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Plant-like enzymes and enzymes of possible cyanobacterial origin in Trypanosomatidae |
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| Enzyme |
Function in algae and plants |
Location in alga or plants (Plastid or Cytosol)* |
Function in trypano-somatid |
Glycosomal location in trypanosomatid |
Refs |
|
|
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| Sedoheptulose-1,7-bisphosphatase (SBPase) |
Calvin cycle |
P |
PPP? |
+ |
|
| Glucose-6-phosphate dehydrogenase (G6PDH) |
PPP |
C |
PPP |
+ |
74 |
| 6-Phosphogluconolactonase (6PGL) |
PPP |
P |
PPP |
+ |
74 |
| 6-phosphogluconate dehydrogenase (6PGDH) |
PPP |
P |
PPP |
156 |
|
| Fructose-1,6-bisphosphate aldolase (ALD) |
Calvin cycle |
P |
glycolysis |
+ |
157, 158 |
| Glyceraldehydephosphate dehydrogenase (GAPDH) |
Calvin cycle |
C |
glycolysis |
+ |
134, 159 |
| Phosphoglycerate kinase (PGK) |
Calvin cycle |
P |
glycolysis |
+ |
38 |
| Phosphoglycerate mutase (PGAM) |
glycolysis |
C |
glycolysis |
41 |
|
| α-Hydroxyacid dehydrogenase (AHADH) |
glyoxylate cycle |
C |
aromatic amino-acid metabolism |
160 |
|
| Glycerol-3-phosphate dehydrogenase (G3PDH) |
glycerol metabolism |
P |
glycerol metabolism |
+ |
161 |
| Alternative oxidase (AOX) |
respiration |
mitochondrion |
respiration |
162 |
|
| Aconitase |
Krebs' cycle |
C and mitochon-drion |
Krebs' cycle |
23 |
|
| Vacuolar-H+-pyrophosphatase (V-H+-PPase) |
H+ pump |
vacuole |
H+ pump |
163 |
|
| ω-6-Fatty-acid desaturase |
fatty-acid synthesis |
ER? |
fatty-acid synthesis |
164 |
|
| Superoxide dismutase (SOD) |
ROS protection |
P |
ROS protection |
+ |
|
| Acyl carrier protein (ACP) |
fatty-acid synthesis |
P |
fatty-acid synthesis |
165, 166 |
|
| Adenylate kinase (ADK) |
energy balance |
P |
energy balance |
+ |
|
|
*Several enzymes, while of plastid or cyanobacterial origin, are found in the plant or algal cytosol. For example, the glycosomal trypanosomatid GAPDH and its cytosolic counterpart from Euglena gracilis are close relatives of the GAPDH isoenzyme 1 from cyanobacteria [134]. Interestingly, this isoenzyme is clearly distinct form the plastid GAPDH of plants, which has been derived from the cyanobacterial isoenzyme 3 [59]. Modified from [22]. Abbreviations: PPP, pentosephosphate pathway; ER, endoplasmic reticulum; ROS, reactive oxygen species. Supplementary material is available at: http://www.icp.ucl.ac.be/~opperd/Supplementary/table.html | |||||
Hannaert et al. Kinetoplastid Biology and Disease 2003 2:11 doi:10.1186/1475-9292-2-11 |
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