPSTKGKLTGMSFRVPTPDVSVVDLTFRATRDTSIQEIDAALKKASQTYMKGILGYTDEELVSTDFINDARSSMYDAKATLQNNLPGEKRFFKIVSWYDNEWGYSHRVVDLVRFMGAKDGASSKM- O96423 MAPIKVGINGFGRIGRMVFQSMCEDNVLGTELDVVAVVDMSTDAEYFAYQMKFDTVHGRPK-YTVEVAKSSPSAK-KPDVLVVNGHRILCVKADRNPADLPWGKLGVDYVIESTGLFTDKAKAEGHVKGGAKKVVISAPASGGAKTIVMGVNQHEYNPATHHVVSNASCTTNCLAPIVHVLTKENFGIETGLMTTIHSYTATQKTVDGVSIKDWRGGRAAAVNIIPSTTGAAKAVGMVIPSTKGKLTGMSFRVPTPDVSVVDLTFRATRDTSIQEIDAALKKASQTYMKGILGFTDEELVSSDFINDARSSIYDSKATLQNNLPGEKRFFKVVSWYDNEWGYSHRVVDLVRFMGAKDRSSSKL- AAD17498 ------GINGFGRIGRMVFQSMCEDNVLGTELDVVAVVDMSTDAEYFAYQMKFDTVHGRPK-YTVEVAKSSPSAK-KPDVLVVNGHRILCVKAERNPADLPWGKLGVDYVIESTGLFTDKAKAEGHVKGGAKKVVISAPASGGAKTIVMGVNQHEYNPATHHIVSNASCTTNCLAPIVHVLTKENFGIETGLMTTIHSYTATQKTWTGVSIKDWRGGRAAAVNIIPSTTGAAKAVGMVIPSTKGKLTGMSFRVPTPDVSVVDLTFRATRDTSIQEIDAALKKASQTYMKGILGYTDEELVSSDFINDARSSIYDSKATLQNNLPGEKRFFKVVSWYDNEWGYSHRVVDL--------------- AAK09324 MAPIKVGINGFGRIGRMVFQSMCEDNVLGNEIDVVAVVDMSTDAEYFAYQMKFDSVHGRPK-YTVEVAKSSPSAK-KPDVLVVNGHRILCVKAERNPADLPWGKLGVEYVIESTGLFTDKAKAEGHVKGGAKKVVISAPASGGAKTIVMGVNQHEYNPATHHVVSNASCTTNCLAPIVHVLTKENFGIETGLMTTIHSYTATQKTVDGVSIKDWRGGRAAAVNIIPSTTGAAKAVGMVIPSTKGKLTGMSFRVPTPDVSVVDLTFRATRDTSIQEIDAALKKASRTYMKGILGFTDDELVSSDFINDARSSIYDSKATVQNNLPGEKRFFKVVSWYDNEWGYSHRVVDLVRFMGAKDRSCAKL- AAK32964 MAPLKVGINGFGRIGRMVFQSMCEDNVLGNEIDVVAVVDMSTDAEYFAYQMKYDTVHGRPT-YTVEVAKSAPEVK-KPDVLVVNGHRILCVKAQRNPADLPWGKLGVDYVIESTGLFTNKAKAEGHVKGGAKKVVISAPASGGAKTIVMGVNQHEYDPAKHHVVSNASCTTNCLAPIVHVLTKENFGIETGLMTTIHSYTATQKTVDGVSIKDWRGGRAAAMNIIPSTTGAAKAVGMVIPSTKGKLTGMSFRVPTPDVSVVDLTFRANRDASIQEIDAALKKASKTYMKGILGYTDEELVSSDFINDARSSIYDAKATLQNNLPGEKRFFKIVSWYDNEWGYSHRVVDLVRYMGAKDGASSKM- AAD02467 MAPLKVGINGFGRIGRMVFQSMCEDNVLGNEIDVVAVVDMSTDAEYFAYQMKYDTVHGRPK-YTVEVAKSSAAVK-KPDVLVVNGHRILCVKAQRNPADLPWGKLGVDYVIESTGLFTDKVKAEGHVKGGAKKVVISAPASGGAKTIVMGVNQNEYDSAKHHVVSNASCTTNCLAPIVHVLTKEGFGVETGLMTTIHSYTATQKTVDGVSIKDWRGGRAAAVNIIPSTTGAAKAVGMVIPSTKGKLTGMSFRVPTPDVSVVDLTFRATRDTSIQEIDAALKKASKTYMKGILGFTDEELVSADFINDARSSIYDSKATLQNNLPGEKRFFKVVSWYDNEWGYSHRVVDLVRFMGAKDRASSKM- Q27890 MAPIKVGINGFGRIGRMVFQAICDQGLIGTEIDVVAVVDMSTNAEYFAYQMKHDTVHGRPK-YTVEAVKSSPSVE-TADVLVVNGHRIKCVKAQRNPADLPWGKLGVDYVIESTGLFTDKLKAEGHIKGGAKKVVISAPASGGAKTIVMGVNQHEYSPASHHVVSNASCTTNCLAPIVHVLTKENFGIETGLMTTIHSYTATQKTVDGVSLKDWRGGRAAAVNIIPSTTGAAKAVGMVIPSTKGKLTGMSFRVPTPDVSVVDLTFRATRDTSIQEIDKAIKKAAQTYMKGILGFTDEELVSADFINDNRSSVYDSKATLQNNLPGEKRFFKVVSWYDNEWAYSHRVVDLVRYMAAKDAASSKM- AAD02466 MAPVKVGINGFGRIGRMVFQAMCEQGVLGKDFDVVAVVDMSTDAEYFAYQMKYDSVHGKPK-YTVEVAKSSPSVK-KPDVLVVNGHRIQCVKAQRNPADLPWSKLGVEYVIESTGLFTNKAKAEGHLKGGAKKVIISAPASGGAKTIVMGVNNQEYNPSSHSVVSNASCTTNCLAPLVHVLLKEGFGVETGLMTTIHSYTATQKTVDGVSLKDWRGGRAAAMNIIPSTTGAAKAVGEVLPVTKGKLTGMSFRVPTPDVSVVDLTFTAAKDTSIKEIDEAFKRASKTYMKGILSYTDEELVSSDFYNNNNSSIYDSKATLQNNLPGEKRFFKVVSWYDNEWGYSHRVVNLLSFMIKKDRAGSKI- AAD02468 MAPIKVGINGFGRIGRNVFQAICEGNHLGTDIDVVAVADMSTDAEYFSYQIVDDSVHGKPRSYGVEVAKSNPSVE-KPDVLVVNGHRIQCVKAARNPADLPWGKLDIEYVIESTGLFTKKTQAEGHIKGGAKKVVISAPASGGVKTIVMGVNEKEYDPSSHHIVSNASCTTNCLAPLVHVLTKEGFGLETGLMTTIHSYTATQKTVDGVSIKDWRGGRAAAINIIPSTTGAAKAVGEVIPTTKGKLTGMAFRVPTPDVSVVDLTFTATRDTSIKEIDAALKKA-VTYIKGILSFTDEELVSTDFINDNHSSIYDSKATLQNNLPNEKRFFKLVSWYDNEWGYSHRVVDLIIYMAKRDAASAKL- CAA52632 MAPIKVGINGFGRIGRMVLQAICDQGLLGTEIDVVAVVDMSTDADYFSYQIRYDSVHGRFK-HKVDVAASPECEPGKHDTLVINGHKVKCVKATRNPSDLPWGKLGVDYVIESTGLFTDKSKAEGHIKAGAKKVIISAPAKGGAKTIVMGVNQHEYNPNEHSVVSNASCTTNCLAPIVHVLNKEGFGIKVGLMTTIHAYTATQKTVDGVSQKDWRGGRAASVNIIPSSTGAAKAVGEVLPETKGKLTGMAFRVPTPDVSVVDLTFTTTKDTSIKEIDAALKRAAASYLRGILDISKEELVSTDFIHNPNSSIYDSLATLQNNLPTEKRFFKVVSWYDNEWGYSNRVVDLVRFMNSKDSKSHAKL AAC37245 MAPVKIGINGFGRIGRMVFQALCDQGLLGTTFDVVGVVDMATDADYFAYQMKYDSVHGKFK-HTVSTKKSDANLA-EADIIVVNGHEIKCIMATRNPEDLPWGKLGVEYVVESTGLFTEADKARGHLKAGAKKVIISAPGKGDLKTIVMGVNHTEYQAS-MDVVSNASCTTNCLAPLVHVLLKEGVGVEKGLMTTIHAYTATQKTVDGPSKKDWRGGRAAAINIIPSTTGAAKAVGEVLPAVKGKLTGMAFRVPTPDVSVVDLTFLAEKDTSIKEIDSLLKKASQTYLKGILGFTDEELVSTDFVHDNRSSIYDSLATLQNNLPGEKRLFKVVSWYDNEWGYSNRVVDLLKHMSGN-------- QUARTET PUZZLING TREE :---P22512 :100: :100: :---AAD17501 : : :100: :-------AAD17502 : : :--------100: :-----------CAA37079 : : : :---------------AAD17500 : : :---AAK11315 : :-97: : : :---AAK11301 : : : :-95: :---AAK54643 : : :-64: : : : :---AAK08119 : : : :-96: : :-------AAK11316 : : : : : :-66: :---O96423 : : : : :-53: : : : :-88: :---AAD17498 : : : : : : : :-99: : :-------AAK09324 : : : : : : : : : :-----------AAK32964 : : :-99: : : : : : :---------------AAD02467 : : : : : :-56: :-------------------Q27890 : : : : :---AAD02466 : :-----------------79: : :---AAD02468 : :-------------------------------CAA52632 : :-------------------------------AAC37245 Glucose-6-phosphate isomerase T14631 T. cruzi P13377 T. brucei P42861 L. mexicana *NP_709894 Shigella flexneri T14631 ------------------------MAVASFNMPHEITRRMRPLGVDADTSLTSCPSWRRLQELYEIHGSESILKNFDECKDRFQRYSLEVDLRSSDKNFVFLDYSKTHINDEIKDVLFKLVEERGIRAFMRALFAGEKVNTAENRSVLHIALRNRSNRPIFVNGHDVMPLVNKVLEQMKKLSEKVRRGEWKGQSGKPIRHVVNIGIGGSDLGPMMACEALRPFSDRRISMHFVSNIDGTHLSEVLNLVDLESTLFIIASKTFTTQETITNALSARNEFLKFLSSRGISEAGAVAKHFVALSTNAEKVKEFGIDEENMFQFWDWVGGRYSLWSAIGLSVMISIGYDNFVELLTGAHIMDEHFINAPTENNLPIILALVGIWYNNFFGSETQAILPYDQYLWRLPAYLQQLDMESNGKGATKNGRMVSTHTGPIIFGEAGTNGQHAFYQLIHQGTKLIPCDFIGAIQTQNYIGEHHRILMSNFFAQTEALMIGKTPEEVKRELESAGGKSEDEIQLLIPQKTFTGGRPSNSLLVKALTPRALGAIIAMYEHKVLVQGAIWGINSYDQWGVELGKLLAKSILLQLQPGQKVTNHDSSTNGLIELFNERSHL P13377 MSSYLDDLRIDLAAS-PASGGSASIAVGSFNIPYEVTRRLKGVGADADTTLTSCASWTQLQKLYEQYGDEPIKKHFEADSERGQRYSVKVSLGSKDENFLFLDYSKSHINDEIKCALLRLAEERGIRQFVQSVFRGERVNTTENRPVLHIALRNRSNRPIYVDGKDVMPAVNKVLDQMRSFSEKVRTGEWKGHTGKAIRHVVNIGIGGSDLGPVMATEALKPFSQRDLSLHFVSNVDGTHIAEVLKSIDIEATLFIVASKTFTTQETITNALSARRALLDYLRSRGIDEKGSVAKHFVALSTNNQKVKEFGIDEENMFQFWDWVGGRYSMWSAIGLPIMISIGYENFVELLTGAHVIDEHFANAPPEQNVPLLLALVGVWYINFFGAVTHAILPYDQYLWRLPAYLQQLDMESNGKYVTRSGKTVSTLTGPIIFGEAGTNGQHAFYQLIHQGTNLIPCDFIGAIQSQNKIGDHHKIFMSNFFAQTEALMIGKSPSEVRRELEAAGERSAEKINALLPHKTFIGGRPSNTLLIKSLTPRALGAIIAMYEHKVLVQGAIWGIDSYDQWGVELGKVLAKSILPQLRPGMRVNNHDSSTNGLINMFNELSHL P42861 MSDYFSKLKEHVVESTEINGCTPSIATATFNAPYEVARKTKMLGVT-DSSLLNLPAWKRLQSLYEKYGNDSILSHFEKDHQRFQRYSIEIDLHS-DDNFLFLDYSKSHINDEIKDALVALAEERGVRAFAKAMFDGQRVNSTENRAVLHVALRNRSNRPIIVDGKDVMSDVNNVLAQMKDFTERVRSGEWKGQTGKSIYNIVNIGIGGSDLGPVMVTEALKPFSKRDLHCFFVSNVDGTHMAEVLKQVNLEETIFIIASKTFTTQETLTNAMSARNALMSYLKENGISTDGAVAKHFVALSTNTEKVREFGIDTVNMFAFWDWVGGRYSVWSAIGLSVMLSIGYDNFVEFLTGAHVMDNHFASTPTEQNLPMMLALVGIWYNNFFGSETQAVLPYDQYLWRLPAYLQQLDMESNGKGVTKKSGAVAVQTGPIVFGEAGTNGQHAFYQLIHQGTKIIPCDFIGCVQTQNRVGDHHRTLMSNFFAQTEALMVGKNAEEVRQELVKSG-MSGDAIENMIPHKTFTGSRPSNSILVNALTPRALGAIIAMYEHKVLVQGAIWGINSYDQWGVELGKVLAKSILPQLKSGNIVSDHDGSTNGLINMFNTRAHL NP709894 -------------------------------------------MLMKNINPTQTAAWQALQKHFDEMKDVTIADLFAKDGDRFSKFSATFDDQM------LVDYSKNRITEETLAKLQDLAKECDLAGAIKSMFSGEKINRTENRAVLHVALRNRSNTPILVDGKDVMPEVNAVLEKMKTFSEAIISGEWKGYTGKAITDVVNIGIGGSDLGPYMVTEALRPYKN-HLNMHFVSNVDGTHISEVLKKVNPETTLFLVASKTFTTQETMTNAHSARDWFLKAAG---DEK--HVAKHFAALSTNAKAVGEFGIDTANMFEFWDWVGGRYSLWSAIGLSIVLSIGFDNFVELLSGAHAMDKHFSTTPAEKNLPVLLALIGIWYNNFFGAETEAILPYDQYMHRFAAYFQQGNMESNGKYVDRNGNVVDYQTGPIIWGEPGTNGQHAFYQLIHQGTKMVPCDFIAPAITHNPLSDHHQKLLSNFFAQTEALAFGKSREVVEQEYRDQG-KDPATLDYVVPFKVFEGNRPTNSILLREITPFSLGALIALYEHKIFTQGVILNIFTFDQWGVELGKQLANRILPELKDDKEISSHDSSTNGLINRYKAWRG- QUARTET PUZZLING TREE :---T14631 :100: : :---P13377 : :-------P42861 : :-------NP709894 GRP78 AAC37174 T. brucei S33210 T.congolense AAA30201 T. cruzi AAL29192 L. donovani *Q03685 Nicotiana tabacum *AAF88019 Arabidopsis thaliana AAC37174 GKVEACVGIDLGTTYSVVGVWQKGDVHIIPNEMGNRITPSVVAFTDTERLIGDGARNQLPQNPHNTIYTIKRLIGRKYTDAAVQADKKLLSYEVIARDGKPKVQVMVGGKKKQFTPEEISAMVLQKMKEIAETYLGEKVKNAVVTVPAYFNDAQRQSTKDAGTIAGLNVVRIINEPTAAAIAYGLNKAGEKNILVFDLGGGTFDVSLLTIDEGFFEVVATNGDTHLGGEDFDNNMMRHFVDMLKKKKNVDISKDQKALARLRKACEAAKRQLSSHPEARVEVDSLTEGFDFSEKITRAKFEELNMDLFKGTLVPVQRVLEDAKLKKSDIHEIVLVGGSTRVPKVQQLISDFFGGKELNRGINPDEAVAYGAAVQAAVLTGESEVGGRVVLVDVIPLSLGIETVGGVMTKLIERNTQIPTKKSQVFSTHADNQPGVLIQVYEGERQLTKDNRLLGKFELSGIPPAARGVPQIEVTFDVDENSILQVSAMDKSSGKKEEITITNDKGRLSEEEIERMVREAAEFEDEDRKVRERVDARNSLESVAYSLRNQVNDKDKLGGKLDPNDKAAVETAVAEAIRFLDENPNAEKEEYKTALETLQSVTNPIIQKTYQSAGGGDKPQPMDDL S33210 GKVEACVGIDLGTTYSVVGVWQKGDVHIIPNEMGNRITPSVVAFTDTERLIGDGAKNQLPQNPHNTIYTIKRLIGRKYTDAAVQADKKLLSYEVVARDGKPKLQVMVGGQAKQFTPEEISAMVLQKMKEIAETYLGEKVKNAVVTVPAYFNDAQRQSTKDAGTIAGLNVVRIINEPTAAAIAYGLNKAGEKNILVFDLGGGTFDVSLLTIDEGFFEVVATNGDTHLGGEDFDNNMMRYFVDMLKKKKNVDISKDQKALAGCARRAEAAKRQLSSHPEARVEVDSLTEGFDFSEKITRAKFEELNMDLFKGTLIPVQRVLEDAKLKKSDIHEMVLVGGSTRVPKVQQLISDFFGGKELNRGINPDEAVAYGAAVQAAVLTGESEVGGRVVLVDVIPLSLGIETVGGVMTKLIERNTQIPTKKSQIFSTHADNQPGVLIQVYEGERQLTKDNRLLGKFELTGIPPAARGVPQIEVTCDVDENSILQVSAMDKSSGKKEEITITNDKGRLSEEEIERMVREAAEFEDEDRKYGERVEARNSLESAAYSLRNQVNDKDKLGGKLSADDKAAVEAAVKEAIRFLDENPNAEKEEYKTALDTMQSVTNPIVQKAYQSAGAGDKPQPMDDL AAA30201 GKVEACVGIDLGTTYSVVGVWQKGDVHIIPNDMGNRITPSVVAFTETERLIGDGAKNQLPQNPHNTIYAIKRLIGRKYSDTTVQTDKKLLSYEVVAKDGKPKVEVEVGGKKKQFTPEEVSAMVLQKMKEIAETYLGEKVKNAVVTVPAYFNEPQRQSTKDAGTIAGLNVVRIINEPTAAAIAYGLNKAGEKNILVFDLGGGTFDVSLLTIDEGFFEVVATNGDTHLGGEDFDNNMMRYFVDMLKKKKNVDVSKDQKALARLREACEAAKRQLSSHPEARVEVDSLTEGFDFSEKITRAKFEELNMELFKGTLVPVQRVLEDAKLKKSDIHEIVLVGGSTRVPKVQQLIRDFFGGKEPNRGINPDEAVAYGAAVQAAVLTGESEVGGRVVLVDVIPLSLGIETVGGVMTKLIERNTQIPTKKSQVFSTYQDNQPGVLIQVYEGERQMTKDNRLLGKFELSGIPPRPRAVPQIEVTFDVDENSILQVSAVDKSSGKKEEITITNDKGRLSEEEIERMVREAAEFEGEDRKVRERVDARNSLESVAYSLRNQVNDKEKLGGKLSADDKSAVEAAVKEAMQFLDDNPNADKEEYDEARDKLQSVTNPIIQKVYQSGGGADRPEPMDDL AAL29192 GKVEACVGVDLGTTYSVAGVWQKGEVHIVTNEMGNRITPSVVAFTDAERLVGDGAKNQLPQNPENTIYAIKRLIGRKYVDPTVQNDKKLLSYHIVAKTGKPLVQVTVKGQQKRFTPEEVSAMVLQKMKEISETFLGEKVKNAVVTVPAYFNDAQRQATKDSGKIAGLNVVRIINEPTAAAIAYGLNKAGEKNILVFDLGGGTFDVSLADNRRGFFEVVATNGDTHLGGEDFDNNMMKFFVDGLKRKQNVDISNDQKALARLRKACEAAKRQLSSHPEARVEVDSLVEGYDFSEKITRAKFEELNMALFKNTLVPVQKVLEDAKLKKSDIDEIVLVGGSTRIPKVQQLIKDFFSGKEPNKGINPDEAVAYGAAVQAAVLTGESEVGGKVVLVDVIPLSLGIETVGGVMTKLIERNTQIPTKKSQIFSTYQDNQPSVLIQVFEGERGMTKDNRLLGKFDLSGIPPAPRGVPQIEVAFDVDENSILQVTASDKSSGKREEITITNDKGRLSEEEIERMVREAAEFEDEDRKVRERVEAKNSLESIAYSLRNQINDKDKLGDKLAADDKKAIEEAVKDALDFVDENPNADREEFEAARTKLQSVTNPIIQKVYQGTAGSGEADAMDDL Q03685 TKLGTVIGIDLGTTYSCVGVYKNGHVEIIANDQGNRITPSWVAFTDGERLIGEAAKNQAAVNPERTIFDVKRLIGRKFDDKEVQRDKKLVPYEIVNKDGKPYIQVKIKGETKVFSPEEISAMILTKMKETAEAYLGKKIKDAVVTVPAYFNDAQRQATKDAGVIAGLNVARIINEPTAAAIAYGLDKGGEKNILVFDLGGGTFDVSILTIDNGVFEVLATNGDTHLGGEDFDQRIMEYFIKLIKKKHGKDISKDNRALGKLRREAERAKRALSSQHQVRVEIESLFDGVDFSEPLTRARFEELNNDLFRKTMGPVKKAMEDAGLEKNQIDEIVLVGGSTRIPKVQQLLKDYFDGKEPNKGVNPDEAVAYGAAVQGGILSGEGDETKDILLLDVAPLTLGIETVGGVMTKLIPRNTVIPTKKSQVFTTYQDQQTTVTISVFEGERSLTKDCRLLGKFDLTGIAPAPRGTPQIEVTFEVDANGILNVKAEDKASGKSEKITITNDKGRLSQEEIERMVKEAEEFAEEDKKVKERIDARNSLETYVYNMRNQINDKDKLADKLESDEKEKIETATKEALEWLDDNQSAEKEDYDEKLKEVEAVCNPIITAVYQRSGGAPDDDSHDEL AAF88019 TKLGSVIGIDLGTTYSCVGVYKNGHVEIIANDQGNRITPSWVGFTDSERLIGEAAKNQAAVNPERTVFDVKRLIGRKFEDKEVQKDRKLVPYQIVNKDGKPYIQVKIKGETKVFSPEEISAMILTKMKETAEAYLGKKIKDAVVTVPAYFNDAQRQATKDAGVIAGLNVARIINEPTAAAIAYGLDKGGEKNILVFDLGGGTFDVSVLTIDNGVFEVLSTNGDTHLGGEDFDHRVMEYFIKLIKKKHQKDISKDNKALGKLRRECERAKRALSSQHQVRVEIESLFDGVDFSEPLTRARFEELNNDLFRKTMGPVKKAMDDAGLQKSQIDEIVLVGGSTRIPKVQQLLKDFFEGKEPNKGVNPDEAVAYGAAVQGGILSGEGDETKDILLLDVAPLTLGIETVGGVMTKLIPRNTVIPTKKSQVFTTYQDQQTTVSIQVFEGERSLTKDCRLLGKFDLNGIPPAPRGTPQIEVTFEVDANGILNVKAEDKASGKSEKITITNEKGRLSQEEIDRMVKEAEEFAEEDKKVKEKIDARNALETYVYNMKNQVNDKDKLADKLEGDEKEKIEAATKEALEWLDENQNSEKEEYDEKLKEVEAVCNPIITAVYQRSGGAPEDESHDEL QUARTET PUZZLING TREE :---AAC37174 :100: :100: :---S33210 : : :100: :-------AAA30201 : : : :-----------AAL29192 : :---------------Q03685 : :---------------AAF88019 HEXBP Q04832 L. major *EAA31369 Neurospora crassa AAB47542 T. equiperdum AAC61751 T. cruzi Q04832 -MSETEDVKRPRTESS-TSCRNCGKEGHYARECPEADSKGDERSTTCFRCGEEGHMSRECPN-EARSGAAGAMTCFRCGEAGHMSRDCPNSAKPGAAK-----GFECYKCGQEGHLSRDCPSSQGGSRGGYGQKRGRSGAQGGYSGDRTCYKCGDAGHISRDCPNGQGGYSGAGDRTCYKCGDAGHISRDCPNGQGGYSGAGDR-KCYKCGESGHMSRECPSAGS-------TGSGDRACYKCGKPGHISRECPEAGGSYGGSRGGGDRTCYKCGEAGHISRDCPSS-------------------------- EAA31369 ----MDSFAAP--QGT-RACFTCGQTTHQARDCPN---KG---AAKCYNCGNEGHMSRDCPE-GPKD---NARTCYRCGQTGHISRDCSQSGG-GQSS-----GAECYKCGEVGHIARNC--SKGG--ASYG---------GGYQ-------------N-----SGYGGGFGGPQKTCYSCGGIGHMSRDCVNG------S----KCYNCGESGHFSRDCPKD---------SGSGEKICYKCQQPGHVQSQCPSA--------------------------------------------------------- AAB47542 MADEASTAKRHRAEGG-NNCHRCGQPGHFARECPN-VPPGAMGDRACYTCGQPDHLSRDCPSNRGTAPMGGGRACYNCGQPGHFSRECPNMRGGPMGGAPMGGGRACYNCVQPGHFSRECPNMRGG------------------P---------------------MGGAPMGGGRACYHCGQPGHFSRECPN-MRGANMGGGR-ECYQCRQEGHIASECPNAPDDAAAGGTAAGGGRACYKCGQPGHLSRACPVTIRTDSKGGVPMYRPSSQCEHATPTYTFAIKRCHLTTLLRFDCTYIFVESVGSVIKKQ AAC61751 MAEEIPMNKRPRIEGGGSTCHRCGETGHFARECPN-IPPGAMGDRACYNCGQPGHLSRGCPT-RPPGAMGG-RACYNCGQPGHPSRECPTRPPGAMG------GRACYNCGQPGHLSRECPTRPPG------------------T---------------------MG------DRACYKCGRMGHLSRECPNRPAGGFRGVARGACYHCQQEGHLARDCPNAPP----G-----GERACYNCGQTGHTSRACPVK--------------------------------------------------------- QUARTET PUZZLING TREE :---AAB47542 :100: : :---AAC61751 : :-------Q04832 : :-------EAA31369 HGPRT P43152 L. donovani CAC45077 L. major AAF61462 L. tarentolae Q27541 Crithidia fasciculata *NP_349799 Clostridium acetobulyticum *NP_814058 Enterococcus faecalis AAB46391 T. cruzi Q07010 T. brucei P43152 MSNSAKSPSGPVGDEGRRNYPMSAHTLVTQEQVWAATAKCAKKIAEDYRSFKLT-TDNPLYLLCVLKGSFIFTADLARFLADEGVPVKVEFICASSYGTGVETSGQVRMLLDVRDSVENRHILIVEDIVDSAITLQYLMRFMLAKKPASLKTVVLLDKPSGRKVEVLVDYPVITIPHAFVIGYGMDYAESYRELRDICVLKKEYYEKPESKV------------------------ CAC45077 MSNSAKSPSGIVGDEGRRNYPMSAHTLVTQEQVWAATAKCAKKIAEDYRSFKLT-TGNPLYLLCVLKGSFIFTADLARFLADEGVPVKVEFICASSYGTGVETSGQVRMLLDVRDSVENRHILIVEDIVDSAITLQYLMRFMLAKKPASLKTVVLLDKPSGRKVEVLVDYPVITIPHAFVIGYGMDYAESYRELRDICVLKKEYYEKPESKV------------------------ AAF61462 MSNSVKSPSDHVGDVGRRNYPMSARTLVTQEQVWAATAKCAKKIAADYKDFHLT-ADNPLYLLCVLKGSFIFTADLARFLADEGVPVKVEFICASSYGSGVETSGQVRMLLDVRDSVENRHIMLVEDIVDSAITLQYLMRFMLAKKPASLKTVVLLDKPSGRKVDVLVDYPVITIPHAFVIGYVWTFAD-LRGVPDICVLKKEYYEKAESKL------------------------ Q27541 MSN-AASPATSAAP--VRHYPMSCRTLATQEQIWSATAKCAKQIAEDYKQYNLS-DENPLYLLCVLKGSFMFTADLARFLCDEGVPVRIEFICASSYGTDVKTSGEVRLLLDVRDPVENRHLLIVEDIVDSAITLEYLKRFLQAKQPASLKTVVLLDKPSGRKVTLSVDYPVITIPHAFVIGYGMDFAEAYRELRDVCVLKKEYYEKPASKL------------------------ NP349799 ------------------MREDIKEVLLDEEKINEKVKELGKKISEDYKGKDL-------ILIGILKGSVVFMGNLVKYID---IPCAIDFMSVSSYGNGTSTSGIVKVLKDLDSDVEGKDILIVEDIIDSGVTLKYLMGHISGKKPNSIEIITLLNKPERRRVEINVKYTGFIVPDYFLVGYGLDYAEKYRNLPYIGILKDEIYE------------------------------ NP814058 -----------------MIEKDIEKVLISKEEILAKSAELGKQLTEEYQGKNP-------LVVGILKGAVPFMADLTREIN---TYLELDFMDVSSYGNATVSSGEVKIVKDLDTNVEGRHILIVEDIIDSGRTLAYLVDLFRYRKAASVKIVTLLDKPEGRVVDIKADYVGFDVPNEFVVGYGLDYAETYRNLPYIGVLKPEVYESN---------------------------- AAB46391 ---------------MPREYEFAEKILFTEEEIRTRIMEVAKRIADDYKGKGLRPYVNPLVLISVLKGSFMFTADLCRALSDFNVPVRMEFICVSSYGEGVTSSGQVRMLLDTRHSIEGHHVLIVEDIVDTALTLNYLYHMYFTRRPASLKTVVLLDKREGRRVPFSADYVVANIPNAFVIGYGLDYDDTYRELRDIVVLRPEVYAEREAARQKKQRAIGSADTDRDAKREFHSKY Q07010 -------------MEPACKYDFATSVLFTEAELHTRMRGVAQRIADDYSNCNLKPLENPLVIVSVLKGSFVFTADMVRILGDFGVPTRVEFLRASSYGHDTKSCGRVDVKADGLCDIRGKHVLVLEDILDTALTLREVVDSLKKSEPASIKTLVAIDKPGGRKIPFTAEYVVADVPNVFVVGYGLDYDQSYREVRDVVILKPSVYETWGKELERRKAAGEAKR------------- QUARTET PUZZLING TREE :---NP349799 :--------100: : :---NP814058 : :-94: :---P43152 : : :-83: : : :-79: :---CAC45077 : : : : : :100: :-------AAF61462 : : : :-----------Q27541 : :-------------------AAB46391 : :-------------------Q07010 HSP60 AAD16417 L. donovani Q95046 T. cruzi Q37683 T. brucei *Q39727 Euglena gracilis AAD16417 ------MLRSAVCLAGKDVRFGEEARRSMQKGVTRAVAAVATTLGPKGRNVIIEQAYGAPKITKDGVTVAKAIEFKDRFENMGAQLVRQVCNQTNDLAGDGTTTSAVLVDSIFGEGFKCIAQGTNPIDMKRGMDVAVDYVQTSLLKQSRPIKGSEDIVRVATISANGDEEIGKMIGQAMDKVGRDGVITAQDGKTMATELEVVEGMKIERGFLSPYFVTDAKA?KA?LEDLYVLVSKKKISTIQTLLPALNHVAQQGRPLLIIADDVESEALTTLIFNKLQGKLKVCCVKAPGFGDTKEGMLEDIAVFTGAKVVGDENTGVELDAKNFDPSILGSVKKVTVTKDDTVMLNGGGDAAAVQERQQLLRDRIEQEAVEYNREKLQERLAKLSGGVAVIKVGGATELEVSEKKDRVVDAVCSTRAAVQEGIVAGGGTALLRASKELENLL------TNEHLSRDQRTGVTIVRNAIR-LPAMKIAANAGKE-GAVIVEKVLEASEESVGYDAQNDRYVNMFEAGIIDPTRVVRVAISDATSVASLMMTAEAAIVEAPKESKKDKNGKKTAAAEAEDDEELFGSY Q95046 ------MFRSAARFAGKEIRFGTEARQSMQKGVQRAVSAVATTLGPKGRNVIIEQSYGAPKITKDGVTVAKAIEFKDPFENMGAQLVRQVCNKTNDLAGDGTTTSAVLVASVFSESLRCIATGTNPIDMKRGMDRAVGVILQSVAEQSRKVTSTENIVQVATISANGDEELGRLIGQAMEKVGKDGVITTQDGKTMTTELEVVEGMSIDRGYISPYFVTDAKAQKAELEDAFVLVSAKKVSSIHTILPALNHVVRTGRPLLIIADDVESEALTTMIFNKLQGKLKIACVKAPGFGDNKTAMMQDIAIFAGARLVGEEGSGLELDAENFDPAILGTVKKATITKDDTVLLNGGGESSMVKERVELLRGLIDGETSDYNREKLQERLAKLSGGVAVIKVGGGSEVEVNEKKDRITDALCSTRAAVQEGIVPGGGVALLRASKALDSLLG------DSSLTADQRTGVQIIRNAVR-LPAHTIVLNAGKE-GAVVVEKVLENNDVTVGYDAQRDRYVNMFEAGIIDPARVVRVAITDAVSVASLMMTAEAAIVDLPKEETPAAGGMGGMGGMGGMGDMY---- Q37683 ------MFRCVVRFGAKDIRFGTEARQSMLKGVQRAVEAVATTLGPKGRNVIIEQSYGAPKITKDGVTVAKSIEFKDPFENMGAQLVRQVCNKTNDLAGDGTTTSAVLVASIFSEGIKSIATGTNPIDMKRGMDRAVEVILKNIESQSRTVTNTENVVQVATISANGDVELGKLIGEAMEKVGKDGVITTQDGKTLTTELEVVEGMSVDRGYISPYFVTDAKTQKAELEDAFVLVSAKKLNNIHTILPVLNHVVRSGRPLLIIADDVESEALTTMIFNKLQGKLKIACVKAPGFGDNKAAMLQDIAIFSGACVVGEEGSGVELDAEKFEASILGSVKKATITKDDTVLLNGGGDVAMMKERVDLVRGLIERETSDYNREKLQERLAKLSGGVAVIRVGGASEVEVNEKKDRITDALCSTRAAVQEGIVPGGGPALLRASKALDGLLQ------DQSLTADQRTGVQIIRNAVR-LPAHRIVANAGRE-GAVVVEKVLENTDAAVGYDAQLDRYVNMFEAGIIDPARVVRVALTDAASVASLMMTAEAAVVDLPKDDAPAAGGMGGMGGMGGMDGMY---- Q39727 MNRAGVLARRGYSSKGKDILFGVDARVKMLAGVNRLSQAVSVTLGPKGRNVVIEQPFGAPKITKDGVTVAKAIEFKDSFENLGAQLVRQVANTTNEIAGDGTTTSTVLANTIFSEGYKAVTQGTSPVDMKRGIDRAVEVVLQSLTEQSKTIVSKEEVTQVATISANGDVEIGQLIGHAMEKVGKAGVITVSDGKTLDTELEVVEGMSLDRGYISPYFVTNAKTQKVEIEDAFILLCQKKVSTIQQILPVLEHIAKANRPLVIIADDVDSEALATLIINKINGKLKVCAVKAPGFGDNKTNMLHDVAIFTGGEVYNEE-LGMNLE-QHFDHRILGFAKKVSVGKDQTIILNGAGDPKAVEERKELIQGMLGKTDSSYEKEKLNERLAKLSGGVAVIKVGGASDVEVGEKKDRVTDALNATRAAVSEGIVPGGGAALLYASSALAELAA------DPTLTEDQKTGVRIVMSAIK-LPAITIVKNAGGE-GAVVIHQLLAEKKMQQGYDAQQGKYVNMFEAGIIDPAKVVKTALVDAASVAGLMITTEAAITDIPAPAPAAGGGMDGMGGMGGMGGMG-GMY QUARTET PUZZLING TREE :---Q95046 :100: : :---Q37683 : :-------AAD16417 : :-------Q39727 HSP70 CAA47952 T. cruzi P11145 T. brucei CAA59793 L. infantum P17804 L. donovani Q07437 L. mexican amazonensis P14834 L. major AAG01344 L. braziliensis *A27077 Homo sapiens *AAF09496 Manduca sexta CAA47952 MTYEGAIGIDLGTTYSCVGVWQNERVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTNSPFDAKRLIGRKFSDPVVQSDMKHWPFKVITKGDDKPVIQVQFRGETKTFNPEEVSSMVLSKMKEIAESYLGKQVKKAVVTVPAYFNDSQRQATKDAGTIAGMEVLRIINEPTRAAIAYGLDKVEDGKERNVLIFDLGGGTFDVTLLTIDGGIFEVKATNGDTHLGGEDFDNRLVSHFTDEFKRKNKGKDLTTSQRALRRLRTACERAKRTLSSAAQATIEIDALFDNVDFQATITRARFEELCGDLFRGTLQPVERVLQDAKMDKRAVHDVVLVGGSTRIPKVMQLVSDFFGGKELNKSINPDEAVAYGAAVQAFILTGGKSKQTEGLLLLDVTPLTLGIETAGGVMTSLIKRNTTIPTKKSQIFSTYADNQPGVHIQVFEGERAMTKDCHLLGTFDLSGIPPAPRGVPQIEVTFDLDANGILNVSAEEKGTGKRNQIVITNDKGRLSKADIERMVSEAAKYESQDKEQRERIDAKNGLENYAFSMKNTVNEPNVAGKIEEADKNTITSAVEEALQWLNNNQEASKEEYEHRQKELENLCTPIMTKMYQGMGAG---GGMPGGMPGGMPGGMPGGAN----------PSSSSGPKVEEVERGRIPEDVLMAASARERITRWFSPL P11145 MTYEGAIGIDLGTTYSCVGVWQNERVEIIANDQGNRTTPSYVAFTDSERLIGDAAKNQVAMNPTNTVFDAKRLIGRKFSDSVVQSDMKHWPFKVVTKGDDKPVIQVQFRGETKTFNPEEISSMVLLKMKEVAESYLGKQVAKAVVTVPAYFNDSQRQATKDAGTIAGLEVLRIINEPTAAAIAYGLDKADEGKERNVLIFDLGGGTFDVTLLTIDGGIFEVKATNGDTHLGGEDFDNRLVAHFTEEFKRKNKGKDLSSNLRALRRLRTACERAKRTLSSAAQATIEIDALFENIDFQATITRARFEELCGDLFRGTLQPVERVLQDAKMDKRAVHDVVLVGGSTRIPKVMQLVSDFFGGKELNKSINPDEAV?YGAAVQAFILTGGKSKQTEGLLLLDVAPLTLGIETAGGVMTALIKRNTTIPTKKSQIFSTYSDNQPGVHIQVFEGERTMTKDCHLLGTFDLSGIPPAPRGVPQIEVTFDLDANGILSVSAEEKGTGKRNQIVITNDKGRLSKADIERMVSDAAKYEAEDKAHV??IDAKNGLENYAFSMKNTINDPNVAGKLDDADKNAVTTAVEEALRWLNDNQEASLEEYNHRQKELEGVCAPILSKMYQGMGGGDGPGGMPEGMPGGMPGGMPGGMGG-----GMGGAAASSGPKVEEVD------------------------- CAA59793 MTFEGAIGIDLGTTYSCVGVWQNERVDIIANDQGNRTTPSYVAFTDSERLIGDAAKNQVAMNPHNTVFDAKRLIGRKFNDSVVQSDMKHWPFKVTTKGADKPVISVQYRGEEKTFTPEEISSMVLLKMKETAEAYLGKQVKKAVVTVPAYFNDSQRQATKDAGTIAGLEVLRIINEPTR-AIAYGLDKGDDGKERNVLIFDLGGGTFDVTLLTIDGGIFEVKATNGDTHLGGEDFDNRLVTFFTEEFKRKNKGKNLASSHRALARLRTACERAKRTLSSATQATIEIDALFENVDFQATITRARFEELCGDLFRSTIQPVERVLQDAKMDKRSVHDVVLVGGSTRIPKVQSLVSDFFGGKELNKSINPDEAVAYGAAVQAFILTGGKSKQTEGLLLLDVTPLTLGIETAGGVMTALIKRNTTIPTKKSQIFSTYADNQPGVHIQVFEGERAMTKDCHLLGTFDLSGIPPAPRGLPQIEVTFDLDANGILNVSAEEKGTGKRNQITITNDKGRLSKDEIERMVNDAMKYEEDDKAQRDRVEAKNGLENYAYSMKNTLSDSNVSGKLEDSDKATLNKEIDVVLEWLSSNQEAAKEEYEHKQKELESVCNPIMTKMYQSMG------GAAGGMPGGMPGMSGMSGG------AGPAGGASSGPKVEEVD------------------------- P17804 MTFDGAIGIDLGTTYSCVGVWQNERVDIIANDQGNRTTPSYVAFTDSERLIGDAAKNQVAMNPHNTVFDAKRLIGRKFNDSVVQSDMKHWPFKVTTKGDDKPMIAVQYRGEEKTFTPEEISSMVLLKMKETAEAYLGKQVKKAVVTVPAYFNDSQRQATKDAGTIAGLEVLRIINEPTR-AIAYGLDKGDDGKERNVLIFDLGGGTFDVSLLTIDGGIFEVKATNGDTHLGGEDFDNRLVTFFTEEFKRKNKGKNLASSHRALRGLRTACERAKRTLSSATQATIEIDALFENVDFQATITRARFEELCGDLFRSTIQPVERVLQDAKMDKRSVHDVVLVGGSTRIPKVQSLVSDFFGGKELNKSINPDEAVAYGAAVQAFILTGGKSKQTEGLLLLDVTPLTLGIETAGGVMTALIKRNTTIPTKKSQIFSTYADNQPGVHIQVFEGERAMTKDCHLLGTFDLSGIPPAPRGVPQIEVTFDLDANGILNVSAEEKGTGKRNQITITNDKGRLSKDEIERMVNDAMKYEADDRAQRDRVEAKNGLENYAYSMKNTLGDSNVSGKLDDSDKATLNKEIDVTLEWLSSNQEATKEEYEHKQKELESVCNPIMTKMYQSMG------GAGGGMPGGMPDMSGMSGG------AGPAGGASSGPKVEEVD------------------------- Q07437 MTFDGAIGIDLGTTYSCVGVWQNDRVEIIANDQGNRTTPSYVAFTDSERLIGDAAKNQVAMNPHNTVFDAKRLIGRKFNDLVVQSDMKHWPFKVTTKGDDKPVISVQYRGEEKTFTPEKISSMVLLKMKETAEAYLGKQVKKAVVTVPAYFNDSQRQATKDAGTISGLEVLRIINEPTAAAIAYGLDKGDDGKERNVLIFDLGGGTFDVTLLTIDGGIFEVKATNGDTHLGGEDFDNRLVTFFTEEFKRKNKGKNLASSHRSLRRLRTACERAKRTLSSATQATIEIDALFDNVDFQATINRARFEELCGDLFRSTIQPVERVLQDAKMDKRSVHDVVLVGGSTRIPKVQSLVSDFFGGKELNKSINPDEAVAYGAAVQAFILTGGKSKQTEGLLLLDVTPLTLGIETAGGVMTALIKRNTTIPTKKSQIFSTYADNQPGVHIQVFEGERAMTKDCHLLGTFDLSGIPPAPRGVPQIEVTFDLDANGILNVSAEEKGTGKRNQITITNDKGRLSKDEIERMVNDAMKYEADDKAQADRVEAKNGLENYAYSMKNTLGDSNVSGKLDDTDKSTLNKEIEAALEWLSSNQEATKEEYEHKQKELENVCNPIMTKMYQSMG------GGAGGMAG-MPDMSSMSG-------ARPAGGASSGPKVEEVD------------------------- P14834 MTFDGAIGIDLGTTYSCVGVWQNERLDIIANDQGNRTTPSYVAFTDSERLIGDAAKNQVAMNPHNTVFDAKRLIGRKFNDSVVQSDMKHWPFKVTTKGDDKPVISVQYRGEEKTFTPEEISSMVLLKMKETAEAYLGKQVKKAVVTVPAYFNDSQRQATKDAGTIAGLEVVRIINEPTAAAIAYGLDKGDDGKERNVLIFDLGGGTFDVTLLTIDRGIFEVKATNGDTHLGGEDFDNRLVTFFTEEFKRKNKGKNLASSHRALRRLRTACERAKRTLSSATQATIEIDALFENIDFQATITRARFEELCGDLFRSTIQPVERVLQDAKMDKRSVHDVVLVGGSTRIPKVQSLVSDFFGGKELNKSINPDEAVAYGAAVQAFILTGGKSKQTEGLLLLDVTPLTLGIETAGGVMTALIKRNTTIPTKKSQIFSTYADNQPGVHIQVFEGERAMTKDCHLLGTFDLSGIPPAPRGVPQIEVTFDLDANGILNVSAEEKGTGKRNQITITNDKGRLSKD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- AAG01344 MTFEGAIGIDLGTTYSCVGVWQNERVEIIANDQGNRTTPSYVAFTDSERLIGDAAKNQVAMNPHNTVFDAKRLIGRKFNDSVVQADMKHWPFKVTTKGDDKPVITVQFHGEEKTFTPEEVSSMVLLKMKETAEAYLGKQVKKAVVTVPAYFNDSQRQATKDAGTIAGLEVLRIINEPTAAAIAYGLDKGDDGKERNVLIFDLGGGTFDVTLLTIDGGIFEVKATNGYTHLGGEDFDNRLVTFFTEEFKRKNKGKDLSSSHRALRRLRTACERAKRTLSAATQATIEIDALFDNVDFQATITRARFEELCGDLFRSTIQPVERVLQDAKMDKRSVHDVVLVGGSTRIPKVQSLVSDFFGGKELNKSINPDEAVAYGAAVQAFILTGGKSKQTEGLLLLDVTPLTLGIETAGGVMTALIKRNTTIPTKKSQIFSTYADNQPGVHIQVYEGERAMTKDCHSLGTFDLSGIPPAPRGVPQIEVTFDLDANGILNVSAEEKGTGKRNQITITNDKGRLSKDDIKRMVNDASKYEQADKEQRERVDAKNGLENYAYSMKNTISDPNVAGKLDESDKEALNKAIEAALSWLNSNQEASKEEYEHQQKELENTCNPIMTKMYQSMGGA---GGAPGGMPGGMPDMSGMGGMGGMGGASAPDAGASSGPKVEEVD------------------------- A27077 MSKGPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTNTVFDAKRLIGRRFDDAVVQSDMKHWPFMVVNDAG-RPKVQVEYKGETKSFYPEEVSSMVLTKMKEIAEAYLGKTVTNAVVTVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDK-KVGAERNVLIFDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVNHFIAEFKRKHK-KDISENKRAVRRLRTACERAKRTLSSSTQASIEIDSLYEGIDFYTSITRARFEELNADLFRGTLDPVEKALRDAKLDKSQIHDIVLVGGSTRIPKIQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAILSGDKSENVQDLLLLDVTPLSLGIETAGGVMTVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTKDNNLLGKFELTGIPPAPRGVPQIEVTFDIDANGILNVSAVDKSTGKENKITITNDKGRLSKEDIERMVQEAEKYKAEDEKQRDKVSSKNSLESYAFNMKATVEDEKLQGKINDEDKQKILDKCNEIINWLDKNQTAEKEEFEHQQKELEKVCNPIITKLYQSAG------GMPGGMPGGFPG--GGAPP-----SGGAS----SGPTIEEVD------------------------- AAF09496 MAKAPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTDRLIGDAAKNQVAMNPNNTIFDAKRLIGRKFEDATVQADMKHWPFEVVSDGG-KPKIKVAYKGEDKTFFPEEVSSMVLTKMKETAEAYLGKTVQNAVITVPAYFNDSQRQATKDAGTISGLNVLRIINEPTAAAIAYGLDK-KGSGERNVLIFDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVNHFVQEFKRKYK-KDLTTNKRALRRLRTACERAKRTLSSSTQASIEIDSLFEGIDFYTSITRARFEELNADLFRSTMEPVEKSLRDAKMDKSQIHDIVLVGGSTRIPKVQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAILHGDKSEEVQDLLLLDVTPLSLGIETAGGVMTTLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVFEGERAMTKDNNLLGKFELTGIPPAPRGVPQIEVTFDIDANGILNVSAVEKSTNKENKITITNDKGRLSKEEIERMVNEAEKYRNEDEKQKETIQAKNALESYCFNMKSTMEDEKLKDKISDSDKQTILDKCNDTIKWLDSNQLADKEEYEHKQKELEGICNPIITKLYQGAG------GMPGGMPGGMPGFPGGAPG-----AGGAAPGGGAGPTIEEVD------------------------- QUARTET PUZZLING TREE :---CAA47952 :------------100: : :---P11145 : : :---CAA59793 :100: :-84: : : :-98: :---P17804 : : : : : : :-51: :-------Q07437 : : : : : :-98: :-----------AAG01344 : : : :---------------P14834 : :-----------------------A27077 : :-----------------------AAF09496 HSP90 AAM93755 Bodo uncinatus AAM93754 Bodo saltans P06660 T. cruzi P12861 T. brucei Q25293 L. infantum P27741 L. mexicana amazonensis AAM93752 Cryptobia helicis AAM93753 Cryptobia helicis AAM93750 Trypanoplasma borreli AAM93751 Cryptobia salmositica AAM93746 Dimastigella trypaniformis *AAM93747 Rhynchomonas nasuta AAM93748 Bodo saliens *AAM93744 Rhynchopus sp. *AAM93745 Diplonema pallidum AAM93755 -----------------------SNKEIFLRELISNASDACDKIRYQSPTNKGVLGSETHLRIRVIPDKASKTLTIWDSGIGMTKADMVNNLGTIARSGTKAFMEAIESGGDISMIGQFGVGFYSAYLVADRVTVVSKNNDDDAYVWESSAGGTFTVTPYTGTD--MTRGTRIILHMKEDQQEYLEERRVKDLIKKHSEFIGYDIELQVEKTSEKEVTDEDE-EEKK-AENEEEEEPKVEEVKEG-EDK--------AKKTKKVKEVTKSFEVQNKNKPIWTRDPKDVTKEEYGSFYKAVSNDWEEPLAYKHFSVEGQLEFRSILFAPKRAPFDAFEPNKKRNNIKLYVRRVFIMDNCEDLCPEWLGFLKGVVDSEDLPLNISRENLQQNKILKVIKKNIVKKALELFEEISENKEDYKKFYEQFSKNLKLGIHEDQANRKKLCELLRYHSTTSAEEMTTLKDYVTRMKPEQKSIYYITGDSKKKLENSPFLEEAKRRGVEVLFMVDPIDEYVMQQVKDFEDKKFVCLTKEGVKFEETEEEKKQREEEKASFEKLCKSMKEVLGEKVEKVVLTERLSTSPCILVTSEFGWSAHMEQIMRHQALRDSSMSAYMMSKKTMEINPKHAIVKELRRRVDAEQNDKSVKDLVFLLFDTALLTSGFMLEDPTTYAERIHR---------------------------------------- AAM93754 -----------------------SNKEIFLRELISNASDACDKIRYQSLTNKDVLGTETHLRIRVIPDKANKTITLWDSGIGMTKADMVNNLGTIARSGTKAFMEAIESGGDISMIGQFGVGFYSAYLIADRVTVVSKHNDDDAYVWESSAGGTFTVTPYSGTD--MTRGTRIILHLKEDQQEYLEERRIKDLIKKHSEFIGYDIELQVEKTSEKEVTDEDE-EEKK-ADDDEE--PKVEEVK----DE--------KKKTKKVKEVTKEFEIQNKNKPIWTRDPKDVTKEEYGSFYKAISNDWEEPLQYKHFSVEGQLEFRCILFAPKRAPFDMFEPNKKRNNIKLYVRRVFIMDNCEDLCPEWLGFLKGVVDSEDLPLNISRVNLQQNKVLKVIKKNIVKKALELFEEIAENKEDYLKFYEQFGKNLKLGIHEDQTNRKKLLELLRYYSTQASEEPTTLKDYVTRMKPEQKTIYYITGDSKKKLESSPFIEEAKRRGVEVLFMVDPIDEYVMQQVKDFEDLKFVCLTKEGVKFEESEDEKKQKEEEKASFEKLCKAMKEILGDKVEKVVLTDRLSTSPCILVTSEFGWSAHMEQIMRNQALRDSSMSSYMMSKKTMEINSKHGIVRELRRRVENEQNDKAVKDLVYLLFDTSLLTSGFNLEDPTAYAERIHR---------------------------------------- P06660 MTETFAFQAEINQLMSLIINTFYSNKEIFLRELISNSSDACDKIRYQSLTNQAVLGDESHLRIRVVPDKANKTLTVEDTGIGMTKAELVNNLGTIARSGTKAFMEALEAGGDMSMIGQFGVGFYSAYLVADRVTVVSKNNDDEAYTWESSAGGTFTVTPTPDCD--LKRGTRIVLHLKEDQQEYLEERRLKDLIKKHSEFIGYDIELMVEKATEKEVTDEDEDEAAA-TKNEEGEEPKVEEVKDD-AEEGE-----KKKKTKKVKEVTQEFVVQNKHKPLWTRDPKDVTKEEYAAFYKAISNDWEEPLSTKHFSVEGQLEFRAILFVPKRAPFDMFEPSKKRNNIKLYVRRVFIMDNCEDLCPEWLAFVRGVVDSEDLPLNISRENLQQNKILKVIRKNIVKKALELFEEIAENKEDYKKFYEQFGKNVKLGIHEDSANRKKLMELLRFHSSESGEDMTTLKDYVTRMKEGQKCIYYVTGDSKKKLETSPFIEQARRRGFEVLFMTEPIDEYVMQQVKDFEDKKFACLTKEGVHFEETEEEKKQREEEKTAYERLCKAMKDVLGDKVEKVVVSERLATSPCILVTSEFGWSAHMEQIMRNQALRDSSMSAYMMSKKTMEINPAHPIVKELKRRVEADENDKAVKDLVYLLFDTALLTSGFTLDDPTSYAERIHRMIKLGLSLDDE-DNGNEEAEPAAAVPAEPVAGTSSMEQVD P12861 MTETFAFQAEINQLMSLIINTFYSNKEIFLRELISNSSDACDKIRYQSLTNQSVLGDEPHLRIRVIPDRVNKTLTVEDSGIGMTKADLVNNLGTIARSGTKSFMEALEAGGDMSMIGQFGVGFYSAYLVADRVTVVSKNNEDDAYTWESSAGGTFTVTSTPDCD--LKRGTRIVLHLKEDQQEYLEERRLKDLIKKHSEFIGYDIELMVENTTEKEVTDEDEDEEAA-KKAEEGEEPKVEEVKDG-VDADA-----KKKKTKKVKEVKQEFVVQNKHKPLWTRDPKDVTKEEYASFYKAISNDWEEQLSTKHFSVEGQLEFRAILFLPKRAPFDMFEPNKKRNNIKLYVRRVFIMDNCEDLCPEWLGFLRGVVDSEDLPLNISRENLQQNKILKVIRKNIVKKALELFEELAGNKEDYKKFYEQFSKNVKLGIHEDSTNRKKLMELLRFHSSESGEEMTTLKDYVTRMKEGQKCIYYVTGDSKKKLETSPFIEQARRRGMEVLFMTDPIDEYVMQQVKDFEDKKFACLTKEGVHFEETEEEKKQREEEKASYERLCKAMKEVLGDKVEKVVVSDRLATSPCILVTSEFGWSAHMEQIMRNQALRDSSMSAYMMRKKTMEINTTHAIVKELKRRVEADENDKAAKDLIFLLFDTSLLTSGFTLDDPTAYADRIHRMIKLGLSLDD--DAEEEEAQAPVAAAANSSTGASGMEEVD Q25293 MTETFAFQAEINQLMSLIINTFYSNKEIFLRELISNASDACDKIRYQSLTDPSVLGESPRLCIRVVPDKENKTLTVEDNGIGMTKADLVNNLGTIARSGTKAFMEALEAGGDMSMIGQFGVGFYSAYLVADRVTVTSKNNSDESYVWESSACGTFTITSTPESD--MKRGTRITLHLKEDQMEYLEPRRLKELIKKHSEFIGYDIELMVEKTTEKEVTDEDE-EDTK-KADED-EEPKVEEVREG-DEG-------EKKKTKKVKEVTKEYEVQNKHKPLWTRDPKDVTKEEYAAFYKAISNDWEDPRATKHFSVEGQLEFRSIMFVPKRAPFDMFEPNKKRNNIKLYVRRVFIMDNCEDLCPDWLGFVKGVVDSEDLPLNISRENLQQNKILKVIRKNIVKKCLEMFDEVAENKEDYKQFYEQFGKNIKLGIHQDTANRKKLMEFVRFYSSESGEEMTTLKDYVTRMKAGQKSIYYITGDSKKKLESSPFIEQAKRRGLEVLFMTEPIDEYVMQQVKDFEDKKFACLTKEGVHFEESEEEKQQREEEKAACEKLCKTMKEVLGDKVEKVIVSECLSTSPCILVTSEFGWSAHMEQIMRNQALRDSSMAQYMMSKKTMELNPRHPIIKELRRRVDADENDKAVKDLVFLLFDTSLLTSGFQLEDPTGYAERINRMIKLGLSLDEEEEVVAAEATVAETAPAEVTAGTSSMEQVD P27741 MTETFAFQAEINQLMSLIINTFYSNKEIFLRDVISNASDACDKIRYQSLTDPSVLGDATRLCVRVVPDKENKTLTVEDNGIGMTKADLVNNLGTIARSGTKAFMEALEAGADMSMIGQFGVGFYSAYLVADRVTVTSKNNSDEVYVWESSAGGTFTITSAPESD--MKLPARITLHLKEDQLEYLEARRLKELIKKHSEFIGYDIELMVEKTTEKEVTDEDE-EEAK-KADEDGEEPKVEEVTEG-EEG-------KKKKTKKVKEVTKEYEVQNKHKPLWTRDPKDVTKEEYAAFYKAISNDWEDPPATKHFSVEGQLEFRAIMFVPKRAPFDMLEPNKKRNNIKLYVRRVFIMDNCEDLCPDWLGFVKGVVDSEDLPLNISRENLQQNKILKVIRKNIVKKCLEMFEEVAENKEDYKQFYEQFGKNIKLGIHEDTANRKKLMELLRFYSTESGEVMTTLKDYVTRMKAEQNSIYYITGDSKKKLESSPFIEQAKRRGFEVLFMTEPYDEYVMQQVKDFEDKKFACLTKEGVHFEESEEEKRQREEEKATCEKLCKTMKEVLGDKVEKVTVSERLSTSPCILVTSEFGWSAHMEQMMRNQALRDSSMAQYMMSKKTMELNPKHPIIKELRRRVEADENDKAVKDLVFLLFDTSLLTSGFQLEDPT-YAERINRMIKLGLSLDEEEEEEAVEAAVAETAPAEVTAGTSSMELVD AAM93752 -----------------------SNKEIFLRELISNASDACDKIRYQSLTNKEVLGDEPELRIRLIPDKTNKTLTIEDSGIGMTKADMVNNLGTIARSGTKAFMEAIESGGDMSMIGQFGVGFYSAYLVADRVLVVSKHNDDEAHVWESSAGGTFTVSKCDDPS--IKRGTRIILHLKEDQLEYLEERRIKDLIKKHSEFIGYPIELQIEKTTEKEVTDDEEEEKKD-EEKKEDEEPKVEEVKEG-EEK--------KKKTKKVKEVTKNFEVQNKNKPLWTRDPKDVTKEEYASFYKAVSNDWEDHLHVKHFSVEGQLEFKAILYVPKRAPFDMFEPNKKRNNIKLYVRRVFIMDNCEELCPEWLGFLKGVVDSEDLPLNISRESLQQNKILKVIRKNIVKKALEMFEEIAENKEDYAKFYEQFSKNIKLGIHEDTSNRKKLCELLRFHSTKSLEEPTTLKDYITRMKEGQKSIYYITGDSKKKLENSPFLEEARRRDIEVLFMVDPIDEYVMQQVKDFEDFKFVSLTKEGVKFEETEEEKKRKEEEKASFEKLCKQMKEILGDKVEKVVLTERLSTSPCILITSEFGWSAHMEQIMRNQALRDSSMSSYMVSKKTMEINPNHSIVKELRKRADADQCDKTIRDLVYLLFDTALLTSGFALEDPTTYAERIYR---------------------------------------- AAM93753 -----------------------SNKEIFLRELISNASDACDKIRYQSLTDKEVLGDEPELRIRLIPDKTNKTLTIEDSGIGMTKADMVNNLGTIARSGTKAFMEAIESGGDMSMIGQFGVGFYSAYLVADRVLVVSKHNDDEAHVWESSAGGTFTVSKCDDPS--FKRGTRIILHLKEDQLEYLEERRIKDLIKKHSEFIGYPIELQIEKTTEKEVTDDEEVEKKD-EEKKEDEEPKVEEVKEG-EEK--------KKKTKKVKEVTKNFEVQNKNKPLWTRDPKDVTKEEYASFYKAVSNDWEDHLHVKHFSVEGQLEFKAILYVPKRAPFDMFEPNKKRNNIKLYVRRVFIMDNCEELCPEWLGFLKGVVDSEDLPLNISRESLQQNKILKVIRKNIVKKALEMFEEIAENKEDYAKFYEQFGKNVKLGIHEDTANRKKLCELLRFHSTKSLEEPTTLKDYITRMKEGQKSIYYITGDSKKKLENSPFLEEARRRDIEVLFMVDPIDEYVMQQIKDFEDFKFVSLTKEGVKFEETEEEKKRKEEEKASFEKLCKQMKEILGDKVEKVVLTERLSTSPCILITSEFGWSAHMEQIMRNQALRDSSMSSYMVSKKTMEINPNHSIVKELRKRADADQSDKTIRDLVYLLFDTALLTSGFALEDPTTYAERIYR---------------------------------------- AAM93750 -----------------------SNKEIFLRELISNSSDACDKIRYQSLTNKDLLGEESHLRIRVIPDKANKTLTIWDTGIGMTKAEMVNNLGTIARSGTKAFMEAIESGGDMSMIGQFGVGFYSAYLVADRVVVASKNNDDEAHVWESSAGGTFTVSPLEDES--FPRGTRIMLHLKEDQLEYLEERRLKDLVKKHSEFIGYDIELMIEKTTEKEVTDDEEEEKKDDEEKKDDEEPKVEEVKD--EEK--------KKKTKKVKEVSKTYEVQNKQKPLWTREPKEVTKEEYAAFYKAVSNDWEDHLHVKHFSVEGQLEFRCILFVPKRAPMDMFEPTKKRNNIKLYVRRVFIMDNCEDLCPEWLGFLKGVVDSEDLPLNISRENLQQNKILKVIKKNIVKKALEMFEEMSENKEDYAKFYEQFGKNLKLGIHEDSANRKKLCELLRYHSTKALEEPTTLKDYVTRMGENQKKIYYITGDSKKKLENSPFLEEAKRRDVEVLFMVDPIDEYVMQQVKDFEDHKFVCLTKEGLKFEETEEEKKKKEEEKASYDKLCKQMKEILGDKVEKVILTERLATSPCILVTSEFGWSAHMEQIMRNQALRDSSMSSYMVSKKTMEINPHHSIVKELRKRVDADQSDKTIKDLVYLLFDTSLLTSGFSLEDPTTYAERIHR---------------------------------------- AAM93751 -----------------------SNKEIFLRELISNSSDACDKIRYQSLTNKDLLGEESHLRIRVIPDKANKTLTIWDTGIGMTKAEMVNNLGTIARSGTKAFMEAIDSGGDMSMIGQFGVGFYSAYLVADRVVVASKNNDDEAHVWESSAGGTFTVSPLEDES--FPRGTRIMLHLKEDQLEYLEERRLKDLVKKHSEFIGYDIELMIEKTTEKEVTDDEEEEKKDDEEKKDDEEPKVEEVKD--EEK--------KKKTKKVKEVTKTYEVQNKQKPLWTRDPKDVTKEEYAAFYKAVSNDWEDHLHVKHFSVEGQLEFRCVLFVSKRAPMDMFGPTKKRNNIKLYVRRVFIMDNCEDLCPEWLGFLKGVVDSEDLPLNISRENLQQNKILKVIKKNIVKKALEMFDELSENKEDYAKFYEQFGKNLKLGIHEDSANRKKLCELLRYHSTKALEEPTTLKDYVTRMGENQKTIYYITGDSKKKLENSPFLEEAKRRDVEVLFMVDPIDEYVMQQVKDFEDHKFVCLTKEGLKFEETEEDKKKKEEEKASYDKLCKQMKEILGDKVEKVILTERLATSPCILVTSEFGWSAHMEQIMRNQALRDSSMSSYMVSKKTMEINPNHSIVKELRKRVDADQSDKTIKDLVYLLFDTSLLTSGFSLEDPTTYAERIHR---------------------------------------- AAM93746 -----------------------SNKEIFLRELISNSSDALDKIRFQSLTNKDVLEAEPRMVIELIADKAAKTLTIQDTGIGMTKADLVNNLGTIARSGTKAFMEAIEQGGDISMIGQFGVGFYSAYLVADRVQVYSKHNDDDAYLWESSAGGTFTVMPAPESG--LTRGTRMVLHMKEDQLEYLEERRIKELVKKHSEFIGYDILLQVEKTTEKEVTDDDEEEGA--------------EKKEG-EEK----------KTKKVKEVTKSWEVLNKHKSLWTRDPKEVTKEEYAAFYKAISNDWEDPLATKHFTVEGQPEFRAILFAPKRAPFDMFEPNKKRNNIKLYVRRVFIMDNCEDLCPEWLGFLKGVVDSEDLPLNISRENLQQNKILKVIKKNIVKKALELFEDIAANKEDYKKFYEQFGKNLKLGVHEDAQNRKKLMDLMRYNTTKALEEPTTLKDYVTRMKEGQQSIYYITGDSKKKLENSPFLEEAKRRDIEVIFMVDPIDEYVMQQVKDFEDKKFVCLTKEGVTFEETEEEKKAKEEAKAAFEKLSKQIKDILGDKVEKVVLSDRLSTSPCILVTSEFGWSAHMEQIMKHQALRDSSMSSYMVSKKTLEINPSHAIIKELRRKVDSDAGDKAVKDLVYLLYDTALLSSGFNLEDPAGYAERIHR---------------------------------------- AAM93747 -----------------------SNKEIFLRELISNASDALDKIRFMSITDREVLKGEENLHIQIVPDKAAKTITIIDTGIGMTKSDLVTNLGTIARSGTKAFMEAIEAGGDISMIGQFGVGFYSAYLVADSVKVYSKHNDDEAHLWESSAGGTFTVTQVGDCG--LVRGTKIVLQLKEDQLEYLEERRIKDLIKKHSEFIGYDIELQVEKTTEKEVTDDDEEE-----------------PKEG-EEK----------KKKKVKEVTKEFEVQNKHKPLWTRDPKECTKEEYGAFYKAITNDWEDHLAVKHFSVEGQLEFKCILFVPKRAPFDMFEPNKKKNNIKLYVRRVFIMDNCEDLCPEWLGFIKGVVDSEDLPLNISRENLQQNKILKVIKKNLTKKALEMFEDIASNNEDYKKFYEQFGKNLKLGLHEDSANRPKLMELLRYNSTKSLEEMTTLKDYITRMKEGQNSIYYITGDSKKKLETSPFIEEAKRRDFEVIFMVDPIDEYVMQQVKDFEGKKFVCLTKEGVKFDETEEEKKRKEEEKASYENLTKQMKDILGDKVEKVVLTDRLSTSPCILVTSEFGWSAHMEQIMKHQALRDSSMSSYMVSKKTMEINPSHPIVKELKRKVDENASDKTVKDLVYLLFDTSLLASGFNLDDPNSYAERIHR---------------------------------------- AAM93748 -----------------------SNKEIFLRELISNASDALDKIRFQSLTDTEVLAAEPRMHIQIIPDKANKTLTLQDSGIGMTKADLVNNLGTIARSGTKAFMEAIEQGGDISMIGQFGVGFYSAYLVADRVTVTSKHNDDEAYTWESSAGGTFTVTPAGAAGAELKRGTRIVLALKEDQQEYLEERRLKDLVKKHSKFIGYEIELLVEKSTEKEVTDDEAEEEPK---ADEDDEPKVEDADEK-KDK----------KTKKVKEVTKEFELLNKNKPLWTRDPKDITKEEYGAFYKAISNDWEDHAAVKHFSVEGQLEFRCILFAPKRAPFDMFEPSKKRNNIKLYVRRVFIMDNCEELCPEWLGFIKGVVDSEDLPLNISRENLQQNKILKVIRKNIVKKALEMFEELAENNEDYKKLYEQFGKNLKLGIHEDSTNRKKLCEMLRYNSTKATEEPTSLKDYVTRMKEGQQSIYYITGDNKKNLESSPFIEEAKRRDFEVIFMVDPIDEYVMQQVKDFEDKKFVCLTKEGVKFEETEEEKAKKEEEKAAFEKLTKQMKDILGDKVEKVVLTERLATSPCILVTSEFGWSAHMEQIMKAQALRDSSMSSYMVSKKTMEINPNHGIIRELKNKVEGDQSDKTVKDLVYLLFDTALLTSGFSLEDPAGYAER------------------------------------------- AAM93744 -----------------------SNKEIFLRELISNSSDALDKIRHQSLVDKEALGEEERLQIQITTDKANKTITITDTGIGMTKADMVNNLGTIARSGTKAFMEALEAGADMSMIGQFGVGFYSAYLVSDKVTVISKHNDDECHAWESSAGGTFTVTKHDDPE--LKRGTRIICHLKDDQLEYLEEKKIKDLVKKHSEFIGYDIQLEVEKTQEREVTDDEEEEEEKKEEEKKEGE--EDEPKK--EEVKD---EEKKKKTKKVKEVTKGMETLNKNKPLWTRDPKEITKEEYASFYKAISNDWEDHLAVKHFAVEGQLEFRAILFIPRRAPFDMFEPNKKKNNIKLYVRRVFIMDNCEDLIPEWLGFVKGIVDSEDLPLNISRENLQQNKILKVIKKNIAKKALEMFEELSENKEDYAKFYEHFGKNVKLGIHEDSQNRKKLSEFLRYYSTKSGDEMTSLKDYVTRMKEGQKELYYITGENKGKLETSPFIEQCKKRGYEVLLMTDPIDEYAMQQLKEYEDKKFRCVTKEGLKFEETEEEKKKREEEKASYETLCKTMKDILGDKVEKVVLSDRLAQAPCILVTSEFGWSAHMEQIMKMQALRDNSTSSYMVSKKTMEINPSHPIMKTLKAKADNDANDKAVKDLVLLLHETSLLTSGFSLEDPTSYAERIHR---------------------------------------- AAM93745 -----------------------SNKEIFLRELISNSSDALDKIRHMSLLDKDVLGDEPELKIRISVDKANKTLTLMDTGIGMTKTDLVANLGTIARSGTKAFMEALEAGADMSMIGQFGVGFYSAYLVSDKVTVISKHNDDECYVWESAAGGTFTVAPYSDPE--LKRGTRIICHLKDDQLEYLEEKRIKDLVKKHSEFIGYDIELEVEKTKETEVTDDEEEEEDKKDEKKEDEEKKDDEEKKDDEEKKDGEEEEKKKKTKKVKEVTKEWEKLNKNKPLWTRDPKEITKEEYAAFYKAISNDWEDHLAVKHFAVEGQLEFRAILFVPRRAPFDMFEPNKKKNNIKLYVRRVFIMDNCEDLVPEWLSFIKGIVDSEDLPLNISRENLQQNKILKVIRKNIVKKALEMFEEVSENKEDYAKFYEHFGKNLKLGIHEDTQNRKKLSEFLRYFSTKSGDETTSLKDYVTRMKEGQKEIFYITGDSKGKLENSPFIEQCKKRGYEVLLMTDPIDEYAMQQLKEFEDKKFRCVTKEGLKFEETEDEKKKHEEEKAAFETLCKTMKDILGDKVEKVMLSDRLAQAPCILVTSEFGWSAHMEQIMKNQALRDSSSSSYMVSKKTMEINPSHPIVKTLKQKADSDANDKTVKDLVLLLFETSLLTSGFSLDDPTNYAERIHR---------------------------------------- QUARTET PUZZLING TREE :---AAM93746 :-83: :---------87: :---AAM93747 : : : :-------AAM93748 : : :---AAM93752 : :100: :-99: : :---AAM93753 : : :----100: : : : : :---AAM93750 : : : :100: : : : :---AAM93751 : : : : :-70: :---Q25293 : : :100: : : : :---P27741 : : :100: : : : : :---P06660 : : : :100: : :-93: :---P12861 : : : : :---AAM93755 : :----100: : :---AAM93754 : :-----------------------AAM93744 : :-----------------------AAM93745 Malate dehydrogenase AAC05706 T. cruzi AAC79434 T. brucei CAB55506 L. major *P25077 Salmonella typhimurium *CAA68326 Escherichia coli AAC05706 MVNVAVIGAAGGIGQSLSLLLLRELPFGSTLSLYDVAG-APGVAADLSHIDRAGITVKYAAGKLPPVPRDPALTELAEGVDVFVIVAGVPRKPGMTRDDLFNVNAGIVMDLVLTCASVSPSACFCIVTNPVNSMVPIAAQTLRKIGVYNKNKLLGVSLLDGLRATRFINNAR-HPLVVPYVPVVGGHSDITIVPLYSQIPGPLPDESTLKEIRKRVQVAGTEVVKAKAGRGSATLSMAEAGARFTMHVVKALMGLDTPMVYAYVDTDGKHECPFLAIPVVLGKNGIERRLPIGPITTVEKEMLEEAVGVVKKNIEKAETFARSKL AAC79434 MVSVAVIGAAGGIGQSLSLLLLRQLPYGSTLSLYDVAG-APGVAADLSHVDRAGVTVKYAAGKLPPVKRDPALAELARGVDVFVIVAGVPRKPGMSRDDLFNVNAGIIMDLVLTCGSSSPQACFCVVTNPVNSTVPIAAEALKKLGIYNKNKLLGVTLLDGLRATRFINNAR-HPLAVASVPVVGGHSDVTIVPLFSQLPGPLPEEGELTQIRKRVQVAGTEVVKAKAGRGSATLSMAEAGARFAMFVVNAITGQSSPMVYAYVDTDGTQNCSFLAIPVVLGKNGIEKRLPIGPMNAVEKEMLKQSISVVKANIEKGMNFARSKL CAB55506 MVNVCVVGAAGGIGQSLSLLLVRQLPYGSTLSLFDVVG-AAGVAADLSHVDNAGVQVKFAEGKIG-HKRDPALAELAKGVDVFVMVAGVPRKPGMTRDDLFKINAGIILDLVLTCASSSPKAVFCIVTNPVNSTVAIAAEALKSLGVYDRNRLLGVSLLDGLRATCFINEAR-KPLVVSQVPVVGGHSDTTIVPLFYQLPGPLPEQATLDKIVKRVQVAGTEVVKAKAGRGSATLSMAEAGARFALKVVEGLTGTGNPLVYAYVDTDGQHETTFLAIPVVLGMNGIEKRLPIGPLHSTEETLLKAALPVIKKNIVKGSEFARSHL P25077 -MKVAVLGAAGGIGQALALLLKNQLPSGSELSLYDIAPVTPGVAVDLSHIPTA-VKIKGFSGEDA-------TP-ALEGADVVLISAGVARKPGMDRSDLFNVNAGIVKNLVQQIAKTCPKACVGIITNPVNTTVAIAAEVLKKAGVYDKNKLFGVTTLDIIRSNTFVAELKGKLPTEVEVPVIGGHSGVTILPLLSQIPGVSFTEQEAAELTKRIQNAGTEVVEAKAGGGSATLSMGQAAARFGLSLVRALQGEKGVVECAYVEGDGQYAR-FFSQPLLLGKNGVEERKSIGTLSAFEQHSLDAMLDTLKKDIQLGEDFINK-- CAA68326 -MKVAVLGAAGGIGQALALLLKTQLPSGSELSLYDIAPVTPGVAVDLSHIPTA-VKIKGFSGEDA-------TP-ALEGADVVLISAGVRRKPGMDRSDLFNVNAGIVKNLVQQVAKTCPKACIGIITNPVNTTVAIAAEVLKKAGVYDKNKLLGVTTLDIIRSNTFVAELKGKQPGEVEVPVIGGHSGVTILPLLSQVPGVSFTEQEVADLTKRIQNAGTEVVEAKAGGGSATLSMGQAAARFGLSLVRALQGEQGVVECAYVEGDGQYAR-FFSQPLLLGKNGVEERKSIGTLSAFEQNALEGMLDTLKKDIALGQEFVNK-- QUARTET PUZZLING TREE :---AAC05706 : :100:---AAC79434 : : : :---CAB55506 : :-------P25077 : :-------CAA68326 Multidrug resistance protein (including MDR-A and MDR-E) P21441 L. tarentolae CAB64569 L. major AAB05634 L. tarentolae CAB64568 L. major CAC83020 T. brucei AAA65541 L. tarentolae AAB51191 L. tropica CAC83023 T. brucei AAC09044 T. cruzi CAA89197 T. cruzi *CAC28731 Dictyostelium discoideum P21441 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVDNGHVTIAMADLG------TVVEIAQVRCQQEA--QR-KFAEQLDELWGGEPAYTPTVEDQASWFQ-QLYYGWIGDYIYKAAA-GNITEADLPPPTRSTRTYHIGRKLSRQAHADIDASRRWQGYIG-----CEVVYKSEAEAKGVLRWVGHLQQSDYPRSLVAGVEWRMPP-------RHRRLAVLG------------SAAALHNGVVHGERLFWPHEDNYLCSCEPVEQLYVKSKYNL-----------------------IPPRP--PPSPDLLRTLFKVHWYHVWAQILPKLLSDVTALMLPVLLEYFVKYLNAD--------------------------------------NATWGWGLGLALTIFLTNVIQS---CSAHKYDHISIRTAALFETSSMALLFEKCFTVSRRSLQRPDMSVGRIMNMVGNDVDNIGSLNWYVMY-FWSAPLQLVLCLLLLIRLVGWLRVPGMAVLFVTLPLQAVISKHVQDVSERMASVVDLRIKRTNELLSGVRIVKFMGWEPVFLARIQDARSRELRCLRDVHVANVF-FMFVNDATPTLVIAVVFILYHVSGKVLKPEVVFPTIALLNTMRVSFFMIPIIISSILQCFVSAKRVTAFIECPD----------------THSQVQDIASIDVP---------DAAAIFKGAS---IHTYLPVKLPRC-----KSRLTAMQRSTLWFRRRGVPETEWYEVDS--PDASAS---SLAVHSTTVHMGSTQTVITDSDGAAGEDEKGEVEEGDREYYQLVSKELLRNVSLTIPKGKLTMVIGSTGSGKSTLLGALM-GEYSVESGELWAERSIAYVPQQAWIMNATLRGNILFFDEERAEDLQDVIRCCQLEADLAQFCGGLDTEIGEMGVNLSGGQKARVSLARAVYAN-RDVYLLDDPLSALDAHVGQRIVQDVILGRLRGKTRVLATHQIHLLPLAD-YIVVLQHGSIVFAGDFAAFSATA--------------LEETLRG---ELKGSKDVESCSSD----------VDTESATAETAPYV---------------------------AKAKGLNAEQETSLAGGEDPLRSDVEAG---------RLMTTEEKATGKVPWSTYVAYLKSCGGLEAWGCLLATFALTECVTAASSVWLSIWSTG-SLMWSADTYLYVYLFIVFLEIFGSPLRFFLCYYLIRIGSRNMHRDLLESIGVARMSFFDTTPVGRVLNRFTKDMSILDNTLNDGYLYLLEYFFSMCSTVIIMVVVQPFVLVAIVPCVYSYYKLMQVYNASNRETRRIKSIAHSPVFTLLEESLQGQRTIATYGKLHLVLQEALGRLDVVYSALYMQN--------VSNRWLGVRLEFLSCVVTFMVAFIGV-IGKMEGASSQNIGLISLS------------LTMS-----------MTLTETLNWLVRQVAMVEANMN--------SVERVLHYTQEVEHEHVPEMGE------------------------------------LVAQLVRS--ESGRGANVTET-------------------VVIESAGAASSALHPVQAGSLVLEG--VQMRYREGLPLVLRGVSFQIAPREKVGIVGRTGSGKSTLLLTFMRMVEVCGGVIHVNGREMSAYGLRDVRRHFSMIPQDPVLFDGTVRQNVDPFLEASSAEVWAALELVGLRERVASESE----------------------------GIDSRVLEGGSNYSVGQRQLMCMARALLKRGSGFILMDEATANIDPALDRQIQATVMSAFSAYTVITIAHRLHTVAQYDKIIVMDHGVVAEMGSPRELVMNHQSMFHSMVESLGSRGSKDFYELLMGRRIVQPAVLSD-------------------------------------- CAB64569 MRHRLSRAHLFCCRLVPPPRGRLDSPPPPMPRAFTFALAVTLGSALEPDQPGCSTLPLRMRERSCLSRCAVASPHLALAQDLPTASPASAAIHKQTYTLLQPHVHPPPLLCRGVRCVALTLSSSLLCWRPAHSSITACCAAELRSARGLLSLVFSLPAFRLSLSPPTLTLTHTTSPLLSINAGPSHPAGLLYCLLPSHNCTSSSPPPSAPASVNAKVLLPLSLFLGFFQRAAALTSEHRFPDAAACIHTALVAAMQYEDPRHHSSGLAERRALPKGGHPNGAGERLATASKATALNRQAALHERDALKQRVTELWGPPKHYVECDEDRASFIH-RMGYFLVYPMVLLASR-EQISFEDMPPPTRDVRAHECGLRLSRAVQAAMYERNAWNCMVG-----TEVVSTLDASSRGVLRWVGVPQQGGYTR-MMAGVEWSVPP-------ALRTAARSDD----------SGASPFFDGVAHGEHLFTP-EQSGMSTLEEVTCVRLLSLDGKP-----VD---------------AASVP-TPRRLSLMRVLPASLPEYFWWQFPFKLGGDVCTITIPFLLKVFVHFISER--------------------------------------NQSWAHGLALAVTFFLTQLIQS---VCLHRFYYVSIKCGLQYRSALNGLIFEKVFTISNKALAHPQMNTGRIINMMSTDTEQANQFMQYCMY-IWSSPMMFIISISFLSRLVGWCSIMAVVALLMTLPINGWLMKWQMAARRKLVKATDVRVKAANEFFSGVRIAKFMTWEPRFIANIEEKRALEVSYLKQVQTVRVW-TSFVSMTTPQVMIAAVFMVYYLLGHDLTPTVVYPTISLVGILRMPFNMLPWVFTVSAQYLVAMTRINKFLECDDA---------------TCSTVQDMEEYWREQREHS-AACQLAAVLEKVD---VTAFVPVKLPFAP----KVKTSLLSRALRMLCCEQCKPTKRHPPPS--VVVENTGYVSPASASRHIVEGCSGTVHTATPTSTRSAKTP--QMKTDEFFELEPKVLLRDVSVSVLRGKLTVVLGATGSGKSTLLQSLL-SQFEISEGRVWAERSIAYVPQQAWIMNATVRSNILFFDEEDAARLADAVRVSQLEADLAQLSGGLETEIGEKGVNLSGGQKARVSLARAVYAN-RDVYLLDDPLSALDAHVGERVVEECFLGALAGKTRVLATHQVHIVPRAD-YVVALGDERVEFSGSSADFMRTS--------------IYASLAA------VEADSPTGKGAG---------ANAEAEDGDAACGG---------------------------LSDPEEGSAKPVRRAAPSAGAAAPTAAA---------QLMTVEEKASGMVAWGTYRAYLRFCGGRLWSIGVLAMFGVTELFTISSMLCLSMWTAR-RFDLSDASYLLMYMGCVVMGTLTVPLRFYFSFEVMRRGCVRMHHAVLRSVSRGTMEFFDTTPLGRILNRFSRDVDVTDNTLPMSMLQMMNCLFGILSSLLVTFFTQPLVIFVLAPCGYLYYRIMVFYNSANREIRRTSSVAKSPLFSLLGEALTGSATITAYHRASTVMQEALRRLDLVYSCSILEN--------MANRWLGVRVEFLSNIVVSTIVLIGIGRTVLMETHEEWIALVSLS------------LTMA-----------TQTTAMLNWLLRQVASVEADMN--------SVERLQYYIDHVPKEAMPELDA------------------------------------EVDALER---RTGMAADVTGT-------------------VVIEPASPTGAAPHIVQAGSLVFEG--VQMRYREGLPLVLRGVSFRIAPREKVGIVGRTGSGKSTLLLTFMRMVEVCGGEIRVNGREIGSYGLRELRRQFSMIPQDPVLFDGTVRQNVDPFLEASSAEVWAALELVGLRERVASESE----------------------------GIDSCVLEGGSNYSVGQRQLMCMARALLKKGSGFILMDEATANIDPALDRQIQATVMSAFSAYTVITIAHRLHTVAQYDKIIVMDHGAVAEMGSPRELVMNRQSIFHSMVEALGRSEAARVIQVAMA------------------------------------------------- AAB05634 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ILRICPRPTRDVRAHECGLRLSRAVQAAMYERNAWNCMVG-----AEVVSTLDAASRGVLRWVGVPQQGGYTR-MMAGVEWSVPP-------AVRTAARSDE----------SGASPFFDGVAHGEHLFTP-EHRGMSTLEEVTCIRFLSRYEGS-----MD---------------IRCVADRPRRLSLTRVLLGSLPEYFWWQFPFKLVGDVCTLSIPFLLKAFVHFISDR--------------------------------------NQGWAYGLGFAY-VLLAQLMQS---TCLHRFYYISIKGGLQYRSALNGLIFEKIFTISNKALAHPQMHTGRIINMMSTDTEQANQFMQYCMY-MWSSPMVFLISITFLSRLVGWCAIMAVVALLMTLPINGWLMKWQMGARRKLVKATDVRVKAANEFFSGIRIAKFMAWERRFIANIEEKRALEVSYLKQVQTARIWSTSFLNMATPPVMIAAVFIVYYLLGHELTPTVLYPTISLLGIIRMPFNMLPWVFSMAVQFLISIGRIQRFLECDNA---------------TCANVQGHGGVFQGAARAQ-RCVPVSCCTGGRG---CDAFVPVKLPFAP----KLKTPYFRRPCECCAASSASP--RRDTP----RRR--------QWLRRVRGFVFIAVFFVSPRGNGSRKK---GPGVDDFFELEPKTLLRGVSVSLLRGKLTVVLGATGSGKSTLLQSLL-SQFEVSGGRLWADGTIAYVPQQAWIMNATVRGNILFFDEEDAARLAQAVRVSQLEADLAQLGGGLDTEIGEKGVNLSGGQKARVSLARAVYAN-RDVYLLDDPLSALDAHVGERVMEECFLGALAGKTRVLATHQVHIVPRAD-YVVRCAMVAWSSAGTSVEFMRTS--------------IYASMAA------SEADAATGKIVD---------VDAEDGEGDTSCAD---------------------------GCYNDKAPAKLVGNVAPAEGAAVGRPAA---------QLMKVEEKASGTVPWS-VREYFMLCEACVMAD--SADVGVTEVFNISAMLCLSMWTAR-RFDLSTTSYLLLYIGCVVLGDADGACASTSPTRQMRRGCVRLHHGVLRSVSRGTMEFFDTTPLGRILNRFSRDVDVADNTLPMSMLQYLLVVS-------CDILRAPIVIVVLVPCVYLYYRIMVFYNSANREIRRTSSVVKSPLFSLLGEALTGSATITAYHRASTVMQEALRRLDLVYSCSILEN--------MANRWLGVRVEFLSNVVVSMIVLIGIGRTVLMETNTEWIALVSLS------------LTMA-----------TQTTATLNWLLRQVASVEADMN--------SVERLLYYTHEVPQEHMPELDA------------------------------------EVNALEK---RTGRTAEVTET-------------------VVIEFAGAASSALHPVQAGSLVLEG--VQMRYREGLPLVLRGVSFQIAPREKVGIVGRTGSGKSTLLLTFMRMVEVCGGVIHVNGREMSAYGLRDVRRHFSMIPQDPVLFDGTVRQNVDPFLEASSAEVWAALELVGLRERVASESE----------------------------GIDSRVLEGGSNYSVGQRQLMCMARALLKRGSGFILMDEATANIDPALDRQIQATVMSAFSAYTVITIAHRLHTVAQYDKIIVMDHGVVAEMGSPRELVMNRQSIFYSMVELLSRNEKARVIQATLSG------------------------------------------------ CAB64568 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLQETIDEELSMEMTEALPCAPPPG------RSRHQSDPLYDYRS--EHLALQARLAEIWGPEAPYTPVPEETSSWFK-RYSYGWVYETVVLASK-EKLTHEALPPPTRDVRAHECGLRLSRAVQAAMYERNAWNCMVG-----TEVVSTLDASSRGVLRWVGVPQQGGYTR-MMAGVEWSVPP-------ALRTAARSDD----------SGASPFFDGVAHGEHLFTP-EQSGMSTLEETTTLRLDLTSRG-------G---------------VVEIP-TPKRLPLTRLLAFKLPYYLWMQVPFLLVSNICVITLPSILQAFVAFLDDDPG------------------------------------TQTWGRGLGLVAGIFLVQAMQS---VCNQRFNYISFRCGLQYRSALNSLIFEKCMIISSKSLAQPDMNAGRVINMMSTDVERVYFFMLFCMF-LWSSPVVLLLAIVQLWRLVGWCAIIAVASFLATIPLNAFFMGIQMRARRDIAKAADARVKATSEFFSGIRVAKFMTWEPCFVANIEEKRAVELFFLNKIQNARVA-TSFVNNATPMLMIALVFTVYYCTGHELSTTVVFPTIALLGVLRQPFQQIPWVFTIAVQFLISIGRIRRFLECDDA---------------TCSTVQDMEEYWREQREHS-AACQLAAVLEKVD---VTAFVPVKLPFAP----KVKTSLLSRALRMLCCEQCKPTKRHPPPS--VVVENTGYVSPASASRHIVEGCSGTVHTATPTSTRSAKAP--QMKTDEFFELEPKVLLRDVSVSVLRGKLTVVLGATGSGKSTLLQSLL-SQFEISEGRVWAERSIAYVPQQAWIMNATVRSNILFFDEEDAARLADAVRVSQLEADLAQLSGGLETEIGEKGVNLSGGQKARVSLARAVYAN-RDVYLLDDPLSALDAHVGERVVEECFLGALAGKTRVLATHQVHIVPRAD-YVVALGDERVEFSGSSADFMRTS--------------IYAGMASGLTVNKEEGDAESSESA----------LDAEEEEAEVMVDR---------------------------SASKGEGPDE----ED--DAAARDPAAR---------SFVVEEEKASGGVPWRTYLAYFRYCGGAHVAATIVLVFAVTELITVSSSVWLSRWTTK-EEGESNALYLTVYLLMVLVGGAGYPFRFVVSYTAMRHGCSALHRTILRSVTAGTIEFFDRTPLGRLLNRFSRDIDTLDNGLQMSTISLLECLFSISVSMLVTTYSQPFVLIALAPCGYLYYRLMVFYNSANREIRRYTSVMKTPVFTQLTELTNGLATITAYGKAKKVMAEALERLDVVHSCGNLEN--------NTNRWLAVRVELLSNIVVTAIAFVGV-ITTCLRSNRIDIGLISLS------------LTMA-----------MQTTGELNWLVRMVATMEADMN--------SVERLQYYIDHVPKEAMPELDA------------------------------------EVDALER---RTGMAADVTGT-------------------VVIEPASPTGAAPHIVQAGSLVFEG--VQMRYREGLPLVLRGVSFRIAPREKVGIVGRTGSGKSTLLLTFMRMVEVCGGEIRVNGREIGSYGLRELRRQFSMIPQDPVLFDGTVRQNVDPFLEASSAEVWAALELVGLRERVASESE----------------------------GIDSCVLEGGSNYSVGQRQLMCMARALLKKGSGFILMDEATANIDPALDRQIQATVMSAFSAYTVITIAHRLHTVAQYDKIIVMDHGAVAEMGSPRELVMNRQSIFHSMVEAGGPSARRHFLSLVRRRDNESAPYSKCG------------------------------------- CAC83020 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MTPNKTPVGDIKLDDNTETNYPINTSGGEPTENHAD------TDLDTQYKIHEYDT--RHAELKQRLMQIWGDDVEYVARGEENANWLQ-KITYTWVKKYIRTAVK-EELTLEGLPTAQSDHRAHKCGRQLSAVTAESYYRRHLWDPIVG-----AGVSRRGDSQSRGTLRWVGVLQSGRYKE-VMAAVTWQTPP-------LQRLSEHEN------------GVSPFFSGAVHGEVLFPP-EASNNSTMEKPEDLQLLGCGSVS-----AN---------------VLDQLAFPGRISAARNLFNAKRGIILWQFPLRVLGDLLTLTVPLILKEYIRYLDAP--------------------------------------SHTWGRGMLLAFGLFVAHCVQS---VVLHWFYHMGIKGGLCWRSALSAVILEKCFVISPKALALPEMNTGRILNMLTTDVERANEFVQLCLY-LWSSPVIFIASTFLLYSLVGWSALVTVVVLPLTLTLNGYIVRQAMKIQRKIMKVADSRVKATNEFISGIRIVKFMAWEPSFIAAIEKQRDTELRYLRRLQRCHTL-TSFLNNAMPPLTIAIVFVTYHLLGNKLTPEVVFPTLMLLSVIRMPFLLLPMTLRTVTQFVISMKRVSVFLECEN----------------TVKGVGDVTELLATQKKAPPCWCEAAAVFDNAE---VTALFPVKLPRIP----TVVTSLCGRIMARLCCCGACQPKRHSLSP--LEVIDSEDEGEGSTQAGNEKPPGRPGGNQKQPSPEETPRGVNKKVGEARYQLRPKKLLRDISIEVPKGKLTVVLGATGSGKSTLLETLL-GNFEVTHGSVLAAKSFAYVPQQPWIMNATLRDNILFFTPENEERLHKAVRVCQLEADLQQLPAGMETEIGEKGINLSGGQKARVSLARAVYAD-RDFYILDDPLSALDAHVGELIVRDLILGHLACKTRVLATHQLHVLPHAD-FVVAMEDGTVKFAGESKDFMRSP--------------LCKKLAA-------EGCERKHEGS----------SDREVDENDILDGKP--------------------------VHSNGNEPTQDGGNEGG-EKKNTEAVDG---------RLTLMEEKAVGSVPWKTYKRYVGACGGGCKALLVIFTYFFTELLTVAANLWLSMWSTN-KFKLDETTNLYVYLGIVIAGTISVPLRYTTTFGSMRHGSRTLHRFLLRSISTGKMSFFDTTPLGRIVNRFSRDIDRLDNSLPMTFIFLMQVTFSIISAIAVYIGSQPYVLVALIPVCYVYYRLTLFYSASNREIRRVGSTAKAPLMSLVGEALVGSSTISAYGCQTAIMKKALAYIDLVYASSLLEN--------AANRWIGLRVEFLNTVVILVIALTGV-IGAMLGVDSHDIALVSLS------------LTMA-----------LMTTAALNWLVRMCGSMEADMN--------SVERILYYTDNIENEDMPELDE------------------------------------LVRAAKKAEETTPRPKASSAT-------------------TTAVHVPVNGPVERNVVPGWVEFRD--VDLRYRDGLPLVLNKVSFRVNPGQKVGIVGRTGSGKSTLLLTFMRMIDTCGGEIIVSGRPIASYGLRELRQLFSMIPQDPVLFDGTVASNLDPFSQATPEEVWRALELVGMRGHVAAESG----------------------------GIEARVQEGGLNYSVGQRQLVCLARALLKRDSAFILMDEATANIDHALDKQIQNTVRTAFANHTVITIAHRLHTVAQYDKIIVMDNGVVAECGAPRDLALSTSSKFRELLNSLGTNEVKNFMAVVEGAAASRSSG----------------------------------------- AAA65541 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MADSSSISPSWLPAGAPEAVAFPPSS---AEHDLEELKDRDREQQ-ISSSLWKQRVIDLWGAEPLYEEQPEDSSGWITGTLLYQWIGHYIREAAR-EQLTESDLPKPTRKYRAYNAGVVLSAELQRQRARRHAWDGYVG-----ARVGVAWDDASDGVLRWVGAVQQYGTPGQLYAGVEWSVAPSRRRGGCVRRCIGWLLCRGGSASVP-DQGPGAYHRGEVDGEHLFDAVEDDTVLTCERVEDVVFRLGCQGDASEVTST-----RVLLK---EMPASAQQCPRTIQVWWAVWTLFRQSIHHIVLLGIIRNACQLMTPLLLKFFVMYLGSVNEHKDGGEGGLTVATASPASAVELSCGVVRCASNASAPDISWQRGVGLAALMFVTMSSKH---LLETSSTTLRRRSSLQVRNALSAALFEKVFTMSSKALHHPAFNVGRLTNLMSTDVDVMGRFIMMFWS-MVSTPFMLVLVFYQLYVLLGGSAFVGVAVALVLMPLQTYIVRNMSTSYRNKAQATDHRVKATTEFFSGIRVAKFMSWEPFFISRIEKLRSVELSHLKKLQQAIMM-VFFQFNATPGFVIASVFFTFSVTGHTLTPTVVFPAIALFNLLMGLVSMLPFTLQLMTKLFVSLRRLNMFFDAEDELVSVVQDIATAETHKMLKAISPVGCTDGAQHQSLSSAPMDEVAAEFVH-ADISTYVPQELQKAEGAPEPNGTVCVAADRSPLPNADASLSAHPPSPSTAPSASADPAMEPLTTERNTESHGDAAASPEPLSSPAHTLNSEVVFNEDSTYILNTKTLLTDVNLRVPRGRLTVVLGPTGSGKSTLLDALI-GALAVTRGRVACSRRLAYVPQQPWLMNATLRENVVFFGAPDAAAFERALRSSQLASDLELLANGADTEIGENGVNVSGGQKARVSLARAVYAD-RDVYVLDDPLSALDAHVGERVMRECICGALAGKTRVLATHQAHVAQDADCVIVLAANGRVSFQGSREAYYRDH--------------LAQQMNQ-----RGTAATENTTGAA--------EGGPTQASVAVAKKWS-------------------------DFIEEEPPARDSTSTAVLEAQGLTSESNG---------KLMTEEEHFKGGVGWEIYARYMKACGGLGVCVSVVVLYLVTEVVMMSTSIWLALWSTK-WLPLSATQYSFIYVGLSFASALATPLRYWLSMTVMRRASREVHRELLRSVACATLQFFDTTPLGRIVNRFTNDMSNIDSDLQGSYSYLLSTISAFFSTVAMMVVTQVFVLVIIIPCMVAYYYLLKFYARANREIKRLVNRANSPMISALQEAIGGRWTAQAYGAAPAMLQKAIRCADVVFTCSYLQL--------GAELWLPVRIQLLS-TSITVAVALGAVAAIHLSLLPSHIGLLSLS------------LTLA-----------LEISSLLDGIVTVLASVEADMN--------SIERVFYMTDHIDHEDLQEAVA-----------------------------------AEVQRITEDAQGTAQPCTEAFE------------ESGERAVLDDSTSPLLIRQSDNTQFGSLVLEH--VDMRYRPGLPLVLRDVCFAVAPGQKVGVVGRTGSGKSTLLLAFLRLVEVCGGRMLVCGRDARDYGVRQLRQLFSMIPQDPLLFDGTVRSNVDPFGSCGDAAVWRALRQVGMEERVRGEAG----------------------------GLDGRVQEGGANYSVGQRQLLCLARALLTR-SAFLLMDEATANVDPALDRQIQRTVQHTFRDYTVITIAHRLHTVAACDAIVVMDQGRVLEFGSPRELVERQGSAFGALVRSLGSEGEQLFREAMLTRLQSSSVKRRRCWPCECFGMRFFFFRCIVLQHRICADVWNYSEYGFVGW AAB51191 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVESSSASPSSLLAGAAEAIAFPPSA---AERDLEEFEERDREQQ-ISRSLWAQRVSDLWGTEPPYEEQPEDRSGWIFGSLFYQWIGHYIREASR-EQLTESGLPKPTRQYRAYNAGVALSADVQRQRARRHAWDGYVG-----ARVGVAWDDASDGVLRWVGAVQQYGTPGRLYAGVEWRVPPSRRRGCCVRRCMGWLLCRGCSAPVP-EQGPGAYHRGEVDGEHLFDPVEDDTVLTCERVEDVVFRLGLRDDASQVSST-----RALLK---ELPESAQQCPHPIQVWWAVWTLFRQSIMHVVVLGIIRNGCQLMTPLLLKWFVAYLGGVGERKGRSEAGLTDTITSPVSSLDFFFAWVHRVSSAGSPGIGWQRGVWLAALMFVTMVGET---LAGNKQYHVRRRSSLQVRNALSAALFEKVFTMSPKATHHPAFNAGRLTNLMSTDVEVMGRFIMMFWT-LASTPFMLAIVFYQLYVLLGASVYVGGVVALVFMPLQAYMVRKMSSSYRRKAQATDHRVKATTEFFSGIRVAKFMSWEPFFIRRIEKLRSVELSHLKKLQQAIMM-VFFQFNATPGFVIASVFFTFSVTGHTLTPTIVFPAIALFNLLMGLVSMLRLALQLMTKLFVSLRRLNMFFDADDELVPAVEDIPLAASRAMPTDVSRAAGAATAQQQTPSFILIHDVAAEFVH-ADLSTYAAQELKKTDGALEAK-SAETAADRAPLPEAEAFLPDRQPSSSSAAPRPAGPVTEPLNAKGSHTGHGDAAASSEPLSSSAQKSTAEITFNEDSIYVLKTKTLLADVDLRVPRGRLTVVLGPTGSGKSTLLDALI-GALAVTGGRVACSRRLAYVPQQPWTMNATLRDNVIFFGAPDAAAFERAVRSSQLASDLALLADGAETEIGENGINLSGGQKAPVSLARAVYAD-RDVYLLDDPLSALDAQVGEAVMRECVCGALAGKTRVLATHQVSAALRG--PGCAAGGGRVAFQGSGEAYYKDH--------------LARQVSQ-----RGAASSDDTEGAA--------EKEAPVANITAEKKLS-------------------------DLMEEEPPAADTTLTAVSEVEGRAIENKG---------KLLTEEERFRGGVGWDVYVRYMKACGGVGACVSIMALYLATEVVMMSTSIWLALWSTK-WLPLSATQYSFIYVGLSFASALATPLRYWLSMSMMRRASREVHQELLRLLACATLQFFDTTPLGRIVNRFTNDMSNIDSDLQGSYSYLLSTISAFFSTVAMMVATQVFVLGILIPCMVAYYYLLKFYARANREIKRLVNRVNSPMLSVLQEAIGGRWTVQAYGAAPAVIQKALQCADVVYTCSYLQL--------GAELWLSVRIQMLS-ASITVAVALGAVAAMHLSFLPSHIGLLSLS------------LTLA-----------LEISSLLDGIVTVLASVEADMN--------SIESVFYMTDHIEHEDLQEAAA-----------------------------------AEVQRITEGAHGPERRCAETLA------------ESEEPSGLDNWSSPLLIRQSGNTQFGALVLEP--VDMRYRPGLPLVLRDVCFAVGPGQKVGVVGRTGSGKSTLLLAFLRLVEVCGGPMLVCAGDAGDYGVRDLRALFSTIPQDPLLFEGTVRSNVDPFGCCGDAAVWRALRQVGMEERVRGEAG----------------------------GLDGRVQEGGANYSVGQRQLLCLARALLKRGSAFLLMDEATANVDPALDRQIQRTVQHTFRDYTVVTIAHRLHTVAACDVILVMDQGRVLEFGSPRELVERQGSAFGALVRSLGRDGEQLFREAMRSALRE--------------------------------------------- CAC83023 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MNADSGEESREPLLRGGHSNDSNNHTDTNDAGTTEVHITADVT---PKPTMDILLRSEQQLN-TRRHLWQAQIHALLGPEPPYALRPEDRAGFLFGRLYHTWTGPLMSLAARGVSLVPEDIPLPTRDVRAFNSGLRLLQTLEEQKFRRFGWDSYTADGDDAAVVRHRRDRQSVGLLRWVGPVQQLRRPRQMYAGVEWKSAP-RHRVREQRRSMRKREKKGEELDTNGEKNVMPFHNGVIDGEHLFSTTDGAHTATCEAVGDIVFISPFESQGQERQSNPQGSTRKTYKNGIFMPITSQKPPKHISVARALFDTFGSSVYILIPIQMLQDACQLAAPVILQKYIEYVQMSDQ--------------------------------------DWKGGVALVATLCFFSLVQS---AAGNKLTQMSRRVGLTFHNALLTVLFTKCATVARKGLAHPDMSVGRIVNMVSNDVGSARSLPTLLPI-MVGAPLRLAVGALLLYQLVGLSALAGLGVVLVFLPLQGVLMGRFFGFLNTIARLRDERLKATNELLSGIRVAKYMSWEPALVCQIEKKRREELKALRSIQHMYII-VAFLSNAVPSLVVAAVFVLFHVLGNELTPTVVFPTIALFRLIQMPFIMIPVSVSAFSRFIVSMRRISAFLENDD-----VESG----LLEMQKHERDGRQIRGPDHIRWSLIGGDSTAVIEFMNAAISTYAPHKLPPCES--ELKKANKKGKSNGGITGDRVEGGDDADDREGRGDIQTTENNNGNAGGGRCHGHGQSHAHGHGHGHGAADGTTEY-------YEVRRKELLHNVTLRIPKGSLTCIVGETGCGKSTLLESLLPGGYEITSGTLRAPATVAYVPQQPWIMNATLRENILFFSDMDEARFRRALRCAQLDCDLELLANGVETEIGENGVNLSGGQKARVGLARALYAE-RDVYLLDDPLSALDVHVGEKVLQDCLLGELSGTTRVLATHQLHVLRHADLIVVLGSEGTTVFTGNYEEYKTFTGEAAGDSHRGDDDVNDGQSAN-----DNSACDETHEGISTEMPRERDDTMGPGERDNGVTTWDPLNNVETTSHGNGGDAAACESPLIDDYCDDSPAETGAASGKHTKLQKLSPLEDG---KKEVSGKLMTDEEVATGSVPFAIYARYAAASGGAKTCVPLLILFVLTEVVMVSPFLWLSFFTMK-TFNLPVNTYLFVYGGLVFASVLCSPLRWATGYGVLRAGSYRLFERLLRSVVAAPMSFFDTTPLGRVINRFSKDMTNIDEIIPDSIVYFVQCALSLTSSVAVMVASQYLVIAAIIPCGFIYYRLMLFYNNANRELRRVTNRVSSPGFSILGEMLAGRSCMDAFGKTPSFLTEALRRVDVVSACSYVEV--------VCNCWLAVRIDLLV-TVVLTAIS-GLGVYLVLQFGTVDVGLLSLS------------LTMA-----------VNISTILTSMVGQAATVEANMN--------SVERVLHYAHNIEHEDLMEDMEKAIKKQEERDRQMEKNERKKNKKGVASAGKNRMDGAEVNRPTNGMSGPNGHDFEAARGSCVSIRVTGGAESDEENGGTDRPSTAHVPSRHFHYTTSLAVEFCNVSMRYRQGQPLVLRDLTFRITTGQKVGVIGRTGSGKSSLLLTLLRMVDIEGGNILIEGHPIRSYRLRKLRQLFSVIPQDPVLFDGTLRDNLDPLHTSSDEEIFETLRLVGMQDRITSSAE----------------------------GLRSRVVDCGANFSVGQRQLLCMARALLRRDSRFVLMDEATANIDPALDRQLQYAIRHTFVTHTVITVAHRLHTLASYDLLLLLKDGRVVETGRPRDLVMDENSRFSRMVAAMGENALKNFMEATERDSFPR-------------------------------------------- AAC09044 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MCGMRTLAWRCATA-G--TVTVRG----TPLGGVRAA---ERT--PRQLYAGVEWRVPP-THRLKEENRNASRS----------------PFTNGVVEGEYLFNTSSGNATATCERVDDIVIHCPLPEK-KRRQGG--------------MPVTTQKRPKPMSVARALFTALGYHVYVLIPFRLLRDTCQLAVPVVLQYYIEYIETADP--------------------------------------SWRDGLLLVLAFSLLTLVQS---AAGSKLTQLGWRSGYTFQNALQGVLFEKCGTILRKALSHPEMSVGRIVNMVSSDMNSARSFPLMLPF-LFGAPLQLTFALALLYRLVGWCAFAGFGVLILFMPLQGILMRRYYAVYGRLSRATDARLKVTNEFFGGVRIRKFMSWEPSFIRRIEERRRE-LAALAASQLLYVS-ISFLTNAIPAFVVAVVFFLYIEMGHEFTPTIVFPAIALLGIMQTTFVRILSAFQVGSLRCVHAP-ITKFIECED-----ADDG----MREMLLQHTPQQAI--PERSKTGCIHHDASWRRSSH--------GYHLHICT---ETTRSRAAGRKERAMR---------------RAQVSSTELD----------------------------------------QRSPSR---H--YTRIPKGKLTCVVGDTGSGKSTLIESLL-GGHEVTSGFLRSLPNIAYVPQQAWIMNATLKENILFFSDMDEARFRRALRCTQLESDLKLLLNGVETEIGEKGVNLSGGQKARVSLARAVYATGRELYLLDDPLSALDAHVGEHVMHECILGELRSTTRMLVTHQLHQLRYADHIILLQEGGTVAFAGSYEDYGRFI---AGREATPIVAAAAEAAAA-----AASSSVEGGEAVG--------ELRAPKSEITGVNNGDEDNNDNDLSHN-----A--STLLFYDDEDNEEQSQQQQQQKQQNKNREKKKEDGSTEEKNMDGKLMTDEEKAVGAVSLLTYVKYLETCGGATLCGLVFLLFIVTEFLLVSPSLWLSFWSVK-RFELEPKTYLLLYVAFVAASALCSPLRNASAYAVLRIGSWRLHSQLLRSVAVAPMSFFDTTPLGRVMNRFSKDMSTIDSNLQSSVIFFFQSTLSVISSIAVMAISQYFVLIAIIPCLLVYYRLMVFYNSANREMRRIANRSNSPVFSVLGEMLSGRWTIAAYDLWSQKPC------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ CAA89197 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSRRMREMWGVGEPYTPMAESTPRGAA-LVLHMDLGVNPARKKR--ANAGGGFAASTPHRPCTRVRTEAFSVTRRSLSRGHRWSVLVG-----MTVASRRDRLSRGTLRWVGVPQSGGYHE-IMAAVTWTRPR---------RIVAECS------------ASTCRSSAGFLRRDVFTN---AILDTETQLEYTVMREQQSG-----------------------------LIRCERFLVRDLLSPAGAVLWSSPDKIIEDICTLTLTILLQKYVVYSRAN---------------------------------------LPAVSGLLLVMALFIVQAVQSVQSAALHSYYYISINGGLRFRSALTAVIFEKCLVVAPKSFAIPEMSTG-EYNMVSTDVERADEFLQFCMY-LWSSPFVAVFPIFLLYRLVGWSALVAVAALSTTLPLNALVMRRMMRLRRR-SRHDGRRVKATNESLSGIRIAKFMAWEPRFIASIEAKRDIELQYLKGVQVCRVL-TSFINDATPPVMIAVVLLLYHLLGHELTPEIVFPAISLLAIIRMPSMMIPTVFTSAVQFLVSMARISAFLDCEN----------------SPGALWTSAPTTLRRERAP---AHGARWPLSLR-------IPTLQHLCP---STPTSNSSIYFPHRFASCGASAAVTPAAQK--KKGQSPAQSRATTAAAQTVHHPTTTGQTTSMKRRGE-RRTCLAEGSFELLVSLAKVILGPLSIEIPKGKLTVIIGPTGSGKTTLLRGLL--VSTSDARSCVATRSIAYVPQQPMIMNQTLRTNVLFLPPETLRGLQETVRACQLESDLKLWLAGDADEMVR-GINLSQ-QKARGSLARAVYAD-RRVYLLDDPLSALDAHVGERIVADVLLGQLACKTRILATHQLQVLSRAD-YVVVMGDGAVRFAGRREEFMGSP--------------VYKEVVA-----KMRGSSNTRERS------------ERGRGDDVLDGAP-------------------------------------VLDNGAHLGGSLAAQGG------------N--DDVEKRGLYCGHVRDIFTCMPWCLLC--ISIISLTEMISLSQRVLRCVDTT---LRSVPQTYLDVYIALVLFGPVTVPLRFSIRIQCDEDKAPAIYTAHSSVGLIGTVSYFDTTPLGRIVNRFSRDVDCIDNQLQMTFLFLLRVLYSIFSSLAVAIDSQPYVILALLPRWFFTTVDGPLQRHQQR-IRRVGSIVKAPMISLLGEALVGSLPSRHTDAVASIMKESLRGIDRVCVCFAETNDRVASSDCGHVCIHAVRMGMWLVRSMAGPRLHGWVSKLCLGYAVAMKGLISEARTLLEPVILMHVITIASRRHGHDSSVRTTWSSLVSHALRHVTAQLACANNWHDGADMTRDRILHYTTTLIMRRCLRWTG------------------------------------CDELRRR----TRRAADVTAT-------------------VPGEASARSKGQHPETTAGWLEFRE--VEMRYRAGLPLVLDRVSFRIEPRQKVGVVGRTGSGKSTLAATLMRMVEICGGRHHRVGAADLRYGLRELRQQFSMIPQDPVLFDGTVRSNLDPLLDSTPAEVWRALELVGMRELLELESG----------------------------GIDGRVQEGGSNYSVGQR-TLCLARALLRRGRRFILMDEATANIVHALDQQIQHTVMTAFNSHTVITIAHRLHTVAAYDIIIVMDHGVVAESGSPRELVSDRRPRFSELVGRAGEAGGPEVHGECGCCGGFVMTGCFRWHPAEKSKSDFSF------------------------- CAC28731 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAEFPDEKEKEISLPNPVADQRHRDDEIEEAHRSDEDVEKIAIGSSVVEENDEKRAELNRMR-TNATNTSVTTAATIHPHVKPKPWYKQPNPLRWGKIAPIPETRR-----PSPEYNAGFFRSLFFSWMGPLMTLELNDIYQVNPARSVDP------LTERMRESYKRR--------VEKGDKYPLLWAMHETFFWEFWIGGMCQLAASILQVMSPFTLR--------------------------YLIQFATNAWVATHSGAPPPGIGSGLGLVFGITAMQILQSLCINHFIYRGMLIG-------------------------------------GMARASLISLIYEKSMVISGRAK--AGGADASDVPAAKAAAEKDAKKKSKKKGKKGQAGVEGDGAGWGNGRIINLMSVDTYRVDQASGLFHI-IWTAPVSIIITLVLLLVNLTYSALAGFALLIIGIPVLTKAIKSLFARRKAINKITDQRVGLTQEILQSVRFVKFFGWESSFLKRLQEFRDREVSAIQVLLALRNA-IMAISISLPIFASMLAFITYSLTNHGLAPAKVFSSLALFNGLRMPLNMLPLVIGQVTDAWSSISRIQDFLLSEE------------------REDEAIIKPDAP----------NAIEVHDAS------FTWERTPTQE-----NESTVGGAGPKSKPEKGAKGKPKD------VEAATPPSGDDS--S--------------------------------TLVEEQEPFKLQDLNFTIGRNELVAVIGSVGSGKTSLLSALA-GDMRKTSGEVVLGAQRAFCPQYAWIQNATLKDNILFGKEMDPEWYRDVIKACALQPDLDMLPNNDLTEIGERGITISGGQKQRLNIARAIYFD-ADIVLMDDPLSAVDAHVGRHIFDNAILGLLKDKARILATHQLWVLNRCD-RIIWMDGGRIQAVDTFDNLMRDS----------------------------EEFRQLLEST------------AQEEKKDEAEAP--------------------------------------AATSEEEAPKKKKKAKG----------LMQAEERAVASVPWSVYTSYVKASGSYLNAPIVLVLLVISQGSNIMTSLWLSWWTSD-KFGLSLGQYIGAYAGLGAMQALLMFAFMVSLSMFGTTASKNMLRQATFRVLRAPMSFFDTTPLGRITNRFSRDVDVMDNNLTDALRMYFFSIGAIISTFALIIAYFYYFAIALVPLFTLFLFATGYYRSSAREVKRFEAVLRSTVFAKFNEGLSGVASIRAYGLQNRFVEDMRKAIDDMDSAYFLTY--------SNQRWLSTRLDMIG---NALVFTTGILVVTSRFSVNPSIAGLVLS------------YILA-------------IVQMIQFTVRQLAEVENGMN--------AVERLLYYGTQLEEEAPSKTID--------------------------------------------------------------------------------------VRPSWPEKGEIIFDN--VEMRYRAGLPLVLQGLNVHIQGGERIGIVGRTGAGKSSIMSTLFRLVEISGGHITIDGIDISTIGLQDLRSRLAIIPQDPTLFRGTVRSNLDPFGEHTDLELWSALRQADLVQDDQATTTTATPSASGNALVVAETPAASNGNSNNRIGLDSVVEEDGLNFSLGQRQLMALARALVRG-SQIIVCDEATSSVDMETDDKIQRTMASAFRGKTLLCIAHRLRTIINYDRICVMDKGRIAEIGTPMELFEMEGGIFRGMCERSGIRAEDIRLAREIVDNDRAL------------------------------------------- QUARTET PUZZLING TREE :---AAA65541 :100: : :---AAB51191 :---------95: : : :---CAC83023 : :100: : :---AAC09044 : : :---CAB64569 : :-97: : :100: :---AAB05634 : : : : :-91: :-------CAB64568 : : : : : : :---CAC83020 :-92: :----100: : : :---CAA89197 : : : :---------------P21441 : :-------------------CAC28731 Oligopeptidase B AAC80228 T. cruzi AAC80459 T. brucei AAD24761 L. major *BAB75610 Nostoc sp. AAC80228 ----------MKCGPIATPKDHEVVFGYVEGENRGNNAMNPPRRRNDPLFWLRDDSRKNPEVIAHLKLEQAYFEERTADIKDFSETIFKEYFSHIKETDISAPYRYDGYTYYTREVEGLSYKIHCRVPLGMTPGKSED-EQVILDENKLAEGKSFCMVHEVKPAPPDHNLVAYSVDYVGNEMYTIRFTD-----NAVTDVVEGTNGQILWGPNASCFFYITKDAAERNYKIWRHIIGRPQSEDVCLYTENDLLFSTAMAISGDGNTLIIGSGSFETTESHLLDLRKGNGHTTLEMVRPRERGVRYDVELHGTETLLILTNKDNCMNGKVVSATRNTPS--DWENVIVPHSEDVFIGEIGVFAKFVVLSGRRGGIT--RVWAMPVG-SDGLFRSGAFVQEVSFDEPVFTAFPVFSHMKMYDTETLRVSYTSMSTPTTWFDLHVVNGTRTIVKVREVLGNFDAKNYTCRRLFATAPDRTKIPLSIVHDVSLDMSKPHPTVLYAYGSYGACVEPEFSVKYLPYLDRGVIYVIAHVRGGGEMGRAWYEVGAKYLTKRNTFSDFIACAEYLIEIGLTTPSQLACEGRSAGGLLIGAVLNMRPDLFRVALAGVPFVDVMTTMCDPSIPLTTGEWEEWGNPNEYKFFDYMNSYSPVDNVRAQDYPHLMIQAGLHDPRVAYWEPAKWASKLRALKTDSNEVLLKMDLESGHFSPSDRYRYWREMSFPQAFVLKHLN--ARTLLRR AAC80459 --------MQTERGPIAAHRPHEVVFGKVEGEDRGANPMDPPRRRVDPLFWLRDDNRADPEVLAHLHLEKDYYEKRAVDIKDLAETIYQEHISHIEETDMSAPYVYDRFLYYTRDVKGLSYKLHCRVPAGKTPGEGED-EEIVLDENKLAEGKSFCVVGCVAPAPPEHALVAYSVDYCGDEVYSIRFVR-----DVVADKVEGTNGSVVWGPNAECFFYITKDASKRDNKVWRHIIGQPQSEDVCLYTDDDPLFSVGVGRSGDGKTLIICSMSSETSESHLLDLRKGVKHNTLEMVRPREKGVRYTVEMHGTDTLIVLTNKDKCVNGKVVLTKRSAPT--DWGTVLIPHDDKVTIDDVAVFAKFAVLSGRRDGLT--RVWTVRLG-PDNLFSS-ATLKELHFDEPVFTAHVVCSQMKTYDASLLRLRYSSMTTPTVWYDEDVLSGERKVVKARKVGGGFESKNYVCRRELATAPDGTKVPISLVYDTSIDLKKPNPTMLYGYGSYGICIEPEFNSRFLPYVDRGMIYAIAHVRGGGEMGRTWYEVGGKYLTKRNTFMDFIACAEHLISSGLTTPAQLSCEGRSAGGLLVGAVLNMRPDLFHVALAGVPFVDVMTTMCDPSIPLTTGEWEEWGNPNEYKFFDYMNSYSPIDNVRAQDYPHLMIQAGLHDPRVAYWEPAKWASKLRELKTDSNEVLLKMDLESGHFSASDRYKYLRENAIQQAFVLKHLN--VRQLLRK AAD24761 -MSSDSSVAASAQPPIAAKKPHRVKFGYVEGEDRGPNPMNPPRYREDPYFWMRDDDRKDPAVIEHLNKEKVYFQARSADIAQLRDDIYAEHISHINEDDMSAPYVYGKYRYYTREVKGKPYKIYCRVFTDKEPGDVAA-EEVIIDVNQVAEGKAFCDVMEVKPAPPEHDLVAFSVDMSGNEVYTIEFKRISDPSQTIADKVSGTNGEIVWGPDHTSLFYVTKDETLRENKVWRHVMGKLQSEDVCLYEEHNPLFSAFMYKAADTNTLCIGSQSPETAEVHLLDLRKGNAHNTLEIVRPREKGVRYDVQMHGTSHLVILTNEGGAVNHKLLIAPRGQPS--DWSHVLVDHSEDVFMESIAVRSNYLVVAGRRAGLT--RIWTMMADSQDGVFQAGTGLREVVMEEPIFTVHLVESQMLEYEEPTFRMEYSSLATPNTWFDVSPQDTLAPLVKVREVGGGFDAANYKVERRFATAPDQTKIPLSVVCHKDLDMSQPQPCMLYGYGSYGLSMDPQFSIQHLPYCDRGMIFAIAHIRGGSELGRAWYEIGAKYLTKRNTFSDFIAAAEFLVNAKLTTPSQLACEGRSAGGLLMGAVLNMRPDLFKVALAGVPFVDVMTTMCDPSIPLTTGEWEEWGNPNEYKYYDYMLSYSPMDNVRAQEYPNIMVQCGLHDPRVAYWEPAKWVSKLRECKTDNNEILLNIDMESGHFSAKDRYKFWKESAIQQAFVCKHLKSTVRLLVRR BAB75610 MMNKDKISQNQITPPIADKQPQVLEL---HG-DR----------RVDNYFWMRDID--NPKVVAYLEAENSYTKVMMQHTETLQKTLYNEMLSRIKETDLSVPYRKDNYYYYSRTEAGKDYRIHCRK-----EGDLDAPEEVILDENELAAGHDFFELGIFAISP-NHQILAYSYDTSGSEQYTLLFLDLTTR-ELYPETIADTYFSFCWCNDNQTSFYTKIDAANRPYQLFKHTLGTPPTKDELIYHEPDHAYALYVGKTRSQAYILMTLQSSITTEVHYLDAN--NPESNFQIIYPREPGVEYDVEHH-SDYFYIVTN-EAATNFKLVKTPLTMPSKENWQTV-IPHREDVLLSGVSLFINHLVIYERKDGLQTARVQNISTGSES----------NIIFPEPTYQFY--EGNNPEFNTNILRFNYTSLITPPSVFDYDMETHEQELKKQTEVLGDYDKNQYQSEWLLATAEDGTQIPISIIYKKVTKKDGKNPLLMTGYGAYGASYPASFSSARLALLDRGVVFAIAHIRGGEEMGRKWYEDG-KFLQKKNTFTDFIACAEYLIKEGWTTSDRLAITGGSAGGLLMGAVINLRPKLFKVVVADVPFVDVVTTILDTSLPLSAMEWEEWGNPNDQIYYEYMKSYSPYDNVEAKDYPHLLITAGLNDSRVKYWEPAKWTAKLRELKTDHHVLLLKTNMDAGHSGASGRYESLRELAFEYAFILDRLGL-------- QUARTET PUZZLING TREE :---AAC80228 :100: : :---AAC80459 : :-------AAD24761 : :-------BAB75610 Paraflagellar rod component (including PAR-2 and PAR-3) Q26789 T. brucei PAR-3 AAC32018 T. cruzi PAR-3 AAO25623 L. mexicana PAR-3 AAA30221 T. cruzi PAR-2 P22225 T. brucei PAR-2 AAB17719 L. mexicana PAR-2 (Note: PAR-2 was used to root PAR-3 and vice versa.) Q26789 -------------------MAAVDDATGLEAARKQKIHNLKLKTACLENEELVQELHVSDWSETQRQKLRGAHLKAEELVAAVDVGTKWNLTEVYDLAKLMRVCGLEMSQRELYRPEDKAQFMDIIAMKKVLQDLRQNRNKTRVVSFTQMIDNAIAKVEKVEEDVRRSQLDATQLAQVPTQTLKQVEDIMNVTQIQNALASTDDQIKTQLAHVEKTNEIQNVAMHDGEMQVAEEQMWTKVQLQERLIDLIQDKFRLISKCEEENQAFSKIHEVQKQANQETSQMKDAKRRLKQRCETDLKHIHDAIQKADLEDAEATKRHAANKEKSDRYIRENEDRQEETWNKIQDLERQLQKLGTERFDEVKRRIEEIDREEKRRVEYSQFLEVASQHKKLLELTVYNCDLAIRCTGLVEELVSEGCAAVKARHDKTSQDLAALRLDVHKEHLEYFRMLYLTLGSLIYKKEKRMEEIDRNIRTTHIQLEFCVETFDPNAKKHADMKKELYRLRQGVEEELAMLKEKQAKALEEFKESEEVSGRCWHRVQPPCDENNEEVLTRRSKMVEYRSHLTKQEEVKIAAEREEIKRALTAQLWCRWRAGPHRKQHCTHASN---SVAAIIM-- AAC32018 --------------------MSAEEATGLEAARKQKIHNLKLKTACLENEELIQELHVSDWSETQRQKLRGAHLKAEELVASVDVGTKWNLTEAYDLAKLMRVCGLEMSQRELYRPEDKAQFMDIIGVKKVLQDLKQNRNKTRVVSFTQMIDNAIAKMEKVEEELRRSQLDATQLAQVPTRTLKQIEDIMNATQIQNALASTDDQIKTQLAQLEKTNEIQNVAMHDGEMQVAEEQMWTKVQLQERLIDLIQDKFRLITKCEEENQPFKKIYEVQKQANQETSQMKDAKRRLKQRCETDLKHIHDAIQKADLEDAEAMKRHAANREKSDGFVRENEERQEEAWNKIQDLERQLQKLGTERFEEVKRRIEEVDREEKRRVEYSQFLEVASQHKKLLELTVYNCDLAIRCTGLVEELVSEGCAAVKARHDKTSQDLAALRLEVHKEHLEYFRMLYLTLGSLIYKKEKRMEEIDRNIRTTHIQLEFCVETFDPNAKRHADMKKELYKLRQGVEEELAMLKEKQAKALEDFKESEEALDRAGIEFNHPVDENNEEVLTRRSKMVEYRSHLSKQEEVKIAAEREEIKRARLLR-----TGGGGSGEQPRIGNN----TAPARLE- AAO25623 -------------------MMTPEDATGLEAARKQKIHNLKLKTACLENEELVQELHISDWSETQRQKLRGAHEKGEELLASVEVGTKWNLMEAYDLAKLMRVCGLEMSQRELYRPEDKPQFMDIIGVKKVLQDLRQNRNKTRVVSFTQLIDNSIAKMEKVEEELRRSQLDATQLAQVPTRTVKMMEDIMNATQIQNALASTDDQMQTQLAQLEKTNEIQNVAMHDGEMQIAEEQMWTKVQLQERLIELLKDKFGLIGKCEEENAQFKEIYEVQKQANHETSQMKDAKRRLRQRCETDLKHIQDAIQKADLEDAEAVKRYAGNKERSERAVKENEEMQEEAWNKIQDLERQLQNLGTDRFDEVKRRIEEVDREEKRRVENAQFLEVAAQHKKLLELTVYNCDLAMRCTGLVEELVSEGCAGVKARYDKTNQDLAALRLEVHKEHLEYFRMLYLTLGSLIYKKEKRLEEVDRNIRLAHIQLEFCVETFDPNAKKHADMKKELYKMRQGVEEELAMLKEKQAAALDDFKESEEALDAAGIEFSHPVDENNEEVLTRRSKMVEYKSHLTKQEEVRIAAEREEIKRARLLR-----SGGASAAAQITSGSMNADYAASTQLEG AAA30221 MSYKEASGAVGPADQQQPA-VPEVTDVTLEAARKQKIHNLKLKTSCLSNEEFIQDLHVSDWSETQKQKLLAAHEKAQELLSSVEGGTKWNLTEAYDIKKLMRVCGLQLSVRELYKPEDKPHFMEVVALKKTLNELKQHHNKTRTVSFTGTIDNAIAKLEKIEDELRRSQLDASEMAQVPVAVLKNLEECMNVTVVQTALLGNEEQIKAQLAAIEKAKEIRNVAIADGEMAIAEEQYYIKAQLLEHLVELVADKFRIIGQTEDENKPFGRIQDVQKKSFQETSAIKDAKRRLKQRCEDDLKNLHDAIQKADMEDAEAMKRFATQKEKSEKFIQENLDRQDEAWRRIQELERVLQRLGTERFEEVKRRIEENDREEKRKVEYQQFLDVCGQHKKLLELSVYNCDLAMRCIGMMEELVAEGCSAIKSRHDKTNEELGDLRLQVHQEYLEAFRRLYKTLGQLVYKKEKRLEEIDRNIRTTHIQLEFAIETFDPNAKKHSDAKKELYKLRAQVEEELEMLKDKMAQALEMFGPTEDALNQAGIEFVHPAEEVEDGNLTRRSKMVEYRAHLAKQEEVKIAAEREELKRSKTLQ-----------SQQYRGKTV----QQITQ--- P22225 MSGKEVEGVVSPADQQQPA-VPEVTDITLEAARKQKIHNLKLKTACLSNEEYVQDLHVSEWSETQKQKLQAAHEKAHELLASVEGGTKWSLTEAYDIKKLMRVCGLEMSVRELYKPEDKPQFMEIVALKKTMNELKQHHNKTRTVSFTGMIDNAIAKLEKIEDELRRSQLDASEMAQVPVAALKNIEDTMNVAVVQTALLGNEEQIKAQLAAVEKANEIRNVAIADGEMAIAEEQYYIKAQLLEHLVELVADKFRIIGQTEDENKSFSKIHEVQKKSFQESASIKDAKRRLKQHCEDDLRNLHDAIQKADLEDAEAMKRFATQKEKSERFIHENLDKQDEAWRRIQELERVLQRLGTERFEEVKRRIEENDREEKRKVEYQQFLDVCGQHKKLLELSVYNCDLALRCMGMLEEIVAEGCSAVKSRHDKTNDELSDLRLQVHQEYLEAFRRLYKTLGQLVYKKEKRLEEIDRNIRTTHIQLEFAIETFDPNAKLHSDKKKDLYKLRAQVEEELEMLKDKMAQALEMFGPTEDALNQAGIDFVHPAEEVESGNMDRRSKMVEYRAHLAKQEEVKIAAEREELKRSKMLQ-----------SQQYRGRTM----PQITQ--- AAB17719 MS--IAADMAYPAEAAAAADVPEVSDVTLEAARKQKIHNLKLKTACLSNEEFIQDLHVSDWSETQKQKLAAAHEKAAELLAAAESGTKWALTEAYDVQKLMRVAGLEMSVRELYKPEDKPQFMEIVALKKTLNELKQHPNKTRTVSLTATIDNGVVKMEKAEEELRQSQLDASDLAKVPVPVLKSLEDCMNVTVVQTALQGNEDQIAAQLASIEKACEIRDVAIADGEMAIAEEQYYIKAQLLEHLVELVADKFRIIGQTEDENKSFDRIADTQKRAFQETAALKDGKRRLKGRCEDDLRSLHDAIQKADLEDAEALKRYATQKEKSEQLIAENVDRQEDAWRKIQELERALQRLGTERFEEVKRRIEENDREERRRVEYQQFLDVCGQHKKLLELSVYNCDLALRCSGMVEEFVAESCSAIKARHDKTGDELAELRLQEHQEYLEAFRRLYKTLGQLVYKKEKRLEEIDRQIRTSHIQLEFAIETFDPNAKKHSDLKKELYKLRAQVEEELEMLKDKMAQALEMFGPTEDALHQAGIEFVHPAEEVEDGNLNRRSKIVEYRAHLAKQEEVKIAAEREELKRTKVLQ-----------AQQYRGKTV----QQITE--- QUARTET PUZZLING TREE :---AAA30221 :-78: :100: :---AAB17719 : : :100: :-------P22225 : : : :-----------AAO25623 : :---------------AAC32018 : :---------------Q26789 Periredoxin Q26695 T. brucei CAA09922 T. cruzi AAL37182 T. cruzi AAC31146 L. major AAC79432 L. major AAL25847 L. infantum AAK00633 L. donovani AAG40074 L. chagasi AAK82654 L. donovani AAC72300 Crithidia fasciculata AAC15095 Crithidia fasciculata *BAA32086 Cyprinus carpio Q26695 MSCGDAKLNHPAPHFNEVALMPNGTFKKVDLASYRGKWVVLFFYPLDFTFVCPTEICQFSDRVKEFNDVDCEVIACSMDSEFSHLAWTNVERKKGGLGTMNIPILADKTKSIMKAYGVLKEEDGVAYRGLFIIDPQQNLRQITINDLPVGRNVDETLRLVKAFQFVEKHGEVCPANWKPGSKTMKADPNGSQDYFSSMN CAA09922 MSCGDAKLNHPAPDFNETALMPNGTFKKVALTSYKGKWLVLFFYPMDFTFVCPTEICQFSDRVKEFSDIGCEVLACSMDSEYSHLAWTSIERKRGGLGQMNIPILADKTKCIMKSYGVLKEEDGVAYRGLFIIDPKQNLRQITVNDLPVGRDVDEALRLVKAFQFVEKHGEVCPANWKPGDKTMKPDPEKSKEYFGAVA AAL37182 MSCGDAKLNHPAPDFNETALMPNGTFKKVALSSYKGKWLVLFFYPMDFTFVCPTEICQFSDRVKEFSDIGCEVLACSMDSEYSHLAWTSVEAKRGGLGQMNIPILADKTKCIMKSYGVLKEEDGVAYRGLFIIDPKQNLRQITVNDLPVGRDVDEALRLVKAFQFVEKHGEVCPANWKPGDKAMKPDPEKSKEYFGAVA AAC31146 MSCGNAKINSPAPSFEEVALMPNGSFKKISLSSYKGKWVVLFFYPLDFSFVCPTEVIAFSDSVSRFNELNCEVLACSIDSEYAHLQWTLQDRKKGGLGTMAIPMLADKTKSIARSYGVLEESQGVAYRGLFIIDPHGMLRQITVNDMPVGRSVEEVLRLLEAFQFVEKHGEVCPANWKKGAPTMKPEPNASVEGYFSKQ AAC79432 MSCGNAKINSPAPSFEEVALMPNGSFKKISLSSYKGKWVVLFFYPLDFTFVCPTEVIAFSDSVSRFNELNCEVLACSIDSEYAHLQWTLQDRKKGGLGTMAIPMLADKTKSIARSYGVLEESRGVAYRGLFIIDPHGMLRQITVNDMPVGRSVEEVLRLLEAFQFVEKHGEVCPANWKKGAPTMKPEPKASVEGYFSKQ AAL25847 MSCGDAKINCPAPPFEEVALMPNGSFKKISLAAYKGKWVVLFFYPLDFTFVCPTEIIAFSENVSRFNELNCEVLACSMDSEYAHLQWTLQDRKKGGLGAMAIPMLADKTKSIARAYGVLAEKQGVAYRGLFIIDPNGMVRQITVNDMPVGRNVEEVLRLLEAFQFVEKHGEVCPANWKKGAPTMKPEPKASVEGYFSKQ AAK00633 MSCGNAKINCPAPPFEEVALMPNGSFKKISLAAYKGKWVVLFFYPLDFTFVCPTEIIAFSENVSRFNELNCEVLACSMDSEYAHLQWTLQDRKKGGLGAMAIPMLADKTKSIARAYGVLEEKQGVAYRGLFIIDPNGMVRQITVNDMPVGRNVEEVLRLLEAFQFVEKHGEVCPANWKKGAPTMKPEPKASVEGYFSKQ AAG40074 MSCGDAKINCPAPPFEEVALMPNGSFKKISLAAYKGKWVVLFFYPLDFSFVCPTEIIQFSENISRFNELNCEVLACSMDSEYAHLQWTLQDRKKGGLGAMAIPMLADKTKSIARAYGVLEEKQGVAYRGLFIIDPNGMVRQITVNDMPVGRNVEEVLRLLEAFQFVEKHGEVCPANWKKGDPGLKVDHNK--------- AAK82654 MSCGDAKINCPAPPFEEVALMPNGSFKKISLAAYKGKWVVLFFYPLDFSFVCPTEIIQFSENVSRFNELNCEVLACSMDSEYAHLQWTLQDRKKGGLGTMAIPMLADKTKSIARAYGVLEEKQGVAYRGLFIIDPNGMVRQITVNDMPVGRNVEEVLRLLEAFQFVEKHGEVCPANWKKGDPGLKVDHNK--------- AAC72300 MSCGAAKLNHPAPEFDDMALMPNGTFKKVSLSSYKGKYVVLFFYPMDFTFVCPTEIIQFSDDAKRFAEINTEVISCSCDSEYSHLQWTSVDRKKGGLGPMAIPMLADKTKAIARAYGVLDEDSGVAYRGVFIIDPNGKLRQIIINDMPIGRNVEEVIRLVEALQFVEEHGEVCPANWKKGDAKKKEGH----------- AAC15095 MSCGAAKLNHPAPEFDDMALMPNGTFKKVSLSSYKGKYVVLFFYPMDFTFVCPTEIIQFSDDAKRFAEINTEVISCSCDSEYSHLQWTSVDRKKGGLGPMAIPMLADKTKGIARAYGVLDEDSGVAYRGVFIIDPNGKLRQIIINDMPIGRNVEEVIRLVEALQFVEEHGEVCPANWKKGDAKKKEGH----------- BAA32086 MAAGKAHIGKPAPDFTAKAVMPDGQFKDLSLSEYKGKYVVLFFYPLDFTFVCPTEIIAFSDAVEEFRKINCEVIGASVDSHFCHLAWINTPRKQGGLGHMNVPLVADSLRSISQDYGVLKEDEGIAYRGLFIIDDKGILRQITINDLPVGRSIDETLRLVQAFQFTDKHGEVCPAGWKPGKDTIKPDVQQSKDYFSKQH QUARTET PUZZLING TREE :---AAC72300 :--------100: : :---AAC15095 : :100: :---AAG40074 : : :-----99: : : : :---AAK82654 : : : : :100: :---AAC31146 : : :100: : : : :---AAC79432 : :-93: : : :---AAL25847 : :-97: : :---AAK00633 : : :---CAA09922 : :100: :--------100: :---AAL37182 : : : :-------Q26695 : :-------------------BAA32086 Proteasome subunit alpha-5 CAC82813 T. cruzi Q9XZG5 T. brucei CAB86711 L. major *Q9LSU1 Oryza sativa *AAK44060 Arabidopsis thaliana CAC82813 MFSSKTEYDRGVNTFSPEGRIFQIEYAIEAIKLGSTSLGIQTPDAVVIAAEKRVPSVLVDPSSMNKILEIDYHMGTVLSGMVADARILVEHARVEAQNHRFTYDEPMRVESCALATCDLSVRFGESGGRKKLMSRPFGVSLLIAGVDENGPQLWQTDPSGTYTRYDAQAIGAGAEAAQTVFNEIYHRNMTVEEAETLAVRILKQVMEEELTKSNIEIAIVPACTGKLEVYDQTKIQRIIDRLTEE- Q9XZG5 MFSSKTEYDRGVNTFSPEGRIFQIEYAIEAIKLGSTSLGIQTPDAVIIAAEKRVPSTLVDPSSVNKILEIDHHIGTVLSGMVADARILVDHARVEAQNHRFTYDEPMSVESCALATCDLSVQFGESGGRKKLMSRPFGVSLLIAGVDENGPQLWQTDPSGTYTRYDAQAIGGGAEAAQTVFSERYHRNMTVEEAENLTVQILRQVMEEKLTKTSVEIAIVPVSTGRLQIYDQEQIQRIIDRQAEEN CAB86711 MFTSKSEYDRGVNTFSPEGRIFQIEYAVEAIKLGSTSLGIRTPKGVVLAAEKRVPSTLVVPSSMSKIMEIDSHIAAVMSGMVADARILVEHARVESQNHRFTYNEPMSVESCTLATCDLSIQFGESGGKRKLMSRPFGVSLLIAGVDEKGPQLWQTDPSGTHTRYDAQAIGGGAEAAQSVFTERYHRNMTLEEGETLAVDILKQVMEDQLSPENIEVAVVRADDGKLHMYTPTEIKAIMSRMPE-- Q9LSU1 MFLTRTEYDRGVNTFSPEGRLFQVEYAIEAIKLGSTAIGLKTKDGVVLAVEKRVTSPLLEPSSVEKIMEIDEHIGCAMSGLIADARTLVEHARVETQNHRFSYGEPMTVESTTQAICDLALRFGE--GDEESMSRPFGVSLLIAGHDENGPSLYYTDPSGTFWQCNAKAIGSGSEGADSSLQEQYNKELTLQEAETIALSILKQVMEEKVTPNNVDIAKVSP---NYHLYTPAEVEAVIARL---- AAK44060 MFLTRTEYDRGVNTFSPEGRLFQVEYAIEAIKLGSTAIGVKTKEGVVLAVEKRITSPLLEPSSVEKIMEIDDHIGCAMSGLIADARTLVEHARVETQNHRFSYGEPMTVESTTQALCDLALRFGE--GEEESMSRPFGVSLLIAGHDENGPSLYYTDPSGTFWQCNAKAIGSGSEGADSSLQEQFNKDITLQEAETIAVSILKQVMEEKVTPNNVDIAKVAP---AYHLYTPQEVEAVISRL---- QUARTET PUZZLING TREE :---CAC82813 :100: :100: :---Q9XZG5 : : : :-------CAB86711 : :-----------Q9LSU1 : :-----------AAK44060 Protein kinase A, regulatory subunit AAO33766 T. cruzi AAG16958 T. brucei CAB95241 L. major *AAN78131 Onchocerca volvulus AAO33766 MAEEENTLSLFLEACRKEGVKQPNTILMDFFRSNPSPSQIEEIDLSHNYVGNRGILAVLDLIEKLPSFRFLNCSNQKLYNTDLSEDSVRGNATVDRIVEVFKVHPTANALDISNNPISNYAGRKLLVLAQVNRRICRVELSETRVDFDLRKRITQQCEKNTIALWEAQASEGADEERGFGEGPVWVPKQAPADLTTIGGGRNRRRTVRSEGIDPEKAKLYQAPYFEKSEDEMNLITKLLTHNVLFSFLNTKDIKVVAGAMQRATFKHDDCIMEAGQTTCNKLYIIQSGHADIIKEGQKVYLKTEGTAVGELELMYDTPVVATVKVCTDELIAWVLDRDTYRNLVMGTAIRRRETYIQFLANVPFLGGLDSYEKLQLADALSSEEFSPGEYIIHYGEEGEWLYIIMEGTVEVIG-RDADGEPTKVCEFTQGDHIGELEFLNNHRTVADVVATTHVITAKLNRRHFEMCLGPVIDVLKRCADDPKYEYYQNVLKTGAA-QPSYVDDV AAG16958 MSEKGTSLNLFLAACQKEGVKQPNTFLVEFFTKKPELSEVEEIDLSKNYIGNRGILALLDVISELPCFRFLNCSNQKLYNTDLNEDSVRGNATIDRIVDVFKSHPTANALDLSHNPISNYAGRRLLLLTQNNKRICRVELVDTRIDFELRSRITQQCEKNTIAIWESQAQE-KEEERAFGESVTWVPTQTSADLTAIGGGRKRRTTVRGEGIDPEKAKSYVAPYFEKSEDETALILKLLTYNVLFSFLDSRDLMTVAGAMWRVEFKQDDCIMEAGQTTCDKLYIIQDGKADIIKEGQKVYLKVEGTAVGELELMYQTPTVATVKVCTPELIAWALDRDTYRHLVMGSAIRRRETYIQFLTNIPFLSGLDNYEKLQLADALSSDEFEPGDYIIRYGEEGEWLYIILEGSVDVVG-RDDDGNEKHVWEFGKGDHVGELEFLNNHANVADVVAKTHVVTAKLNRRHFEMCLGPVIDVLKRTSQQPNYEYYQSKLKTTLR-AEGRK--- CAB95241 MSAGDTPVSLFLQACNQEGVKTPNPKLVEFFQSHETFDSILEIDLSNNYIGNRGLLAVLGVIEHLSCFRCLNAMDQKLYNSDFSEEAVKGNAVIDRIVEVFKVHPTANSLNLSNNPISNYAGRKLLSLAQVNRRMCLIEVSDTRIDFDLRNKIAKQCEENTRNMWDAEQDENANSCAVFGENLEWVPTQATADLTSLGAGRARRQTVRVEGIDPEAAKNYVPPVHEKSQEDTDMICKLLSHNVLFGFLGSKDILTVAGAMYREEFVKDERIIEFGQTHCDKLYVIQSGEADVIKEGQKVFVKTEGTAVGELELLYDTPAVATVKVSTEVLVAWVLDRETYRNLVMGSCIRRRETYMSMLAKVPFLQSLDAYERMQIADALTSDEFAAGDYIIHYDEEGEWLYIIIEGTVEVIG-RDAAGNKTKVCEFHSGDHIGELEFLNKHRTVADIVAVTGVTTAKLNRRHFEMCMGPVMDVLKRNSTSAKYDYYQQVLQQQQQGAPAAVQ-- AAN78131 ------------------------------------------------------------------------------------------MASGDSSEEAQLAQCQAYVQRHNIQQLVKEAIVSLCINKPENPVLFLKEHFEK--LYDQRSQVSSPRIEATDD--DDTIDE---------------PP-------KLQQGNRRRLAVSAEVPDENEAANYDKVVIPKDDETRRALEAAMCKNILFSHLEGDEQKAIFDAMFPVEKKKGETIIEQGE-EGDNFYVIDSGEVDVFVNGEYALSIKEGGSFGELALIYGTPRAATVVAKSDVVKCWAIDRITYRQILMGSTMRKRKLYDEFLSKVQILSDLDKWERANVADALERCDFEPGTHVVEQGHPGDEFFIIVEGQADVLQKRSDDAPFEIVGHLSSSDYFGEIALLLDRPRAATVIAKTPLKCVKLDRARFERVMGPVREILKR--DVSNYNSYVKLMT------------- QUARTET PUZZLING TREE :---AAO33766 :100: : :---AAG16958 : :-------CAB95241 : :-------AAN78131 Pteridine reductase Q01782 L. major A45168 L. major AAB61214 L. mexicana CAA78031 L. tarentolae AAG09193 T. cruzi AAG09194 T. cruzi AAN62582 T. cruzi AAO18339 T. cruzi AAC38850 T. cruzi AAG09196 T. cruzi AAG09195 T. cruzi AAC23562 T. brucei *NP_778899 Xylella fastidiosa *NP_641040 Xanthomonas axonopodis Q01782 -----MTAPTVPVALVTGAAKRLGRSIAEGLHAEGYAVCLHYHRSAAEANALSATLNARRPNSAITVQADLSNVATAPVSGADGSAPVTLFTRCAELVAACYTHWGRCDVLVNNASSFYPTPLLRNDEDGHEPCVGDREAMETATADLFGSNAIAPYFLIKAFAHRFAGTPAKHRGTNYSIINMVDAMTNQPLLGYTIYTMAKGALEGLTRSAALELAPLQIRVNGVGPGLSVLVD-DMPPAVWEGHRSKVPLYQRDSSAAEVSDVVIFLCSSKAKYITGTCVKVDGGYSLTRA A45168 -----MTAPTVPVALVTGAAKRLGRSIAEGLHAEGYAVCLHYHRSAAEANALSATLNARRPNSAITVQADLSNVATAPVSGADGSAPVTLFTRCAELVAACYTHWGRCDVLVNNASSFYPTPLLRNDEDGHEPCVGDREAMETATADLFGSNAIAPYFLIKAFAHRSR-HPSQASRTNYSIINMVDAMTNQPLLGYTIYTMAKGALEGLTRSAALELAPLQIRVNGVGPGLSVLVD-DMPPAVWEGHRSKVPLYQRDSSAAEVSDVVIFLCSSKAKYITGTCVKVDGGYSLTRA AAB61214 -----MTAPTVPVALVTGAAKRLGSSIAEGLHAEGYAVCLHYHRSAAEANTLSATLNARRPNSAITVQADLSNVAKAPVSGADGSAPVTLFTRCAALVAACYTHWGRCDVLVNNASSFYPTPLLRSDEDGHEPCVGDREAMEAAAADLFGSNAIAPYFLIKAFAHRSR-HPSRAARTNYSIVNMVDAMTNRPLLGYTIYTMAKGALEGLTRSAALELAPLQVRVNGIGPGLSVLAD-DMPPAVREDYRSKVPLYQRDSSAAEVSDVVIFLCSSKAKYITGTCVKVDGGYSLTRA CAA78031 ----MTTSPTAPVALVTGAAKRLGSSIAEALHAEGYTVCLHYHRSAADASTLAATLNARRPNSAITVQADLSNVATASFSETDGSVPVTLFSRCSALVDACYMHWGRCDVLVNNASSFYPTPLLRKDAGEGGSSVGDKESLEVAAADLFGSNAIAPYFLIKAFAQRVADTRAEQRGTSYSIVNMVDAMTSQPLLGYTMYTMAKEALEGLTRSAALELASLQIRVNGVSPGLSVLPD-DMPFSVQEDYRRKVPLYQRNSSAEEVSDVVIFLCSPKAKYITGTCIKVDGGYSLTRA AAG09193 MNETSHEASECPAAIITGGARRIGHSIAVRLHQQGFRVVVHYRHSEGAAQRLVAELNAARAGSAVLCKGDLSLSS-------------SLLDCCEDIIDCSFRAFGRCDVLVNNASAYYPTPLLPGDDTNG---AAEAKPIDAQVAELFGSNAVAPLFLIRAFVRRQ-GEGSAWRSRNLSVVNLCDAMTDLPLPGFCVYTMAKHALGGPTRAAALELAPR----NAVAPGLSLLPP-QMPQETQEEYRRKVPLGQSEASAAQIADFIAFLVSKDAGYITGTTLKVDGGLILARA AAG09194 MNETSHEASECPAAIITGGARRIGHSIAVRLHQQGFRVVVHYRHSEGATQRLVAELNAARAGSAVLCKGDLSLSS-------------SLLDCCEDIIDCSFRAFGRCDVLVNNASAYYPTPLLPGDDTNG---AAEAKPIDAQVAELFGSNAVAPLFLIRAFARRQ-GEGSAWRSRNLSVVNLCDAMTDLPLPGFCVYTMAKHALGGPTRAAALELAPR----NAVAPGLSLLPP-QMPQETQEEYRRKVPLGQSEASAAQIADFIAFLVSKDAGYITGTTLKVDGGLILARA AAN62582 MNETSHEASECPAAIITGGARRIGHSIAVRLHQQGFRVVVHYRHSEGAAQRLVAELNAARAGSAVLCKGDLSLSS-------------SLLDCCEDIIDCSFRAFGRCDVLVNNASAYYPTPLLPGDDTNG---AAEAKPIDAQVAELFGSNAVAPLFLIRAFARRQ-GEGGAWRSRNLSVVNLCDAMTDLPLPGFCVYTMAKHALGGLTRAAALELAPRHIRVNAVAPGLSLLPP-AMPQETQEEYRRKVPLGQSEASAAQIADVIAFLVSKDAGYITGTTLKVDGGLILARA AAO18339 MNETSHEALECPAAIITGGARRIGHSIAVRLHQQGFRVVVHYRHSEGAAQRLVAELNAARAGSAVLCKGDLSLSS-------------SLLDCCEDIIDCSFRAFGRCDVLVNNASAYYPTPLLPGDDTNG---AAEAKPIDAQVAELFGSNAVAPLFLIRAFARRQ-GEGGAWRSRNLSVVNLCDAMTDLPLPGFCVYTMAKHALGGLTRAAALELAPRHIRVNAVAPGLSLLPP-AMPQETQEEYRRKVPLGQSEASAAQIADVIAFLVSKDAGYITGTTLKVDGGLILARA AAC38850 MNETSHEASECPAAIITGGARRIGHSIAVRLHQQGFRVVVHYRHSEGAAQRLVAELNAARAGSAVLCKGDLSLGS-------------SLLDCCEDIIDCSFRAFGRCDVLVNNASAYYPTPLLPGDDTNG---AADAKPIDAQVAELFGSNVVAPLFLIRAFARRQ-GEGDSWRSRNLSVVNLCDAMTDLPLPGFCVYTMAKHALGGLTRAAALELAPRHIRVNAVAPGLSLFPP-AMPQETQEEYRHKVPLGQSEASAAQIADAIAFLVSKDAGHITGITLKVDGGLILARA AAG09196 MNETSHEASECPAAIITGGARRIGHSIAVRLHQQGFRVVVHYRHSEGAAQRLVAELNAARAGSAVLCKGDLSLGS-------------SLLDCCEDIIDCSFRAFGRCDVLVNNASAYYPTPLLPGDDTNG---AADAKPIDAQVAELFGSNVVAPLFLIRAFARRQ-GEGGAWRSRNLSAVNLCDAMTDLPLPGFCVYTMAKHALGGLTRAAALELAPRHIRVNAVAPGLSLFPP-AMPQETQEEYRHKVPLGQSEASAAQIADAIAFLVPKDAGY?TGITLKVDGGLILARA AAG09195 MNETSHEASECPAAIITGGARRIGHSIAVRLHQQRFRVVVHYRHSEGAAQRLVAELNAARAGSAVLCKGDLSLSS-------------SLLDCCEDIIDCSFRAFGRCDVLVNNASAYYPTPLLPGDDRNG---AADAKPIDAQVAELFGSNVVAPLFLIRAFARRQ-GEGGAWRSHNLSVVNLCDAMTDLPLPGFCVYTMAKHAPGGLTRAAALELAPRHIRVNAVAPGLSLSPP-AMPQETQEEYRHKVPLGQSEASAAQIADAIAFLVSKDAGYITGITLKMDGGLILARA AAC23562 --------MEAPAAVVTGAAKRIGRAIAVKLHQTGYRVVIHYHNSAEAAVSLADELNKERSNTAVVCQADLTNSN-------------VLPASCEEIINSCFRAFGRCDVLVNNASAFYPTPLVQGDHED----NSNGKTVETQVAELIGTNAIAPFLLTMSFAQRQKGTNPNCTSSNLSIVNLCDAMVDQPCMAFSLYNMGKHALVGLTQSAALELAPYGIRVNGVAPGVSLLPV-AMGEEEKDKWRRKVPLGRREASAEQIADAVIFLVSGSAQYITGSIIKVDGGLSLVHA NP778899 ------MSDPSKVALITGGARRIGKAIVHHLHAHGYRVAVHAHQSGHELHAFLTELERTRPSITLALLGDLHENA-----------------VPETLIARCAGHFGRLDVLINNASNFYPTPL--------------GEVTPAQWDDLFAINAKAPFFLAQAATPLL-------RKHRGAIINLTDLHGTQPLRQHAVYTAAKAALEMLTRSLALELAPQ-VRVNAIAPGAILWPTQGIAEAAKQALLARTPLAR-TGTVEEIAEAVLWLLE-SANFITGHTLRLDGGRTLT-- NP641040 ------MTDSSKVVLITGAARRIGAQIATTLHAAGYCVALHAHRSAEVLDARVAELCAQRAGSAHALHADLRLPD-----------------APAQLVAGCLAAFGRLDGVVNNASAFYPTAI--------------GEATAAQWDDLFAVNARAPFFIAQAAAAQL-------RQRRGAIVNLTDLHAQQPMRNHPLYGASKSALEMLTRSLALELAPH-VRVNAVAPGAILWPEEGKSADAKHALLARTPLAR-IGTPEEIAEAVRWLLD-DASFVTGHTLHVDGGRQLS-- QUARTET PUZZLING TREE :---Q01782 :100: :100: :---A45168 : : :----100: :-------AAB61214 : : : :-----------CAA78031 : : :---AAC38850 : :-77: : :-93: :---AAG09196 :100: : : : : : :-------AAG09195 : : : : : : :---AAG09193 : : :100:-----91: : : : : :---AAG09194 : : : : : :100: :-----------AAN62582 : : : : : :-----------AAO18339 : : : :---------------AAC23562 : :-----------------------NP778899 : :-----------------------NP641040 P-type H+-ATPase AAL87542 T. cruzi AAB70152 T. cruzi AAL87541 T. cruzi P11718 L. donovani P12522 L. donovani AAP30857 T. brucei *BAC42716 Arabidopsis thaliana *CAC29435 Vicia faba *CAD29295 Oryza sativa AAL87542 MNQKN---DNSVLNNSNNGNFNEQHPPQKSQKRQSVLSKAIS-EHKEDGVD-EVPMLPPS-KGLTTAEAKELLAKYGRNELPEKKTPSWLIFARNLWGPMPFVLWVAIIIEFALEN-------WPDGAILLAIQLANATIGWYETIKAGDAVAALKNSLKPVATVHRDGTWQQLDAALLVPGDLVKLASGSAVPADCSINEGV-IDVDEAALTGESLPVTMGTDHMPKMGSNVVRGEVDGTVQYTGQNTFFGKTAVLLQSVESDLGNIHVILSRV-MVVLTSFSF-TLCLICFIYLMVKFKESFRRSLQFSVVVLVVSIPIALEIVVTTTLAVGSKKLSRHKIIVTKLTAIEMMSGVNMLCSDKTGTLTLNKMEIQDQ-CFTFEKGYDLRSVLVLAALAAKWREPPRDALDTMVLG-AADLDECDN-YTQTEFVPFDPTTKRTAATLVDKRTNEKFSVTKGAPHVIIQLVYNQDEINDQVVEIIDSLAARGVRCLSVAKT--------DSQGRWHLCGILTFLDPPRPDTKETIRRSKQYGVDVKMVTGDHVLIAKEMCRMLNLDPNILTADKLPKV-DVNDLPDDLGEKYGEMMLGVGGFAQVFPEHKFMIVEALRQYGFTCAMTGDGVNDAPALKRADVGIAVQGATDAARAAADMVLTGPGLSVVVEAMLVSRQVFQRMLSFLTYRISATLQLVCFFFIACFSLTPRNYGSVDADFQFFHLPVLMFMLITLLNDGCLMTIGYDRVVPSKLPQRWNLPVVFTIAIILAAVACSSSLMLLWIALEGWGEETYPNSWFKALGLAQLKQGKVVTLLYLKISISDFLTLFSSRTGGRWFFTMAPGLVLLIGAIISLFVSSMVASFWHTSRPDGLLTEGLAWG-DTNSERLLPLWVWIYCIVWWLIQDAVKVGAHMLMEWMDLFGCVSKAYGGKVVEQYMENKIT---EPAN---------------------------------------------------------------------- AAB70152 MNQKN---DKSVLNNSNNGNFNEQHPPQKPQKRQSVLSKAIS-EHKEDGVD-EVPMLPPS-KGLTTAEAEELLAKYGRNELPEKKTPSWLIFVRNLWGPMPFALWVAIIIEFALEN-------WPDGAILLAIQLANATIGWYETIKAGDAVAALKNSLKPVATVHRDGAWKQLDAALLVPGDLVKLASGSAVPADCSINEGV-IDVDEAALTGESLPVTMGTDHMPKMGSNVVRGEVDGTVQYTGQNTFFGKTAVLLQSVESDLGNIHVILSRV-MVVLTSFSF-TLCLICFIYLMVKFKESFRRSLQFSVVVLVVSIPIALEIVVTTTLAVGSKKLSRHKIIVTKLTAIEMMSGVNMLCSDKTGTLTLNKMEIQDQ-CFTFEKGHDLRSVLVLAALAAKWREPPRDALDTMVLG-AADLDECDN-YTQTEFVPFDPTTKRTAATLVDKRTNEKFSVTKGAPHVIIQLVYNQDEINDQVVEIIDSLAARGVRCLSVAKT--------DSQGRWHLCGILTFLDPPRPDTKETIRRSKQYGVDVKMITGDHVLIAKEMCRMLNLDPNILTADKLPKV-DVNDLPDDLGEKYGEMMLGVGGFAQVFPEHKFMIVEALRQYGFTCAMTGDGVNDAPALKRADVGIAVQGATDAARAAADMVLTGPGLSVVVEAMLVSRQVFQCMLSFLTYRISATLQLVCFFFIACFSLTPRNYGSADADFQFFHLPVLMFMLITLLNDGCLMTIGYDRVVPSKLPQRWNLPVVFTIAIILAAVACGSSLMLLWIALEGWSDETYPNSWFKALGLAQLKQGKVVTLLYLKISISDFLTLFSSRTGGRWFFTMAPGLVLLIGAIISLFVSSMVASFWHTSRPDGLLTEGLAWG-DTNSERLLPLWVWIYCIVWWLIQDAVKVGTHKLMEWMDLFGCVSRAYGGKVVEQYEDETPN---SGNKNESKEPTV-------------------------------------------------------------- AAL87541 -------------------------------------------------------MLPPS-KGLTTAEAEELLAKYGRNELPEKKTPSWLIFVRNLWGPMPFALWVAIIIEFALEN-------WPDGAILLAIQLANATIGWYETIKAGDAVAALKNSLKPVATVHRDGAWQQLDAALLVPGDLVKLASGSAVPADCSINEGV-IDVDEAALTGESLPVTMGTDHMPKMGSNVVRGEVDGTVQYTGQNTFFGKTAVLLQSVESDLGNIHVILSRV-MVVLTSFSF-TLCLICFIYLLAEFYETFRRSLQFSVVVLVVSIPLALEIVVTTTLAVGSKKLSRHKIVVTKLTAIEMMSGVNMLCSDKTGTLTLNKMEIQDQ-CFTFEKGYDLRSVLVLAALAAKWREPPRDALDTMVLG-AADLDECDN-YTQTEFVPFDPTTKRTAATLVDKRTNEKFSVTKGAPHVIIQLVYNPDEINDQVVEIIDSLAARGVRCLSVAKT--------DSQGRWHLCGILTFLDPPRPDTKETIRRSKQYGVDVKMITGDHVLIAKEMCRMLNLDPNILTADKLPKV-DVNDMPDDLGEKYGEMMLGVGGFAQVFPEHKFMIVEALRQYGFTCAMTGDGVNDAPALKRADVGIAVQGATDAARAAADMVLTGPGLSVVVEALLVSRQVFQCMLSFLTYRISATLQLVCFFFIACFSLTPRNYGSVDADFQFFHLPVLMFMLITLLNDGCLMTIGYDRVVPSKLPQRWNLPVVFTIAIILAAVACGSSLMLLWIALEGWGEETYPNSWFKALGLAQLKQGKVVTLLYLKISISDFLTLFSSRTGGRWFFTMAPGLVLLIGAIISLFVSSMVASFWHTSRPDGLLTEGLAWG-DTNSERLLPLWVWIYCIVWWLIQDAVKVGAHMLMEWMDLFGCVSKAYGGKVVEQYEDETSN---SGNKNESKEPTV-------------------------------------------------------------- P11718 MSSKKYELDAAAFEDKPESHSDAEMTPQKPQRRQSVLSKAVS-EHDERATGPATDLLPPS-KGLTTEEAEELLKKYGRNELPEKKTPSWLIYVRGLWGPMPAALWIAIIIEFALEN-------WPDGAILFAIQIANATIGWYETIKAGDAVAALKNSLKPTATVYRDSKWQQIDAAVLVPGDLVKLASGSAVPADCSINEGV-IDVDEAALTGESLPVTMGPEHMPKMGSNVVRGEVEGTVQYTGSLTFFGKTAALLQSVESDLGNIHVILRRV-MFSLCAISF-MLCMCCFIYLLARFYETFRHALQFAVVVLVVSIPIALEIVVTTTLAVGSKHLSKHKIIVTKLSAIEMMSGVNMLCSDKTGTLTLNKMEIQEQ-CFTFEEGNDLKSTLVLAALAAKWREPPRDALDTMVLG-AADLDECDN-YQQLNFVPFDPTTKRTAATLVDRRSGEKFDVTKGAPHVILQMVYNQDEINDEVVDIIDSLAARGVRCLSVAKT--------DQQGRWHMAGILTFLDPPRPDTKDTIRRSKEYGVDVKMITGDHLLIAKEMCRMLDLDPNILTADKLPQIKDANDLPEDLGEKYGDMMLSVGGFAQVFPEHKFMIVETLRQRGYTCAMTGDGVNDAPALKRADVGIAVHGATDAARAAADMVLTEPGLSVVVEAMLVSREVFQRMLSFLTYRISATLQLVCFFFIACFSLTPKAYGSVDPHFQFFHLPVLMFMLITLLNDGCLMTIGYDHVIPSERPQKWNLPVVFVSASILAAVACGSSLMLLWIGLEGYSSQYYENSWFHRLGLAQLPQGKLVTMMYLKISISDFLTLFSSRTGGHFFFYMPPSPILFCGAIISLLVSTMAASFWHKSRPDNVLTEGLAWG-QTNAEKLLPLWVWIYCIVWWFVQDVVKVLAHICMDAVDLFGCVSDASGSGPIKPYSDDMKVNGFEPVKKPAEKSTEKAL------NSSVSSASHKALEGLREDTHSPIEEASPVNVYVSRDQK--------------- P12522 MSSKKYELDAAAFEDKPESHSDAEMTPQKPQRRQSVLSKAVS-EHDERATGPATDLLPPS-KGLTTEEAEELLKKYGRNELPEKKTPSWLIYVRGLWGPMPAALWIAIIIEFALEN-------WPDGAILFAIQIANATIGWYETIKAGDAVAALKNSLKPTATVYRDSKWQQIDAAVLVPGDLVKLASGSAVPADCSINEGV-IDVDEAALTGESLPVTMGPEHMPKMGSNVVRGEVEGTVQYTGSLTFFGKTAALLQSVESDLGNIHVILRRV-MLALCAISF-ILCMCCFIYLLARFYETFRHALQFAVVVLVVSIPIALEIVVTTTLAVGSKHLSKHKIIVTKLSAIEMMSGVNMLCSDKTGTLTLNKMEIQEQ-CFTFEEGNDLKSTLVLAALAAKWREPPRDALDTMVLG-AADLDECDN-YQQLNFVPFDPTTKRTAATLVDRRSGEKFDVTKGAPHVILQMVYNQDEINDEVVDIIDSLAARGVRCLSVAKT--------DQQGRWHMAGILTFLDPPRPDTKDTIRRSKEYGVDVKMITGDHLLIAKEMCRMLDLDPNILTADKLPQIKDANDLPEDLGEKYGDMMLSVGGFAQVFPEHKFMIVETLRQRGYTCAMTGDGVNDAPALKRADVGIAVHGATDAARAAADMVLTEPGLSVVVEAMLVSREVFQRMLSFLTYRISATLQLVCFFFIACFSLTPKAYGSVDPNFQFFHLPVLMFMLITLLNDGCLMTIGYDHVIPSERPQKWNLPVVFVSASILAAVACGSSLMLLWIGLEGYSSQYYENSWFHRLGLAQLPQGKLVTMMYLKISISDFLTLFSSRTGGHFFFYVPPSPILFCGAIISLLVSTMAASFWHKSRPDNVLTEGLAWG-QTNAEKLLPLWVWIYCIVWWFVQDVVKVLAHICMDAVDLFGCVSDASGSGPIKPYSDDMKVNGFEPVKKPAEKSTEKAL------NLSVSSGPHKALEGLREDTHVLNESTSPVNAFSPKVKK--------------- AAP30857 MGDTG---PKGVPGTNDAG---EVHKPQKPQRRQSVLSKAIS-EHREGDDG-SVPLVPPS-KGLTSAEAEELLLKYGRNELPEKKTPSWLIFLRNLWGPMPIVLWIVIIIQFALQH-------FADGAVLLGIQLANALIGWYETIKAGDAVAALKNSLKPIATAYRDGTWQQIDAALLVPGDLVKLGSGSAVPADCTINEGV-IDVDEAALTGESLPVTMGTEHMPKMGSNVVRGEVDATVQYTGQSTFFGKTATLLQSVEADIGSIRIILMRV-MVISSSFSF-VLCLICFIYLMVNFKQKFRDALQFAVVVLVVSIPIALEIVVTTTLAVGSKKLSKHKIIVTRLTAIETMSGVNMLCSDKTGTLTLNKMEIQEQ-CFTFEKGHDLRSLLVLSALAAKWREPPRDALDTMVLG-AADLDECDN-YEQLEFVPFDPTTKRTAATLVDKRSGEKFSVTKGAPHVIIEMVHNQDEINDSVVDIIDKLASRGIRCLSVAKT--------DSAGRWHLCGILTFLDPPRPDTKETIRRSRQYGVDVKMITGDHVLIAKEMCRMLDLDPNILTAEKLPKV-DVNDMPSDLGEKYGDMMLSVGGFAQVFPEHKFLIVEALRQRGYTCAMTGDGVNDAPALKRADVGIAVQGATDAARAAADMVLTDPGLSVVVDAMFVSRQVFQRMLSFLTYRISATMQLVCFFFIACFSLTPHDYGIENPEFQVFYLPVMMFMLITLLNDGCLMTIGYDRVVPSKLPQRWNIPVVFTSAIIMSVVACASSLLLLWMALDAYDEKRYPNSWFGKLNIPSLKEGKIVTLLYLKISISDFLTLFSSRTGGRFFFSMAPGTILLVGAVISLVISTIAASVWKKSSSDGVPVEGLARG-ETVADRLYPLWVWIYCILWWIVQDVVKVLTHMLMEAFDIFGCVSRASGGKEIV-YNAKSSK---EPI----------------------------------------------------------------------- BAC42716 ---------------------MTTTVEDNREVLEAVLKEAVDLENVPIEEV--FENLRCSKEGLTTQAADERLALFGHNKLEEKKESKFLKFLGFMWNPLSWVMEAAAIMAIALANGGGKPPDWQDFVGIITLLVINSTISFIEENNAGNAAAALMARLAPKAKVLRDGRWGEQDAAILVPGDIISIKLGDIVPADARLLEGDPLKIDQSALTGESLPVTKSSGDGVYSGSTCKQGEIEAVVIATGVHTFFGKAAHLVDTTN-QIGHFQQVLTAIGNFCICSIAVGMLIEIVVMYPIQH--RAYRPGIDNLLVLLIGGIPIAMPTVLSVTMAIGSHRLSQQGAITKRMTAIEEMAGMDVLCSDKTGTLTLNKLTVDKNLIEVFMKGVDADTVVLMAARASRLEN--QDAIDAAIVGMLADPKDARAGIQEVHFLPFNPTDKRTALTYIDN-EGNTHRVSKGAPEQILNLAHNKSEIERRVHAVIDKFAERGLRSLAVAYQDVPEGRKDSAGGPWQFVGLMPLFDPPRHDSAETIRRALNLGVSVKMITGDQLAIGKETGRRLGMGTNMYPSSALLGQ-NKDESIVALP--VDELIEKADGFAGVFPEHKYEIVKRLQARKHICGMTGDGVNDAPALKKADIGIAVADATDAARSASDIVLTEPGLSVIISAVLTSRAIFQRMKNYTIYAVSITIRIVLGFMLLA--L-----------IWQFDFPPFMVLIIAILNDGTIMTISKDRVKPSPLPDSWKLSEIFATGVVFGSYMAMMTVIFFWVSYKTDFFPR-TFGVATLEKTAHDDFRKLASAIYLQVSIISQALIFVTRSRS-WSFVERPGIFLMIAFILAQLVATLIAVYANWS---FAAIEGIGWG----WAG----VIWLYNIIFYIPLDFIKFFIRYALSGRAWDLVIEQRVAFTRQKDFGKEQRELQWAHAQRTLHGLQAPDT-KMFTDRTHVSELNQMAEEAKRRAEIARLRELHTLKGHVESVVRLKGLDIETIQQAYTV CAC29435 -----------------------MAEEQKPETLQAVLKETVDLENIPIDEV--FENLRCSREGLTSEAAEQRLTIFGHNKLEEKRESKLLKFLGFMWNPLSWVMEAARIMAIALANGGNKAPDWQDFVGIITLLIINSTISFIDQNNAGNAAAALMASLAPKAKVLRDGRWSEQDAAILVPGDIISIKLGDIVPADARLLEGDPLKIDQSALTGESLPVTKAPGDGVYSGSTCKQGEIECVVIATGVHTFFGKAAHLVDTTN-QVGHFQKVLTAIGNFCICSIAVGMLIELVVMYPIQH--RRYRPGIDNLLVLLIGGIPIAMPTVLSVTMAIGSHRLSQQGAITKRMTAIEEMAGMDVLCSDKTGTLTLNKLTVDKNLVEVFAKGVDAETVVLMAARASRLEN--QDAIDTAIVGTLADPKEARAGIQEVHFLPFNPTDKRTALTYTDQ-EGKMHRVSKGAPEQILNLAHNKTDIERRVHAVIDKFAERGLRSLAVAYQEVPEGRKESPGSPWQFIGLMPLLHPPRHDSAETIRRALDLGVNVKMITGDQLAIGKETGRRLGMGTNMYPSSALLGQ-HKDESIAALP--VDDLIEKADGFAGVFPEHKYEIVKRLQARKHICGMTGDGVNDAPALKKADIGIAVADATDAARSASDIVLTEPGLSVIISAVLTSRAIFQRMKNYTIYAVSITIRIVLGFMLLA--L-----------IWKFDFPPFMVLIIAILNDGTIMTISKDRVKPSPLPDSWKLSEIFTTGVVLGRYLAMMTVIFFWAAYKTDFFPK-VFGVATLEKYAHDDFRKLASAIYLQVSTISQALIFVTRSRG-WSYVERPGLLLVAAFIVAQLIATLIAVYASWS---FAAIEGIGWG----WAG----VIWLYNIIFYIPLDFIKFFTRYALSGRAWDLVIEQRIAFTRQKDFGKEQRELQWAHAQRTLHGLQPPDT-KMFTERTHVTELNQMAEEAKRRAEIARLRELHTLKGHVESVVRLKGLDIDTIQQAYTV CAD29295 -------------------------MAEKGDNLEAVLNESVDLENIPLEEV--FEHLRCNREGLTSANAEQRLNLFGPNRLEEKKESKFLKFLGFMWNPLSWVMEAAAIMAIALANGGGKPPDWQDFVGIITLLIINSTISFIEENNAGNAAAALMARLAPKAKVLRNGRWSEEEAAILVPGDIISVKLGDIIPADARLLEGDPLKIDQSALTGESLPVTKGPGDGVYSGSTCKQGEIEAVVIATGVHTFFGKAAHLVDSTN-QVGHFQKVLTAIGNFCICSIAIGMVVEIIVMYPIQH--RDYRPGIDNLLVLLIGGIPIAMPTVLSVTMAIGSHRLAQQGAITKRMTAIEEMAGMDVLCSDKTGTLTLNKLTVDKSLIEVFQRGVDQDTVILMAARASRTEN--QDAIDATIVGMLADPKEARAGIQEVHFLPFNPTDKRTALTYIDG-EGKMHRVSKGAPEQILNLAHNKTEIERRVRAVIDKFAERGLRSLGVAYQQVPDGRKESPGGPWQFVGLLPLFDPPRHDSAETIRRALNLGVNVKMITGDQLAIGKETARRLGMGTNMYPSSALLGQ-DKDESIVALP--VDELIEKADGFAGVFPEHKYEIVKRLQARKHICGMTGDGVNDAPALKKADIGIAVDDSTDAARSASDIVLTEPGLSVIISAVLTSRAIFQRMKNYTIYAVSITIRIVLGFMLLA--L-----------IWKFDFPPFMVLIIAILNDGTIMTISKDRVKPSPQPDSWKLSEIFATGVVLGSYLAMMTVIFFWVAYKTDFFPR-VFHVESLEKTAQDDFQKLASAVYLQVSTISQALIFVTRSRS-WSFVERPGFLLVFAFFVAQLIATLIAVYANWG---FASIKGIGWG----WAG----VIWLYNIVFYLPLDIIKFLIRYALSGRAWDLVLEQRIAFTRKKDFGTQENQLKWATAQRTIHGLQPAATAAVFRDMTSYNDLNQLAEEARRRAEIARLRELTTLKGRMESVVKQKGLDLETIQQSYTV QUARTET PUZZLING TREE :---P11718 :----100: : :---P12522 :-91: : : :---AAL87542 : : :-67: :100: :-98: :---AAB70152 : : : : : :-------AAL87541 : : : :---------------AAP30857 : : :---BAC42716 :-------------76: : :---CAC29435 : :-------------------CAD29295 Ribosomal protein P0 P39096 L. donovani chagasi P39097 L. infantum P26796 T. cruzi BAB39163 T. congolense *P50346 Glycine max *NP_187531 Arabidopsis thaliana P39096 -MPSITTAKR--EYEERLVDCLTKYSCVLFVGMDNVRSQQVHDVRRGCRGKAEFIMGKKTLQAKIVEKRAQAKDASPEAKPFNDQCEEYNLLSGNTGLIFTNNAVQEITSVLDGHRVKAPARVGAI-PCDVVVPAGSTGMEPTQTSFFQALNIATKIAKGMVEIVTEKKVLSVGDKVDNSTATLLQKLNISPFYYQVNVLSVWDRGVLFTREDLMMTEDMVEKMLMEGLSNVAAMALGAGIPTSSTIGPMLVDAFKNLLAVSVATSYEFEEHN-GKELREAAINGLLAG-SGSAAAEPAAAAPAAPSAAAKEE-------------PEES---DEDDFGMGGLF---- P39097 -MPSITTAKR--EYEERLVDCLTKYSCVLFVGMDNVRSQQVHDVGRALRAKAEFMMGKKTLQGKIVEKRAQAKDASPEAKHFNDQCEEYNLLSGNTGLIFTNNAVQEITSVLDAHRVKRAARVGAISPCDVIVAAGSTGMEPTQTSFFQALNIATKIAKGMVEIVTEKKVLSVGDKVDNSTATLLQKLNISPFYYQVNVLSVWDRGVLFTREDLMMTEDMVEKMLMEGLSNVAAMALGAGIPTSSTIGPMLVDAFKNLLAVSVATSYEFEEHN-GKELREAAINGLLAG-SCSAAAEPAAAAPAAPSAAAKEE-------------PEES---DEDDFGMGGLF---- P26796 -MPSVSEAKR--EYEERFNGCLTKYGRVLFCLMDNVRSQQVHDVRRDLRGLGELVMGKKTLQKKIVERRAEDKKASAYDKLLYNTCIEKKLLCGNTALIFTNEEIPVITAVLDKHRVQAPARVGAIAPCDVIVPAGNTGMEPKATSFFQALNIATKIAKGTVEIVSDKKVLSVGDRVDNSTATLLQKLDISPFYYQVEVQSVWDRGMLFLREDLSITDDVVEKYLLEGISNVAALSLGAGIPTAATLPHMIMDAFKTLLGASVATEYEFDEFD-GKNLRKAALEGNLGGGVADAAAAADTGAAAAPAAAAEPE--------------EED---DDDDFGMGALF---- BAB39163 -MPSISQEKR--DYEDRLNGCLTKYSRVLFCLMDNVRSQQVHGVRRDLRGKGELVMGKKTLQKKIVEKRAEDSKATDSDKLFHQTCADKQLLCGNTSMIFTNEDVTEITKVLDGHRVQAPARVGAIAPCDVIVPAGNTGMEPKATAFFQALNIATKISKGTVEIVSDKKVLSTGDKVDNSTATLLQKLDISPFYYQVEVQSVWDRGVLFTREDLAVTDDVVEKYLLEGISNISAMSMGAGIPTAATLPHMIVDAFKTLLGASVATNYEFEEYD-GKNLRQAALEGKLGGGAAPAASSGGAAAAAAPAAAALPLRLRKRRKTTTLAWALSSKKCNGDLIDFFSNFFPFS P50346 MAPKQTKAEKKIAYDAKLCDLMEEYGQILVVNSDNVGSNQLQNIRKGLRGDSVVLMGKNTMMKRSVRMHAEKTGNNAYLNLIP-------LLVGNVGLIFTKGDLKEVSEEVAKYKVGAPARVGLVAPIDVVVPPGNTGLDPSQTSFFQVLNIPTKINKGTVEIITPVELIRKGDKVGSSEAALLAKLGIRPFSYGLVVLSVYDNGSVFSPEVLDLTEDDLIGKFAAGVSMVTSLSLAISYPTLAAAPHMFVNAYKNVLAVAVETDYSFPEADKVKEYLKDPSKFAVAA-VAAPAAASGAPAAAAKEEEKKEEP------------AEES-----DDDMGFSLFD--- NP187531 -MVKATKAEKKIAYDTKLCQLIDEYTQILVVAADNVGSTQLQNIRKGLRGDSVVLMGKNTMMKRSVRIHSENTGNTAILNLLP-------LLQGNVGLIFTKGDLKEVSEEVAKYKVGAPARVGLVAPIDVVVQPGNTGLDPSQTSFFQVLNIPTKINKGTVEIITPVELIKQGDKVGSSEAALLAKLGIRPFSYGLVVQSVYDNGSVFSPEVLDLTEDQLVEKFASGISMVTSLALAVSYPTLAAAPHMFINAYKNALAIAVATEYTFPQAEKVKEYLKDPSKFAVAS-VAAVSADAGGGAPAAAKVEEKEE-------------SDEE-----DYGGDFGLFDEE- QUARTET PUZZLING TREE :---P39096 :100: : :---P39097 :100: : : :---P26796 : :100: : :---BAB39163 : :-----------P50346 : :-----------NP187531 S-adenosyl methionine decarboxylase AAA61968 L. donovani AAF67754 L. infantum AAC26796 T. cruzi P50244 T. brucei *AAM08497 Dictyostelium discoideum *AAF52917 Drosophila melanogaster AAA61968 ----------MNVCSNTTKDPLTLMAMWGSMKGYNPE-QGFSFEGPEKRLEV----ILR-----CTLETHVDGLRSLDDSVWSGVVGSLNAQIVSRESNEYINSYVLTESSLFVMKNRIILITCGTTTLLNSIPNILEAISAVRG--ELEWVSFMHKNYSFPWMQKGPHTSLADEFATLKQHFPTGKPYIFGPVDSDHYFLF---CYDDIIRP-CSSE-------DDTQLSMTMYGLDKEQTKHWFSDRFISTSAETAAIRAATHLDRVVDGTWTLHDLQFEPCGYSINAIRDE-EYQTMHITPEDHCSFASYETNSRAANYSDRMKKVLGVFRPQRFTVIVFLDPESPVGKAYNEGKGIGVEPEYYPEYNLLHRTTNEFAPGYVAMKINY--VRTAAVEETDTAVGGAEPGAEGGPD- AAF67754 MKHGNYSLATMNVCSNTTKDPLTLMAMWGSMKGYNPE-QGFSFEGPEKRLEV----ILR-----CTLETHVDGLRSLDDSVWSGVVGSLNAQIVSRESNEYINSYVLTESSLFVMKNRIILITCGTTTLLNSIPNILEAISAVRG--ELEWVSFMHKNYSFPWMQKGPHTSLADEFATLKQHFPTGKPYIFGPVDSDHYFLF---CYDDIIRP-CSSE-------DDTQLSMTMYGLDKEQTKHWFSDRFISTSAETAAIRAATHLDRVVDGTWTLHDLQFEPCGYSINAIRDE-EYQTMHITPEDHCSFASYETNSRAANYSDRMKKVLGVFRPQRFTVIVFLDPESPVGKAYNEGKGIGVEPEYYPEYNLLHRTTNEFAPGYVAMKINY--VRTAAVEETVTAVGGAEAGAEGGPD- AAC26796 ------------MLSN--KDPLSLMAMWGSVKGYDPN-QGASFEGPEKRLEV----IMR-----ITDETHSEGLHALGDGVWKGVVGSLNAQIVSKESNEYIRSYVLTESSLFVMRDRIILITCGTTTLLNAVPFVLDAVSDVRG--EVEWVSFMHKNYSFPWEQKGPHLSMAEEFNTLRTYFPSGKPFIFGPVDSDHYFLF---VYDDVIRP-CETE-------NDTQLSMTMYGLDRTQTKHWFSDRFISTGTETAAIRKATKLNKVADDSWKLHDLQFEPCGYSINTIRGA-EYQTIHITPEDHCSFASYETNTPAVNYSERINTVLGVFAPIRFSVIVFIDPDSDVGRLYQKGQNVGVEAEYYPKYELQNRTVNEFAPGYVVMKMNY--ARRAEVAEKDSTDSVEE--------- P50244 -------------MSS-CKDSLSLMAMWGSIARFDPK-HERSFEGPEKRLEV----IMR-----VVDGTHVSGLLAHDDDVWQKVIDAICAHIVSREFNEYIRSYVLSESSLFVMKDRVILITCGTITLLNCVPLICEAVSTVCG--EVEWVSFMHKNYSFPWEQKGPHLSMAEEFKTLRSHFPSGQPFIFGPIDSDHYFLY---LDSDVVQPSCS---------DDAQLSMTMYGLDRNQTKHWYSDKMLPTGPETAVIREATGLSEVVDDSWILHDLQYEPCGYSINAIRGS-EYQTIHITPEEHCSFASYETNTCALNYSKCICGVLRVFDPERFSVIVFIDPDSAVGKSYHSGGTIGVEPEYYPNYEAHHRTVNEYTPGHWVLKVNY--VKRAVGTVGTSAASGAKE-------- AAM08497 -------MENNNDYKN-RSTEIFNEADAGFVYQSNSNDYSDGFEGPEKKLDIRFGPISKGSVKSIAGSPSKVGLRTIDKEKWQTVLDSARCTIISQTSNDHMDSYVLSESSLFVYPRRAMIKTCGTTTLLHLIAKMVQ-VGKECGL-EVEMVVFSRKNLNQPSKQVFPHCSFSDEVNFLNKIFD-GQAYVMGDVNKDHWNLY---IADFRKNP-TLQR-------TEQTFEVMMHDLDETVMKQFFKREGVS-AWDTTVN---SGIADLLPGS-MIDDFQFDPCGYSMNGLLNE-FYWTIHITPESHCSYVSFDTNVALADYNQLLAKVLNVFKPGRFTAALYAEDGAPCGDPYT---AFDVN---VPSYAIQNKTVHGFDGGYDVVVSNYQQLDKKVNFSNDDLIQSIESTNIDLIQV AAF52917 ---------------------------------MLEN-GSHFFEGVEKLLEI----WFE------ESSNGDDDLRNISRSDWENVLSNVNCQIISTSKNDIIDAFVLSESSMFVSKRRWILKTCGTTTPLKCLGQLLK-LAEANGYNVVADLFYSRKNFTRPEAQITPHQGFTEEVTYLDSIFPNGRSYCLGSMNLECWYLYTFSRSDIKITPQLISDEKNVDSDPDQTIEILMQDLDPETMSIFYKNKFND-ANGATVK---SGIDTILPTM-HIDDFLFDPCGYSMNGINDKGEYMTIHITPENQFSYVSFETNVALSNYRKLINQVINTFKPGKFIVTIFAN---KCSLAYETMKELEVEYSQGSHWKRTDMQCCNF-PSYNLLFAQY---SHSEKTG-DNL-------------- QUARTET PUZZLING TREE :---AAA61968 :-74: : :---AAF67754 :100: : : :---AAC26796 : :-72: : :---P50244 : :-----------AAM08497 : :-----------AAF52917 THT P13865 L. enrietti AAC70946 L. mexicana Q06221 T. brucei Q06222 T. brucei AAC32782 T. congolense Q27115 T. vivax AAA21207 T. cruzi *AAO50932 Dictyostelium discoideum P13865 MSDRVEVNE----RRS---------DSVSEKE-----------------------PAR--DDARKDVTDDQEDAP---PFMTANNARVMLVQAIGGSLNGYSIGFVGVYSTLFGYSTNCASFLQENSCTTVPNADCKWFVSPTGSSY-CGWPEVTCRKEYAYSSPAEMPGALARCEADSRCRWSYSDEECQNPSGYSSSESGIFAGSMIAGCLIGSVFAGPLASKIGARLSFLLVGLVGVVASVMYHASCAADEFWVLIVGRFVIGLFLGVICVACPVYTDQNAHPKWKRTIGVMFQVFTTLGIFVAALMGLALGQSIRFDHDGDQKVMARMQGLCVFSTLFSLLTVVLGIVTRESRAKFDGG--EEGRAELNPS----EYGYVEMIPRLLMGCVMAGTLQLTGINAVMNYAPTIMGSLGLA-PLVGNFVVMLWNFVTTLASIPLSYVFTMRHVFLFGSIFTSCMCLFMCGIPVYPGVSKKLEAKNGVAITGILLFILGFEVCVGPCYYVLTQDMFPPSFRPRGASFTQVAQFIFNLIINVCYPIATESISGGPSGNQDKGQAVAFIFFGGLGLICFVIQVFFLHPWDEE--------------RDGKK-VVAPAIGKKELSEESIGNRAE-- AAC70946 MLPPPQIPQPLKPKKVKLPHTSHAASSFQPSKRHLTPLPLQESKYISEKVPNPMKPPIADGIDEFVEESISPNKELSPSFFSISNFRMIMVQAIGGCLNGYSIGFVGVYSTLFGYSTNCANFRSERGCTTAPNADCQWFANATGTSY-CGWPEITCRRTYTYSSVAEMPGAIAQCEADSRCRWSYSAKECQNPSGYSSSESGIFAGSMIAGCLIGSVFAGPLASTIGARLSFLLVGLVGVVSSVMCHVSASENEFWVLVVGRFVIGLFVGVIGVACPVYTDQNAHPKWKRTIGVMFQVFTTLGIFIAAAVGLALGQSTYFDRNKDQMVMARMQGLCAFSTLFSLLTILLGIVMSESRAKFGGDD-EEGGIELDPN----EYSYVEMVPRLLMGAVMAGTLQLTGINAVMNYAPAIMGSLGLA-PLVGNFVVMLWNFVTTLASIPLSYVFTMRQLFLFGSLFTSSMCLFMCGIPVYPGVSKKTEVKNGVAITGILLFILGFEVCVGPCYYVLTQDMFPLSFRPRGASFTQVAQFIFNLIINVCYPIATEHISGGPSGNQDKGQAVAFIFFGCVGMICFIIQVFFLHPWDEK--------------RDGKKRPATPAGGKRELSSSLSGNRAE-- Q06221 -------------------------------------------------MTERRDNVSHAPDAIEGPNDGAHAEDTSPGFFSLENLGVAQVQVVGGTLNGYVIGYVAVYLLLYLTATECK-FTTEGACGGRKIYGCKWSGT------TCKFENPKCSEGSDPS------------------------DSCKNEVAYTSVYSGIFACAMIVGSMVGSIIAGKCITTFGLKKSFIIVSITCTIACVVVQVAIEYNNYYALCTGRVLIGLGVGILCSVFPMYVNENAHPKLCKMDGVLFQVFTTLGIMLAAMLGLILDKTGASKE--EANMAGRLHVFSAVPLGLSVAMFLVGMFLRESTATFAQDDDGKADGGMDPN----EYGWGQMLWPLFMGAVTAGTLQLTGINAVMNYAPKITENLGMD-PSLGNFLVMAWNFVTSLVAIPLASRFTMRQMFITCSFVASCMCLFLCGIPVFPGVAGKE-VKNGVATTGIALFIAAFEFGVGSCFFVLAQDLFPPSFRPKGGSFVVMMQFIFNILINLLYPITTEAISGGATGNQDKGQAVAFILFGLIGLICSVLQFFYLYPYDAN-------------QDHENDHGGEPVEQKTYPVEAS-PRN---- Q06222 -------------------------------------------------MTERRDNVSHAPDAIEGPNDGAHAEDTSPGFFSFENLGVAQVQVVGGTLNGFSIGFVAVYILLYEVATNCSLFKTTEACKAVGSYGCEWKDTE-----VCSWKK-ECDSDSDGV------------------------NPCESLIGYSSLYSGIFASAMIVGSMVGSIIAGKCITMFGLKKSFIIVGVMSVVASALNHISVATNEFWVLCAGRVLMGIGLGVVCVICPMYVNENAHPKLSKVDGVLFQVFITFGIMLAAMLGLILDKTVNYDN--DPDMAGRFHGFCAVSSVLSVAMFLVGMFLRESTATFSQDDDGKADGGMDPN----EYGWGQMLWPLFMGAVTAGTLQLTGINAVMNYAPKITENLGMD-PSLGNFLVMAWNFVTSLVAIPLASRFTMRQMFITCSFVASCMCLFLCGIPVFPGVAEEK-VKNGVATTGIALFIAAFEFGVGSCFFVLAQDLFPPSFRPKGSSFVVMMQFIFNILINLLYPITTEAISGGATGDQDKGQAVVFILFGLIGLICFVLQFFYLYPYDAN-------------QDHENDHGTEPVERILSPVDVPTPRN---- AAC32782 -------------------------------------------------MSDAQEGRERAPDTVMVSPDEVH-EDNAPRFFSAENLGVVQVQVIGGTLNGFSIGFVAVYLMLYEVSTNCSLAKAGASCEGMKNVKCKWSDDD-----GCTWAN-ACDSVRDP-------------------------NVCLDKVGYDALHSGIFASSMIVGSMIGSIVTERFITMFGLKKSFLIVAIIGVVASAMNHIAVGTDEFWVLCPARLLMGLGLGIVCVLCPMYVNENAHSKHRKVDGVMFQVFITFGIMLAALLGLALYYTVDYET--NVAMVDRLHGFCAVSSILAVVMFIAGIFLRESKTKFVNEGSGKVEGELDPN----EYSWGEMMWPLFMGTMTAGTLQLTGINAVMNYAPKITENLGMD-PPLGNFLVMMWNFVTALVAIPLASRFTMRQMFITCSFIASCTCLFLCGIPVFPGVAEES-VKNGVATTGIALFIAAFEFGVGSCFFVLAQDLFPPSFRPKGASFVVMMQFVFNILVNLLYPITTEAISGGASGNQDKGQAVSFILFGLIGLVCFVLQYFYLYPYEAK-------------SVEGSPS--DPQQRMASPIEVATPRN---- Q27115 -------------------------------------------------MPEYPTEDTNASGKTSGSSPDDHTDDNAPSFFSCENLCIVQVPVSTGSLNGFSIGFVAVYMHLYEIFSGCSALESSGACSG--NSKCTWIPNNS----TCVWKD--CNGAAGA-------------------------TTCKDGSGYNSLESGLFACSMIVGSMIGSIFAGKFLSKFGLKMSFIVSGVLGIVGSALIHVATRGSTLWVMCVGRFLMGLVLGLVCVASPMYVNENAHPKYRKTIGVLFQVFTTFGIMFAALLGLAIVKTPGHDK--ASGLLWRMQVFCSVSTALSALLLVLGLVVRKSKTSFAGGVDSAGEGVLDPN----EYSVRQMLGPLAVGAVTAGTLQLTGINAVMNYAPEIMRNIGMD-PMEGNSAVMSWNFVTALVAIPLVSRFTMRQLFLACSFMASCACLIMCGIPVYPGVASVD-NRNIVATVGIAVFIAAFEFGVGSCFFVLAQDLFPRSFRPTGSSFVVMAQFIFNIMINLLYPITVEAISGGKGKSPEKGQSVSFIIFGIIGIICFVLQLRYLTPWEDGQGTSTSPTARCNAPTSPNNGEGEPATADMSPVEMSTPKHSGAA AAA21207 -------------------------------------------------MPSKKQTDVSVGDRQ---------PDETLTFCSLENLKVAQVQVVGGTLNGFSIGFVAVYAYFYLMSTDCSMYKKEVACNRVLNAECSWNKTRG----ECGWNGFTCFLGHGKDK--------TPCLDDSRCKWVYSDEECKNPTGYSSSYNGIFAGAMIVGAMIGSIYAGQFAARFGHKVSFLIVGIVGVVSSVMYHVSSATNEFWVLCVGRLLIGVVLGLVNVACPMYVDQNAHPKFLHVDGVLFQVFTTFGIMFAAAMGLAIGQSVNFDK--DIKMDARMQGYCAFSTLLSVLMVALGIFLGESKTKFTSGKHEDDGTALDPN----EYSYLQMLGPLAMGLVTSGTLQLTGINAVMNYAPKIMGNLGMV-PLVGNFVVMAWNFVTTLVSIPLARVLTMRQLFLGASLVASVSCLLLCGVPVYPGVADKN-VKNGVAITGIAVFIAAFEIGLGPCFFVLAQELFPRSFRPRGSSFVLLTNFIFNVIINVCYPIATEGISGGPSGNQDKGQAVAFIFFGCIGLVCFVLQVFFLYPWEES-----TP------QNHGDTNEESALPERQSPIEVATPGNRQAA AAO50932 -------------------------------------------------------------------------------------------------------------MKYLANISNKSWLIVTQSCLG--GLVFGYATG-------------IIVGTLDP---------------------------IAIKFNTSTVIKGVIVCSILVGALIGSFAGGFAANKFGRKPLLLFTALTCICGAIGSGLGEN---VATICILRFIHGLGVGSSSSVCPLMVAEMVPIKRRGIFGSFFQISITVGILIANILAYVIKGNWRLMFCLGSIPGGLLFFVWFVIAESPVFLAKKSAKTTTTTNQESNENQIETQPQNNQGTKFTIIFSKKMRKPMLVGVLLATLAQLTGINAFMYFSNTIFKDAGINNPEIASVALQVWNVLTTLIAIFLVDKLGRRVLLFTGSIVMTTCDLLIALFFVVLTGSAKG--WSSIVFL--FIFVGAFEASIGTLFWFVINEILPEDSKSIGAPVINACQWTFNTILSFFFLVVVEYL----------GQSTMFWIFGGIGVFCTIFLYFNLPKSLGTSKNTTEDISIPQDQLEQTIEELENEKNNEINSSKLPPAQMQA- QUARTET PUZZLING TREE :---P13865 :100: :-96: :---AAC70946 : : : :-------AAA21207 :-78: : : :---Q06221 : : :-91: : :-82: :---Q06222 : : : :-------AAC32782 : :---------------Q27115 : :---------------AAO50932 TPIS P48499 L. mexicana AAM20942 L. infantum P52270 T. cruzi CAA27559 T. brucei *P12863 Zea mays *P48491 Arabidopsis thaliana P48499 MSAKPQPIAAANWKCNGTTASIEKLVQVFNEHTIS--HDVQCVVAPTFVHIPLVQAKLRNPKYVISAENAIAKSGAFTGEVSMPILKDIGVHWVILGHSERRTYYGETDEIVAQKVSEACKQGFMVIACIGETLQQREANQTAKVVLSQTSAIAAKLTKDAWNQVVLAYEPVWAIGTGKVATPEQAQEVHLLLRKWVSENIGTDVAAKLRILYGGSVNAANAATLYAKPDINGFLVGGASLKPEFRDIIDATR----- AAM20942 MSSKPQPIAAANWKCNGTTASIEKLVQVLNEHNIS--HDVQCVVAPTFVHIPLVQAKLRNPKYAVSAENAIAKSGAFTGEVSMPILKDLGINWVILGHSERRTYYGETDEIVAQKVADACKQGFMVIACIGETLQQREANQTAKVVLSQTSAIATKLPTEAWDQIVLAYEPVWAIGTGKVATPEQAQEVHALLRKWVSEKIGADVAARLRILYGGSVSAGNAKTLYMKPDINGFLVGGASLKPEFRDIIDATR----- P52270 MASKPQPIAAANWKCNGSESLLVPLIETLNAATFD--HDVQCVVAPTFLHIPMTKARLTNPKFQIAAQNAITRSGAFTGEVSLQILKDYGISWVVLGHSERRLYYGETNEIVAEKVAQACAAGFHVIVCVGETNEEREAGRTAAVVLTQLAAVAQKLSKEAWSRVVIAYEPVWAIGTGKVATPQQAQEVHELLRRWVRSKLGTDIAAQLRILYGGSVTAKNARTLYQMRDINGFLVGGASLKPEFVEIIEATK----- CAA27559 -MSKPQPIAAANWKCNGSQQSLSELIDLFNSTSIN--HDVQCVVASTFVHLAMTKERLSHPKFVIAAQNAIAKSGAFTGEVSLPILKDFGVNWIVLGHSERRAYYGETNEIVADKVAAAVASGFMVIACIGETLQERESGRTAVVVLTQIAAIAKKLKKADWAKVVIAYEPVWAIGTGKVATPQQAQEAHALIRSWVSSKIGADVAGELRILYGGSVNGKNARTLYQQRDVNGFLVGGASLKPEFVDIIKATQ----- P12863 -MGR-KFFVGGNWKCNGTTDQVEKIVKTLNEGQVPPSDVVEVVVSPPYVFLPVVKSQLRQEFHVAAQNCWVKKGGAFTGEVSAEMLVNLGVPWVILGHSERRALLGESNEFVGDKVAYALSQGLKVIACVGETLEQREAGSTMDVVAAQTKAIAEKIK--DWSNVVVAYEPVWAIGTGKVATPAQAQEVHASLRDWLKTNASPEVAESTRIIYGGSVTAANCKELAAQPDVDGFLVGGASLKPEFIDIINAATVKSA- P48491 -MAR-KFFVGGNWKCNGTAEEVKKIVNTLNEAQVPSQDVVEVVVSPPYVFLPLVKSTLRSDFFVAAQNCWVKKGGAFTGEVSAEMLVNLDIPWVILGHSERRAILNESSEFVGDKVAYALAQGLKVIACVGETLEEREAGSTMDVVAAQTKAIADRVT--NWSNVVIAYEPVWAIGTGKVASPAQAQEVHDELRKWLAKNVSADVAATTRIIYGGSVNGGNCKELGGQADVDGFLVGGASLKPEFIDIIKAAEVKKSA QUARTET PUZZLING TREE :---P52270 :100: : :---CAA27559 :100: : : :---P48499 : :-92: : :---AAM20942 : :-----------P12863 : :-----------P48491 Trypanothione reductase CAC94295 L. donovani CAB89598 L. major P39040 Crithidia fasciculata P39051 T. brucei P13110 T. congolense P28593 T. cruzi AAK71226 T. vespertilionis *P48642 Oryza sativa *AAK96868 Arabidopsis thaliana CAC94295 -------------------------------------------------------------------------------MS----RAYDLVVLGAGSGGLEAGWNPAVTHKKKVGPSSMCRRR--TVRRSSLGGTCVNVGCVPKKLMVTGAQYMDLIRESGGFGWEMDRESLCPHWKTLIAAKNKVVNSIYESYKSMFADTEGLSFHMGFGAINTLTRWWCASRKTHTATCWDPRHGLHPHCHRLLADAPRS-PRRRVLHHE-----QRGFYLEDAPKRMLCVGGCYIAVEFAGIFNGYKPQGGYVDLCYRGDLILRGFDTEVRKSLTKQLGANGIRVRTNLNPTKITKNEDGSNHVHFNDGTEEDYDQVMLAIGRVPRSQALQLAKAGVRTGKNGAVQVDAYSKTSVDNIYAIAIGDVTNRVMLTPVAINEGAAFVETVFGGKPRATDHRKVACRVFSIPPIGTCGMTEEEAAKNYE-TVAVYASSFTPLMHNISGSKHKEFTIRIITNESNGEVLGVHMLGDSAPEIIQSVGICMQMGAKISGFHSTIGVHPTSAEELCSMRTPAYFYE------SGKRVEKLS-SNL CAB89598 -------------------------------------------------------------------------------MS----RAYDLVVLGAGSGGLEAGWNAAATYKKKVAVVDVQATHG-PPFFAALGGTCVNVGCVPKKLMVTGAQYMDLIRESGGFGWEMNRESLCPNWKTLIAAKNKVVNGINESYKSMFADTEGLSFHMGFGALQDAH--TVLVRKSEDPNS-DVLETLDTE-YILIATGSWP-TRLGVPGDEFCITSNEAFYLEDAPKRMLCVGGGYIAVEFAGIFNGYKPRGGYVDLCYRGDLILRGFDTEVRKSLTKQLGANGIRVRTNLNPTKITKNEDGSNHVHFNDGTEEDYDQVMLAIGRVPRSQTLQLDKAGVQTAKNGAVQVDAYSKTSVDNIY--AIGDVTNRVMLTPVAINEGAAFAETVFGGKPRATDHTKVACAVFSIPPIGTCGMTEEEAAKNHE-TVAVYESCFTPLMHNISGSKHKEFMIRIITDQPSGEVLGVHMLGDSAPEIIQSVGICMKMGAKISDFHNTIGVHPTSAEELCSMRTPAYFYE------NGKRVEKLS-SNL P39040 -------------------------------------------------------------------------------MS----RAYDLVVIGAGSGGLEAGWNAASLHKKRVAVIDLQKHHG-PPHYAALGGTCVNVGCVPKKLMVTGANYMDTIRESAGFGWELDRESVRPNWKALIAAKNKAVSGINDSYEGMFADTEGLTFHQGFGALQDNH--TVLVRESADPNS-AVLETLDTE-YILLATGSWP-QHLGIEGDDLCITSNEAFYLDEAPKRALCVGGGYISIEFAGIFNAYKARGGQVDLAYRGDMILRGFDSELRKQLTEQLRANGINVRTHENPAKVTKNADGTRHVVFESGAEADYDVVMLAIGRVPRSQTLQLDKAGVEVAKNGAIKVDAYSKTNVDNIY--AIGDVTDRVMLTPVAINEGAAFVDTVFANKPRATDHTKVACAVFSIPPMGVCGYVEEDAAKKYD-QVAVYESSFTPLMHNISGSTYKKFMVRIVTNHADGEVLGVHMLGDSSPEIIQSVAICLKMGAKISDFYNTIGVHPTSAEELCSMRTPAYFYQ------KGKRVEKID-SNL P39051 -------------------------------------------------------------------------------MS----KIFDLVVIGAGSGGLEAGWNAATLYKKRVAVIDVQTHHG-PPHYAALGGTCVNVGCVPKKLMVTGAQYMDHLRESAGFGWEFDGSSVKANWKKLIAAKNEAVLDINKSYEGMFNDTEGLDFFLGWGSLESKN--VVVVRETADPKS-AVKERLQAD-HILLATGSWP-QMPAIPGVEHCISSNEAFYLPEPPRRVLTVGGGFISVEFAGIFNAYKPPGGKVTLCYRNNLILRGFDETIREEVTKQLTANGIEIMTNENPAKVSLNTDGSKHVTFESGKTLDVDVVMMAIGRIPRTNDLQLGNVGVKLTPKGGVQVDEFSRTNVPNIY--AIGDITDRLMLTPVAINEGAALVDTVFGNKPRKTDHTRVASAVFSIPPIGTCGLIEEVAAKEFE-KVAVYMSSFTPLMHNISGSKYKKFVAKIVTNHSDGTVLGVHLLGDGAPEIIQAVGVCLRLNAKISDFYNTIGVHPTSAEELCSMRTPSYYYL------KGEKMETLPESSL P13110 -------------------------------------------------------------------------------MS----KAFDLVIIGAGSGGLEAGWNAATLYKKRVAVVDVQTVHG-PPFFAALGGTCVNVGCVPKKLMVTGAQYMDQLRESAGFGWEFDASTIKANWKTLIAAKNAAVLDINKSYEDMFKDTEGLEFFLGWGALEQKN--VVTVREGADPKS-KVKERLQAE-HIIIATGSWP-QMLKIPGIEHCISSNEAFYLEEPPRRVLTVGGGFISVEFAGIFNAYKPVGGKVTLCYRNNPILRGFDYTLRQELTKQLVANGIDIMTNENPSKIELNPDGSKHVTFESGKTLDVDVVMMAIGRLPRTGYLQLQTVGVNLTDKGAIQVDEFSRTNVPNIY--AIGDVTGRIMLTPVAINEGASVVDTIFGSKPRKTDHTRVASAVFSIPPIGTCGLTEEEAAKSFE-KVAVYLSCFTPLMHNISGSKYKKFVAKIITDHGDGTVVGVHLLGDSSPEIIQAVGICMKLNAKISDFYNTIGVHPTSAEELCSMRTPSHYYI------KGEKMETLPDSSL P28593 ------------------------------------------------------------------------------MMS----KIFDLVVIGAGSGGLEAAWNAATLYKKRVAVIDVQMVHG-PPFFSALGGTCVNVGCVPKKLMVTGAQYMEHLRESAGFGWEFDRTTLRAEWKKLIAVKDEAVLNINKSYEEMFRDTEGLEFFLGWGSLESKN--VVNVRESADPAS-AVKERLETE-NILLASGSWP-HMPNIPGIEHCISSNEAFYLPEPPRRVLTVGGGFISVEFAGIFNAYKPKDGQVTLCYRGEMILRGFDHTLREELTKQLTANGIQILTKENPAKVELNADGSKSVTFESGKKMDFDLVMMAIGRSPRTKDLQLQNAGVMIK-NGGVQVDEYSRTNVSNIY--AIGDVTNRVMLTPVAINEAAALVDTVFGTNPRKTDHTRVASAVFSIPPIGTCGLIEEVASKRYE-VVAVYLSSFTPLMHNISGSKYKTFVAKIITNHSDGTVLGVHLLGDNAPEIIQGVGICLKLNAKISDFYNTIGVHPTSAEELCSMRTPSYYYV------KGEKMEKPSEASL AAK71226 -----------------------------------------------------------------------------------------------------------TLYKKRVAVIDVQMVHG-PPFFSALGGTCVNVGCVPKKLMVTGAQYMEHLRESAGFGWEFDRTTLRAEWKKLIASKDEAVLNINKSYEEMFRDTEGLEFFMGWGSLESKN--VVNVRESAEPDS-AVKERLETE-HILLASGSWP-HMPNIPGIEHCISSNEAFYLPEPPRRVLTVGGGFISVEFAGIFNAYKPKDGQVTLCYRGEMILRGFDHTVREELTKQLTANGIQILTKDNPAKVELNADGSKSVTFESGKKMDFDLVMMAIGRSPRTKDLQLQNAGVMIK-NSGVQVDEYSRTNVPNIY--AIGDVTNRVMLTPVAINEAAALVDTVFGTTPRKTDHTRVASAVFSIPPIGTCGLIEEVASKRYE-VVAVYLSSFTPLMHKISGSNYKTFVAKIITNHSDGTVLGVHLLGDNAPEIIQGVGVCLKLNAKISDFY------------------------------------------- P48642 ------------------------------------------------------------MARKMLKDEEVEVAVTDGGS-----YDYDLFVIGAGSGGVRGSR-TSASFGAKVAICELPFHPISSDWQGGHGGTCVIRGCVPKKILVYGSSFRGEFEDAKNFGWEING-DINFNWKRLLENKTQEIVRLNGVYQRILGNSG-VTMIEGAGSLVDAH--TVEVTK-PDGSK-----QRYTAKHILIATGSRA-QRVNIPGKELAITSDEALSLEELPKRAVILGGGYIAVEFASIWKG---MGAHVDLFYRKELPLRGFDDEMRTVVASNLEGRGIRLHPGTNLSELSKTADG-IKVVTDKGEEIIADVVLFATGRTPNSQRLNLEAAGVEVDNIGAIKVDDYSRTSVPNIW--AVGDVTNRINLTPVALMEATCFSKTVFGGQPTKPDYRDVPCAVFSIPPLSVVGLSEQQALEEAKSDVLVYTSSFNPMKNSISKRQEKTVMKLVVDSETD-KVLGASMCGPDAPEIIQGMAVALKCGATKATFDSTVGIHPSAAEEFVTMRTLTR---------RVSPSSKPK-TNL AAK96868 MASTPKLTSTISSSSPSLQFLCKKLPIAIHLPSSSSSSFLSLPKTLTSLYSLRPRIALLSNHRYYHSRRFSVCASTDNGAESDRHYDFDLFTIGAGSGGVRASR-FATSFGASAAVCELPFSTISSDTAGGVGGTCVLRGCVPKKLLVYASKYSHEFEDSHGFGWKYET-EPSHDWTTLIANKNAELQRLTGIYKNILSKAN-VKLIEGRGKVIDPH--TVDV----DG-------KIYTTRNILIAVGGRP-FIPDIPGKEFAIDSDAALDLPSKPKKIAIVGGGYIALEFAGIFNG---LNCEVHVFIRQKKVLRGFDEDVRDFVGEQMSLRGIEFHTEESPEAIIKAGDGSFSLKTSKGTVEGFSHVMFATGRKPNTKNLGLENVGVKMAKNGAIEVDEYSQTSVPSIW--AVGDVTDRINLTPVALMEGGALAKTLFQNEPTKPDYRAVPCAVFSQPPIGTVGLTEEQAIEQYG-DVDVYTSSFRPLKATLSGLPDRVFMKLIVCANTN-KVLGVHMCGEDSPEIIQGFGVAVKAGLTKADFDATVGVHPTAAEEFVTMRAPTRKFRKDSSEGKASPEAKTA-AGV QUARTET PUZZLING TREE :---P28593 :100: : :---AAK71226 :100: : : :---P39051 : :-88: :100: :---P13110 : : : : :---CAC94295 : : :100: : :-64: :---CAB89598 : : : :-------P39040 : :---------------P48642 : :---------------AAK96868