Table 1 |
||||
|
Genes associated to drug resistance in Leishmania |
||||
|
Species |
Gene |
Resistance to |
Cross resistance |
Reference |
|
|
||||
|
L. amazonensis |
lamdr |
vinblastine |
adriamycin |
[73] |
|
vinblastine |
||||
|
doxorubicin |
[39] |
|||
|
actinomycin-D |
||||
|
KDNA |
pentamidine |
[64] |
||
|
ribonucleotide |
||||
|
reductase |
hydroxyurea |
[74] |
||
|
gene |
||||
|
NAGT |
tunicamycin |
[51] |
||
|
L. donovani |
ldNTt1.1 |
tubericidin |
[41] |
|
|
ldmdr1 |
vinblastine |
puromycin |
||
|
anthracyclins |
||||
|
methotrexate |
[43] |
|||
|
IMPDH |
mycophenolic acid |
[53] |
||
|
L. enriettii |
lemdr |
vinblastine |
puromycin |
[37] |
|
L. infantum |
H-circle |
methotrexate |
[75] |
|
|
L. major |
H-circle |
primaquine |
methotrexate |
[28] |
|
terbinafine |
||||
|
SQS1 |
terbinafine |
|||
|
SQS1 |
itraconazole |
|||
|
TOR |
tubericidin |
|||
|
TUB2 |
tubericidin |
|||
|
DHFR-TS |
antifolates |
|||
|
PTR1 |
antifolates |
|||
|
L. tarentolae |
H-circle |
methotrexate |
||
|
ltpgpA-E |
vinblastine |
|||
|
arsenite |
||||
|
antimoniates |
||||
|
gsh |
arsenite |
[57] |
||
|
Cyb |
antimycin-A |
[70] |
||
|
DHFR-TS |
folates |
|||
|
Ltdth |
methotrexate |
|||
|
PTR1 |
||||
|
L. tropica |
ltpgpE |
methotrexate |
[76] |
|
|
ltmdr |
daunomycin |
[38] |
||
|
|
||||
|
Ponte-Sucre Kinetoplastid Biology and Disease 2003 2:14 doi:10.1186/1475-9292-2-14 |
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