Figure 1.

Multiple-point mutation model. A (reference) input DNA sequence, g_i,0, encodes an amino acid sequence, Ag_i,0, at generation '0'. Random selection and mutation of nucleotides generate a new sequence, g_i,1, at generation '1', which encodes a mutated amino acid sequence, Ag_i,1. The variability of a gene i, g_i,j, at generation j, is estimated by measuring the difference between Ag_i,0 and Ag_i,j.