|
IC50 values of iron chelators for bloodstream forms of T. brucei 427-221a and T. congolense STIB910, and for human myeloid leukaemia HL-60 cells, and IC50 ratios of cytotoxic to trypanocidal activities of the chelators. |
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| Compound |
IC50 (μM) |
IC50 ratio |
|||
|
|
|
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| T. brucei |
T. congolense |
HL-60 cells |
T. brucei/HL-60 |
T. congolense/HL-60 |
|
|
|
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| Deferoxamine |
3.3 |
3.4 |
97.0 |
29.4 |
28.5 |
| 2,3-Dihydroxybenzoic acid |
220 |
n.d.† |
n.d |
n.d. |
n.d |
| Ethylenediamine-di-o-hydroxyphenylacetic acid |
120 |
n.d. |
325 |
2.7 |
n.d. |
| 5-Sulfosalicylic acid |
>1000 * |
>1000 * |
>1000 * |
1 |
1 |
| Tropolone |
12.5 |
18.7 |
6.2 |
0.5 |
0.3 |
| 5-Methyl-tropolone |
15.7 |
20.0 |
31.1 |
2.0 |
1.6 |
| 2,2'-Bipyridine |
46.2 |
67.0 |
28.3 |
0.6 |
0.4 |
| 2,4,6-Tris(2-pyridyl)-1,3,5-triazine |
28.6 |
75.0 |
90.1 |
3.2 |
1.2 |
| 1,10-Phenanthroline |
3.3 |
5.3 |
8.5 |
2.6 |
1.6 |
| 4,7-Diphenyl-1,10-phenanthroline |
2.0 |
4.5 |
48.3 |
24.2 |
10.7 |
| Bathocuproine‡ |
3.0 |
>10 * |
>10 * |
>3.3 |
1 |
| 8-Hydroxyquinoline |
2.1 |
206 |
7.7 |
3.7 |
0.03 |
| Dimethylglyoxime |
>100 * |
>100 * |
>100 * |
1 |
1 |
| Quercetin |
16.3 |
62.6 |
>100 * |
>6.1 |
>1.6 |
|
*The highest concentration tested. †n.d., not determined. ‡Cu1+ chelator. | |||||
Merschjohann and Steverding Kinetoplastid Biology and Disease 2006 5:3 doi:10.1186/1475-9292-5-3 |
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